Standard name | |
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Human Ortholog | |
Description | Protein involved in cytochrome c oxidase (Complex IV) assembly; involved in delivery of copper to Complex IV; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; ortholog implicated in cardiac defects in zebrafish and human; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 1 | 0 | 0 | 0 | 0 | – | 10 | 7 | 7 | 6 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
Bud | 1 | 0 | 4 | 3 | 5 | 1 | – | 7 | 6 | 12 | 8 | 15 | 2 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 3 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 1 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 6 | 10 | 1 | 5 | 10 | 11 | – | 25 | 33 | 39 | 21 | 50 | 3 | 7 | 6 | 3 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 393 | 331 | 128 | 232 | 407 | 451 | – | 399 | 400 | 351 | 304 | 342 | 242 | 380 | 420 | 40 | 25 | 26 | 394 | 320 | 124 | 82 | 274 | 307 |
Endoplasmic Reticulum | 1 | 7 | 1 | 3 | 10 | 19 | – | 17 | 3 | 18 | 7 | 20 | 1 | 0 | 4 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 2 | 2 |
Endosome | 0 | 0 | 0 | 0 | 1 | 0 | – | 0 | 3 | 7 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 1 | 3 | 2 | 1 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 4 | 2 |
Mitochondria | 2 | 0 | 3 | 6 | 4 | 28 | – | 50 | 158 | 101 | 150 | 209 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Nucleus | 14 | 3 | 2 | 0 | 2 | 2 | – | 9 | 6 | 13 | 6 | 7 | 2 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Nuclear Periphery | 0 | 1 | 0 | 1 | 0 | 0 | – | 2 | 3 | 1 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 1 | 0 | 0 | 0 | 11 | 16 | – | 35 | 55 | 25 | 15 | 13 | 0 | 1 | 2 | 0 | 2 | 1 | 5 | 3 | 0 | 0 | 4 | 6 |
Unique Cell Count | 404 | 339 | 130 | 236 | 426 | 500 | 498 | 561 | 496 | 427 | 542 | 245 | 381 | 426 | 40 | 27 | 28 | 408 | 342 | 130 | 90 | 297 | 333 | |
Labelled Cell Count | 418 | 353 | 139 | 250 | 450 | 528 | 556 | 678 | 576 | 520 | 676 | 251 | 388 | 436 | 45 | 28 | 32 | 408 | 342 | 130 | 90 | 297 | 333 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 9.4 | 11.4 | 6.0 | 7.4 | 8.1 | 7.0 | – | 6.7 | 6.0 | 6.7 | 5.9 | 5.6 | 10.0 | 10.8 | 10.3 | 13.3 | 13.8 | 14.0 | 8.6 | 10.2 | 10.1 |
Std Deviation (1e-4) | 1.4 | 1.6 | 1.0 | 1.0 | 1.5 | 1.2 | – | 1.3 | 1.2 | 7.4 | 1.3 | 1.2 | 1.6 | 1.6 | 1.4 | 4.0 | 2.3 | 3.5 | 1.2 | 1.6 | 1.8 |
Intensity Change (Log2) | – | – | – | 0.3 | 0.43 | 0.22 | – | 0.16 | -0.0 | 0.15 | -0.02 | -0.1 | 0.74 | 0.85 | 0.77 | 1.14 | 1.2 | 1.22 | 0.52 | 0.76 | 0.75 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | – | 2.2 | 2.4 | 2.9 | 2.1 | 3.3 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -0.1 | -1.5 | -3.1 | – | -5.1 | -6.6 | -6.6 | -6.5 | -7.9 | 0.3 | 1.6 | 0.1 | 0.8 | -1.8 | -1.7 |
Endoplasmic Reticulum | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 1.5 | – | 2.8 | 6.3 | 4.9 | 7.3 | 8.0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | – | 3.1 | 3.7 | 2.6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 4.1086 | 5.6592 | 4.6725 | 4.9164 | 4.4868 | 5.5769 | 4.8423 | 5.8067 | 4.9127 | 3.9713 | 4.5696 | 5.1445 | 6.5334 | 8.0543 | 7.3297 | 6.4975 | 6.5231 | 6.8554 |
Actin | 0.0549 | 0.0009 | 0.0765 | 0.1975 | 0.018 | 0.0009 | 0.0085 | 0.0043 | 0.0291 | 0.0153 | 0.0013 | 0.0087 | 0.0285 | 0.001 | 0.0124 | 0.0009 | 0.0303 | 0.0013 |
Bud | 0.0029 | 0.0001 | 0.002 | 0.0008 | 0.0005 | 0 | 0.0004 | 0.0002 | 0.0011 | 0.0013 | 0.0004 | 0.0002 | 0.0006 | 0.0001 | 0.0008 | 0.0006 | 0.0002 | 0 |
Bud Neck | 0.0053 | 0.0004 | 0.0039 | 0.0038 | 0.0038 | 0.0013 | 0.0014 | 0.0004 | 0.0024 | 0.0043 | 0.0026 | 0.0031 | 0.0005 | 0.0002 | 0.0015 | 0.0009 | 0.0011 | 0.0026 |
Bud Periphery | 0.0062 | 0.0001 | 0.0019 | 0.0007 | 0.0004 | 0 | 0.0005 | 0.0001 | 0.0011 | 0.0015 | 0.0006 | 0.0002 | 0.0009 | 0.0001 | 0.0007 | 0.0003 | 0.0003 | 0 |
Bud Site | 0.0133 | 0.0011 | 0.0124 | 0.0022 | 0.0093 | 0 | 0.003 | 0.0012 | 0.0073 | 0.0015 | 0.0029 | 0.0007 | 0.0009 | 0.0006 | 0.002 | 0.001 | 0.0008 | 0.0001 |
Cell Periphery | 0.0006 | 0.0002 | 0.0005 | 0.0002 | 0.0002 | 0.0001 | 0.0003 | 0.0002 | 0.0003 | 0.0003 | 0.0004 | 0.0001 | 0.0002 | 0.0002 | 0.0001 | 0 | 0.0001 | 0 |
Cytoplasm | 0.6531 | 0.9652 | 0.7086 | 0.7425 | 0.7351 | 0.9268 | 0.8368 | 0.9776 | 0.8574 | 0.8111 | 0.9098 | 0.9007 | 0.8436 | 0.9799 | 0.9133 | 0.93 | 0.7824 | 0.9677 |
Cytoplasmic Foci | 0.0452 | 0.0015 | 0.0491 | 0.0053 | 0.0424 | 0.0024 | 0.0177 | 0.0025 | 0.0224 | 0.0189 | 0.0045 | 0.0167 | 0.0065 | 0.0018 | 0.0227 | 0.0079 | 0.0247 | 0.009 |
Eisosomes | 0.0004 | 0 | 0.0005 | 0.0003 | 0.0002 | 0 | 0.0001 | 0 | 0.0002 | 0 | 0 | 0 | 0.0004 | 0 | 0.0001 | 0 | 0.0003 | 0 |
Endoplasmic Reticulum | 0.0314 | 0.001 | 0.0021 | 0.0022 | 0.0038 | 0.0025 | 0.006 | 0.0022 | 0.0039 | 0.0146 | 0.0026 | 0.0041 | 0.0056 | 0.0013 | 0.0013 | 0.0029 | 0.0005 | 0.0016 |
Endosome | 0.042 | 0.001 | 0.0486 | 0.0069 | 0.0038 | 0.0108 | 0.0224 | 0.0007 | 0.017 | 0.0847 | 0.0286 | 0.0278 | 0.0088 | 0.0004 | 0.0071 | 0.0174 | 0.0145 | 0.0018 |
Golgi | 0.0149 | 0.0018 | 0.0233 | 0.0251 | 0.0065 | 0.03 | 0.0135 | 0.0005 | 0.0162 | 0.0244 | 0.012 | 0.0111 | 0.0094 | 0.0001 | 0.0095 | 0.0014 | 0.0242 | 0.0022 |
Lipid Particles | 0.0139 | 0.0009 | 0.009 | 0.0022 | 0.0206 | 0.0001 | 0.0168 | 0.0001 | 0.0029 | 0.0017 | 0.0019 | 0.0029 | 0.0173 | 0 | 0.0098 | 0.0002 | 0.0323 | 0.0015 |
Mitochondria | 0.0058 | 0.0136 | 0.0178 | 0.0027 | 0.0126 | 0.0152 | 0.0097 | 0.0001 | 0.0132 | 0.0044 | 0.0131 | 0.0028 | 0.011 | 0 | 0.0068 | 0.0016 | 0.0222 | 0.0002 |
None | 0.0735 | 0.0064 | 0.0219 | 0.0029 | 0.0013 | 0.008 | 0.0361 | 0.0078 | 0.0088 | 0.0013 | 0.0052 | 0.0028 | 0.0309 | 0.0123 | 0.0029 | 0.0248 | 0.0008 | 0.0012 |
Nuclear Periphery | 0.0091 | 0.0004 | 0.0009 | 0.0008 | 0.0005 | 0.0002 | 0.0087 | 0.0003 | 0.0033 | 0.004 | 0.0006 | 0.0049 | 0.0174 | 0.0003 | 0.0004 | 0.0022 | 0.0002 | 0.0003 |
Nucleolus | 0.0011 | 0 | 0.0005 | 0 | 0.0003 | 0 | 0.0027 | 0 | 0.0002 | 0.0001 | 0.0004 | 0.0002 | 0.0002 | 0 | 0 | 0.0001 | 0.0001 | 0 |
Nucleus | 0.0032 | 0.0028 | 0.0024 | 0.0012 | 0.0008 | 0.0008 | 0.0058 | 0.0014 | 0.0027 | 0.0024 | 0.0016 | 0.0077 | 0.0064 | 0.0011 | 0.0015 | 0.0038 | 0.0008 | 0.0017 |
Peroxisomes | 0.0079 | 0.0022 | 0.0125 | 0.0017 | 0.1389 | 0.0001 | 0.0019 | 0.0001 | 0.0038 | 0.0012 | 0.0005 | 0.0005 | 0.007 | 0 | 0.0042 | 0.0008 | 0.0617 | 0.0083 |
Punctate Nuclear | 0.0099 | 0.0002 | 0.0022 | 0.0005 | 0.0006 | 0.0001 | 0.0037 | 0.0003 | 0.0045 | 0.0005 | 0.0002 | 0.0023 | 0.0019 | 0.0003 | 0.0024 | 0.0007 | 0.0018 | 0.0003 |
Vacuole | 0.004 | 0.0003 | 0.0028 | 0.0002 | 0.0004 | 0.0003 | 0.0026 | 0.0001 | 0.0014 | 0.0038 | 0.0088 | 0.0019 | 0.0007 | 0.0002 | 0.0003 | 0.002 | 0.0004 | 0.0002 |
Vacuole Periphery | 0.0016 | 0.0001 | 0.0007 | 0.0002 | 0.0001 | 0.0003 | 0.0015 | 0 | 0.0006 | 0.0028 | 0.002 | 0.0007 | 0.0013 | 0 | 0.0001 | 0.0006 | 0.0003 | 0 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 10.5086 | 25.0508 | 16.2652 | 22.8159 | 22.7081 | 24.5065 | 25.3289 | 35.259 | 25.6553 | 31.8453 |
Translational Efficiency | 4.0136 | 1.5805 | 1.7141 | 1.843 | 1.968 | 2.1681 | 1.9153 | 1.3492 | 2.7539 | 1.6734 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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