Standard name
Human Ortholog
Description Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0.05 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0.05 0.06 0.07 0.08 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 – 0 0 0 0 0 0.1 0.13 0.19 0.05 0.09 0.06 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0.09 0.05 – 0.06 0 0 0 0 0 0.07 0.11 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.05 0 0.11 0.09 0.05 0.14 – 0.08 0.18 0.18 0.22 0.21 0 0 0 0 0.14 0.07 0 0 0 0 0 0
Nucleus 0.17 0.28 0.16 0.08 0.07 0.07 – 0.06 0.05 0.06 0.07 0.07 0.11 0.07 0.05 0.09 0.19 0.09 0.16 0.16 0.06 0.05 0.06 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.86 0.83 0.93 0.86 0.8 0.79 – 0.78 0.75 0.72 0.75 0.75 0.83 0.79 0.76 0.88 0.75 0.82 0.69 0.7 0.59 0.61 0.57 0.56
Peroxisomes 0 0 0 0.05 0 0 – 0.06 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0.15 0.15 0.25 0.37 0.46 0.45 – 0.5 0.48 0.5 0.44 0.51 0.24 0.31 0.33 0.18 0.09 0.23 0.11 0.07 0.26 0.24 0.22 0.28
Vac/Vac Membrane 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud 0 0 2 5 3 8 – 12 11 21 20 7 0 0 0 0 1 1 0 2 3 3 4 7
Bud Neck 5 0 21 14 18 10 – 10 13 26 11 13 9 9 4 1 0 2 0 3 4 0 4 1
Bud Site 1 0 7 6 8 18 – 19 29 45 44 56 1 1 0 1 3 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 4 0 2 8 17 21 – 20 5 17 4 4 26 46 63 6 14 10 0 0 0 3 2 3
Endoplasmic Reticulum 0 0 1 1 0 1 – 0 0 0 0 0 0 0 0 0 2 2 0 0 0 1 3 0
Endosome 1 0 1 4 43 30 – 47 14 25 19 15 10 25 36 0 3 7 1 2 10 4 10 13
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Mitochondria 9 4 49 32 25 88 – 65 103 141 133 153 3 3 3 3 22 12 1 0 1 0 1 1
Nucleus 29 58 69 26 34 44 – 48 30 51 44 50 31 27 18 11 30 16 26 36 28 9 19 8
Nuclear Periphery 0 2 2 1 1 2 – 5 3 1 4 1 0 0 0 0 0 1 0 0 0 0 1 2
Nucleolus 144 172 405 297 366 494 – 607 420 575 462 546 225 286 257 109 119 141 115 160 258 119 179 177
Peroxisomes 0 2 3 19 18 27 – 49 30 23 21 28 2 4 2 1 0 2 0 0 1 0 1 1
SpindlePole 25 32 109 128 211 283 – 391 270 398 272 370 65 112 110 22 14 39 17 16 115 47 68 89
Vac/Vac Membrane 0 1 0 2 3 2 – 3 1 0 0 1 2 0 0 0 2 2 1 2 5 3 5 4
Unique Cell Count 168 207 434 346 458 629 779 558 803 614 727 270 360 336 124 159 173 168 229 435 198 315 319
Labelled Cell Count 218 271 671 543 747 1028 1277 929 1323 1034 1244 374 513 493 154 210 235 168 229 435 198 315 319


Nucleolus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.3 10.6 6.3 7.2 6.7 5.4 – 5.7 4.9 5.0 5.0 5.0 8.2 8.4 8.1 13.1 11.4 12.4 11.0 10.1 9.9
Std Deviation (1e-4) 1.8 2.4 1.7 2.6 1.8 1.7 – 1.9 1.6 1.5 1.4 1.5 2.3 2.3 2.6 4.2 4.0 4.0 5.7 2.6 2.5
Intensity Change (Log2) – – – 0.19 0.1 -0.21 – -0.14 -0.37 -0.33 -0.34 -0.33 0.38 0.41 0.37 1.06 0.86 0.98 0.8 0.68 0.66

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 – 1.7 0 2.7 3.1 0 0 0 0 0 0 0
Bud Neck -0.5 -0.7 -3.1 – -3.8 0 -1.4 -2.8 -3.0 -1.0 -1.7 -2.8 0 -2.8 -2.1
Bud Site 0.1 0.2 1.3 – 1.0 0 3.3 4.1 4.4 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 3.4 3.2 – 2.6 0 2.3 0 0 6.1 7.2 9.1 0 0 0
Endoplasmic Reticulum 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 6.3 4.3 – 5.0 0 3.4 3.3 2.6 0 5.3 6.7 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria -0.9 -3.2 1.3 – -1.7 0 2.9 4.4 4.2 -5.0 -5.9 -5.7 -3.0 0.8 -1.6
Nucleus -3.6 -4.0 -4.6 – -5.5 -5.5 -5.4 -4.5 -4.9 -1.6 -3.6 -4.6 -2.0 0.9 -2.1
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus -3.5 -5.8 -6.6 – -6.9 0 -9.0 -7.6 -7.8 -4.2 -5.8 -6.7 -2.0 -6.2 -4.4
Peroxisomes 4.0 3.2 3.5 – 4.6 0 2.5 2.9 3.2 0 0 0 0 0 0
SpindlePole 3.6 6.5 6.6 – 8.5 0 8.3 6.4 8.6 -0.3 1.9 2.3 -1.7 -4.3 -0.7
Vacuole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.77 4.5977 3.9915 3.5625 3.5682 3.638 2.9947 3.6514 3.0577 2.9128 2.8593 3.0455 5.169 5.8635 5.3698 5.1451 4.6019 5.3393
Actin 0.0032 0 0.0004 0.0001 0.0007 0.0002 0.006 0 0.0015 0.0019 0.029 0.004 0.0168 0 0.005 0.0002 0 0.0047
Bud 0.0001 0.0001 0.0001 0 0.0001 0.0001 0.0004 0 0.0001 0.0006 0.0003 0 0.0003 0 0.0012 0.0001 0.0001 0
Bud Neck 0.0014 0.0003 0.0007 0.0004 0.0005 0.0006 0.007 0.0016 0.0004 0.0021 0.0047 0.0006 0.0011 0.0006 0.0006 0.0025 0.0004 0.0007
Bud Periphery 0.0001 0.0002 0.0001 0 0.0003 0.0002 0.0008 0 0.0002 0.0007 0.0007 0.0001 0.0004 0.0001 0.001 0.0002 0.0001 0.0001
Bud Site 0.0045 0.0004 0.0015 0.0001 0.0004 0.0002 0.0047 0.0003 0.0019 0.0021 0.001 0.0002 0.0015 0.0003 0.0064 0.0007 0.0002 0.0002
Cell Periphery 0.0002 0.0001 0.0002 0 0.0001 0.0001 0.0005 0.0003 0.0002 0.0003 0.0008 0.0001 0.0003 0.0001 0.0002 0.0003 0.0001 0.0001
Cytoplasm 0.0009 0.0001 0.0009 0 0.0001 0.0001 0.0016 0 0.0005 0.0004 0.0009 0.0001 0.0016 0 0.001 0.0012 0 0.0001
Cytoplasmic Foci 0.0249 0.0005 0.0027 0.0022 0.0176 0.0069 0.0305 0.0009 0.0067 0.0106 0.0211 0.004 0.0328 0.0043 0.0045 0.0075 0.0014 0.0019
Eisosomes 0.0001 0 0 0 0.0001 0 0.0002 0 0 0 0.0006 0 0.0002 0 0 0 0 0
Endoplasmic Reticulum 0.0004 0.0001 0.0005 0 0.0002 0.0002 0.0019 0 0.001 0.0001 0.0004 0.0002 0.0013 0 0.0006 0.0013 0 0.0004
Endosome 0.0123 0.0009 0.005 0.0057 0.0041 0.0062 0.0167 0.0003 0.0075 0.0169 0.0236 0.0013 0.0143 0.0004 0.0036 0.0288 0.0001 0.0021
Golgi 0.0053 0.0001 0.0013 0.0091 0.004 0.0032 0.0034 0.0001 0.0023 0.0086 0.0148 0.0011 0.0093 0.0001 0.001 0.0021 0.0001 0.001
Lipid Particles 0.0279 0.0033 0.0117 0.0199 0.0593 0.0131 0.0313 0.0025 0.0266 0.0241 0.0703 0.0142 0.0354 0.0048 0.0026 0.028 0.0019 0.0062
Mitochondria 0.0049 0.0003 0.0107 0.0035 0.0742 0.0032 0.0113 0 0.0075 0.0133 0.0183 0.0028 0.0021 0.0001 0.0011 0.0007 0.0006 0.0007
None 0.0008 0.0001 0.0004 0 0.0002 0.0001 0.0025 0 0.0002 0.0002 0.0172 0.0001 0.0032 0 0.0003 0.0004 0 0.0002
Nuclear Periphery 0.005 0.0029 0.0061 0.0006 0.0026 0.001 0.0144 0.0002 0.0029 0.0001 0.0057 0.0049 0.002 0 0.0076 0.0028 0.0002 0.0026
Nucleolus 0.7831 0.8979 0.8612 0.848 0.7313 0.8334 0.7399 0.878 0.8434 0.8008 0.5687 0.8294 0.7461 0.8578 0.8769 0.7375 0.7297 0.8325
Nucleus 0.0675 0.0841 0.0784 0.0786 0.0536 0.0577 0.059 0.0969 0.0762 0.1062 0.0506 0.0556 0.0682 0.1002 0.0735 0.1306 0.0714 0.0564
Peroxisomes 0.0136 0 0.0011 0.0006 0.0038 0.0011 0.0064 0.0001 0.0056 0.0033 0.0103 0.0011 0.0122 0.0002 0.0024 0.0009 0.0001 0.0003
Punctate Nuclear 0.042 0.0052 0.0143 0.0304 0.0447 0.0702 0.0531 0.017 0.0121 0.0044 0.1486 0.0797 0.0495 0.0303 0.0094 0.0517 0.1931 0.0894
Vacuole 0.0016 0.0024 0.0016 0.0002 0.0008 0.0009 0.0055 0.0016 0.0021 0.0022 0.0073 0.0003 0.001 0.0005 0.0009 0.002 0.0003 0.0002
Vacuole Periphery 0.0005 0.001 0.0011 0.0004 0.0014 0.0014 0.0028 0.0002 0.0008 0.0009 0.005 0.0003 0.0005 0.0001 0.0004 0.0007 0.0001 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 8.6746 10.8563 5.7542 6.8581 8.9976 1.734 4.3123 7.9378 4.6959 5.2575
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2035 1896 1157 82 384 1396 433 1783 2419 3292 1590 1865

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 906.82 990.96 1129.56 1232.95 769.35 989.47 1123.78 1161.72 885.00 990.33 1127.99 1164.85
Standard Deviation 344.47 178.14 162.42 231.58 126.83 167.67 157.96 213.18 323.88 173.78 161.24 214.52
Intensity Change Log 2 — 0.128011 0.316873 0.443226 — 0.363016 0.546648 0.594550 — 0.240645 0.426897 0.514658

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000200 0.000235 0.000349 0.000670 0.000376 0.000309 0.000347 0.000429 0.000228 0.000266 0.000348 0.000439
Bud Neck 0.002642 0.002641 0.004280 0.012242 0.002938 0.004975 0.003994 0.013285 0.002689 0.003631 0.004202 0.013239
Bud Site 0.000827 0.000586 0.000990 0.005993 0.000615 0.001447 0.000790 0.003057 0.000793 0.000951 0.000936 0.003186
Cell Periphery 0.000051 0.000030 0.000024 0.000372 0.000052 0.000075 0.000032 0.000101 0.000051 0.000049 0.000026 0.000113
Cytoplasm 0.000694 0.000644 0.000162 0.000656 0.000241 0.001213 0.001418 0.001571 0.000622 0.000885 0.000504 0.001531
Cytoplasmic Foci 0.001179 0.001958 0.000855 0.007243 0.001408 0.002102 0.000800 0.003589 0.001215 0.002019 0.000840 0.003750
Eisosomes 0.000164 0.000155 0.000085 0.000101 0.000153 0.000404 0.000086 0.000137 0.000162 0.000260 0.000085 0.000135
Endoplasmic Reticulum 0.001018 0.000907 0.000664 0.001379 0.002574 0.001667 0.001612 0.000563 0.001265 0.001229 0.000922 0.000599
Endosome 0.000518 0.001185 0.000167 0.007784 0.001144 0.002507 0.000348 0.001753 0.000617 0.001746 0.000216 0.002018
Golgi 0.000761 0.000821 0.000735 0.001507 0.001494 0.001362 0.000616 0.001609 0.000877 0.001050 0.000703 0.001604
Lipid Particles 0.000272 0.000457 0.000081 0.000243 0.001062 0.000694 0.000369 0.000455 0.000398 0.000557 0.000160 0.000446
Mitochondria 0.000861 0.001081 0.000860 0.003208 0.000890 0.003253 0.001308 0.003703 0.000865 0.002002 0.000982 0.003681
Mitotic Spindle 0.012152 0.020711 0.068137 0.100684 0.058707 0.014668 0.049882 0.041899 0.019543 0.018148 0.063166 0.044484
None 0.001075 0.000734 0.000323 0.007158 0.001189 0.000631 0.000716 0.001296 0.001093 0.000690 0.000430 0.001553
Nuclear Periphery 0.000234 0.000459 0.000402 0.000543 0.000942 0.000423 0.000421 0.000927 0.000346 0.000444 0.000407 0.000910
Nuclear Periphery Foci 0.003646 0.005072 0.001535 0.000973 0.021302 0.004557 0.000814 0.001467 0.006449 0.004854 0.001339 0.001446
Nucleolus 0.684829 0.682045 0.701380 0.588867 0.660367 0.666233 0.725728 0.687574 0.680945 0.675340 0.708010 0.683234
Nucleus 0.271023 0.253423 0.189244 0.201383 0.203679 0.267426 0.182593 0.214587 0.260333 0.259361 0.187433 0.214006
Peroxisomes 0.016868 0.025374 0.028706 0.050384 0.037251 0.021191 0.026667 0.014874 0.020104 0.023600 0.028151 0.016436
Vacuole 0.000623 0.000731 0.000606 0.005742 0.001799 0.003444 0.000866 0.003660 0.000810 0.001882 0.000676 0.003751
Vacuole Periphery 0.000363 0.000754 0.000414 0.002867 0.001817 0.001418 0.000594 0.003464 0.000594 0.001036 0.000463 0.003438

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.62 -5.21 -5.28 -4.93 -2.93 0.95 0.01 -1.30 -3.54 -1.74 -1.66 -5.15 -8.13 -6.66 -1.87
Bud Neck 0.00 -6.57 -3.85 -3.85 -3.29 -2.98 -2.53 -14.07 -12.72 -11.77 -3.66 -7.10 -16.86 -15.64 -13.62
Bud Site 1.37 -2.17 -2.83 -2.95 -2.65 -1.65 -1.49 -8.81 -5.70 -7.77 -0.35 -2.27 -8.79 -8.65 -8.20
Cell Periphery 2.99 3.09 -1.10 -1.20 -1.21 -1.34 1.03 -4.06 -2.26 -5.34 0.42 3.00 -4.43 -4.73 -6.16
Cytoplasm 0.12 2.59 -0.04 -0.13 -1.58 -1.62 -1.20 -3.93 -0.85 -0.05 -0.74 -0.04 -2.89 -1.79 -2.25
Cytoplasmic Foci -1.31 0.29 -3.18 -2.87 -3.22 -0.54 1.40 -3.35 -3.18 -4.64 -1.80 0.79 -4.97 -3.66 -5.37
Eisosomes 1.17 13.89 4.57 3.71 -1.82 -7.19 8.68 1.69 7.55 -3.64 -6.31 15.70 2.52 6.86 -3.81
Endoplasmic Reticulum 1.50 1.84 -0.98 -1.18 -1.36 2.65 0.89 5.62 8.72 0.89 0.49 0.82 6.73 7.25 1.04
Endosome -1.51 3.09 -1.02 -0.89 -1.08 -1.81 1.50 -1.00 1.09 -3.23 -3.06 2.95 -2.93 -0.35 -3.87
Golgi -0.29 -0.70 -1.43 -1.33 -1.31 0.48 5.32 -0.14 -0.42 -2.14 -0.92 1.14 -1.63 -1.21 -1.91
Lipid Particles -0.85 1.20 0.10 1.07 -1.94 0.84 1.40 1.39 1.10 -0.23 -0.85 1.47 -0.17 0.65 -1.61
Mitochondria -1.36 -0.47 -1.97 -1.76 -1.93 -4.49 -2.12 -4.95 -0.74 -3.94 -4.78 -1.93 -5.32 -3.02 -4.99
Mitotic Spindle -3.48 -12.52 -3.27 -2.92 -0.71 6.31 0.91 2.01 -7.99 0.90 0.81 -11.36 -7.38 -7.94 4.12
None 1.31 5.09 -0.90 -0.97 -1.05 1.25 0.37 -0.30 -1.98 -0.66 2.13 3.03 -0.97 -1.97 -2.41
Nuclear Periphery -2.99 -4.33 -2.44 -1.14 -1.40 1.54 1.36 -0.19 -4.81 -4.14 -1.29 -1.39 -5.60 -4.95 -5.30
Nuclear Periphery Foci -1.84 4.76 5.89 5.38 2.44 5.74 7.04 6.81 5.77 -2.74 2.15 8.48 8.11 6.62 -0.21
Nucleolus 0.44 -0.73 3.52 3.43 3.66 -0.93 -4.37 -1.28 -0.51 3.89 0.92 -2.64 1.93 1.30 3.91
Nucleus 3.08 13.69 2.54 1.81 -0.85 -7.26 1.54 -1.85 7.04 -3.60 0.22 13.57 6.98 7.23 -5.18
Peroxisomes -7.46 -10.11 -4.73 -3.63 -2.94 6.85 3.95 9.53 4.65 6.24 -3.58 -7.96 2.57 6.32 10.19
Vacuole -0.62 -0.96 -2.00 -1.96 -1.95 -1.57 0.24 -2.25 -1.12 -3.20 -3.84 -0.63 -5.69 -3.94 -5.45
Vacuole Periphery -1.48 -1.84 -1.72 -1.40 -1.66 0.25 0.81 -1.06 -3.25 -4.87 -1.58 0.41 -4.76 -4.10 -5.33
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan
Localization
Cell Percentages nucleolus (94%)
Cell Cycle Regulation No
Subcompartmental Group nucleolus-2

Tma23

Tma23


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Tma23-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available