Standard name
Human Ortholog
Description Vacuolar carboxypeptidase Y (proteinase C, CPY); broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; involved, along with functional homolog Prc1p, in vacuolar zymogen activation, breakdown of the autophagic body, and autophagosome-dependent protein synthesis; role in phytochelatin synthesis; localizes to the vacuole lumen; member of the serine carboxypeptidase family; N-glycosylated
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.44 0.21 0.16 0.18 0.05 0.05 0.07 0.1 0.12 0.09 0.12 0.12 0.29 0.48 0.56 0.14 0.18 0.14 0.13 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.06 0.06 0 0.05 0 0.05 0.05 0 0.05 0.07 0.1
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.36 0.1 0.16 0.05 0.05 0.08 0.05 0 0.08 0.09 0.05 0.06 0 0 0 0.07 0 0.05 0 0 0 0 0 0
Nucleus 0.2 0.16 0.23 0.27 0.21 0.4 0.4 0.38 0.34 0.34 0.29 0.25 0.11 0.07 0.07 0.44 0.42 0.48 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.32 0.73 0.63 0.64 0.77 0.58 0.55 0.63 0.64 0.62 0.67 0.69 0.66 0.55 0.54 0.52 0.44 0.38 0.72 0.83 0.89 0.82 0.78 0.73
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 1
Bud 0 0 0 1 0 0 0 2 1 0 0 0 0 1 0 0 0 0 1 1 2 1 2 3
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 1 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 11 32 40 46 13 27 47 83 54 55 18 29 49 171 190 27 26 14 9 6 3 1 8 10
Endoplasmic Reticulum 0 0 2 0 0 0 1 2 0 2 0 1 1 1 0 5 9 2 2 0 0 0 1 1
Endosome 0 1 5 8 5 3 2 3 0 0 0 0 11 23 20 6 7 3 3 7 9 4 15 25
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1 0 1 4
Mitochondria 9 15 40 12 14 42 31 30 35 50 7 14 6 6 5 13 4 5 0 0 3 1 3 4
Nucleus 5 24 59 70 54 203 261 309 157 200 43 59 19 26 22 84 62 48 0 6 2 0 2 2
Nuclear Periphery 0 3 1 3 11 15 10 2 7 11 3 0 0 0 1 1 0 1 1 0 1 0 3 5
Nucleolus 0 0 0 2 10 10 17 6 3 6 3 2 1 0 0 4 1 1 0 1 0 0 2 1
Peroxisomes 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 1 1 1 1 1 0 0 0 0 3 1 3 1 1 0 0 1 0 0 0 3
Vac/Vac Membrane 8 109 163 166 202 299 360 516 291 359 100 163 113 196 183 100 64 38 54 132 261 70 180 192
Unique Cell Count 25 150 257 260 262 512 649 821 456 582 149 237 170 356 337 193 146 99 76 159 294 86 230 265
Labelled Cell Count 33 184 311 309 310 600 730 955 549 683 174 268 203 426 425 242 174 112 76 159 294 86 230 265


Vacuole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.3 6.0 5.4 6.3 11.9 12.8 12.7 13.9 13.5 12.9 12.6 12.6 5.4 5.1 5.2 9.0 10.1 12.0 4.9 5.8 6.5
Std Deviation (1e-4) 1.3 2.0 1.4 2.0 3.6 5.0 5.3 5.4 5.6 5.1 5.1 4.9 1.4 1.3 1.6 3.6 3.7 5.0 1.0 2.1 2.1
Intensity Change (Log2) – – – 0.22 1.14 1.25 1.24 1.36 1.32 1.25 1.22 1.22 -0.01 -0.09 -0.07 0.73 0.89 1.15 -0.15 0.09 0.28

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.6 -4.0 -4.8 -3.8 -2.4 -1.4 -2.6 -1.0 -1.1 3.3 8.3 10.1 -0.5 0.6 -0.3
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0.8 0 0 0 0 0 0 0 0 2.4 2.6 2.4 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria -4.1 -3.8 -3.1 -5.4 -6.8 -3.3 -3.0 -3.3 -3.4 -3.9 -6.4 -6.4 -2.9 -4.0 -2.7
Nucleus 1.0 -0.6 4.6 4.9 4.3 3.2 3.3 1.3 0.5 -3.1 -5.5 -5.8 4.6 4.1 4.7
Nuclear Periphery 0 2.9 2.3 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0.1 3.4 -1.3 -2.2 -0.2 0.1 -0.5 0.8 1.3 0.6 -2.1 -2.2 -2.5 -3.8 -4.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.5648 2.3562 1.2617 1.1445 0.864 1.4481 2.3139 2.0764 2.041 1.7153 1.7728 1.9822 3.7768 5.5165 4.4382 4.5006 4.6602 4.4807
Actin 0.0889 0 0.0194 0 0 0.0104 0.002 0.0001 0.0012 0.0002 0 0.0021 0.0746 0.02 0.0361 0 0.0164 0.0037
Bud 0.0007 0.0005 0.0006 0.0005 0.0002 0.0009 0.0009 0.0028 0.0052 0.0008 0.0008 0.0006 0.0009 0.0003 0.0005 0.0004 0.0018 0.0004
Bud Neck 0.0071 0.0006 0.0009 0.0006 0.0008 0.0014 0.0025 0.0115 0.0097 0.0013 0.0185 0.0019 0.0021 0.003 0.0012 0.0009 0.0029 0.0013
Bud Periphery 0.0009 0.0012 0.001 0.0017 0.0007 0.0026 0.0022 0.0031 0.0054 0.0023 0.0007 0.0013 0.0017 0.0008 0.0013 0.001 0.0019 0.0014
Bud Site 0.0274 0.0014 0.0087 0.0006 0.0005 0.001 0.0034 0.0209 0.0071 0.0007 0.0207 0.001 0.0041 0.0018 0.0015 0.0009 0.0016 0.0009
Cell Periphery 0.0015 0.0021 0.003 0.0029 0.0024 0.0038 0.002 0.0024 0.0018 0.0009 0.0012 0.0013 0.0026 0.0044 0.0029 0.0028 0.0112 0.0052
Cytoplasm 0.0036 0.0592 0.0169 0.0021 0.0096 0.02 0.0657 0.0768 0.0909 0.0833 0.062 0.0916 0.0015 0.0189 0.0136 0.0051 0.0022 0.0048
Cytoplasmic Foci 0.047 0.0108 0.0209 0.0011 0.0033 0.0349 0.0531 0.0325 0.0379 0.0537 0.0348 0.0451 0.0129 0.0051 0.0081 0.0085 0.043 0.0133
Eisosomes 0.0012 0 0.0002 0 0 0.0001 0.0002 0.0001 0.0001 0.0001 0 0.0001 0.0005 0.0002 0.0003 0 0.0001 0.0001
Endoplasmic Reticulum 0.0012 0.01 0.0015 0.0006 0.0027 0.0037 0.0135 0.0094 0.0087 0.0023 0.0041 0.0058 0.0096 0.0016 0.0037 0.0007 0.0005 0.0014
Endosome 0.1024 0.0663 0.1499 0.0828 0.1675 0.1212 0.275 0.162 0.1836 0.1955 0.3113 0.239 0.1199 0.0791 0.1232 0.226 0.1301 0.1018
Golgi 0.0131 0.0021 0.016 0.0034 0.0022 0.0065 0.0146 0.0029 0.0052 0.0111 0.0039 0.0119 0.0234 0.0072 0.0082 0.0088 0.0404 0.0119
Lipid Particles 0.0426 0.002 0.0245 0.0081 0.0031 0.0202 0.0264 0.0109 0.0209 0.0314 0.0094 0.0154 0.0496 0.0477 0.04 0.0142 0.0818 0.0183
Mitochondria 0.0455 0.0974 0.0384 0.0093 0.0011 0.0323 0.0385 0.0094 0.0176 0.0044 0.0014 0.0044 0.0831 0.0267 0.061 0.0392 0.0474 0.0124
None 0.1844 0.0428 0.0941 0.0002 0.0006 0.0282 0.1242 0.146 0.2229 0.1979 0.0034 0.1636 0.0025 0.0227 0.0426 0.0004 0.0862 0.0183
Nuclear Periphery 0.0023 0.0362 0.004 0.0016 0.0043 0.0084 0.0126 0.009 0.0083 0.0034 0.0066 0.005 0.0206 0.0079 0.005 0.0016 0.0009 0.0097
Nucleolus 0.0044 0.0025 0.0029 0.0038 0.0019 0.0073 0.0052 0.0118 0.0041 0.0027 0.0027 0.0023 0.0047 0.0052 0.0142 0.0084 0.035 0.0075
Nucleus 0.0012 0.0043 0.0024 0.0043 0.0067 0.0071 0.0154 0.0098 0.0071 0.0041 0.006 0.0052 0.0027 0.0132 0.0037 0.0028 0.0069 0.0093
Peroxisomes 0.0368 0.0003 0.0083 0.0002 0.0003 0.0024 0.0075 0.0024 0.0038 0.0095 0.0006 0.0031 0.0232 0.0009 0.0016 0.0016 0.0091 0.0011
Punctate Nuclear 0.0019 0.0002 0.0029 0 0.0001 0.0014 0.0049 0.0023 0.0021 0.0009 0.0006 0.0013 0.002 0.0003 0.0004 0.0001 0.0009 0.0014
Vacuole 0.2601 0.4368 0.3899 0.6872 0.6702 0.5184 0.273 0.399 0.2905 0.3032 0.4244 0.336 0.3693 0.5354 0.4528 0.5141 0.3948 0.6007
Vacuole Periphery 0.1257 0.2232 0.1935 0.189 0.1219 0.1677 0.0574 0.0749 0.0658 0.0902 0.0868 0.0622 0.1885 0.1974 0.1781 0.1623 0.085 0.1752

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 213.9183 196.1649 205.9851 196.7744 251.8557 298.6302 222.5111 208.3787 281.1591 250.2786
Translational Efficiency 1.0306 0.9437 0.9266 1.3392 0.931 0.8292 1.0064 1.1863 1.0326 1.0806

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2106 1199 998 1816 2392 1232 1948 72 4498 2431 2946 1888

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 746.32 734.75 780.77 976.77 738.15 745.67 933.10 1069.57 741.98 740.28 881.50 980.31
Standard Deviation 116.88 122.97 132.26 172.60 92.52 130.03 127.09 211.16 104.71 126.71 147.66 175.13
Intensity Change Log 2 — -0.022541 0.065103 0.388225 — 0.014623 0.338118 0.535045 — -0.003941 0.207310 0.463098

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000020 0.000202 0.000245 0.000338 0.000072 0.000347 0.000083 0.000070 0.000048 0.000276 0.000138 0.000327
Bud Neck 0.026306 0.035576 0.028436 0.024873 0.033432 0.035041 0.026621 0.024683 0.030095 0.035305 0.027236 0.024866
Bud Site 0.014493 0.028177 0.034003 0.038705 0.009514 0.020513 0.015975 0.027992 0.011846 0.024293 0.022082 0.038297
Cell Periphery 0.003657 0.000410 0.000167 0.000203 0.000348 0.001198 0.000133 0.000163 0.001897 0.000809 0.000145 0.000201
Cytoplasm 0.036097 0.209079 0.092242 0.060906 0.172650 0.131011 0.023224 0.052847 0.108714 0.169515 0.046605 0.060599
Cytoplasmic Foci 0.009048 0.074348 0.054442 0.026772 0.059709 0.077743 0.013273 0.011977 0.035989 0.076068 0.027220 0.026208
Eisosomes 0.000038 0.000048 0.000044 0.000019 0.000059 0.000082 0.000030 0.000020 0.000049 0.000065 0.000035 0.000019
Endoplasmic Reticulum 0.004093 0.001440 0.001836 0.001074 0.001807 0.003591 0.002315 0.001311 0.002877 0.002530 0.002152 0.001083
Endosome 0.058185 0.048741 0.191480 0.147663 0.048286 0.066631 0.209436 0.122929 0.052921 0.057808 0.203353 0.146720
Golgi 0.001145 0.001990 0.010614 0.012394 0.000821 0.004123 0.003778 0.002501 0.000973 0.003071 0.006094 0.012017
Lipid Particles 0.001263 0.003041 0.002122 0.000919 0.003115 0.005911 0.001529 0.000638 0.002248 0.004495 0.001730 0.000909
Mitochondria 0.003608 0.003932 0.002048 0.005489 0.002332 0.012056 0.003459 0.000604 0.002929 0.008049 0.002981 0.005303
Mitotic Spindle 0.000461 0.001899 0.016935 0.026513 0.000317 0.009245 0.009850 0.004018 0.000384 0.005622 0.012250 0.025655
None 0.001139 0.002496 0.002084 0.000535 0.000654 0.001352 0.000625 0.000204 0.000881 0.001916 0.001119 0.000522
Nuclear Periphery 0.000395 0.000384 0.000751 0.001597 0.000350 0.001425 0.002688 0.000456 0.000371 0.000911 0.002032 0.001553
Nuclear Periphery Foci 0.000215 0.000283 0.006909 0.001922 0.000140 0.000546 0.002439 0.000723 0.000175 0.000416 0.003954 0.001876
Nucleolus 0.001467 0.001564 0.017684 0.004474 0.000966 0.003427 0.017131 0.004743 0.001200 0.002508 0.017318 0.004485
Nucleus 0.012142 0.043903 0.054621 0.017297 0.050978 0.046117 0.031195 0.015697 0.032794 0.045025 0.039131 0.017236
Peroxisomes 0.000715 0.006310 0.013010 0.006187 0.002292 0.009030 0.004636 0.003363 0.001554 0.007688 0.007473 0.006079
Vacuole 0.786494 0.520487 0.423050 0.560566 0.601594 0.551493 0.572164 0.683323 0.688166 0.536200 0.521649 0.565248
Vacuole Periphery 0.039020 0.015691 0.047277 0.061554 0.010565 0.019119 0.059414 0.041739 0.023888 0.017428 0.055302 0.060799

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.35 -6.94 -3.72 -1.27 -0.42 -2.66 -0.67 -0.88 2.20 -0.46 -3.90 -5.12 -3.38 -0.52 -1.98
Bud Neck -2.78 -0.87 -1.34 1.91 -0.28 -0.48 1.91 0.75 0.92 0.16 -2.25 0.72 0.45 2.52 -0.21
Bud Site -5.10 -8.25 -10.04 -3.62 -1.52 -5.49 -4.73 -2.35 -1.25 -1.63 -7.51 -8.17 -12.20 -5.74 -6.70
Cell Periphery 9.52 10.32 10.25 3.97 -1.01 -2.57 8.91 3.94 3.15 -0.48 4.80 10.91 10.61 3.67 -2.21
Cytoplasm -21.65 -10.46 -11.44 13.48 1.68 5.04 24.44 5.46 3.43 -1.37 -10.82 11.72 2.91 12.16 -6.77
Cytoplasmic Foci -16.42 -14.20 -9.63 12.15 8.68 -3.78 17.53 13.61 14.03 0.34 -12.74 5.05 6.07 16.89 1.40
Eisosomes -3.30 -2.36 7.25 10.63 8.15 -4.06 8.80 7.24 9.56 1.80 -4.94 5.68 13.54 15.76 9.94
Endoplasmic Reticulum 9.95 7.30 11.11 1.33 4.95 -3.79 -3.33 1.30 4.02 3.04 1.35 3.74 10.33 5.00 7.69
Endosome 2.88 -16.16 -12.73 -14.85 6.49 -5.08 -25.78 -2.79 -2.05 3.20 -1.57 -29.95 -15.28 -13.91 10.86
Golgi -2.00 -11.19 -8.03 -7.08 -0.05 -5.48 -7.39 -2.16 2.05 1.66 -5.71 -12.89 -8.33 -6.03 -3.62
Lipid Particles -3.58 -3.24 0.29 4.10 4.43 -4.03 6.06 9.56 7.59 4.16 -5.23 1.92 6.51 8.13 4.71
Mitochondria -0.22 2.11 -1.38 -1.21 -4.49 -6.88 -1.96 4.03 7.95 4.52 -5.79 -0.03 -2.60 3.15 -2.64
Mitotic Spindle -2.71 -6.97 -11.69 -10.87 -3.68 -5.07 -7.83 -1.60 0.98 1.68 -5.68 -10.44 -11.79 -9.27 -6.04
None -1.56 -1.68 0.86 2.34 3.99 -3.00 -0.70 1.69 3.66 1.89 -2.36 -1.27 0.67 3.02 2.75
Nuclear Periphery -0.15 -3.37 -7.20 -8.00 -5.41 -2.26 -7.46 -1.76 1.69 6.32 -2.24 -7.88 -8.03 -3.81 0.29
Nuclear Periphery Foci -1.92 -6.52 -3.93 -3.72 4.55 -2.33 -5.83 -3.39 -0.90 3.64 -2.71 -8.66 -4.07 -3.33 3.57
Nucleolus -0.56 -8.76 -6.98 -6.48 6.73 -5.05 -13.52 -2.70 -1.17 5.99 -4.78 -15.98 -8.08 -4.61 11.35
Nucleus -10.53 -11.07 -8.91 3.17 5.70 1.10 3.15 4.16 3.35 2.71 -5.20 -5.92 -0.37 4.11 4.69
Peroxisomes -5.36 -11.15 -6.17 0.64 5.22 -5.86 -3.51 -0.81 3.97 1.11 -7.88 -10.51 -5.09 2.19 1.83
Vacuole 23.50 33.51 27.45 -1.83 -10.03 4.12 3.77 -2.03 -3.46 -3.12 17.97 23.55 17.17 -1.04 -3.10
Vacuole Periphery 11.25 -1.06 -4.01 -13.96 -2.28 -6.02 -20.43 -3.73 -2.54 2.45 5.50 -14.47 -11.36 -14.45 0.50
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Vacuolar carboxypeptidase Y (proteinase C, CPY); broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; involved, along with functional homolog Prc1p, in vacuolar zymogen activation, breakdown of the autophagic body, and autophagosome-dependent protein synthesis; role in phytochelatin synthesis; localizes to the vacuole lumen; member of the serine carboxypeptidase family; N-glycosylated
Localization
Cell Percentages vacuole (80%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Prc1

Prc1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Prc1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available