Standard name
Human Ortholog
Description Serine protease and general molecular chaperone; cleaves Roq1p, which modifies the substrate specificity of the Ubr1p Ub-ligase, promoting the stress-induced homeostatically-regulated protein degradation (SHRED) of misfolded and native ER-membrane and cytosolic proteins; chaperone activity involved in the heat stress response; promotes apoptosis through proteolysis of Bir1p; role in lipid homeostasis; mammalian Omi/HtrA2 serine protease family member
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0.05 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 – 0 0 0.1 0.11 0.12 0.07 0.06 0.06 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.1 0 0.11 0.14 0.16 0.22 – 0.29 0.33 0 0 0.05 0 0 0 0 0 0 0 0 0
Nucleus 0.98 0.93 0.95 0.92 0.92 0.89 0.88 0.82 0.87 – 0.77 0.75 0.88 0.87 0.8 0.88 0.92 0.9 0.94 0.94 0.91 0.92 0.81 0.66
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0.06 0.06 0.09 0.11 0.16 0.17 – 0.19 0.26 0 0 0 0 0 0 0 0 0 0 0 0.08
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0.1 0.19
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 1 0 0 0
Bud 0 0 0 0 0 1 0 0 3 – 3 2 0 1 0 0 0 0 1 1 1 0 2 6
Bud Neck 0 0 0 0 0 0 0 1 0 – 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 1 1 3 7 7 – 8 14 0 0 2 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 1 0 0 0 0 0 0 0 0
Cytoplasm 6 10 4 6 6 6 10 12 6 – 5 3 38 47 61 27 11 18 2 0 2 1 1 0
Endoplasmic Reticulum 0 0 0 0 1 0 0 0 0 – 0 0 0 1 1 5 4 0 0 1 0 1 1 3
Endosome 1 0 0 0 0 0 0 0 0 – 0 0 0 0 5 3 1 2 3 0 1 0 2 3
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 4 0 0 0 1 2
Mitochondria 0 6 9 17 9 26 41 68 57 – 62 100 0 0 26 7 1 4 0 1 2 0 5 4
Nucleus 380 308 217 163 228 205 255 349 223 – 165 227 317 373 393 358 182 264 377 311 218 247 351 286
Nuclear Periphery 0 0 3 0 5 5 4 5 7 – 5 6 0 5 3 3 0 2 0 1 0 0 0 3
Nucleolus 1 9 3 11 16 20 31 69 44 – 40 78 5 9 22 8 3 4 1 0 0 4 15 33
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 1 0 6 0 0 0 0 0 0 0 0 0
SpindlePole 0 1 0 0 0 0 0 2 0 – 0 1 0 4 9 2 0 1 0 2 0 0 0 3
Vac/Vac Membrane 1 5 2 1 1 2 1 4 0 – 1 3 3 3 3 16 2 9 6 7 7 9 43 84
Unique Cell Count 389 332 229 178 249 231 290 426 256 213 301 362 428 489 409 198 292 402 331 241 270 432 437
Labelled Cell Count 389 339 238 198 267 266 345 517 347 289 435 364 443 531 430 204 304 402 331 241 270 432 437


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 10.2 7.9 6.5 6.6 6.8 6.3 5.8 5.9 5.4 – 5.2 4.8 7.9 7.3 6.3 10.1 11.3 10.8 8.6 8.6 9.0
Std Deviation (1e-4) 1.6 1.6 1.6 1.4 1.4 1.4 1.3 2.1 1.3 – 1.7 1.3 2.0 1.9 1.7 2.9 4.9 2.8 1.9 1.8 1.8
Intensity Change (Log2) – – – 0.01 0.07 -0.05 -0.18 -0.13 -0.27 – -0.33 -0.44 0.28 0.17 -0.04 0.64 0.8 0.74 0.4 0.41 0.48

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 1.2 0.8 0 – 0 0 4.0 4.2 4.7 2.7 2.1 2.5
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 2.3 -0.2 3.0 3.9 4.6 5.9 – 7.2 0 0 0 0.8 -1.7 0 -1.9
Nucleus -1.3 -1.4 -2.3 -2.7 -4.6 -2.9 – -5.3 -6.0 -2.9 -3.1 -5.0 -2.9 -1.2 -1.9
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 2.7 2.9 3.6 4.3 5.8 5.9 – 6.2 0 0 0 2.2 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 – 0 0 0 0 0 2.2 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 10.2807 9.0753 8.6237 8.6713 7.9291 8.7359 10.4201 11.3341 10.475 10.8303 9.8866 10.3462 12.818 12.8442 12.2133 12.265 11.486 12.228
Actin 0.0053 0 0 0 0 0 0.0069 0 0.0019 0 0.0053 0.0024 0.0015 0 0.0054 0 0.0009 0.0055
Bud 0.0001 0 0 0 0 0 0.0006 0 0.0002 0.0001 0.0018 0 0.0002 0 0.0002 0 0.0003 0.0001
Bud Neck 0.0002 0 0 0 0.0001 0.0002 0.0007 0 0.0003 0.0001 0.0004 0.0004 0.0003 0 0.0008 0 0.001 0.0004
Bud Periphery 0.0001 0 0 0 0.0001 0 0.0012 0 0.0005 0.0001 0.0036 0.0001 0.0004 0 0.0003 0 0.0008 0.0001
Bud Site 0.0003 0 0 0 0 0 0.0016 0 0.0011 0 0.0008 0 0.0028 0 0.0016 0 0.0008 0
Cell Periphery 0.0001 0 0 0 0 0 0.0013 0 0.0002 0 0.0003 0.0001 0.0003 0 0.0002 0 0.0006 0
Cytoplasm 0.0074 0 0 0 0 0 0.0049 0.0001 0.0027 0.0001 0.0014 0.0013 0.0035 0 0.0012 0 0.0021 0
Cytoplasmic Foci 0.001 0 0 0 0 0 0.0117 0.0005 0.0079 0 0.0061 0.0008 0.0071 0 0.0082 0 0.0088 0.0001
Eisosomes 0 0 0 0 0 0 0.0001 0 0 0 0 0.0001 0 0 0.0001 0 0 0
Endoplasmic Reticulum 0.0034 0 0 0 0 0 0.0028 0 0.0011 0 0.001 0.0009 0.0019 0 0.0008 0 0.0024 0
Endosome 0.0077 0 0 0 0 0 0.0116 0 0.0042 0 0.0075 0.0019 0.0068 0 0.0057 0 0.0097 0.0001
Golgi 0.0004 0 0 0 0 0 0.0023 0 0.0016 0 0.0022 0.0005 0.0009 0 0.0029 0 0.0021 0.0002
Lipid Particles 0.0003 0 0 0 0 0 0.01 0.0003 0.0071 0 0.0097 0.0003 0.008 0 0.0066 0 0.0166 0.0001
Mitochondria 0.0017 0.0001 0.0001 0.0001 0.0007 0.0002 0.005 0.0002 0.0022 0.0003 0.0057 0.0003 0.0042 0.0001 0.0024 0 0.0123 0.0002
None 0.0031 0 0 0 0 0 0.0019 0.0002 0.0014 0 0.0004 0.0007 0.0019 0 0.0014 0 0.0009 0
Nuclear Periphery 0.039 0.0003 0.0001 0.0004 0.0002 0.0001 0.0312 0.0008 0.0052 0.0009 0.0058 0.0022 0.008 0.0037 0.007 0.0002 0.0108 0.0002
Nucleolus 0.0095 0.0077 0.0044 0.0082 0.0827 0.0344 0.0206 0.017 0.0144 0.0093 0.0514 0.0465 0.0185 0.0132 0.0171 0.0039 0.0818 0.0515
Nucleus 0.9031 0.9917 0.9954 0.9912 0.9159 0.9644 0.8593 0.9795 0.9322 0.9888 0.8759 0.9377 0.9175 0.9824 0.9275 0.9959 0.8258 0.941
Peroxisomes 0.0002 0 0 0 0 0 0.0041 0 0.0018 0 0.0059 0 0.0004 0 0.0024 0 0.0007 0.0001
Punctate Nuclear 0.014 0.0001 0 0.0001 0.0001 0.0005 0.0099 0.0009 0.011 0.0001 0.0063 0.0032 0.0106 0.0004 0.0048 0 0.0118 0.0001
Vacuole 0.0013 0 0 0 0.0001 0.0001 0.0076 0.0002 0.0023 0.0001 0.0048 0.0004 0.0032 0.0001 0.0018 0 0.0063 0.0001
Vacuole Periphery 0.0018 0 0 0 0.0001 0 0.0047 0.0001 0.0006 0.0001 0.0037 0.0003 0.0021 0.0001 0.0018 0 0.0035 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 54.728 49.7471 46.6932 55.8565 52.7998 48.6202 56.8781 56.6559 45.9452 57.193
Translational Efficiency 1.2743 1.1859 1.2203 0.8312 0.9629 1.0821 1.0884 0.8762 1.0804 0.995

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1958 178 158 715 2296 1620 292 112 4254 1798 450 827

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 735.68 1115.16 1213.25 1324.68 816.80 920.83 1301.10 1523.27 779.46 940.07 1270.25 1351.57
Standard Deviation 90.13 189.20 161.11 230.29 130.92 145.39 170.20 319.66 120.93 161.11 172.25 253.59
Intensity Change Log 2 — 0.600100 0.721727 0.848494 — 0.172952 0.671677 0.899117 — 0.391156 0.695611 0.875349

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000076 0.000456 0.000744 0.000699 0.000256 0.000300 0.000734 0.000870 0.000173 0.000315 0.000737 0.000722
Bud Neck 0.001406 0.007101 0.008595 0.020405 0.004868 0.006184 0.008129 0.011669 0.003274 0.006275 0.008292 0.019222
Bud Site 0.000306 0.001723 0.000566 0.001391 0.000677 0.000703 0.000560 0.001480 0.000506 0.000804 0.000562 0.001403
Cell Periphery 0.000282 0.000085 0.000028 0.000087 0.000506 0.000163 0.000025 0.000070 0.000403 0.000156 0.000026 0.000085
Cytoplasm 0.011827 0.008266 0.000089 0.000438 0.003917 0.001134 0.000082 0.000797 0.007558 0.001840 0.000084 0.000487
Cytoplasmic Foci 0.000390 0.000634 0.000016 0.000634 0.000290 0.000476 0.000011 0.003309 0.000336 0.000491 0.000013 0.000996
Eisosomes 0.000012 0.000029 0.000050 0.000033 0.000034 0.000037 0.000052 0.000037 0.000024 0.000036 0.000051 0.000034
Endoplasmic Reticulum 0.002810 0.003267 0.002360 0.001265 0.006498 0.005890 0.002328 0.001585 0.004800 0.005630 0.002339 0.001308
Endosome 0.000265 0.000983 0.000045 0.001289 0.000282 0.000647 0.000034 0.009746 0.000275 0.000680 0.000038 0.002434
Golgi 0.000023 0.001119 0.000043 0.000881 0.000064 0.000209 0.000035 0.003181 0.000045 0.000299 0.000038 0.001192
Lipid Particles 0.000101 0.000151 0.000030 0.000109 0.000120 0.000337 0.000022 0.001705 0.000111 0.000318 0.000025 0.000325
Mitochondria 0.000202 0.004002 0.001051 0.002338 0.000652 0.001873 0.001230 0.010054 0.000445 0.002083 0.001167 0.003383
Mitotic Spindle 0.001388 0.001660 0.000027 0.007194 0.000626 0.001847 0.000025 0.006796 0.000977 0.001828 0.000026 0.007140
None 0.009724 0.001636 0.000476 0.001052 0.006976 0.003546 0.000491 0.000709 0.008241 0.003357 0.000486 0.001006
Nuclear Periphery 0.000355 0.000113 0.000107 0.000459 0.000329 0.000373 0.000112 0.000668 0.000341 0.000347 0.000110 0.000487
Nuclear Periphery Foci 0.000424 0.000618 0.000007 0.000103 0.000373 0.000639 0.000008 0.005285 0.000396 0.000637 0.000007 0.000805
Nucleolus 0.003543 0.003875 0.006334 0.010643 0.008328 0.006378 0.006961 0.018604 0.006126 0.006131 0.006741 0.011721
Nucleus 0.966186 0.962831 0.978168 0.947947 0.963940 0.967622 0.978082 0.912695 0.964974 0.967148 0.978112 0.943173
Peroxisomes 0.000053 0.000344 0.000520 0.000660 0.000216 0.000473 0.000441 0.001156 0.000141 0.000460 0.000469 0.000727
Vacuole 0.000554 0.000861 0.000668 0.001492 0.000821 0.000786 0.000569 0.004757 0.000698 0.000793 0.000604 0.001934
Vacuole Periphery 0.000073 0.000248 0.000077 0.000883 0.000227 0.000384 0.000070 0.004829 0.000156 0.000370 0.000073 0.001417

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.11 -11.49 -7.91 -3.32 -1.00 -1.75 -13.06 -4.96 -4.71 -1.90 -7.06 -18.24 -8.09 -6.49 -1.61
Bud Neck -3.91 -8.70 -11.23 -6.63 -6.55 -1.83 -5.56 -2.62 -2.35 -1.84 -4.86 -10.51 -10.62 -8.68 -7.33
Bud Site -1.44 -4.92 -4.69 -0.08 -3.80 -0.23 0.32 -1.81 -1.76 -1.85 -1.95 -2.04 -4.60 -3.38 -4.24
Cell Periphery 3.73 5.66 3.83 -0.04 -2.47 2.64 3.81 3.41 2.60 -2.85 3.24 5.29 4.28 2.01 -2.86
Cytoplasm 0.64 8.59 8.30 1.38 -4.64 3.18 5.01 3.65 0.70 -1.58 5.65 9.90 9.30 2.03 -4.58
Cytoplasmic Foci -0.62 3.95 -0.17 0.41 -1.55 -1.39 2.53 -1.51 -1.23 -1.73 -1.36 4.40 -1.17 -0.14 -2.29
Eisosomes -3.79 -7.87 -12.63 -1.42 3.20 -0.73 -5.69 -2.06 -1.40 1.21 -3.46 -10.62 -6.46 -0.43 5.34
Endoplasmic Reticulum -1.24 1.54 7.70 4.88 3.67 1.43 12.60 9.43 7.96 1.66 -2.46 11.26 16.58 13.47 5.61
Endosome -1.28 3.31 -1.47 0.23 -1.96 -2.18 4.39 -1.55 -1.44 -1.60 -2.54 5.46 -2.10 -1.36 -2.43
Golgi -1.37 -3.71 -1.78 0.49 -1.71 -1.88 1.12 -2.06 -1.91 -2.09 -2.50 0.48 -2.42 -1.60 -2.45
Lipid Particles -0.69 3.65 -0.38 0.35 -1.48 -1.88 2.00 -1.21 -0.91 -1.32 -2.08 3.06 -1.16 0.49 -1.84
Mitochondria -1.10 -9.74 -9.60 0.40 -5.44 -1.94 -3.73 -2.21 -1.85 -2.04 -2.52 -7.85 -5.37 -1.57 -3.97
Mitotic Spindle -0.12 2.10 -2.28 -2.12 -3.04 -1.47 1.89 -1.67 -1.22 -1.94 -0.92 2.75 -2.76 -2.40 -3.32
None 5.74 7.14 6.55 0.86 -4.92 2.39 6.58 6.20 2.58 -2.88 3.97 9.70 8.78 2.33 -5.27
Nuclear Periphery 4.81 5.91 -2.16 -4.74 -5.01 -0.59 4.43 -1.72 -1.47 -2.63 -0.16 7.08 -2.80 -2.25 -5.63
Nuclear Periphery Foci -0.39 1.63 1.22 1.05 -2.89 -0.88 2.71 -0.97 -0.87 -1.08 -0.87 2.81 -0.39 0.18 -1.26
Nucleolus -0.48 -3.37 -5.62 -5.12 -3.67 1.91 1.23 -2.52 -2.76 -2.69 -0.29 -1.28 -5.23 -5.05 -4.67
Nucleus 0.41 -3.21 4.90 2.11 6.84 -0.87 -5.48 2.85 2.99 3.51 -0.50 -6.21 5.73 5.62 7.98
Peroxisomes -1.95 -4.60 -2.72 -1.06 -0.25 -1.33 -1.34 -2.19 -1.71 -1.96 -2.05 -3.94 -2.89 -1.04 -1.46
Vacuole -0.99 -1.93 -2.00 -1.20 -1.72 0.14 1.62 -1.84 -1.84 -1.92 -0.90 0.42 -2.47 -2.27 -2.52
Vacuole Periphery -1.48 -1.07 -1.82 -1.19 -1.79 -0.84 3.18 -1.25 -1.19 -1.30 -1.30 3.01 -1.98 -1.43 -2.15
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Serine protease and general molecular chaperone; cleaves Roq1p, which modifies the substrate specificity of the Ubr1p Ub-ligase, promoting the stress-induced homeostatically-regulated protein degradation (SHRED) of misfolded and native ER-membrane and cytosolic proteins; chaperone activity involved in the heat stress response; promotes apoptosis through proteolysis of Bir1p; role in lipid homeostasis; mammalian Omi/HtrA2 serine protease family member
Localization
Cell Percentages nucleus (97%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Nma111

Nma111


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Nma111-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available