Standard name
Human Ortholog
Description Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0.17 0.17 0.21 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0.06 0.09 0.06 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.05 0 0.07 0 0 – 0 0.05 0.05 0.07 0.06 0 0 0.05 0.07 0.08 0.11 0 0 0 0 0 0
Cytoplasm 0.97 0.97 0.98 0.88 0.87 0.81 – 0.63 0.68 0.58 0.65 0.56 0.61 0.56 0.5 0.93 0.91 0.94 0.94 0.94 0.91 0.91 0.88 0.83
Endoplasmic Reticulum 0 0 0 0.05 0 0.1 – 0.1 0.08 0.13 0.13 0.15 0.06 0.05 0 0 0 0 0 0 0 0 0.06 0.07
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0.09 0.13 0.1 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0.17 0.13 0.21 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.06 0.07 0.1 – 0.14 0.2 0.18 0.22 0.27 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0.05 0.07 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 – 0.16 0.07 0.1 0.06 0.05 0 0 0 0 0.06 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 0 3 4 0 5 – 6 7 17 9 8 88 84 123 0 0 0 0 0 0 0 1 3
Bud 1 1 15 6 4 3 – 4 9 5 2 9 34 42 35 0 0 0 0 0 1 1 0 3
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 10 26 17 28 12 7 – 14 36 38 37 42 14 15 30 10 15 20 0 0 1 1 1 1
Cytoplasm 498 534 670 354 299 468 – 308 471 438 364 377 322 277 289 139 168 176 494 523 644 310 260 348
Endoplasmic Reticulum 11 9 5 21 13 55 – 47 52 97 72 101 30 25 24 5 1 6 7 9 24 13 19 28
Endosome 1 0 0 0 0 1 – 1 0 0 0 1 45 62 57 0 0 1 4 1 4 1 2 7
Golgi 1 0 0 0 0 0 – 1 0 1 1 1 92 64 124 0 0 1 1 2 1 0 0 5
Mitochondria 4 1 7 25 25 57 – 70 140 139 121 179 0 2 0 1 6 1 2 1 5 0 0 2
Nucleus 3 0 3 2 1 3 – 2 1 8 5 4 0 1 0 2 0 1 2 0 2 0 0 1
Nuclear Periphery 0 0 0 0 0 1 – 1 2 16 1 1 0 0 0 1 0 0 0 1 2 1 0 1
Nucleolus 0 0 0 0 0 0 – 5 0 3 1 1 5 3 5 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 1 5 5 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 18 23 40 0 0 0 0 0 0 0 1 2
Vac/Vac Membrane 5 8 0 3 8 16 – 78 50 77 32 33 3 6 13 3 11 5 5 9 10 6 4 4
Unique Cell Count 516 551 681 403 342 577 492 692 756 562 672 526 491 582 149 184 188 526 557 708 340 296 419
Labelled Cell Count 535 579 720 443 362 616 537 768 839 645 757 652 609 745 161 201 211 526 557 708 340 296 419


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 14.6 18.2 9.8 12.7 7.9 11.7 – 11.3 11.0 11.2 11.4 11.3 18.3 18.2 18.4 20.5 21.2 21.0 17.0 17.5 18.1
Std Deviation (1e-4) 2.5 2.7 1.7 2.0 1.9 2.2 – 2.5 2.4 2.4 2.6 2.5 2.7 3.1 3.1 6.7 6.6 5.4 2.8 3.3 3.6
Intensity Change (Log2) – – – 0.37 -0.31 0.26 – 0.2 0.17 0.19 0.22 0.2 0.9 0.89 0.91 1.06 1.11 1.09 0.79 0.83 0.88

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP70001020WT3HU80HU120HU16001020WT3rpd3Δ_1rpd3Δ_2rpd3Δ_301020WT1AF100AF140AF18001020
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 2.9 2.1 1.5 10.6 10.7 12.2 0 0 0
Bud -0.8 -1.2 -2.5 – -1.9 -1.3 -2.5 -2.8 -1.2 3.7 5.0 3.5 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 3.6 0.9 -1.7 – 0.4 2.6 2.5 3.5 3.4 0.2 0.6 2.5 0 3.6 4.9
Cytoplasm -7.3 -7.4 -10.4 – -16.2 -15.0 -18.2 -15.8 -18.6 -16.7 -18.0 -20.2 -3.6 -4.9 -3.6
Endoplasmic Reticulum 4.7 3.5 7.3 – 7.2 6.3 8.9 8.8 9.8 5.1 4.7 4.0 0 0 0
Endosome 0 0 0 – 0 0 0 0 0 7.8 9.5 8.4 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 11.4 9.7 12.7 0 0 0
Mitochondria 4.9 5.4 7.1 – 9.0 11.5 10.9 11.8 13.7 0 0 0 0 0 0
Nucleus 0 0 0 – 0 0 1.3 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 – 0 0 3.8 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 4.9 5.7 7.0 0 0 0
Vacuole 0 0 4.4 – 10.8 7.1 8.6 6.3 5.9 0 0 3.9 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 15.854 18.6895 17.9195 17.0192 17.4881 16.9128 10.5521 13.7667 12.57 12.2305 10.5907 12.2298 15.1246 17.1531 16.5451 15.4794 15.3272 16.0252
Actin 0.002 0.0008 0.0003 0.0002 0.0006 0.0004 0.0118 0.0015 0.0078 0.0006 0.0116 0.0034 0.0003 0.0004 0.0004 0.0002 0.0001 0.0001
Bud 0.0002 0.0002 0.0001 0.0001 0.0001 0.0001 0.0006 0.0005 0.0007 0.0021 0.0054 0.0008 0.0004 0.0001 0.0001 0.0001 0.0001 0
Bud Neck 0.0003 0.0003 0.0003 0.0005 0.0006 0.0011 0.0008 0.0002 0.0017 0.0006 0.0007 0.0009 0.0008 0.0003 0.0002 0.0004 0.0004 0.0007
Bud Periphery 0.0001 0.0002 0 0 0 0.0001 0.0005 0.0001 0.0006 0.0006 0.0047 0.0004 0.0007 0 0 0 0 0
Bud Site 0.0001 0.0004 0.0001 0.0001 0.0001 0.0001 0.0013 0.003 0.0019 0.0007 0.0056 0.0001 0.0002 0.0002 0.0001 0 0 0
Cell Periphery 0.0001 0.0002 0.0001 0 0.0001 0.0001 0.0002 0.0001 0.0001 0.0001 0.0005 0 0.0003 0.0001 0 0 0 0
Cytoplasm 0.9297 0.9741 0.9726 0.9384 0.9564 0.9367 0.8217 0.9615 0.9315 0.8868 0.9015 0.9422 0.9274 0.9749 0.979 0.9461 0.964 0.9625
Cytoplasmic Foci 0.0041 0.003 0.0028 0.0057 0.0035 0.0047 0.0315 0.008 0.0144 0.0066 0.0046 0.0127 0.0061 0.0031 0.0031 0.0045 0.0051 0.0039
Eisosomes 0 0 0 0 0 0 0.0001 0 0 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.0345 0.0097 0.0121 0.0287 0.0164 0.0319 0.0282 0.0111 0.0079 0.0755 0.0066 0.0148 0.0282 0.0118 0.0105 0.0243 0.0112 0.0194
Endosome 0.0089 0.0045 0.0045 0.0141 0.0104 0.0123 0.0493 0.006 0.0155 0.0118 0.0143 0.0127 0.0106 0.0035 0.0032 0.017 0.0099 0.0066
Golgi 0.0009 0.0012 0.0004 0.0007 0.0006 0.0011 0.0102 0.0015 0.0038 0.0007 0.001 0.0027 0.0005 0.0008 0.0003 0.0006 0.0003 0.0004
Lipid Particles 0.0001 0.0001 0 0 0.0001 0 0.0063 0.0002 0.0005 0.0001 0.0002 0.0001 0.0008 0.0001 0 0 0 0
Mitochondria 0.0006 0.0005 0.0002 0.0006 0.0003 0.0011 0.0071 0.0016 0.0023 0.0008 0.0008 0.0016 0.0006 0.0003 0.0002 0.0004 0.0003 0.0009
None 0.0014 0.0004 0.0004 0.0003 0.0004 0.0005 0.0044 0.0011 0.0021 0.002 0.003 0.0016 0.0062 0.0005 0.0004 0.0006 0.0007 0.0007
Nuclear Periphery 0.0077 0.0013 0.0024 0.0023 0.0035 0.0035 0.0062 0.0008 0.0027 0.0046 0.0214 0.001 0.0057 0.0016 0.0008 0.0015 0.0024 0.0014
Nucleolus 0 0 0 0 0 0 0.0002 0 0.0001 0 0.0002 0 0.0001 0 0 0 0 0
Nucleus 0.0038 0.0015 0.0017 0.0022 0.0025 0.0033 0.0042 0.0011 0.002 0.0028 0.0115 0.0016 0.0041 0.0013 0.0009 0.0015 0.0034 0.0018
Peroxisomes 0.0001 0 0 0.0001 0 0 0.0029 0.0004 0.0009 0.0001 0.0001 0.0016 0.0001 0 0 0 0 0
Punctate Nuclear 0.0002 0.0001 0.0001 0.0001 0.0001 0.0001 0.0038 0.0005 0.0006 0.0005 0.0017 0.0003 0.0007 0.0001 0.0001 0.0001 0.0002 0.0001
Vacuole 0.0044 0.0011 0.0015 0.0045 0.0034 0.0022 0.007 0.0007 0.0021 0.0025 0.0034 0.0012 0.0053 0.0009 0.0005 0.002 0.0014 0.001
Vacuole Periphery 0.0008 0.0002 0.0003 0.0013 0.0008 0.0007 0.0019 0.0002 0.0007 0.0006 0.0012 0.0005 0.001 0.0002 0.0001 0.0007 0.0004 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 49.1459 59.5227 48.3749 67.3693 57.5534 19.0137 47.2869 57.061 68.153 63.3825
Translational Efficiency 3.1628 2.3436 2.4887 2.3943 2.5327 8.7422 2.9782 2.4685 2.2959 2.683

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1584 1963 1117 455 970 965 1737 1636 2554 2928 2854 2091

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1255.12 1448.59 1826.49 2065.42 989.01 1449.68 1787.48 1902.86 1154.05 1448.95 1802.75 1938.23
Standard Deviation 217.91 255.57 289.34 359.35 213.71 250.54 332.87 346.70 251.95 253.93 317.12 355.87
Intensity Change Log 2 — 0.206824 0.541249 0.718610 — 0.551677 0.853870 0.944112 — 0.369036 0.687428 0.822358

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000557 0.000589 0.000453 0.011140 0.000913 0.000711 0.000640 0.003669 0.000692 0.000629 0.000567 0.005295
Bud Neck 0.000647 0.000922 0.002454 0.008327 0.001640 0.001152 0.001555 0.002466 0.001024 0.000998 0.001907 0.003741
Bud Site 0.016780 0.017985 0.012773 0.076657 0.068523 0.022339 0.009395 0.038972 0.036431 0.019420 0.010717 0.047172
Cell Periphery 0.000275 0.000269 0.001301 0.007031 0.001125 0.000286 0.000824 0.002405 0.000598 0.000274 0.001010 0.003412
Cytoplasm 0.714130 0.753620 0.841539 0.438882 0.456172 0.669307 0.854903 0.773622 0.616158 0.725832 0.849672 0.700783
Cytoplasmic Foci 0.165974 0.118024 0.025049 0.100134 0.249884 0.179493 0.024310 0.059726 0.197843 0.138283 0.024599 0.068518
Eisosomes 0.000008 0.000010 0.000003 0.000027 0.000034 0.000014 0.000004 0.000009 0.000018 0.000011 0.000004 0.000013
Endoplasmic Reticulum 0.019837 0.010316 0.004027 0.001618 0.030012 0.012123 0.001723 0.001268 0.023701 0.010911 0.002625 0.001344
Endosome 0.007465 0.007079 0.005119 0.015331 0.015065 0.012197 0.004151 0.004636 0.010352 0.008766 0.004530 0.006963
Golgi 0.029030 0.025538 0.019883 0.036329 0.032494 0.029280 0.011693 0.017449 0.030346 0.026771 0.014899 0.021558
Lipid Particles 0.002712 0.003189 0.010926 0.082473 0.001638 0.005348 0.015057 0.028537 0.002304 0.003901 0.013440 0.040273
Mitochondria 0.001458 0.002363 0.000075 0.000165 0.008713 0.001656 0.000068 0.000307 0.004213 0.002130 0.000071 0.000276
Mitotic Spindle 0.004652 0.007898 0.009356 0.034452 0.006451 0.009069 0.006576 0.009233 0.005335 0.008284 0.007664 0.014720
None 0.001055 0.000976 0.001164 0.000419 0.001696 0.000549 0.001629 0.000674 0.001299 0.000836 0.001447 0.000619
Nuclear Periphery 0.000089 0.000127 0.000205 0.000320 0.000315 0.000125 0.000186 0.000162 0.000175 0.000126 0.000193 0.000196
Nuclear Periphery Foci 0.003749 0.003015 0.017223 0.016464 0.002353 0.002661 0.014503 0.005975 0.003218 0.002898 0.015567 0.008258
Nucleolus 0.000064 0.000095 0.000046 0.000073 0.000375 0.000108 0.000081 0.000088 0.000182 0.000099 0.000068 0.000084
Nucleus 0.003554 0.004285 0.011066 0.004597 0.007159 0.004530 0.011245 0.005222 0.004923 0.004365 0.011175 0.005086
Peroxisomes 0.000295 0.000686 0.000083 0.002550 0.000507 0.001181 0.000160 0.002482 0.000375 0.000849 0.000130 0.002496
Vacuole 0.014993 0.024738 0.032201 0.149914 0.029151 0.035362 0.038410 0.039265 0.020370 0.028239 0.035980 0.063342
Vacuole Periphery 0.012677 0.018280 0.005054 0.013097 0.085780 0.012509 0.002887 0.003834 0.040441 0.016378 0.003735 0.005849

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.28 0.61 -4.40 -4.37 -4.43 1.06 1.07 -4.67 -4.93 -4.93 0.35 0.64 -6.61 -6.63 -6.69
Bud Neck -1.50 -6.45 -12.29 -12.18 -8.76 0.77 -0.36 -2.25 -8.87 -5.48 0.09 -4.15 -10.16 -15.26 -8.67
Bud Site -0.91 2.46 -11.26 -11.05 -11.84 12.64 18.03 6.24 -7.70 -14.83 10.12 16.26 -6.19 -14.21 -18.46
Cell Periphery 0.30 -10.21 -3.63 -3.64 -2.91 7.16 2.07 -4.09 -7.95 -5.44 6.82 -5.63 -6.27 -7.18 -5.09
Cytoplasm -4.27 -12.41 16.45 19.08 23.38 -15.93 -35.49 -23.77 -6.32 11.08 -13.69 -30.16 -6.02 5.80 19.75
Cytoplasmic Foci 8.24 28.40 5.60 0.51 -10.67 7.93 33.62 23.16 14.95 -11.02 11.96 42.63 21.89 12.09 -14.79
Eisosomes -1.75 7.76 -3.63 -3.23 -4.57 1.69 2.50 2.05 1.71 -5.88 1.49 3.05 1.01 -1.37 -7.23
Endoplasmic Reticulum 4.66 8.41 10.34 8.55 3.88 6.12 11.12 11.29 7.20 1.10 7.59 14.10 15.06 10.85 3.17
Endosome 0.62 3.38 -4.98 -5.32 -6.51 1.95 9.15 8.60 7.61 -0.73 2.40 9.73 5.20 3.34 -4.07
Golgi 2.10 4.85 -0.26 -1.29 -2.83 1.50 12.19 8.80 6.54 -3.40 2.73 12.57 7.47 5.14 -3.30
Lipid Particles -1.58 -9.22 -11.23 -11.15 -9.80 -5.34 -12.78 -14.33 -11.87 -5.91 -5.18 -15.29 -17.61 -16.76 -11.21
Mitochondria -1.55 2.99 2.83 6.20 -0.89 6.25 8.38 8.16 2.95 -3.09 3.70 8.44 8.04 6.59 -3.19
Mitotic Spindle -2.55 -4.25 -6.07 -5.47 -5.20 -1.41 -0.72 -3.17 -1.45 -2.82 -2.80 -3.40 -7.03 -5.14 -5.44
None 0.47 -0.71 4.84 3.54 6.42 2.75 0.32 2.53 -0.98 4.22 2.41 -0.45 3.97 2.17 5.75
Nuclear Periphery -1.16 -5.97 -5.58 -4.09 -2.71 1.52 0.80 1.01 -0.36 0.53 0.91 -0.75 -0.31 -0.98 0.18
Nuclear Periphery Foci 1.04 -11.08 -7.40 -7.84 0.78 -0.50 -13.05 -6.61 -6.95 8.97 0.70 -16.46 -8.66 -9.28 9.02
Nucleolus -3.92 2.47 -1.78 1.81 -4.44 1.39 1.50 1.46 1.21 -1.02 1.19 1.51 1.30 1.49 -3.42
Nucleus -3.01 -11.39 -3.52 -2.50 5.67 1.77 -3.21 0.86 -2.74 10.03 0.96 -10.08 -1.45 -4.04 11.38
Peroxisomes -2.54 4.44 -5.75 -4.48 -6.32 -1.61 3.70 -6.01 -2.56 -7.25 -2.73 4.92 -7.98 -5.35 -8.95
Vacuole -5.65 -6.70 -13.79 -12.74 -11.49 -1.74 -4.19 -4.99 -2.94 -0.66 -4.65 -9.27 -15.61 -12.88 -8.59
Vacuole Periphery -3.51 6.44 0.96 3.16 -2.35 14.95 17.38 17.22 7.16 -1.15 10.82 17.77 16.66 10.71 -1.93
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
Localization
Cell Percentages cytoplasm (93%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-5

Lsm7

Lsm7


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Lsm7-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available