Standard name
Human Ortholog
Description Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments; human gene CARS allows growth of the yeast haploid null mutant after sporulation of a heterozygous diploid
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0.05 0 0 0 0 0.06 0.07 0.1 0.08 0.06 0 0.06 0.05 0.05 0 0 0 0 0 0 0
Cytoplasm 0.97 0.99 0.95 0.97 0.94 0.86 0.76 0.69 0.64 0.68 0.65 0.66 0.94 0.94 0.96 0.99 0.96 0.98 0.98 0.94 0.9 0.88 0.86 0.87
Endoplasmic Reticulum 0 0 0 0 0 0.09 0.12 0.16 0.1 0.14 0.14 0.08 0.06 0.05 0 0 0 0 0 0 0 0 0.05 0.05
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0.14 0.11 0.25 0.17 0.25 0.25 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 6 12 11 11 15 11 16 0 0 0 0 0 0 0 1 0 0 0 1
Bud 0 0 2 1 1 0 3 7 5 2 3 12 0 0 1 0 0 0 0 0 0 0 1 2
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 6 3 5 12 6 14 18 19 21 33 34 36 10 14 27 10 14 13 0 0 1 0 0 0
Cytoplasm 206 150 110 232 308 300 325 341 241 308 212 313 164 370 424 209 252 297 204 146 119 164 249 296
Endoplasmic Reticulum 9 1 2 1 11 31 52 80 36 62 47 38 11 21 8 7 8 12 1 2 0 7 14 16
Endosome 0 0 0 0 0 0 0 0 0 0 1 2 0 0 0 0 0 0 0 0 0 0 0 1
Golgi 1 0 0 0 0 0 1 2 1 0 0 0 0 1 0 1 1 0 0 0 0 0 0 1
Mitochondria 1 0 0 2 5 15 60 52 95 78 83 117 0 0 0 1 1 0 0 1 1 3 1 2
Nucleus 0 1 0 1 3 8 3 8 4 5 1 0 1 1 3 0 0 0 0 1 1 0 1 1
Nuclear Periphery 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 1 2 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 1 0 1 0 0 7 18 7 9 7 13 0 4 1 0 7 1 0 0 4 7 15 15
Unique Cell Count 212 152 116 240 326 347 430 494 374 455 328 471 175 392 440 212 262 304 208 156 132 186 289 343
Labelled Cell Count 223 156 119 250 334 374 482 540 422 514 399 547 186 411 464 228 283 323 208 156 132 186 289 343


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 25.3 28.1 16.7 18.6 15.3 14.0 12.3 12.4 11.1 10.9 11.1 10.7 24.3 23.9 25.1 29.9 29.1 31.5 26.7 27.0 28.1
Std Deviation (1e-4) 3.9 5.7 3.0 3.3 2.8 2.8 2.7 2.9 2.6 2.5 2.8 2.6 4.9 5.1 4.9 7.5 6.8 5.9 5.2 6.1 6.6
Intensity Change (Log2) – – – 0.16 -0.13 -0.26 -0.44 -0.44 -0.59 -0.62 -0.6 -0.64 0.54 0.51 0.58 0.84 0.8 0.91 0.67 0.69 0.75

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000102030WT3HU80HU120HU1600102030WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30102030WT1AF100AF140AF1800102030
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0.3 0 0 0 0 0.5 1.1 2.0 1.3 0.5 0 0.8 0.2 0.4 0
Cytoplasm 0.8 -0.1 -2.5 -4.6 -5.7 -6.3 -5.9 -6.3 -6.1 -0.4 -0.2 0.8 2.0 0.6 1.5
Endoplasmic Reticulum 0 0 2.6 3.3 4.1 2.8 3.6 3.7 2.4 1.8 1.7 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 4.3 3.7 6.0 4.8 6.0 6.0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration – – – – – – – – – – – – – – – – – –
Actin 0.0005 0.0004 0.0004 0.0005 0.002 0.0016 0.0062 0.0004 0.0006 0.0005 0.0005 0.001 0.0004 0.0005 0.001 0.0159 0.0019 0.0013
Bud 0.0005 0.0004 0.0008 0.001 0.001 0.0013 0.0008 0.0004 0.0008 0.0015 0.0002 0.0008 0.0006 0.0005 0.001 0.0135 0.0001 0.0005
Bud Neck 0.0006 0.0005 0.0009 0.0007 0.0014 0.002 0.0004 0.0003 0.0005 0.0007 0.0007 0.0013 0.0001 0.0002 0.0005 0.0015 0.0004 0.0006
Bud Periphery 0.0007 0.0002 0.0008 0.0011 0.0013 0.002 0.0006 0.0002 0.0006 0.0008 0.0001 0.0007 0.0001 0.0001 0.0002 0.0125 0 0.0001
Bud Site 0.0003 0.0005 0.0004 0.0003 0.0004 0.0001 0.0005 0.0004 0.0004 0.0003 0.0001 0.0001 0.0001 0.0002 0.0009 0.0073 0 0.0001
Cell Periphery 0.0019 0.0015 0.0011 0.0006 0.0016 0.002 0.0006 0.0006 0.0005 0.0003 0.0001 0.0005 0.0001 0.0001 0.0001 0.0012 0.0005 0
Cytoplasm 0.8343 0.9399 0.9075 0.8057 0.798 0.8121 0.8463 0.951 0.9335 0.8613 0.8977 0.8676 0.9251 0.9888 0.9166 0.5665 0.9704 0.9257
Cytoplasmic Foci 0.0048 0.0037 0.0045 0.0082 0.0118 0.0096 0.0102 0.0047 0.0067 0.0064 0.0078 0.0109 0.0019 0.0017 0.0053 0.0256 0.003 0.0105
Eisosomes 0 0 0 0 0 0.0001 0.0001 0 0 0 0 0 0 0 0 0.0001 0 0
Endoplasmic Reticulum 0.0907 0.0293 0.0385 0.0409 0.076 0.1028 0.0546 0.016 0.0151 0.0083 0.0416 0.0585 0.0256 0.0008 0.0126 0.0087 0.016 0.0141
Endosome 0.02 0.0081 0.014 0.0447 0.0499 0.0302 0.0363 0.0086 0.0195 0.0591 0.0341 0.0323 0.0135 0.0022 0.0398 0.1234 0.0033 0.0338
Golgi 0.0018 0.0018 0.0016 0.0029 0.0072 0.0063 0.0043 0.0018 0.0028 0.0046 0.0037 0.0087 0.0005 0.0003 0.0017 0.0661 0.0006 0.0042
Lipid Particles 0.0003 0.0005 0.0002 0.0003 0.0001 0.0002 0.0007 0.0002 0.0002 0.0007 0.0002 0 0 0 0 0.0065 0.0009 0
Mitochondria 0.0023 0.0009 0.0012 0.0061 0.0035 0.014 0.0049 0.0007 0.0041 0.0026 0.0021 0.0089 0.0023 0.0004 0.0015 0.0248 0 0.0028
None 0.0006 0.0002 0.0003 0.0003 0.0003 0.0007 0.0024 0.0002 0.0005 0.0003 0.0004 0.0005 0.0007 0.0002 0.0004 0.0009 0.0001 0.0004
Nuclear Periphery 0.0059 0.0014 0.003 0.0042 0.0052 0.0019 0.0049 0.0006 0.0013 0.0037 0.0025 0.0012 0.0132 0.0004 0.0017 0.007 0.0008 0.0012
Nucleolus 0.0001 0 0.0001 0 0 0 0.0001 0 0 0.0001 0 0 0 0 0 0.0009 0 0
Nucleus 0.0027 0.0009 0.0017 0.0016 0.0015 0.0013 0.0019 0.0005 0.0008 0.0018 0.0009 0.0006 0.0041 0.0007 0.0011 0.0031 0.0003 0.0008
Peroxisomes 0 0 0 0.0001 0.0001 0.0001 0.0004 0 0.0001 0.0001 0 0.0001 0 0 0.0001 0.0036 0 0.0001
Punctate Nuclear 0.0001 0 0.0001 0.0001 0.0001 0.0001 0.0009 0 0 0.0001 0.0001 0 0.0001 0 0 0.0006 0.0001 0
Vacuole 0.0279 0.0085 0.0204 0.0663 0.0308 0.0089 0.0185 0.0123 0.0096 0.0362 0.0053 0.0041 0.0078 0.0023 0.0094 0.0827 0.0013 0.002
Vacuole Periphery 0.004 0.0011 0.0024 0.0143 0.0078 0.0029 0.0046 0.001 0.0025 0.0108 0.002 0.0023 0.0036 0.0004 0.0061 0.0276 0.0001 0.0017

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 132.897 142.9903 117.5414 125.2262 124.1851 116.7889 112.1124 99.9172 93.2555 119.2091
Translational Efficiency 1.5144 1.4173 1.4369 1.1437 1.2741 1.3529 1.3611 1.1653 1.1839 1.1489

Hit Data

Dataset Hit
Protein Concentration –
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1584 1137 399 528 1357 1793 1237 1640 2941 2930 1636 2168

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1464.25 1991.56 2242.02 2325.69 1590.41 1928.06 2268.44 2494.41 1522.46 1952.70 2262.00 2453.32
Standard Deviation 252.39 406.56 291.45 488.61 373.87 326.52 325.68 449.69 320.56 361.03 317.88 465.14
Intensity Change Log 2 — 0.443737 0.614637 0.667497 — 0.277751 0.512302 0.649300 — 0.359702 0.562263 0.658051

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000255 0.000254 0.000398 0.001102 0.000221 0.000279 0.000248 0.000657 0.000239 0.000270 0.000284 0.000765
Bud Neck 0.000237 0.000411 0.003173 0.003808 0.000491 0.000310 0.001287 0.001296 0.000354 0.000349 0.001747 0.001907
Bud Site 0.021812 0.020628 0.015949 0.040715 0.016773 0.016074 0.011431 0.020372 0.019487 0.017841 0.012533 0.025327
Cell Periphery 0.000632 0.003052 0.005985 0.029573 0.001565 0.001053 0.003469 0.012155 0.001062 0.001829 0.004083 0.016397
Cytoplasm 0.736698 0.818916 0.762530 0.570716 0.721962 0.800778 0.837857 0.784664 0.729898 0.807817 0.819485 0.732558
Cytoplasmic Foci 0.102676 0.033669 0.025198 0.018916 0.072564 0.053996 0.015025 0.010678 0.088782 0.046108 0.017506 0.012684
Eisosomes 0.000003 0.000002 0.000003 0.000011 0.000003 0.000002 0.000002 0.000004 0.000003 0.000002 0.000002 0.000006
Endoplasmic Reticulum 0.002436 0.001252 0.000567 0.001700 0.003666 0.002255 0.000766 0.000774 0.003004 0.001866 0.000718 0.001000
Endosome 0.006329 0.003216 0.004424 0.008702 0.007948 0.005121 0.002939 0.002580 0.007076 0.004382 0.003301 0.004071
Golgi 0.050264 0.047551 0.035918 0.038146 0.058355 0.049261 0.023517 0.023916 0.053997 0.048597 0.026542 0.027382
Lipid Particles 0.000826 0.002381 0.011522 0.033607 0.002514 0.001897 0.008571 0.015879 0.001605 0.002085 0.009290 0.020196
Mitochondria 0.001331 0.000204 0.000056 0.001593 0.000398 0.000484 0.000050 0.001020 0.000901 0.000376 0.000051 0.001160
Mitotic Spindle 0.002357 0.001618 0.004850 0.003265 0.001862 0.001855 0.001293 0.001077 0.002129 0.001763 0.002160 0.001610
None 0.000334 0.000353 0.000560 0.000450 0.001474 0.000264 0.000562 0.000594 0.000860 0.000299 0.000562 0.000559
Nuclear Periphery 0.000115 0.000053 0.000278 0.000526 0.000298 0.000038 0.000084 0.000087 0.000199 0.000044 0.000131 0.000194
Nuclear Periphery Foci 0.001383 0.002643 0.011045 0.006273 0.005173 0.002080 0.004878 0.003215 0.003132 0.002298 0.006382 0.003959
Nucleolus 0.000028 0.000040 0.000085 0.000206 0.000320 0.000039 0.000057 0.000120 0.000163 0.000039 0.000064 0.000141
Nucleus 0.000835 0.001998 0.008533 0.005438 0.004322 0.001102 0.006167 0.003041 0.002444 0.001450 0.006744 0.003625
Peroxisomes 0.000163 0.000171 0.000080 0.000485 0.000143 0.000124 0.000101 0.000244 0.000154 0.000142 0.000096 0.000303
Vacuole 0.017776 0.023669 0.087914 0.205728 0.038570 0.024147 0.071302 0.098371 0.027371 0.023962 0.075354 0.124517
Vacuole Periphery 0.053510 0.037919 0.020936 0.029040 0.061378 0.038840 0.010392 0.019256 0.057140 0.038483 0.012964 0.021639

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.02 -1.22 -4.77 -6.01 -4.91 -0.73 -0.86 -1.77 -1.49 -1.59 -0.38 -0.88 -2.65 -2.57 -2.45
Bud Neck -3.75 -7.88 -11.75 -11.14 -1.39 3.09 -6.61 -4.42 -5.49 0.38 0.03 -10.79 -10.00 -10.05 -0.50
Bud Site 0.55 2.41 -5.17 -5.33 -6.14 0.48 3.26 -2.16 -2.67 -5.02 1.38 5.44 -3.71 -4.71 -7.60
Cell Periphery -5.75 -5.40 -8.23 -7.40 -6.26 1.77 -3.91 -11.15 -12.14 -8.72 -3.41 -7.27 -13.90 -13.11 -10.44
Cytoplasm -7.80 -1.14 10.88 15.92 9.84 -7.76 -10.30 -5.49 2.31 5.34 -10.77 -10.05 0.36 10.08 9.58
Cytoplasmic Foci 17.67 19.21 22.84 6.77 3.23 5.04 17.87 19.77 19.66 4.23 15.43 28.30 31.43 20.96 5.27
Eisosomes 0.88 -1.06 -7.22 -8.56 -7.01 1.20 1.34 -2.89 -3.90 -4.20 1.35 0.54 -5.77 -7.60 -7.20
Endoplasmic Reticulum 3.48 6.00 1.84 -0.88 -2.85 2.16 5.23 5.19 3.81 -0.02 3.01 7.32 6.23 3.36 -1.57
Endosome 6.57 2.98 -1.80 -4.45 -3.14 4.53 8.31 8.48 5.44 1.10 6.89 9.52 6.15 0.75 -1.39
Golgi 0.78 4.10 4.02 3.02 0.33 2.66 11.13 11.40 9.59 -0.05 2.24 12.25 12.51 9.97 0.13
Lipid Particles -4.60 -8.01 -9.10 -8.62 -5.44 1.27 -7.60 -10.52 -10.90 -4.85 -1.50 -11.53 -14.36 -13.84 -7.16
Mitochondria 2.57 2.91 -0.05 -1.13 -1.27 -0.32 2.46 -1.03 -0.83 -1.68 1.85 3.46 -0.33 -1.39 -2.10
Mitotic Spindle 1.43 -3.62 -1.25 -2.28 1.68 0.13 1.03 1.35 1.65 0.74 1.10 -0.42 1.02 0.24 1.56
None -0.44 -2.50 -0.51 -0.38 0.82 3.61 2.72 2.06 -1.17 -0.10 3.55 1.86 1.21 -1.16 0.06
Nuclear Periphery 0.73 -2.16 -2.16 -2.82 -1.17 1.22 0.97 0.98 -2.71 0.15 1.44 0.51 0.10 -3.51 -1.03
Nuclear Periphery Foci -3.27 -8.46 -7.64 -5.14 3.90 5.29 0.22 3.26 -3.83 4.47 2.55 -7.26 -2.32 -5.74 5.84
Nucleolus -1.71 -6.52 -6.12 -5.65 -3.78 2.66 2.46 1.87 -4.04 -4.48 2.50 1.89 0.32 -6.69 -5.84
Nucleus -4.22 -8.97 -7.95 -5.83 2.30 4.23 -2.74 0.86 -7.46 5.65 2.50 -9.28 -4.22 -8.66 5.89
Peroxisomes -0.15 3.91 -4.57 -3.59 -5.91 0.87 1.79 -3.18 -4.07 -4.80 0.47 3.37 -5.13 -4.67 -7.34
Vacuole -2.77 -9.67 -18.77 -18.06 -9.91 5.27 -7.69 -13.19 -17.46 -4.43 1.94 -13.37 -23.27 -24.18 -9.17
Vacuole Periphery 4.11 9.23 7.06 3.14 -1.65 5.78 14.95 11.83 8.35 -5.77 6.98 19.34 14.80 9.00 -5.58
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments; human gene CARS allows growth of the yeast haploid null mutant after sporulation of a heterozygous diploid
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Crs1

Crs1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Crs1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available