Standard name
Human Ortholog
Description Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.09 0.05 0.21 0.18 0.22 0.2 0.18 0.17 0.15 0.13 0.1 0.12 0.16 0.27 0.35 0.13 0.24 0.09 0 0.07 0.06 0.08 0.12 0.09
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.08 0 0 0 0 0 0 0
Endosome 0 0 0.05 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.65 0.27 0.16 0.22 0.29 0.48 0.58 0.49 0.59 0.68 0.74 0.68 0 0 0 0.07 0 0.06 0 0 0 0 0 0
Nucleus 0.6 0.7 0.58 0.64 0.45 0.42 0.44 0.43 0.46 0.41 0.44 0.44 0.75 0.61 0.5 0.69 0.6 0.76 0.66 0.66 0.56 0.63 0.43 0.38
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05
Vac/Vac Membrane 0.06 0.21 0.1 0.08 0.16 0.14 0.08 0.1 0.08 0.09 0.09 0.1 0.09 0.14 0.21 0.17 0.14 0.15 0.24 0.2 0.22 0.23 0.31 0.35
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0 0 0
Bud 1 0 1 1 5 6 11 9 8 14 13 11 0 0 0 0 0 0 0 2 4 1 3 6
Bud Neck 0 0 0 1 0 0 2 1 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 1
Bud Site 0 0 0 0 1 1 15 10 8 18 15 10 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
Cytoplasm 9 6 42 32 56 75 103 100 59 71 40 51 25 40 77 36 44 12 4 10 15 8 22 19
Endoplasmic Reticulum 0 1 0 0 0 0 0 0 0 0 0 0 1 0 1 13 14 3 0 0 1 0 0 2
Endosome 0 0 10 5 17 7 3 15 5 1 0 2 5 4 8 2 5 3 0 0 3 0 2 4
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0 1 0 0 2 0 0 0
Mitochondria 64 32 31 40 73 176 326 290 229 383 310 301 1 1 1 20 8 8 1 1 8 0 5 3
Nucleus 59 83 114 115 115 155 249 257 179 228 184 194 119 89 111 189 110 97 70 90 145 64 79 78
Nuclear Periphery 0 1 0 1 1 1 1 1 2 1 5 6 0 0 0 0 0 1 0 0 1 0 0 0
Nucleolus 0 0 1 1 0 1 3 4 1 3 2 0 0 0 0 1 1 0 0 0 1 0 3 5
Peroxisomes 0 0 1 0 0 0 0 2 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 2 0 0 5 6 10 4 6 0 3 0 1 1 1 1 0 1 1 9 1 4 9
Vac/Vac Membrane 6 25 20 15 42 53 43 59 31 50 36 45 14 20 46 46 26 19 25 27 57 23 57 71
Unique Cell Count 99 118 197 181 255 367 563 597 390 561 417 440 159 146 220 274 182 128 107 137 261 103 186 206
Labelled Cell Count 139 148 223 211 310 480 763 758 526 775 605 623 166 156 247 309 209 144 107 137 261 103 186 206


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.5 4.1 4.8 5.6 4.4 4.0 3.7 3.8 3.5 3.3 3.1 3.3 5.8 5.8 5.5 6.3 6.2 6.3 4.7 6.3 6.1
Std Deviation (1e-4) 0.5 0.6 1.6 5.3 2.2 2.1 1.7 2.0 1.5 1.0 1.3 1.3 1.4 1.5 1.0 1.2 1.7 1.8 0.7 1.8 1.1
Intensity Change (Log2) – – – 0.22 -0.13 -0.26 -0.39 -0.34 -0.45 -0.55 -0.64 -0.53 0.27 0.28 0.19 0.39 0.37 0.39 -0.04 0.4 0.34

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 2.0 1.2 1.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.6194 -0.0914 -0.5088 -0.7604 -1.2944 -0.4293 0.1735 0.1734 0.0495 0.1172 0.2998 -0.1319 -0.3488 -0.1461 -0.7667 -0.8971 -0.624 -0.6613
Actin 0.0093 0.0002 0.0003 0.0003 0.0002 0.0001 0.0277 0.0003 0.0085 0.0275 0.021 0.0018 0.0381 0.0001 0.0192 0.0002 0.0073 0.0001
Bud 0.0003 0.0001 0 0 0.0001 0 0.0031 0.0111 0.0003 0.0197 0.0003 0.0002 0.0013 0.0001 0.0003 0.0003 0.0001 0.0001
Bud Neck 0.0016 0.0006 0.0004 0.0005 0.0004 0.0021 0.0043 0.0011 0.0005 0.0016 0.0006 0.0023 0.0021 0.0005 0.0009 0.0004 0.001 0.0022
Bud Periphery 0.0004 0 0 0 0.0001 0 0.0025 0.0022 0.0004 0.0041 0.0007 0.0003 0.0026 0.0001 0.0003 0.0002 0 0.0001
Bud Site 0.0064 0.0006 0.0002 0.0001 0.0002 0.0001 0.019 0.007 0.0024 0.008 0.0005 0.0002 0.0105 0.0018 0.0022 0.0003 0.0002 0.0001
Cell Periphery 0.0001 0.0001 0 0 0 0 0.0012 0.0001 0.0001 0.0003 0.0002 0 0.0004 0.0001 0.0001 0 0 0
Cytoplasm 0.0371 0.0589 0.0427 0.0369 0.0479 0.0266 0.0567 0.0719 0.0468 0.0096 0.0259 0.0305 0.0354 0.0688 0.0901 0.1156 0.0818 0.056
Cytoplasmic Foci 0.0084 0.0009 0.0036 0.0005 0.0013 0.0024 0.0164 0.0028 0.0078 0.0328 0.0038 0.0027 0.0179 0.0027 0.0034 0.0022 0.0055 0.0048
Eisosomes 0.0003 0 0 0 0 0 0.0005 0 0.0001 0.0002 0.0003 0.0001 0.0003 0 0.0001 0 0.0001 0
Endoplasmic Reticulum 0.0041 0.0025 0.0015 0.0011 0.0012 0.0009 0.0047 0.0018 0.0027 0.0003 0.0019 0.0015 0.0039 0.0021 0.0024 0.003 0.0035 0.0007
Endosome 0.0093 0.0014 0.0018 0.0011 0.0031 0.0012 0.0303 0.0031 0.0138 0.0328 0.0338 0.0053 0.0223 0.0058 0.0041 0.0036 0.0129 0.0036
Golgi 0.0016 0 0.0002 0 0.0001 0 0.0159 0.0001 0.0071 0.0084 0.0298 0.0043 0.0075 0.0002 0.0049 0.0001 0.0009 0.0002
Lipid Particles 0.0043 0.0001 0.0023 0 0.0004 0.0002 0.0339 0.0004 0.0079 0.0227 0.0284 0.005 0.0085 0.0001 0.0019 0.0002 0.0046 0.0006
Mitochondria 0.0016 0.0003 0.0006 0.0007 0.0023 0.0003 0.0425 0.0015 0.0102 0.0067 0.0905 0.0051 0.0108 0.0006 0.0025 0.001 0.0007 0.0002
None 0.1079 0.1174 0.1305 0.0309 0.051 0.0795 0.0247 0.0422 0.0477 0.0351 0.0521 0.0257 0.1077 0.0265 0.0415 0.099 0.039 0.0278
Nuclear Periphery 0.0245 0.0201 0.0243 0.0326 0.0108 0.0121 0.031 0.021 0.0247 0.0048 0.0142 0.0156 0.0228 0.0207 0.0218 0.0185 0.0683 0.0087
Nucleolus 0.0151 0.0075 0.0087 0.0043 0.0069 0.0137 0.0104 0.01 0.0068 0.0053 0.0056 0.017 0.0069 0.0065 0.0043 0.005 0.0084 0.0094
Nucleus 0.721 0.7504 0.7476 0.8736 0.8573 0.7914 0.6102 0.7979 0.7894 0.7491 0.6747 0.8548 0.6719 0.8422 0.7794 0.7362 0.7027 0.8471
Peroxisomes 0.0017 0 0.008 0.0001 0.0002 0 0.0182 0.0002 0.0035 0.0173 0.0045 0.0012 0.0048 0 0.0013 0.0001 0.0004 0.0003
Punctate Nuclear 0.0422 0.0357 0.0259 0.0163 0.014 0.0684 0.0371 0.0203 0.015 0.0108 0.004 0.0248 0.0177 0.0086 0.0163 0.0113 0.0585 0.0367
Vacuole 0.002 0.0027 0.0011 0.0007 0.0017 0.0006 0.0058 0.0042 0.0031 0.0019 0.0037 0.0011 0.0047 0.0094 0.0023 0.0021 0.003 0.0011
Vacuole Periphery 0.0008 0.0004 0.0003 0.0003 0.0006 0.0001 0.0039 0.0008 0.0011 0.0009 0.0037 0.0007 0.0021 0.0029 0.0005 0.0007 0.0011 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 6.4045 4.0895 9.7106 6.2882 7.1175 9.1442 6.8225 5.5815 7.5751 6.7126
Translational Efficiency 0.7756 1.5583 0.4997 0.977 0.8047 0.4023 0.768 1.2352 0.6183 0.7142

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
790 265 157 685 1166 1943 759 1248 1956 2208 916 1933

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 633.85 755.80 943.38 791.49 711.33 746.06 885.42 867.14 680.04 747.23 895.35 840.33
Standard Deviation 76.83 93.24 91.83 117.31 92.12 85.05 104.21 107.78 94.28 86.14 104.50 116.99
Intensity Change Log 2 — 0.253863 0.573698 0.320430 — 0.068773 0.315843 0.285746 — 0.158951 0.443098 0.302193

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000191 0.000355 0.000862 0.000797 0.000037 0.000121 0.000283 0.000466 0.000099 0.000149 0.000382 0.000584
Bud Neck 0.001957 0.005624 0.002734 0.010014 0.000564 0.010845 0.002842 0.013382 0.001127 0.010219 0.002824 0.012189
Bud Site 0.000775 0.002112 0.001010 0.033244 0.000239 0.003204 0.000862 0.013540 0.000456 0.003072 0.000888 0.020523
Cell Periphery 0.000153 0.000147 0.000130 0.000308 0.000132 0.000101 0.000075 0.000188 0.000141 0.000107 0.000085 0.000231
Cytoplasm 0.142332 0.119079 0.017011 0.140377 0.283593 0.099779 0.020295 0.092149 0.226539 0.102095 0.019733 0.109239
Cytoplasmic Foci 0.044463 0.032730 0.001903 0.009970 0.023199 0.018460 0.000286 0.007424 0.031787 0.020173 0.000563 0.008326
Eisosomes 0.000056 0.000056 0.000069 0.000046 0.000028 0.000026 0.000020 0.000031 0.000039 0.000030 0.000028 0.000036
Endoplasmic Reticulum 0.001427 0.003785 0.014377 0.010883 0.000930 0.002071 0.004541 0.005388 0.001131 0.002277 0.006227 0.007335
Endosome 0.001390 0.002436 0.001056 0.005589 0.000892 0.002429 0.000289 0.006271 0.001093 0.002430 0.000420 0.006030
Golgi 0.000653 0.000344 0.000072 0.003642 0.000124 0.000648 0.000024 0.005808 0.000337 0.000612 0.000032 0.005041
Lipid Particles 0.005520 0.004343 0.001484 0.001472 0.002021 0.002483 0.000298 0.000865 0.003435 0.002706 0.000501 0.001080
Mitochondria 0.006431 0.003643 0.000620 0.006097 0.000398 0.006404 0.000577 0.006021 0.002835 0.006073 0.000585 0.006048
Mitotic Spindle 0.000595 0.002058 0.000139 0.025323 0.000606 0.004373 0.000708 0.023619 0.000601 0.004095 0.000611 0.024223
None 0.012002 0.006443 0.001198 0.007237 0.012017 0.005869 0.003371 0.008509 0.012011 0.005938 0.002999 0.008058
Nuclear Periphery 0.001037 0.000933 0.001221 0.002233 0.000579 0.002358 0.000877 0.002520 0.000764 0.002187 0.000936 0.002418
Nuclear Periphery Foci 0.000600 0.000715 0.000711 0.001488 0.000421 0.000402 0.000104 0.001180 0.000493 0.000440 0.000208 0.001289
Nucleolus 0.003808 0.003394 0.001957 0.000811 0.001291 0.003989 0.000849 0.001451 0.002308 0.003917 0.001039 0.001224
Nucleus 0.766112 0.794925 0.937973 0.687477 0.667583 0.823473 0.958251 0.775086 0.707377 0.820047 0.954776 0.744040
Peroxisomes 0.003698 0.004538 0.000342 0.000766 0.000356 0.002602 0.000066 0.001599 0.001705 0.002835 0.000114 0.001304
Vacuole 0.006463 0.011997 0.014985 0.050496 0.004853 0.009447 0.005305 0.029716 0.005503 0.009753 0.006964 0.037080
Vacuole Periphery 0.000336 0.000343 0.000147 0.001732 0.000139 0.000913 0.000075 0.004785 0.000219 0.000845 0.000087 0.003703

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.00 -6.26 -7.86 -3.25 1.07 -5.14 -10.96 -9.63 -7.81 -3.82 -1.83 -8.40 -11.75 -11.44 -4.47
Bud Neck -2.79 -2.45 -8.02 -2.61 -5.31 -8.58 -4.95 -9.04 -0.58 -5.84 -8.50 -4.71 -11.48 -0.81 -7.41
Bud Site -2.52 -1.72 -5.21 -4.76 -4.97 -5.83 -2.93 -6.14 -3.95 -5.49 -5.65 -2.61 -7.75 -6.00 -7.27
Cell Periphery 0.20 -0.40 -3.20 -2.62 -2.61 3.19 5.14 -0.98 -2.74 -3.90 3.74 5.05 -2.84 -4.89 -5.65
Cytoplasm 1.79 14.27 2.41 0.09 -10.88 20.80 31.23 21.81 2.50 -12.77 18.41 33.27 18.72 0.97 -16.93
Cytoplasmic Foci 1.99 11.80 10.07 5.34 -2.71 2.13 14.87 10.55 8.37 -5.00 5.37 17.95 14.17 9.54 -6.04
Eisosomes -0.56 -3.06 -1.09 -0.10 2.56 0.90 1.94 -7.75 -8.87 -9.78 4.08 1.98 -5.46 -9.99 -7.06
Endoplasmic Reticulum -3.66 -9.83 -15.01 -10.07 1.34 -7.64 -13.19 -20.08 -15.79 -5.32 -6.81 -14.94 -23.56 -19.70 -5.19
Endosome -1.75 -0.57 -3.14 -1.47 -2.57 -4.19 4.77 -4.66 -1.74 -5.72 -4.04 4.34 -5.54 -2.30 -6.74
Golgi 0.88 2.10 -1.07 -1.35 -1.65 -2.84 2.00 -2.60 -1.93 -2.72 -1.52 2.72 -2.72 -2.23 -3.20
Lipid Particles 0.86 5.60 6.42 3.31 0.85 -1.29 6.52 3.30 4.24 -5.79 1.65 9.67 7.22 4.80 -5.50
Mitochondria 0.93 2.79 1.16 0.09 -2.39 -6.87 -3.07 -3.83 2.50 -3.48 -2.94 2.60 -0.70 2.49 -4.22
Mitotic Spindle -1.87 0.69 -5.11 -3.91 -5.19 -3.19 -0.65 -6.21 -4.52 -6.02 -3.76 -0.69 -8.06 -5.86 -7.79
None 3.46 7.65 3.62 0.09 -6.06 3.80 5.72 3.58 -0.35 -3.16 4.99 8.22 4.97 -0.39 -4.68
Nuclear Periphery 0.55 -2.76 -11.01 -11.03 -7.54 -6.05 -5.90 -14.52 -3.58 -10.99 -5.48 -5.04 -17.88 -4.66 -13.75
Nuclear Periphery Foci -0.91 -1.39 -5.39 -4.47 -0.95 0.26 4.55 -2.97 -3.00 -3.85 0.43 0.97 -4.82 -5.01 -5.12
Nucleolus -0.15 3.97 7.94 5.41 3.09 -6.51 2.81 0.01 6.42 -2.55 -4.19 6.89 6.26 7.52 -1.07
Nucleus -1.32 -11.17 4.39 4.62 14.30 -14.73 -29.67 -9.22 4.70 19.96 -13.14 -31.84 -4.40 8.24 26.09
Peroxisomes -0.89 4.28 4.06 3.02 -0.77 -5.32 2.76 -1.37 3.70 -2.42 -2.29 4.93 2.81 4.99 -2.87
Vacuole -2.83 -3.82 -12.70 -11.29 -8.13 -4.86 -2.03 -14.26 -12.83 -12.96 -4.82 -3.50 -18.98 -17.38 -16.45
Vacuole Periphery -0.22 2.21 -2.02 -1.97 -2.61 -3.28 2.75 -3.36 -1.85 -3.47 -3.00 3.85 -3.76 -1.85 -4.08
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
Localization
Cell Percentages nucleus (38%), cytoplasm (17%), mixed (43%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Rtc4

Rtc4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rtc4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available