Standard name
Human Ortholog
Description Subunit of a replication-pausing checkpoint complex; Tof1p-Mrc1p-Csm3p acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase; relocalizes to the cytosol in response to hypoxia
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0.05 0.05 0 0 0.06 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0.07 0.09 0.08 0.09 0.06 0.16 0.15 0.09 0.1 0.12 0.05 0.11 0.12 0.15 0.22 0.16 0 0 0 0.05 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.11 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.25 0.49 0.61 0.42 0.75 0.73 0.67 0.74 0.84 0.83 0.84 0.16 0.05 0.08 0 0 0.05 0 0 0 0 0 0
Nucleus 0.94 0.91 0.81 0.71 0.76 0.64 0.66 0.57 0.49 0.48 0.47 0.5 0.8 0.8 0.81 0.74 0.76 0.68 0.87 0.86 0.76 0.75 0.56 0.41
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0.12 0.06 0.06 0 0 0 0 0 0 0 0 0.06
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.07 0.16 0.06 0.06 0.13 0.13 0.26 0.4
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 1 0
Bud 0 0 1 0 1 3 2 9 1 2 1 5 0 0 0 0 0 0 8 3 2 0 1 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0
Bud Site 0 0 4 2 1 2 11 14 8 9 5 12 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 19 4 11 14 14 18 16 41 23 24 18 26 5 18 19 14 10 3 5 3 1 3 5 3
Endoplasmic Reticulum 0 0 0 0 0 0 2 1 0 0 0 0 0 0 0 2 0 2 0 0 0 0 2 0
Endosome 1 0 0 0 0 0 1 1 0 0 0 0 0 0 0 4 1 1 2 0 0 0 4 3
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 3 0 0 0 1 0
Mitochondria 17 50 79 92 76 146 181 175 111 217 143 180 16 8 13 4 2 1 2 1 2 0 2 3
Nucleus 526 185 131 107 138 125 162 149 73 125 81 106 82 128 127 70 35 13 503 188 134 48 106 65
Nuclear Periphery 0 0 0 1 1 1 2 2 1 0 3 1 0 0 0 1 1 0 0 0 0 0 1 2
Nucleolus 6 1 6 0 3 0 4 3 1 1 2 7 12 9 10 0 0 0 12 3 3 1 6 9
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 2 0 2 0 1 0 2 2 3 1 1 0 0 0 0 0 0 0 5 2 4 0 2 1
Vac/Vac Membrane 14 10 3 1 1 5 5 5 2 4 4 7 1 4 2 8 3 3 33 13 23 8 49 63
Unique Cell Count 558 204 162 150 182 194 247 261 149 259 172 214 102 160 157 94 46 19 580 220 178 65 189 158
Labelled Cell Count 585 250 237 217 236 300 388 402 223 383 259 344 116 167 171 105 52 23 580 220 178 65 189 158


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.8 4.1 3.6 3.6 3.7 3.3 3.2 3.2 3.0 2.9 2.8 2.9 5.3 5.5 5.2 8.8 8.3 8.9 4.7 5.2 5.0
Std Deviation (1e-4) 0.7 0.6 0.9 1.0 1.3 0.8 1.3 1.2 1.4 1.2 0.7 1.3 1.3 1.5 1.7 2.7 2.4 2.3 0.7 1.9 1.1
Intensity Change (Log2) – – – -0.0 0.03 -0.14 -0.19 -0.18 -0.27 -0.32 -0.39 -0.35 0.53 0.59 0.52 1.27 1.18 1.29 0.38 0.52 0.46

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.3212 1.716 1.4377 1.2179 0.9207 1.3013 1.7719 2.2935 2.0438 3.0303 1.3434 1.9568 2.6731 3.0183 2.9248 3.5646 2.6128 3.0544
Actin 0 0.001 0 0.0001 0 0 0.0562 0.0001 0.0038 0.0544 0.0039 0.0086 0.0029 0.0003 0.0136 0.0001 0 0
Bud 0 0.0002 0 0 0 0.0001 0.0007 0 0.0002 0.0005 0.0003 0.0001 0.0001 0.0018 0.0004 0 0 0
Bud Neck 0.0002 0.0005 0.0081 0.0001 0.0004 0.0022 0.0015 0.0002 0.0005 0.0004 0.0006 0.0008 0.0019 0.0012 0.0012 0.0001 0.0004 0.0011
Bud Periphery 0 0.0002 0 0 0 0.0001 0.0013 0 0.0003 0.0004 0.0006 0.0001 0.0001 0.0025 0.001 0 0 0
Bud Site 0 0.0033 0.0004 0 0 0.0001 0.0032 0.0003 0.0008 0.0023 0.0006 0.0001 0.0006 0.0036 0.004 0 0.0001 0.0001
Cell Periphery 0 0.0001 0 0 0 0 0.0004 0 0 0.0001 0.0001 0 0.0001 0.0004 0.0002 0 0 0
Cytoplasm 0.0036 0.0072 0.0074 0.0054 0.0052 0.0014 0.0403 0.0054 0.0028 0.0152 0.0171 0.0038 0.0186 0.0049 0.0013 0.0068 0.0027 0.0004
Cytoplasmic Foci 0.0001 0.0026 0.0002 0.0001 0 0 0.016 0.0001 0.0042 0.0199 0.0009 0.0062 0.0054 0.0001 0.0011 0.0001 0 0
Eisosomes 0 0 0 0 0 0 0.0009 0 0.0001 0.0002 0.0001 0 0.0007 0 0.0002 0 0 0
Endoplasmic Reticulum 0.0002 0.0006 0.0005 0.0002 0.0002 0.0001 0.0037 0.0002 0.0006 0.002 0.0057 0.008 0.0012 0.0007 0.0013 0.0001 0.0002 0
Endosome 0.0004 0.0023 0.001 0.0003 0.0003 0.0003 0.0239 0.0003 0.0038 0.0111 0.0104 0.0063 0.0016 0.0001 0.0052 0.0001 0.0005 0
Golgi 0 0.0008 0 0 0 0 0.0065 0 0.0016 0.0097 0.0008 0.0019 0.0006 0 0.0021 0 0 0
Lipid Particles 0 0.0006 0.0001 0 0 0 0.0146 0 0.0056 0.0711 0.0004 0.0045 0.0025 0 0.0035 0 0 0
Mitochondria 0.0002 0.0031 0.0002 0.0001 0.0003 0.0002 0.0035 0.0003 0.0027 0.0039 0.0225 0.0009 0.0006 0.0008 0.0166 0.0003 0.0002 0.0001
None 0.0007 0.0028 0.0017 0.0255 0.0008 0.0003 0.0472 0.0136 0.0039 0.0515 0.0213 0.0099 0.0411 0.0458 0.0202 0.0633 0.0138 0.0001
Nuclear Periphery 0.0102 0.0077 0.008 0.0039 0.0077 0.0034 0.0112 0.0075 0.0041 0.0063 0.0276 0.0032 0.0195 0.0018 0.0169 0.0032 0.0041 0.0009
Nucleolus 0.0081 0.0095 0.0119 0.0029 0.01 0.0133 0.0143 0.0111 0.0402 0.0092 0.0076 0.0077 0.0074 0.0076 0.034 0.0034 0.016 0.0305
Nucleus 0.9646 0.94 0.9475 0.9576 0.9695 0.975 0.7123 0.957 0.9001 0.6961 0.8545 0.9277 0.8603 0.9256 0.8694 0.9178 0.953 0.9611
Peroxisomes 0 0.0025 0 0 0 0 0.0083 0 0.0032 0.0183 0.0003 0.005 0.0045 0 0.0017 0 0 0
Punctate Nuclear 0.0114 0.0139 0.0119 0.0035 0.0051 0.0029 0.0259 0.0034 0.0212 0.0262 0.0214 0.0048 0.0295 0.0009 0.0033 0.0046 0.008 0.0054
Vacuole 0.0002 0.0009 0.0008 0.0001 0.0002 0.0004 0.0065 0.0004 0.0003 0.0007 0.0017 0.0003 0.0007 0.0017 0.0017 0.0001 0.0007 0.0001
Vacuole Periphery 0.0001 0.0002 0.0002 0.0001 0.0001 0.0001 0.0017 0.0002 0.0002 0.0003 0.0017 0.0001 0.0002 0.0002 0.0012 0 0.0001 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 26.1231 4.7766 8.4674 16.1218 25.2099 25.812 6.3725 7.8776 12.1943 27.0507
Translational Efficiency 0.652 0.675 0.3818 0.4561 0.4045 0.6374 0.7484 0.3203 0.4601 0.4176

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1966 21 1091 872 1486 1984 202 98 3452 2005 1293 970

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 635.87 309.37 1017.12 890.59 641.82 777.32 1021.92 966.46 638.43 772.42 1017.87 898.26
Standard Deviation 73.27 8.42 128.60 130.21 82.24 105.12 110.12 113.61 77.31 114.91 125.90 130.65
Intensity Change Log 2 — -1.039399 0.677686 0.486030 — 0.276340 0.671042 0.590541 — -0.233597 0.674352 0.539475

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000025 0.000039 0.000483 0.000933 0.000087 0.000131 0.000847 0.000772 0.000052 0.000130 0.000540 0.000916
Bud Neck 0.001805 0.000012 0.005382 0.018620 0.001737 0.007780 0.004123 0.004441 0.001776 0.007699 0.005185 0.017187
Bud Site 0.000431 0.000027 0.002693 0.009711 0.000424 0.002213 0.000704 0.000902 0.000428 0.002190 0.002382 0.008821
Cell Periphery 0.000145 0.000076 0.000072 0.000163 0.000158 0.000117 0.000058 0.000159 0.000151 0.000117 0.000070 0.000163
Cytoplasm 0.231261 0.000042 0.045443 0.045656 0.067056 0.032213 0.002871 0.002210 0.160575 0.031876 0.038792 0.041266
Cytoplasmic Foci 0.019419 0.000014 0.001049 0.006029 0.007237 0.004606 0.000320 0.000085 0.014175 0.004558 0.000935 0.005428
Eisosomes 0.000022 0.000115 0.000017 0.000032 0.000018 0.000018 0.000040 0.000031 0.000021 0.000019 0.000021 0.000032
Endoplasmic Reticulum 0.000455 0.000001 0.005182 0.008686 0.001214 0.002538 0.009244 0.009832 0.000782 0.002511 0.005816 0.008802
Endosome 0.000524 0.000001 0.000709 0.006864 0.000470 0.001691 0.000295 0.000283 0.000500 0.001673 0.000644 0.006199
Golgi 0.000101 0.000007 0.000704 0.005542 0.000169 0.000670 0.000053 0.000073 0.000130 0.000664 0.000602 0.004990
Lipid Particles 0.001457 0.000052 0.000308 0.000922 0.001810 0.002177 0.000344 0.000217 0.001609 0.002155 0.000314 0.000851
Mitochondria 0.001062 0.000012 0.000864 0.009310 0.001025 0.006439 0.000635 0.001431 0.001046 0.006372 0.000828 0.008514
Mitotic Spindle 0.000240 0.000297 0.001670 0.034323 0.000354 0.007028 0.000246 0.005828 0.000290 0.006957 0.001447 0.031444
None 0.027215 0.999115 0.003654 0.012113 0.027589 0.004570 0.001557 0.011884 0.027376 0.014987 0.003326 0.012090
Nuclear Periphery 0.000476 0.000000 0.000836 0.005414 0.000640 0.001532 0.000567 0.000611 0.000547 0.001516 0.000794 0.004928
Nuclear Periphery Foci 0.000297 0.000028 0.000524 0.003508 0.000542 0.000443 0.000136 0.000244 0.000402 0.000439 0.000464 0.003178
Nucleolus 0.005911 0.000028 0.000478 0.003946 0.013152 0.007703 0.004044 0.012567 0.009028 0.007623 0.001035 0.004817
Nucleus 0.706452 0.000014 0.920224 0.783307 0.874457 0.912175 0.968345 0.942302 0.778774 0.902621 0.927742 0.799371
Peroxisomes 0.000471 0.000119 0.000084 0.001796 0.000768 0.001298 0.000212 0.000532 0.000599 0.001285 0.000104 0.001669
Vacuole 0.002031 0.000001 0.009447 0.031660 0.000982 0.004025 0.005277 0.005473 0.001580 0.003983 0.008795 0.029014
Vacuole Periphery 0.000198 0.000000 0.000177 0.011466 0.000110 0.000633 0.000081 0.000123 0.000160 0.000627 0.000162 0.010320

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.62 -11.81 -13.61 -13.18 -6.91 -2.19 -8.52 -6.90 -6.63 -0.76 -5.29 -13.66 -14.41 -13.29 -6.61
Bud Neck 6.53 -4.06 -13.30 -15.06 -8.20 -6.96 -5.43 -5.06 -0.75 -2.16 -6.84 -4.83 -13.97 -7.34 -8.56
Bud Site 7.85 -3.25 -5.66 -6.03 -2.75 -3.80 -3.97 -3.91 -0.04 -2.17 -3.80 -3.42 -5.83 -3.72 -2.98
Cell Periphery 2.71 5.67 0.57 -2.45 -5.43 2.47 6.30 0.59 -0.22 -1.23 2.48 7.99 1.19 -1.31 -5.49
Cytoplasm 42.96 30.68 31.08 -11.21 1.30 8.76 16.80 17.82 15.50 0.97 31.27 27.70 27.20 -0.10 0.82
Cytoplasmic Foci 14.38 13.50 11.58 -3.34 -1.86 2.66 6.67 6.94 7.86 1.46 9.26 14.54 11.62 3.24 -1.89
Eisosomes -1.15 1.05 -11.65 0.79 -11.62 0.51 -5.65 -4.73 -4.89 0.07 0.95 -2.37 -13.24 -12.36 -10.12
Endoplasmic Reticulum 8.91 -17.69 -17.82 -18.56 -8.23 -6.46 -11.33 -8.08 -7.08 -1.34 -8.83 -19.94 -18.83 -15.18 -7.93
Endosome 6.68 -0.72 -4.17 -5.23 -3.72 -3.26 1.02 -0.17 3.07 -0.97 -3.26 -0.67 -4.20 -1.67 -3.80
Golgi 5.39 -0.86 -1.94 -2.07 -1.28 -1.72 2.70 2.09 2.10 -1.25 -1.89 -0.76 -1.89 -1.10 -1.33
Lipid Particles 8.88 6.78 2.71 -5.98 -3.67 -0.50 2.70 2.78 3.26 0.32 -0.98 5.08 2.89 2.42 -3.60
Mitochondria 2.87 0.19 -3.32 -4.42 -3.54 -5.06 1.30 -0.88 4.58 -1.93 -5.06 0.48 -3.43 1.20 -3.62
Mitotic Spindle -0.09 -1.61 -7.30 -7.30 -6.80 -4.64 -0.43 -1.02 -0.09 -0.98 -4.71 -1.61 -7.34 -5.29 -6.89
None -542.88 12.73 10.18 965.47 -3.18 9.34 10.86 3.37 -0.34 -0.89 4.67 15.66 11.53 3.10 -3.37
Nuclear Periphery 7.90 -6.53 -9.42 -10.38 -8.40 -6.33 -1.24 -2.81 2.28 -2.20 -7.07 -6.71 -9.39 -7.06 -8.48
Nuclear Periphery Foci 3.72 -1.77 -2.54 -3.12 -2.13 1.08 3.37 2.13 1.17 -0.95 0.16 -0.68 -2.35 -2.36 -2.19
Nucleolus 6.88 6.37 2.74 -7.30 -6.30 3.27 5.14 1.56 0.18 -0.93 1.39 9.94 5.48 3.75 -4.83
Nucleus 110.14 -27.01 -9.62 -91.25 10.79 -5.52 -11.64 -3.61 -1.07 2.14 -18.78 -24.22 -4.84 8.38 11.27
Peroxisomes 3.04 3.43 -0.33 -2.09 -2.22 -1.04 2.62 1.71 3.06 -0.70 -2.24 4.25 0.51 2.37 -2.25
Vacuole 11.09 -8.86 -10.75 -11.27 -7.18 -5.81 -3.12 -2.68 -2.21 -1.22 -4.67 -9.64 -11.13 -10.39 -7.35
Vacuole Periphery 1.71 0.31 -3.03 -3.24 -3.08 -4.20 1.32 -1.17 3.93 -1.98 -3.35 0.15 -3.07 -2.56 -3.09
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of a replication-pausing checkpoint complex; Tof1p-Mrc1p-Csm3p acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase; relocalizes to the cytosol in response to hypoxia
Localization
Cell Percentages nucleus (74%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Tof1

Tof1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Tof1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available