Standard name
Human Ortholog
Description Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; role in regulating Hsp90 inhibitor drug sensitivity; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.99 1.0 1.0 0.98 0.96 0.97 – 0.78 0.75 0.75 0.88 0.78 1.0 1.0 1.0 0.95 0.95 0.92 0.98 0.89 0.96 0.97 0.94 0.92
Endoplasmic Reticulum 0 0 0 0 0 0 – 0.06 0 0.07 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 – 0 0.06 0.05 0.06 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 – 0.11 0.16 0.12 0.05 0.09 0 0 0 0.06 0.09 0.11 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 6 6 3 1 5 0 0 0 0 0 0 0 0 0 0 0 0
Bud 2 0 2 0 0 0 – 3 0 1 2 1 0 1 0 1 1 0 3 0 0 0 2 5
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 1 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 2 1 0 0 0 4 – 7 11 11 5 9 3 0 1 3 6 2 0 0 0 0 0 0
Cytoplasm 508 61 114 121 206 342 – 403 261 263 266 240 230 368 341 344 333 340 497 67 108 152 205 214
Endoplasmic Reticulum 3 0 0 1 4 9 – 31 11 23 8 15 0 1 0 5 6 14 1 0 0 0 0 2
Endosome 1 0 0 0 0 0 – 7 1 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0
Golgi 1 0 0 0 0 0 – 0 0 2 1 2 0 0 0 1 2 1 0 0 0 0 0 1
Mitochondria 0 0 0 0 1 1 – 13 20 17 19 20 0 0 1 1 0 0 0 1 0 0 0 0
Nucleus 0 0 0 1 1 0 – 4 0 6 2 1 0 1 0 2 0 0 1 2 0 1 2 2
Nuclear Periphery 0 0 0 0 0 0 – 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 2 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 1 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 2 0 0 0 3 1 – 59 54 41 15 28 0 0 1 20 32 40 1 0 1 0 3 2
Unique Cell Count 513 61 114 123 214 352 517 346 351 304 308 230 368 342 363 352 371 509 76 113 157 218 232
Labelled Cell Count 519 62 116 123 215 357 538 365 370 321 321 233 371 344 378 380 398 509 76 113 157 218 232


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 30.6 32.9 19.4 24.0 25.5 23.3 – 20.8 20.0 19.7 18.6 18.6 31.9 33.0 31.4 40.2 40.4 38.6 29.4 32.1 34.4
Std Deviation (1e-4) 6.5 7.8 4.6 5.5 5.9 5.8 – 6.7 6.8 6.0 6.3 6.3 8.5 12.4 7.1 18.6 21.9 22.8 8.3 11.2 12.5
Intensity Change (Log2) – – – 0.31 0.39 0.26 – 0.09 0.04 0.02 -0.06 -0.07 0.72 0.77 0.69 1.05 1.05 0.99 0.6 0.72 0.82


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -1.4 -2.1 -1.8 – -5.5 -5.9 -5.9 -4.0 -5.5 0 0 -0.6 -2.5 -2.5 -3.2
Endoplasmic Reticulum 0 0 0 – 2.7 0 2.8 0 0 0 0 0 0 0 0
Endosome 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 – 0 0 0 2.7 2.8 0 0 0 0 0 0
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 – 3.8 4.5 3.8 0 3.3 0 0 0 0 3.3 3.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 20.222 27.9651 22.5308 22.0637 15.9937 24.59 21.9226 27.6586 26.0218 23.1441 25.0368 25.0885 26.3448 30.8131 30.113 28.5531 26.835 28.3077
Actin 0.0222 0.0026 0.0123 0.0396 0.0122 0.0005 0.0154 0.0017 0.0046 0.0015 0.0023 0.0016 0.0035 0.0001 0.0059 0.003 0.0059 0.0006
Bud 0.0003 0.0002 0.0006 0.0007 0.0025 0.0001 0.0011 0.0007 0.0008 0.0001 0.0011 0.0001 0.0008 0 0.0001 0.0009 0.0004 0.0001
Bud Neck 0.0005 0.0002 0.0006 0.0005 0.0007 0.0004 0.0013 0.0001 0.0004 0.0007 0.0003 0.0009 0.0003 0.0001 0.0002 0.0003 0.0003 0.0005
Bud Periphery 0.0003 0.0001 0.0005 0.001 0.003 0.0001 0.0011 0.0008 0.0004 0.0001 0.002 0.0001 0.0005 0 0 0.0008 0.0002 0.0001
Bud Site 0.0014 0.001 0.0048 0.0012 0.0045 0 0.0095 0.0039 0.0016 0.0004 0.0008 0.0001 0.0003 0 0.0001 0.0002 0.0005 0
Cell Periphery 0.0002 0 0.0001 0.0001 0.0004 0 0.0003 0 0.0001 0 0.0001 0 0.0001 0 0 0.0001 0.0003 0.0001
Cytoplasm 0.857 0.9797 0.9117 0.893 0.6346 0.947 0.8646 0.9819 0.9313 0.9049 0.9079 0.9576 0.9259 0.9824 0.9706 0.974 0.9109 0.9478
Cytoplasmic Foci 0.0176 0.0008 0.0118 0.0045 0.0135 0.0006 0.0235 0.0003 0.0223 0.0208 0.0018 0.0017 0.0062 0.0002 0.0014 0.0007 0.0145 0.0007
Eisosomes 0.0001 0 0.0001 0.0002 0.0002 0 0.0002 0 0 0 0 0 0 0 0 0 0.0001 0
Endoplasmic Reticulum 0.0044 0.0001 0.0028 0.0015 0.0061 0.0005 0.0022 0.0002 0.0007 0.0006 0.0029 0.0057 0.0015 0.0001 0.0011 0.0006 0.0027 0.0008
Endosome 0.024 0.0014 0.0167 0.0139 0.1298 0.0042 0.0217 0.0003 0.0103 0.0041 0.0427 0.0024 0.0053 0 0.0024 0.0005 0.0038 0.0022
Golgi 0.0081 0.0031 0.0078 0.0096 0.0454 0.006 0.0066 0.0002 0.0048 0.0049 0.0088 0.0005 0.001 0 0.0007 0.0001 0.0009 0.0003
Lipid Particles 0.0107 0.0002 0.0025 0.0068 0.0088 0.0001 0.0052 0 0.0047 0.0047 0.0006 0.0004 0.0065 0 0.0012 0 0.0032 0.0005
Mitochondria 0.0038 0.0043 0.0097 0.0091 0.102 0.0268 0.005 0.0002 0.002 0.0275 0.0129 0.0006 0.0023 0 0.0002 0.0008 0.0031 0.0007
None 0.0036 0.0001 0.0006 0.001 0.0012 0.0003 0.0036 0.0002 0.0006 0.0007 0.0003 0.0004 0.0014 0.0002 0.0008 0.0005 0.0041 0.0004
Nuclear Periphery 0.0098 0.0006 0.0039 0.0045 0.0045 0.0013 0.0041 0.0011 0.0011 0.0022 0.0019 0.0057 0.0038 0.0014 0.0025 0.0015 0.0056 0.0071
Nucleolus 0.0003 0 0.0001 0.0002 0.0005 0 0.0014 0 0.0001 0.0002 0 0 0.0003 0 0 0 0.0041 0.0006
Nucleus 0.0274 0.0047 0.0066 0.0052 0.0066 0.011 0.02 0.008 0.0085 0.0184 0.0072 0.0206 0.0282 0.0152 0.0107 0.015 0.0198 0.0321
Peroxisomes 0.0016 0.0002 0.0036 0.0037 0.0026 0 0.0024 0 0.0039 0.0014 0.0001 0.0001 0.007 0 0.0005 0.0001 0.0008 0.0001
Punctate Nuclear 0.0039 0.0001 0.0008 0.0024 0.0006 0.0002 0.0043 0.0001 0.0011 0.0061 0.0001 0.0009 0.0013 0.0001 0.0006 0.0001 0.0053 0.0004
Vacuole 0.0019 0.0002 0.0012 0.0005 0.012 0.0004 0.0052 0.0002 0.0006 0.0003 0.004 0.0005 0.0029 0.0001 0.0007 0.0004 0.0072 0.0038
Vacuole Periphery 0.0008 0.0001 0.0011 0.0007 0.0084 0.0005 0.0013 0 0.0003 0.0003 0.0019 0.0002 0.0008 0 0.0002 0.0001 0.0063 0.0012

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 169.5708 207.0963 205.9554 201.5881 182.6972 171.8639 236.3787 226.561 267.7078 187.7961
Translational Efficiency 1.2729 1.4615 1.4386 1.7348 1.4849 1.586 1.4996 1.8768 1.549 1.6409

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2021 1107 1067 1516 1853 1753 947 1510 3874 2860 2014 3026

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1835.13 2291.24 3357.88 4598.71 2063.35 2343.28 3441.13 4505.79 1944.29 2323.14 3397.02 4552.34
Standard Deviation 356.76 523.86 644.82 1234.63 412.17 454.22 695.78 1169.47 400.81 483.04 670.55 1203.45
Intensity Change Log 2 — 0.320246 0.871668 1.325347 — 0.183541 0.737894 1.126792 — 0.249508 0.802413 1.223668

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000075 0.000224 0.000128 0.000405 0.000085 0.000059 0.000119 0.000827 0.000080 0.000123 0.000124 0.000616
Bud Neck 0.000312 0.000646 0.001519 0.002953 0.000271 0.000291 0.001152 0.002778 0.000292 0.000428 0.001347 0.002865
Bud Site 0.000831 0.003503 0.001296 0.005552 0.000547 0.000768 0.001483 0.008556 0.000695 0.001826 0.001384 0.007051
Cell Periphery 0.000071 0.000173 0.000426 0.001652 0.000066 0.000055 0.000513 0.000363 0.000069 0.000101 0.000467 0.001009
Cytoplasm 0.861784* 0.798877* 0.554335* 0.647351* 0.820638* 0.865625* 0.653058* 0.689736* 0.842103* 0.839789* 0.600755* 0.668501*
Cytoplasmic Foci 0.003289 0.008040 0.007343 0.007013 0.002263 0.003309 0.009729 0.007717 0.002798 0.005140 0.008465 0.007364
Eisosomes 0.000001 0.000001 0.000001 0.000005 0.000001 0.000001 0.000001 0.000005 0.000001 0.000001 0.000001 0.000005
Endoplasmic Reticulum 0.000137 0.000251 0.000057 0.000088 0.000164 0.000058 0.000029 0.000063 0.000150 0.000133 0.000044 0.000075
Endosome 0.000088 0.000743 0.000086 0.002071 0.000063 0.000167 0.000057 0.001473 0.000076 0.000390 0.000072 0.001773
Golgi 0.000392 0.001380 0.000327 0.002765 0.000310 0.000335 0.000293 0.002600 0.000353 0.000740 0.000311 0.002683
Lipid Particles 0.000208 0.000589 0.000516 0.002031 0.000118 0.000173 0.000787 0.000725 0.000165 0.000334 0.000643 0.001379
Mitochondria 0.000167 0.000341 0.000296 0.000661 0.000171 0.000050 0.000148 0.000561 0.000169 0.000163 0.000226 0.000611
Mitotic Spindle 0.000455 0.004510 0.002117 0.010074 0.001125 0.001572 0.001049 0.007316 0.000775 0.002709 0.001615 0.008698
None 0.017631 0.015394 0.011840 0.011746 0.013501 0.014443 0.010489 0.012264 0.015655 0.014811 0.011205 0.012004
Nuclear Periphery 0.000043 0.000102 0.000743 0.000257 0.000062 0.000050 0.000258 0.000210 0.000052 0.000070 0.000515 0.000233
Nuclear Periphery Foci 0.002129 0.004993 0.001536 0.001175 0.001046 0.001400 0.001243 0.001059 0.001611 0.002790 0.001398 0.001117
Nucleolus 0.000056 0.000409 0.000115 0.000528 0.000098 0.000093 0.000079 0.000227 0.000076 0.000215 0.000098 0.000378
Nucleus 0.109502 0.152234* 0.410970* 0.282792* 0.156248* 0.103918 0.309582* 0.250550* 0.131861* 0.122620 0.363296* 0.266703*
Peroxisomes 0.000009 0.000048 0.000011 0.000085 0.000007 0.000020 0.000008 0.000219 0.000008 0.000031 0.000010 0.000152
Vacuole 0.002675 0.006127 0.006252 0.019756 0.002708 0.007278 0.009868 0.010809 0.002691 0.006833 0.007953 0.015291
Vacuole Periphery 0.000146 0.001414 0.000085 0.001041 0.000510 0.000336 0.000054 0.001943 0.000320 0.000753 0.000070 0.001491

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.98 -8.95 -5.91 -1.32 -1.21 1.55 -8.01 -1.96 -2.08 -1.01 -3.07 -11.98 -3.32 -2.65 -1.28
Bud Neck -3.34 -11.52 -9.86 -8.00 0.75 -1.69 -11.81 -6.30 -5.98 1.79 -3.38 -16.17 -11.39 -10.27 1.84
Bud Site -2.94 -4.31 -7.49 -1.76 -4.28 -2.39 -10.54 -5.00 -4.53 -2.27 -3.35 -8.87 -8.25 -5.14 -4.32
Cell Periphery -7.33 -13.98 -6.28 -5.45 -1.55 1.12 -13.07 -10.81 -11.02 5.94 -5.74 -19.14 -8.37 -7.79 0.76
Cytoplasm 12.39 54.33 42.26 26.15 -11.07 -7.64 30.16 24.74 31.08 -7.87 3.50 58.27 47.12 41.86 -13.57
Cytoplasmic Foci -7.60 -12.42 -11.40 -2.85 3.75 -4.94 -14.26 -11.78 -9.60 6.74 -8.53 -18.86 -16.30 -9.30 7.42
Eisosomes -5.10 -12.06 -11.57 -8.71 -2.78 -2.70 -10.74 -4.78 -4.35 0.71 -5.60 -16.14 -10.55 -8.98 -1.09
Endoplasmic Reticulum -1.06 1.81 3.17 2.07 2.22 1.46 1.60 1.83 2.22 2.09 0.54 2.15 2.85 2.43 3.03
Endosome -3.51 -4.81 -1.49 0.20 -1.12 -2.84 -4.63 -2.25 -1.54 -1.86 -4.28 -6.43 -2.38 -0.80 -1.86
Golgi -2.73 -2.50 -1.04 0.86 -0.56 -0.14 -2.77 -1.54 -1.44 -1.17 -2.36 -3.53 -1.79 -0.50 -1.17
Lipid Particles -4.89 -9.82 -9.50 -7.84 -4.10 -3.02 -11.75 -9.05 -8.37 3.32 -4.92 -15.22 -12.28 -10.92 -1.72
Mitochondria -0.73 -2.19 -1.16 -0.17 0.95 1.80 -0.37 -0.97 -3.17 -0.99 0.26 -2.13 -1.49 -1.91 0.27
Mitotic Spindle -3.04 -6.19 -4.40 -1.17 -1.91 -1.00 -1.71 -2.91 -1.95 -1.40 -3.04 -4.90 -5.28 -2.39 -2.34
None 2.51 6.24 7.57 5.30 3.36 0.31 4.68 4.28 4.20 -0.41 2.33 7.77 8.59 6.53 2.22
Nuclear Periphery -6.24 -6.76 -19.96 -15.23 3.87 -0.39 -16.03 -11.01 -12.45 7.07 -4.44 -9.33 -21.96 -20.34 5.17
Nuclear Periphery Foci -3.33 -0.14 1.50 3.68 0.83 -2.70 -6.88 -1.75 1.02 4.88 -3.55 -2.29 0.31 3.67 2.48
Nucleolus -1.75 -15.76 -1.90 0.53 -0.72 -0.40 -0.86 -1.54 -1.57 -1.30 -1.89 -5.72 -2.31 0.04 -0.96
Nucleus -9.56 -50.52 -30.72 -20.01 17.23 11.14 -23.72 -17.38 -26.45 7.62 1.26 -50.87 -34.15 -33.93 17.77
Peroxisomes -3.36 -5.24 -3.01 0.18 -1.52 -1.46 -6.81 -1.53 -1.06 -1.25 -2.81 -7.80 -2.21 -1.04 -1.58
Vacuole -7.67 -12.38 -20.87 -17.97 -10.39 -9.03 -14.76 -18.02 -13.04 0.00 -11.88 -19.14 -26.89 -21.87 -8.20
Vacuole Periphery -1.57 0.09 -1.27 1.29 -1.50 0.64 1.64 -0.27 -0.85 -1.69 -1.00 1.60 -0.72 0.50 -2.12
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; role in regulating Hsp90 inhibitor drug sensitivity; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Hch1

Hch1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Hch1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available