Standard name
Human Ortholog
Description Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; in concert with Sgs1p-Top2p-Rmi1p, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication s
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0.08 0 0 0.07 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0.06 0.05 0.05 0 0 0 0 0 0 0 0.06 0.07 0.07 0.08 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0.09 0 0 0.06 0.1 0.08 0 0.07 0.05 0 0.09 0.12 0.16 0.05 0 0 0.08 0.05 0.12 0.1 0.11 0.15
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.05 0.05
Mitochondria 0.17 0.05 0 0 0.06 0.08 0.08 0.1 0.21 0.09 0.15 0.11 0 0 0.06 0.05 0 0 0 0 0.06 0.08 0.09 0.06
Nucleus 0.47 0.64 0.5 0.55 0.61 0.43 0.39 0.27 0.25 0.31 0.32 0.38 0.58 0.55 0.41 0.66 0.64 0.68 0.41 0.49 0.35 0.37 0.24 0.22
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.42 0.23 0.21 0.34 0.22 0.34 0.34 0.45 0.39 0.37 0.42 0.43 0.18 0.17 0.22 0.17 0.16 0.11 0.12 0.11 0.1 0 0 0
Peroxisomes 0 0 0.09 0 0 0.07 0.1 0.06 0.13 0.08 0.07 0.08 0.08 0.12 0.23 0 0 0 0 0 0.05 0.06 0.14 0.13
SpindlePole 0 0 0.18 0.06 0.07 0.1 0.11 0.16 0.23 0.18 0.16 0.14 0.14 0.14 0.2 0 0 0 0.13 0.12 0.12 0.1 0.11 0.15
Vac/Vac Membrane 0 0.05 0.05 0 0 0 0 0 0 0 0 0 0.05 0 0 0.05 0.1 0.11 0.09 0.09 0.08 0.16 0.14 0.12
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 0 0 0 0 1 1 1 1 0 1 0 0 0 0 1 0 1 4 1 3 4
Bud 1 0 2 1 1 2 1 2 8 4 4 0 0 0 0 0 0 0 4 8 4 2 5 5
Bud Neck 1 1 1 0 0 0 0 1 2 2 1 1 0 0 0 0 0 0 2 5 1 0 1 1
Bud Site 0 2 1 1 0 4 0 6 24 10 8 22 2 1 0 0 0 0 – – – – – –
Cell Periphery 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1 5 7 8 10 15 14 4 6 4 6 6 8 7 12 20 20 20 0 3 2 0 2 0
Endoplasmic Reticulum 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 5 4 5 0 0 0 0 1 0
Endosome 2 6 24 5 2 19 27 23 6 26 13 4 16 25 31 15 3 6 9 17 43 15 32 47
Golgi 2 1 0 0 0 0 0 1 0 0 0 0 4 0 0 0 3 2 3 2 11 8 16 17
Mitochondria 16 15 10 3 11 24 21 29 67 32 39 33 5 8 12 14 9 6 2 12 20 11 25 20
Nucleus 45 186 138 103 108 128 104 80 79 110 83 118 106 110 81 196 170 175 46 181 121 55 69 70
Nuclear Periphery 0 10 6 3 6 2 8 5 3 6 5 4 4 0 0 3 4 0 2 8 8 0 2 3
Nucleolus 40 66 57 64 39 99 90 135 123 131 110 132 33 35 44 50 43 29 13 41 34 4 12 14
Peroxisomes 0 7 24 5 5 20 27 17 41 28 18 24 14 23 45 10 3 2 1 2 19 9 40 42
SpindlePole 4 10 49 11 12 29 30 48 72 65 41 44 25 28 40 10 6 6 15 44 42 14 33 47
Vac/Vac Membrane 3 14 13 8 3 9 7 12 7 9 4 4 10 7 7 16 27 28 9 34 28 24 40 38
Unique Cell Count 96 292 274 186 177 295 267 299 317 352 260 310 184 200 199 297 267 257 113 369 352 151 294 319
Labelled Cell Count 115 325 333 212 197 352 330 364 439 428 333 392 228 244 272 339 292 280 113 369 352 151 294 319


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 14.6 11.6 11.9 11.6 10.6 13.7 13.5 13.2 11.4 13.4 11.8 12.8 16.0 13.9 14.6 14.9 18.6 17.5 11.4 11.3 11.2
Std Deviation (1e-4) 8.3 5.0 4.1 3.8 3.3 4.1 4.4 5.0 4.3 6.1 4.6 5.3 8.5 6.0 7.2 6.4 9.8 8.4 3.3 4.7 4.5
Intensity Change (Log2) – – – -0.05 -0.18 0.2 0.17 0.15 -0.07 0.16 -0.02 0.1 0.42 0.22 0.29 0.32 0.64 0.55 -0.06 -0.09 -0.09


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 4.3 0 0 4.2 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.0 1.7 1.6 1.6 -1.1 -0.5 0 -0.2 -0.5 1.1 0.6 1.9 2.4 2.6 2.7
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome -2.6 -3.4 -1.0 0.5 -0.5 -3.8 -0.6 -1.7 -4.2 0 1.3 2.3 -1.8 -4.1 -3.2
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria -1.3 1.3 2.3 2.1 2.9 6.3 2.7 4.5 3.2 -0.5 0.2 1.2 0.6 -0.2 -0.9
Nucleus 1.1 2.2 -1.7 -2.7 -5.8 -6.4 -4.9 -4.3 -3.0 1.5 1.0 -2.1 3.8 3.1 4.2
Nuclear Periphery 0 0 0 0.6 -0.5 0 -0.4 -0.2 0 0 0 0 0 0 0
Nucleolus 3.3 0.3 3.4 3.4 6.2 4.7 4.4 5.4 5.6 -0.8 -0.9 0.3 -1.2 -1.4 -3.0
Peroxisomes -2.6 -2.5 -0.9 0.5 -1.4 1.6 -0.4 -0.8 -0.4 -0.4 1.0 4.2 -2.7 -4.1 -4.3
SpindlePole -3.7 -3.4 -2.8 -2.2 -0.6 1.5 0.2 -0.7 -1.2 -1.2 -1.1 0.6 -5.7 -6.0 -5.9
Vacuole -0.2 -1.7 -1.0 -1.3 -0.4 -1.7 -1.5 -2.1 -2.5 0.3 -0.7 -0.7 0.3 2.4 2.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 9.1237 12.1404 12.3346 10.9268 11.1925 11.2092 11.7552 13.3108 14.2879 13.8522 12.8186 12.4495 8.1266 13.2745 9.6761 9.2147 14.8609 9.7702
Actin 0.0259 0.001 0.0039 0.0101 0.0156 0.0096 0.0026 0.0025 0.0067 0.0005 0.0263 0.0067 0.0758 0.0213 0.0098 0.0581 0.0081 0.0023
Bud 0.0006 0.0001 0.0002 0.0007 0.0009 0.0013 0 0.0009 0.0007 0.0001 0.0006 0.002 0.0007 0.0002 0.0002 0.0018 0.0005 0.0005
Bud Neck 0.0042 0.0003 0.0002 0.0007 0.0027 0.0075 0.0006 0.0014 0.001 0.0001 0.0005 0.0099 0.0017 0.0006 0.0002 0.0005 0.0009 0.0029
Bud Periphery 0.0008 0.0005 0.0006 0.0012 0.0024 0.0058 0 0.0014 0.0022 0.0004 0.0011 0.0028 0.0011 0.0005 0.0004 0.0027 0.0008 0.0015
Bud Site 0.0112 0.0003 0.0003 0.0028 0.0023 0.0012 0.0002 0.0009 0.0017 0.0005 0.0005 0.0029 0.0015 0.001 0.0006 0.0023 0.0007 0.001
Cell Periphery 0.0004 0.0002 0.0001 0.0002 0.0006 0.0012 0.0001 0.0004 0.0003 0.0001 0.0001 0.0004 0.0002 0.0001 0.0002 0.0003 0.0001 0.0004
Cytoplasm 0.0065 0.0002 0.0001 0.0033 0.0179 0.0004 0.0132 0.0025 0.001 0.0001 0.0015 0.0073 0.0043 0.0022 0.0004 0.0017 0.0017 0.0002
Cytoplasmic Foci 0.0116 0.0021 0.0046 0.0237 0.1456 0.0042 0.0031 0.0091 0.0055 0.1514 0.0014 0.0087 0.0195 0.022 0.0259 0.0429 0.2121 0.0017
Eisosomes 0.0006 0.0001 0.0001 0.0002 0.0001 0.0003 0.001 0 0.0002 0 0.0002 0.0001 0.0004 0.0001 0.0001 0.0003 0.0001 0.0001
Endoplasmic Reticulum 0.0047 0.0001 0.0001 0.0032 0.0099 0.0006 0.0006 0.0008 0.0005 0.0001 0.0021 0.0012 0.0049 0.0006 0.0003 0.0003 0.0008 0.0001
Endosome 0.0246 0.0027 0.0003 0.0108 0.0144 0.004 0.0008 0.0229 0.0022 0.0016 0.0046 0.0042 0.0516 0.0029 0.0044 0.0057 0.0048 0.0008
Golgi 0.0124 0.0128 0.0005 0.003 0.0051 0.0034 0.0003 0.0152 0.0018 0.0022 0.0016 0.0025 0.0433 0.016 0.0068 0.0123 0.0031 0.001
Lipid Particles 0.0185 0.0032 0.0088 0.0215 0.0398 0.0227 0.0006 0.0034 0.013 0.0588 0.0053 0.0154 0.0124 0.0295 0.0651 0.0254 0.136 0.01
Mitochondria 0.0131 0.0016 0.0098 0.01 0.0063 0.0378 0.0004 0.0491 0.0099 0.0112 0.0534 0.008 0.0113 0.0041 0.0188 0.0278 0.0059 0.0062
None 0.012 0.0001 0.0002 0.0018 0.0034 0.0005 0.2148 0.0003 0.001 0.0003 0.0012 0.0115 0.0023 0.0104 0.0008 0.0021 0.0013 0.0002
Nuclear Periphery 0.0296 0.0633 0.0995 0.0698 0.0837 0.0199 0.0014 0.02 0.0191 0.006 0.1553 0.0134 0.0236 0.0256 0.0122 0.0245 0.0315 0.0222
Nucleolus 0.0815 0.1311 0.1434 0.1172 0.0869 0.1567 0.0401 0.1227 0.1402 0.0339 0.0097 0.201 0.1343 0.2078 0.1715 0.1701 0.0843 0.2735
Nucleus 0.637 0.6331 0.5579 0.5566 0.3326 0.6536 0.7105 0.6432 0.7146 0.5504 0.5709 0.6499 0.4593 0.4948 0.5518 0.412 0.4081 0.5264
Peroxisomes 0.0124 0.0002 0.0004 0.0076 0.0115 0.0071 0.0004 0.0056 0.0017 0.0083 0.0018 0.0015 0.0678 0.0074 0.0071 0.0377 0.0044 0.0023
Punctate Nuclear 0.0881 0.1435 0.1656 0.1519 0.2078 0.0493 0.0092 0.0927 0.0724 0.1724 0.1545 0.0477 0.0785 0.1496 0.1185 0.1673 0.0928 0.1439
Vacuole 0.0022 0.0008 0.0004 0.0015 0.0071 0.0055 0.0001 0.0022 0.0017 0.0005 0.0013 0.0016 0.0028 0.0007 0.0014 0.0012 0.0007 0.0011
Vacuole Periphery 0.0021 0.0028 0.0032 0.0021 0.0034 0.0073 0.0001 0.0025 0.0024 0.001 0.0062 0.0012 0.0028 0.0024 0.0035 0.0032 0.0013 0.0016

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 140.9458 55.1987 24.932 45.7668 79.1884 110.011 38.8253 24.1572 40.3943 87.6369
Translational Efficiency 1.8397 1.6098 1.84 1.9614 2.1782 2.5044 1.862 2.1328 1.9934 1.9478

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
57 165 1432 67 787 1255 1703 20 844 1420 3135 87

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1455.46 1568.83 1397.38 1736.81 1087.27 1164.25 1555.01 1733.40 1112.14 1211.26 1483.01 1736.03
Standard Deviation 480.42 680.63 371.49 526.99 387.96 233.11 404.65 579.50 405.55 344.48 397.68 539.52
Intensity Change Log 2 — 0.108214 -0.058751 0.254965 — 0.098691 0.516214 0.672894 — 0.104149 0.215505 0.448645

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.016673 0.011401 0.002454 0.014027 0.008653 0.004991 0.004263 0.018438 0.009195 0.005735 0.003437 0.015041
Bud Neck 0.014432 0.025911 0.022019 0.044432 0.018473 0.018243 0.031878 0.025811 0.018200 0.019134 0.027375 0.040151
Bud Site 0.006645 0.008809 0.006992 0.030922 0.009354 0.008317 0.009314 0.033753 0.009171 0.008374 0.008254 0.031573
Cell Periphery 0.000133 0.000151 0.000169 0.000398 0.000297 0.000298 0.000153 0.002079 0.000286 0.000281 0.000160 0.000784
Cytoplasm 0.000774 0.000893 0.002010 0.002024 0.002007 0.001942 0.000908 0.015492 0.001924 0.001820 0.001411 0.005120
Cytoplasmic Foci 0.108311 0.086976 0.036209 0.170790 0.051920 0.017937 0.022121 0.089627 0.055729 0.025959 0.028556 0.152132
Eisosomes 0.000536 0.000542 0.000087 0.000276 0.000468 0.000168 0.000150 0.000552 0.000473 0.000212 0.000122 0.000339
Endoplasmic Reticulum 0.003992 0.004597 0.001205 0.002119 0.008646 0.007537 0.001974 0.006215 0.008331 0.007195 0.001623 0.003060
Endosome 0.005311 0.005094 0.002113 0.020738 0.004084 0.002289 0.001172 0.060561 0.004167 0.002615 0.001602 0.029893
Golgi 0.006584 0.010134 0.003021 0.039907 0.004574 0.001810 0.001585 0.014633 0.004709 0.002778 0.002241 0.034097
Lipid Particles 0.052327 0.053495 0.002098 0.054932 0.051069 0.010595 0.003172 0.041007 0.051154 0.015580 0.002682 0.051731
Mitochondria 0.003850 0.013925 0.007816 0.012186 0.011355 0.008521 0.009592 0.011941 0.010848 0.009149 0.008781 0.012130
Mitotic Spindle 0.330890* 0.218706* 0.397777* 0.324636* 0.171786* 0.069836 0.201037* 0.474797* 0.182531* 0.087134 0.290904* 0.359156*
None 0.000709 0.001015 0.001717 0.004489 0.007176 0.004817 0.001589 0.004710 0.006739 0.004376 0.001648 0.004540
Nuclear Periphery 0.002920 0.001811 0.002240 0.002409 0.003151 0.002112 0.002653 0.000626 0.003136 0.002077 0.002464 0.001999
Nuclear Periphery Foci 0.008463 0.003015 0.002909 0.006214 0.027244 0.010326 0.002786 0.003086 0.025976 0.009476 0.002842 0.005495
Nucleolus 0.148071 0.196017 0.181816 0.080060 0.215699 0.195586 0.224468* 0.037693 0.211132 0.195636 0.204985 0.070321
Nucleus 0.184673* 0.283574* 0.296352* 0.076841 0.323625* 0.602242* 0.442442* 0.118996 0.314241* 0.565214* 0.375711* 0.086532
Peroxisomes 0.098088 0.069563 0.027957 0.058846 0.075219 0.027841 0.035786 0.019079 0.076763 0.032689 0.032210 0.049704
Vacuole 0.005566 0.003555 0.002027 0.036354 0.003877 0.003350 0.002027 0.018711 0.003991 0.003374 0.002027 0.032298
Vacuole Periphery 0.001051 0.000816 0.001011 0.017400 0.001323 0.001242 0.000930 0.002194 0.001305 0.001193 0.000967 0.013904

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.48 1.27 0.34 -0.18 -1.61 2.19 2.87 -0.68 -0.98 -1.03 2.04 3.71 -0.70 -1.39 -1.81
Bud Neck -1.70 -2.99 -2.75 -1.78 -1.90 0.24 -7.30 -0.69 -0.73 0.56 -0.30 -6.60 -2.59 -2.54 -1.22
Bud Site -0.69 -1.20 -3.64 -3.40 -3.45 0.62 -2.32 -1.25 -1.30 -1.06 0.52 -1.53 -3.58 -3.68 -3.37
Cell Periphery -0.51 -1.51 -2.51 -2.29 -1.93 0.09 4.20 -1.12 -1.13 -1.22 0.21 3.89 -1.24 -1.27 -1.62
Cytoplasm -0.87 -2.26 -2.41 -1.89 0.56 0.42 2.99 -0.87 -0.89 -0.97 0.51 1.03 -0.79 -0.88 -0.96
Cytoplasmic Foci 0.66 2.35 -0.93 -1.96 -4.12 5.30 4.22 -0.52 -1.25 -1.10 4.47 3.50 -3.40 -4.74 -4.43
Eisosomes 0.12 3.25 1.79 2.20 -4.05 5.88 6.04 -0.04 -0.99 -1.01 5.31 7.23 1.64 -1.37 -2.40
Endoplasmic Reticulum -0.19 2.78 1.71 1.44 -1.25 1.36 8.92 0.77 0.50 -0.70 1.50 9.78 4.31 3.54 -0.93
Endosome 0.13 1.36 -1.69 -1.78 -2.67 1.80 3.30 -1.46 -1.51 -1.55 1.60 3.21 -2.23 -2.42 -2.58
Golgi -0.85 1.58 -1.81 -1.52 -2.18 3.14 3.92 -1.49 -1.97 -2.06 2.22 3.36 -2.17 -2.40 -2.50
Lipid Particles 0.02 3.32 0.56 0.59 -2.55 6.41 8.13 0.62 -1.15 -1.51 5.85 8.71 0.89 -1.85 -2.94
Mitochondria -1.92 -2.97 -1.86 0.42 -0.79 1.67 0.81 0.13 -0.34 -0.07 1.05 1.29 0.02 -0.51 -0.53
Mitotic Spindle 1.89 -0.94 0.03 -1.97 1.05 8.07* -2.42 -2.53 -3.48 -2.23 7.50 -7.80 -3.88 -6.14 -1.63
None -1.94 -5.87 -0.99 -0.85 -0.52 1.48 3.82 0.88 0.19 -0.70 1.60 3.72 1.39 0.41 -0.77
Nuclear Periphery 1.40 0.88 0.76 -0.57 0.11 2.04 1.32 5.56 3.54 4.53 2.27 1.87 2.24 0.48 1.08
Nuclear Periphery Foci 2.22 2.26 1.12 -1.09 -1.12 4.11 7.33 6.64 3.81 -0.04 4.38 7.45 6.38 3.13 -1.11
Nucleolus -1.35 -1.85 1.10 2.77 3.73 1.28 -1.59 2.72 2.42 3.12 0.97 -0.86 4.63 4.30 5.22
Nucleus -2.10 -2.56 1.35 4.26 5.71 -16.53 -5.80 2.64 6.52 3.95 -15.46 -2.95 6.64 15.25 8.51
Peroxisomes 1.48 3.46 1.96 0.85 -2.41 8.39 6.75 7.10 1.43 3.05 8.01 8.25 2.76 -1.73 -1.58
Vacuole 0.71 1.18 -1.59 -1.80 -1.91 0.54 1.65 -1.24 -1.30 -1.40 0.70 2.21 -1.97 -2.04 -2.16
Vacuole Periphery 0.52 0.30 -1.70 -1.74 -1.72 0.11 0.89 -0.45 -0.51 -0.79 0.18 0.89 -1.68 -1.70 -1.77
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; in concert with Sgs1p-Top2p-Rmi1p, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication s
Localization
Cell Percentages nucleus (49%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Rfa2

Rfa2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rfa2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available