Standard name
Human Ortholog
Description Histone deacetylase, component of both the Rpd3S and Rpd3L complexes; regulates transcription, silencing, autophagy and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members; Rpd3(L) recruitment to the subtelomeric region is regulated by interaction with the arginine methyltransferase, Hmt1p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Cytoplasm 0 0 0 0.05 0.07 0 0 0 0 0 0 0 0.07 0.12 0.17 – – – 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Mitochondria 0.22 0 0 0.06 0 0.16 0.19 0.08 0.09 0.17 0.19 0.13 0 0 0 – – – 0 0 0 0 0 0
Nucleus 0.83 0.86 0.89 0.87 0.81 0.77 0.73 0.67 0.71 0.66 0.65 0.65 0.9 0.84 0.78 – – – 0.63 0.7 0.58 0.75 0.68 0.59
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nucleolus 0.28 0.19 0.12 0.17 0.18 0.27 0.34 0.38 0.42 0.44 0.5 0.51 0.05 0 0.05 – – – 0.25 0.22 0.3 0.13 0.16 0.22
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Vac/Vac Membrane 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0.06 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 1 0 0 0 0
Bud 0 0 0 0 2 3 12 7 2 3 2 3 0 0 0 – – – 1 4 6 3 4 4
Bud Neck 0 0 0 0 1 1 4 5 0 0 4 3 0 0 0 – – – 0 0 2 1 0 2
Bud Site 0 0 1 0 2 11 22 16 13 21 24 19 0 0 0 – – – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 – – – 0 0 0 0 0 0
Cytoplasm 1 4 10 13 25 15 15 23 9 4 4 7 37 66 83 – – – 0 1 2 5 4 7
Endoplasmic Reticulum 0 1 1 0 1 0 0 0 0 0 0 0 0 0 1 – – – 0 0 0 0 1 2
Endosome 0 2 13 1 3 2 2 2 0 0 0 0 1 1 3 – – – 3 1 11 5 8 13
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 3 2 1 0 1 2
Mitochondria 40 7 6 15 13 94 122 56 43 98 118 90 1 0 1 – – – 1 0 1 1 5 5
Nucleus 152 218 443 230 281 463 472 442 340 380 411 440 447 445 376 – – – 119 199 317 319 302 290
Nuclear Periphery 0 0 4 2 2 5 10 11 7 6 8 8 0 2 0 – – – 0 0 4 1 3 2
Nucleolus 52 48 61 44 61 166 221 250 202 252 315 345 27 19 24 – – – 48 61 166 53 69 109
Peroxisomes 0 0 0 1 0 0 0 0 0 0 0 0 0 0 5 – – – 0 0 1 0 0 0
SpindlePole 0 1 4 0 0 1 2 0 0 2 1 1 6 13 10 – – – 2 1 13 10 8 20
Vac/Vac Membrane 3 14 3 1 5 9 6 4 3 5 2 3 1 4 4 – – – 6 8 17 16 25 28
Unique Cell Count 183 254 497 263 348 605 649 663 482 578 631 672 496 528 481 191 284 549 428 444 497
Labelled Cell Count 248 295 546 307 396 770 888 816 619 771 889 919 520 551 507 191 284 549 428 444 497


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.4 8.8 7.8 7.2 7.6 6.8 6.8 6.9 7.2 7.2 6.6 6.8 9.4 9.2 8.6 – – – 8.8 8.9 9.4
Std Deviation (1e-4) 1.3 1.3 1.7 2.2 2.2 2.1 1.8 2.0 2.1 2.1 2.2 1.8 1.6 1.7 1.7 – – – 1.4 1.4 1.8
Intensity Change (Log2) – – – -0.11 -0.04 -0.19 -0.2 -0.16 -0.11 -0.11 -0.23 -0.18 0.28 0.25 0.15 – – – 0.18 0.2 0.27

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Bud 0 0 0 3.0 0 0 0 0 0 0 0 0 – – –
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Bud Site 0 0 2.6 3.8 3.1 3.3 4.0 4.1 3.4 0 0 0 – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Cytoplasm 2.2 3.7 0.5 0.3 1.5 -0.2 -1.9 -2.1 -1.4 4.0 6.4 8.1 – – –
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Endosome 0 -1.8 -3.3 -3.4 -3.5 -3.6 -3.9 -4.1 -4.2 -3.2 -3.3 -2.5 – – –
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Mitochondria 3.6 2.4 8.2 9.4 5.4 5.5 8.7 9.3 7.5 0 0 0 – – –
Nucleus -0.7 -3.4 -5.4 -6.9 -8.9 -7.3 -9.0 -9.3 -9.3 0.5 -2.3 -4.6 – – –
Nuclear Periphery 0 0 0 1.1 1.3 1.0 0 0.8 0.6 0 0 0 – – –
Nucleolus 1.7 2.1 6.2 8.5 9.7 10.5 11.3 13.3 13.9 -3.8 -5.2 -4.0 – – –
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 – – –
SpindlePole 0 0 0 0 0 0 0 0 0 0 2.1 1.7 – – –
Vacuole 0 0 1.4 0 0 0 0 0 0 0 0 0 – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 7.3829 7.3276 6.8896 6.2458 6.5355 6.3343 5.6469 5.6369 5.4087 4.8523 4.5993 5.4717 5.8471 5.3352 4.9264 5.3245 4.4619 4.7559
Actin 0.0003 0 0.0001 0 0.0001 0 0.0265 0 0.0049 0 0.102 0.0008 0.0032 0 0.0055 0 0.0413 0
Bud 0.0001 0 0 0 0.0001 0 0.0013 0 0.0003 0 0.0077 0.0004 0.0005 0 0.0002 0 0.0002 0.0001
Bud Neck 0.0005 0.0001 0.0001 0 0.0003 0.0007 0.0018 0.0002 0.0004 0 0.001 0.0014 0.0003 0.0001 0.0002 0 0.0007 0.0008
Bud Periphery 0.0002 0 0.0001 0 0.0003 0.0001 0.0017 0 0.0007 0 0.0139 0.0009 0.0006 0 0.0002 0 0.0005 0.0001
Bud Site 0.0003 0.0001 0.0001 0 0.0003 0.0001 0.0123 0.0001 0.0121 0 0.007 0.0007 0.0022 0 0.0012 0 0.0005 0.0001
Cell Periphery 0 0 0 0 0.0001 0 0.0004 0 0.0008 0 0.0002 0.0002 0 0 0.0001 0 0.0001 0
Cytoplasm 0.001 0.0001 0.0004 0 0 0 0.0041 0.0001 0.0004 0 0.0004 0.0005 0.0057 0 0.0087 0 0.0001 0
Cytoplasmic Foci 0.0001 0 0.0002 0 0 0 0.05 0 0.0035 0 0.0065 0.0027 0.016 0 0.0047 0 0.0003 0
Eisosomes 0 0 0 0 0 0 0.0003 0 0 0 0.0002 0 0 0 0 0 0.0005 0
Endoplasmic Reticulum 0.0005 0 0.0002 0 0 0 0.0017 0 0 0 0.0004 0.0005 0.002 0 0.0062 0 0.0032 0
Endosome 0.0006 0 0.002 0 0.0001 0 0.02 0 0.0002 0 0.0094 0.0067 0.018 0 0.0067 0 0.005 0
Golgi 0 0 0.0005 0 0 0 0.0112 0 0.0005 0 0.0211 0.0014 0.005 0 0.0042 0 0.0073 0
Lipid Particles 0 0 0.0056 0 0.0001 0 0.0202 0 0.0003 0 0.0054 0.0008 0.005 0 0.0016 0 0.0016 0
Mitochondria 0.0007 0.0001 0.0019 0 0.0011 0.0001 0.0105 0.0001 0.0003 0.0001 0.0184 0.012 0.0019 0.0001 0.0098 0.0001 0.0109 0.0001
None 0.0002 0 0.0014 0 0.0001 0 0.003 0 0.0001 0 0.0003 0.0001 0.0024 0 0.0023 0 0.0004 0
Nuclear Periphery 0.0072 0.0036 0.0048 0.0001 0.0012 0.0001 0.0017 0.0002 0.0004 0.0002 0.0009 0.0011 0.0058 0.0003 0.01 0.0003 0.0052 0.0002
Nucleolus 0.055 0.0375 0.0335 0.0142 0.2228 0.111 0.0552 0.0288 0.0318 0.0185 0.1235 0.1263 0.0275 0.0318 0.0282 0.0311 0.2586 0.1129
Nucleus 0.927 0.9499 0.9466 0.9854 0.7694 0.8809 0.7392 0.9696 0.9367 0.9811 0.672 0.8288 0.8722 0.967 0.902 0.9684 0.6606 0.8848
Peroxisomes 0 0 0.0002 0 0.0001 0 0.0251 0 0.0032 0 0.0058 0.0118 0.0055 0 0.0011 0 0.0003 0
Punctate Nuclear 0.0052 0.0083 0.0009 0.0002 0.0035 0.0069 0.0105 0.0008 0.0031 0.0001 0.0024 0.0007 0.0253 0.0005 0.0062 0.0001 0.0015 0.0007
Vacuole 0.0007 0.0001 0.0007 0 0.0002 0.0001 0.0025 0 0.0004 0 0.0008 0.0015 0.0005 0 0.0007 0 0.0004 0.0001
Vacuole Periphery 0.0003 0 0.0009 0 0.0002 0 0.0007 0 0.0001 0 0.0006 0.0008 0.0004 0 0.0005 0 0.0008 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 29.6614 34.8489 30.3567 38.6779 39.0067 39.809 31.4057 40.3255 43.4485 41.5864
Translational Efficiency 1.3518 0.9308 0.9222 0.837 0.8836 0.8526 1.2301 0.7592 0.8084 0.9549

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
966 846 611 1184 2174 157 1866 1334 3140 1003 2477 2518

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 859.89 970.53 1253.57 1283.32 885.44 1030.77 1216.56 1307.78 877.58 979.96 1225.69 1296.28
Standard Deviation 119.20 158.78 175.41 245.31 125.49 132.38 178.23 239.06 124.15 156.49 178.25 242.33
Intensity Change Log 2 — 0.174621 0.543819 0.577657 — 0.219256 0.458341 0.562653 — 0.197438 0.501087 0.570065

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000675 0.001410 0.001340 0.002487 0.000477 0.001971 0.001244 0.001558 0.000538 0.001498 0.001268 0.001995
Bud Neck 0.005807 0.013923 0.022989 0.046212 0.011021 0.009313 0.032746 0.033968 0.009417 0.013202 0.030339 0.039726
Bud Site 0.000594 0.001668 0.002422 0.024407 0.001583 0.002395 0.003391 0.034418 0.001279 0.001782 0.003152 0.029711
Cell Periphery 0.000045 0.000063 0.000068 0.000326 0.000061 0.000094 0.000087 0.000288 0.000056 0.000068 0.000082 0.000306
Cytoplasm 0.000995 0.001938 0.001048 0.007685 0.000620 0.002326 0.001826 0.008946 0.000736 0.001999 0.001634 0.008353
Cytoplasmic Foci 0.000164 0.000824 0.000205 0.034959 0.000186 0.002519 0.000663 0.058479 0.000179 0.001089 0.000550 0.047419
Eisosomes 0.000034 0.000045 0.000075 0.000076 0.000030 0.000057 0.000058 0.000072 0.000031 0.000047 0.000062 0.000074
Endoplasmic Reticulum 0.003217 0.004319 0.001713 0.003070 0.002574 0.005966 0.002312 0.001615 0.002772 0.004577 0.002164 0.002299
Endosome 0.000203 0.000691 0.000105 0.007581 0.000232 0.001223 0.000816 0.010601 0.000223 0.000775 0.000640 0.009181
Golgi 0.000220 0.000652 0.000261 0.008468 0.000170 0.002324 0.000576 0.013137 0.000185 0.000914 0.000499 0.010941
Lipid Particles 0.000327 0.001185 0.000072 0.001051 0.000262 0.006416 0.000101 0.002990 0.000282 0.002004 0.000094 0.002078
Mitochondria 0.002895 0.003521 0.002055 0.008211 0.001256 0.002936 0.002826 0.009610 0.001760 0.003429 0.002636 0.008952
Mitotic Spindle 0.002473 0.004767 0.003541 0.331874 0.002010 0.031525 0.027971 0.572585 0.002153 0.008955 0.021945 0.459399
None 0.002549 0.003056 0.001558 0.003537 0.001534 0.002193 0.003878 0.003461 0.001846 0.002921 0.003306 0.003497
Nuclear Periphery 0.000215 0.000242 0.000138 0.002791 0.000552 0.000248 0.000480 0.001916 0.000448 0.000243 0.000396 0.002327
Nuclear Periphery Foci 0.000677 0.001355 0.000310 0.005109 0.000488 0.001335 0.000872 0.006515 0.000546 0.001352 0.000733 0.005854
Nucleolus 0.108703 0.125209 0.118085 0.111100 0.102310 0.084603 0.105686 0.071431 0.104277 0.118853 0.108744 0.090084
Nucleus 0.868885 0.832524 0.840120 0.363769 0.873528 0.834677 0.810802 0.125490 0.872100 0.832861 0.818034 0.237532
Peroxisomes 0.000915 0.001738 0.002955 0.022769 0.000698 0.005925 0.001616 0.028173 0.000765 0.002394 0.001947 0.025632
Vacuole 0.000235 0.000533 0.000690 0.010580 0.000223 0.001622 0.001521 0.011863 0.000227 0.000703 0.001316 0.011259
Vacuole Periphery 0.000173 0.000335 0.000248 0.003940 0.000184 0.000331 0.000530 0.002882 0.000180 0.000334 0.000461 0.003380

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.11 -10.03 -7.78 -3.27 -3.82 -4.79 -16.85 -6.21 0.76 -1.42 -7.30 -19.39 -9.96 -2.37 -3.51
Bud Neck -8.15 -14.99 -18.62 -14.43 -10.19 0.99 -21.38 -16.68 -15.35 -4.69 -4.52 -25.51 -24.31 -19.92 -8.99
Bud Site -3.00 -7.73 -16.09 -15.00 -14.54 -1.37 -7.01 -17.86 -16.28 -16.19 -1.40 -8.85 -23.49 -22.82 -21.12
Cell Periphery -2.79 -1.83 -13.88 -12.50 -10.72 -1.45 -2.94 -11.97 -6.58 -12.18 -1.41 -3.69 -16.74 -17.03 -16.36
Cytoplasm -1.17 -0.07 -4.13 -2.84 -3.55 -1.25 -3.65 -9.31 -2.80 -7.49 -2.05 -2.33 -9.54 -4.87 -7.77
Cytoplasmic Foci -1.63 -0.06 -11.70 -11.37 -11.69 -1.80 -3.17 -14.71 -13.16 -14.36 -2.27 -3.19 -18.75 -18.10 -18.32
Eisosomes -4.70 -13.59 -14.32 -8.72 -0.36 -5.73 -19.11 -15.33 -2.47 -4.39 -7.70 -23.35 -21.25 -9.67 -4.79
Endoplasmic Reticulum -3.73 6.40 1.84 5.05 -3.55 -5.46 -0.06 1.85 5.85 1.80 -7.39 3.13 2.15 7.95 -0.09
Endosome -1.82 2.26 -5.06 -3.88 -5.24 -2.16 -2.14 -7.38 -4.66 -6.47 -2.34 -1.96 -8.88 -6.69 -7.86
Golgi -1.73 -0.57 -3.38 -2.94 -3.34 -1.53 -4.84 -4.94 -2.11 -4.50 -2.49 -4.72 -5.98 -4.81 -5.48
Lipid Particles -1.23 1.72 -3.15 0.43 -9.19 -1.59 1.08 -5.41 1.17 -6.70 -2.03 1.72 -6.29 0.72 -9.13
Mitochondria -0.32 0.43 -2.23 -1.79 -7.40 -1.24 -5.32 -5.74 -2.35 -3.94 -1.31 -2.05 -6.63 -2.26 -6.45
Mitotic Spindle -0.94 -1.00 -26.35 -25.92 -25.95 -2.52 -12.44 -43.10 -27.69 -35.94 -2.70 -12.27 -48.47 -45.50 -40.37
None -1.12 2.50 -3.61 -2.36 -7.75 -0.95 -6.08 -6.45 -1.70 -0.45 -3.35 -4.63 -8.24 -2.71 -2.41
Nuclear Periphery -0.97 0.72 -11.93 -11.74 -12.28 1.67 -1.14 -9.17 -13.39 -10.93 1.87 -1.35 -13.28 -18.01 -15.07
Nuclear Periphery Foci -1.92 2.51 -7.69 -5.64 -8.48 -1.59 -2.76 -7.64 -6.01 -4.74 -2.39 -2.47 -10.72 -7.73 -6.96
Nucleolus -2.90 -3.05 -8.89 -6.15 -5.02 1.90 -7.28 -3.98 -4.07 2.23 -3.32 -7.83 -9.57 -4.92 -1.86
Nucleus 5.28 5.74 43.80 38.67 36.50 2.23 18.56 78.93 32.47 52.60 6.76 19.24 82.77 63.16 56.79
Peroxisomes -2.36 -6.44 -14.09 -13.43 -12.23 -1.63 -6.30 -17.14 -5.46 -15.90 -2.88 -8.49 -22.15 -18.24 -20.22
Vacuole -3.69 -5.06 -8.69 -8.32 -8.14 -2.77 -4.33 -9.80 -6.52 -7.44 -4.41 -4.75 -13.10 -12.07 -10.18
Vacuole Periphery -3.08 -4.79 -3.83 -3.40 -3.59 -2.07 -2.85 -6.56 -5.40 -5.07 -3.38 -3.27 -6.48 -5.64 -5.42
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Histone deacetylase, component of both the Rpd3S and Rpd3L complexes; regulates transcription, silencing, autophagy and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members; Rpd3(L) recruitment to the subtelomeric region is regulated by interaction with the arginine methyltransferase, Hmt1p
Localization
Cell Percentages nucleus (99%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Rpd3

Rpd3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rpd3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available