Standard name
Human Ortholog
Description Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.09 0.06 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.11 0.08 0.09 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0 0.09 0 0 0 0.05 0 0
Golgi 0 0.05 0 0 0.05 0 0 0 0 0 0 0 0.12 0.12 0.18 0.23 0.45 0.26 0 0.09 0.05 0.08 0.09 0.11
Mitochondria 0.96 0.92 0.96 0.98 0.95 0.95 0.9 0.96 0.95 0.96 0.93 0.98 0.92 0.87 0.77 0.07 0.12 0.08 0.83 0.76 0.71 0.74 0.76 0.65
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0
Nuclear Periphery 0.05 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0 0
Nucleolus 0.1 0 0.05 0 0.09 0.13 0.16 0.13 0.16 0.16 0.1 0.12 0 0 0 0.07 0 0.07 0 0 0 0 0 0
Peroxisomes 0 0.05 0.14 0 0 0 0 0 0 0 0 0 0.1 0.09 0 0.18 0.06 0.18 0.06 0 0.15 0.06 0 0.07
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0 0.07 0 0 0 0 0 0
Vac/Vac Membrane 0.07 0.18 0 0 0 0 0 0 0 0 0 0 0 0.07 0.17 0.15 0.22 0.22 0 0.07 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 0 0 3 2 1 3 1 0 0 0 2 5 1 0 3 3 1 1 1 2 2 18
Bud 2 2 1 1 0 2 3 5 0 3 4 1 2 1 0 2 3 5 0 1 0 1 0 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud Site 1 0 1 0 0 1 2 1 0 0 0 0 0 0 0 0 1 1 – – – – – –
Cell Periphery 1 6 0 4 0 0 0 2 1 1 1 0 8 14 7 14 19 9 0 0 0 0 0 0
Cytoplasm 0 2 1 2 1 4 4 5 5 2 2 1 4 5 9 25 18 13 0 1 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 1 0 0 1 0 2 0 1 3 1 4 4 6 0 0 0 0 1 2
Endosome 1 3 0 0 0 0 1 0 0 0 0 0 6 7 7 20 6 14 3 4 2 7 7 6
Golgi 0 9 0 3 7 0 4 2 1 1 1 1 26 44 58 54 97 40 4 17 4 12 20 34
Mitochondria 145 170 78 118 131 229 300 341 220 240 199 203 201 314 245 17 26 12 125 148 65 106 178 204
Nucleus 0 1 0 0 0 1 1 0 0 0 1 0 0 0 0 14 4 3 0 0 0 0 0 0
Nuclear Periphery 7 11 2 2 6 8 14 14 8 10 6 1 1 3 1 17 7 4 1 0 1 2 0 3
Nucleolus 15 6 4 5 12 32 54 46 37 41 21 25 3 2 4 17 9 11 1 0 0 1 3 1
Peroxisomes 3 9 11 1 2 1 4 4 0 2 2 1 22 32 13 41 14 27 9 4 14 8 8 21
SpindlePole 1 0 0 1 0 1 0 1 1 1 2 0 2 2 1 19 5 10 1 0 0 0 0 1
Vac/Vac Membrane 11 34 3 1 5 6 8 3 7 9 2 1 9 25 54 35 48 33 2 13 0 2 6 13
Unique Cell Count 151 184 81 120 138 240 334 354 231 250 213 208 219 359 318 234 216 151 151 195 92 144 233 312
Labelled Cell Count 187 254 101 138 167 288 396 427 282 310 243 234 287 457 401 279 264 191 151 195 92 144 233 312


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 9.0 10.3 9.3 12.4 23.0 23.6 23.6 25.5 26.4 27.6 27.4 33.0 13.3 13.7 14.1 10.9 13.1 11.9 8.9 10.3 11.9
Std Deviation (1e-4) 2.2 3.0 3.3 3.3 6.6 8.3 10.0 10.4 11.5 12.6 13.6 16.2 4.8 4.2 4.1 4.2 4.2 4.8 3.0 3.3 3.6
Intensity Change (Log2) – – – 0.41 1.3 1.34 1.34 1.45 1.5 1.57 1.55 1.82 0.51 0.55 0.6 0.22 0.49 0.36 -0.07 0.14 0.36


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 2.8 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 2.7 2.2 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 2.7 0 0
Golgi 0 0 0 0 0 0 0 0 0 3.2 3.3 4.2 4.7 7.3 5.1
Mitochondria 0.9 -0.5 -0.3 -1.8 0 -0.4 -0.1 -0.9 0.6 -1.4 -2.3 -3.9 -15.0 -13.6 -13.2
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 1.0 2.1 2.6 2.1 2.5 2.6 1.4 1.8 0 0 0 0.7 0 0.7
Peroxisomes 0 0 0 0 0 0 0 0 0 -0.9 -1.3 0 0.8 -2.0 0.8
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 1.1 3.0 2.7 3.8 3.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 22.8834 41.9449 36.228 35.795 25.7828 37.6385 50.5137 47.9015 46.5719 39.8878 45.5067 46.5086 33.9131 60.1822 51.7433 56.8814 48.6877 51.0757
Actin 0.0764 0.0069 0.0028 0.0062 0.0132 0.0057 0.0031 0.0031 0.0079 0.0167 0.0234 0.0011 0.0374 0.0024 0.0039 0.0002 0.0692 0.0005
Bud 0.0017 0.0003 0.0003 0.0002 0.0011 0.0002 0 0 0.0001 0.0006 0.0001 0 0.001 0.0001 0.0001 0 0.0003 0
Bud Neck 0.002 0.0004 0.0002 0.0001 0.0005 0.0001 0 0 0.0002 0.0002 0 0 0.0004 0.0002 0.0002 0 0.0009 0
Bud Periphery 0.0022 0.0005 0.0004 0.0004 0.0043 0.0004 0 0 0.0002 0.001 0.0001 0.0001 0.0011 0.0001 0.0002 0.0001 0.0005 0
Bud Site 0.0108 0.0036 0.0014 0.0005 0.0006 0.0005 0.0002 0.0001 0.0028 0.0027 0.0003 0.0001 0.004 0.0009 0.0003 0 0.0009 0
Cell Periphery 0.001 0.0016 0.0014 0.0001 0.0008 0.0001 0.0002 0.0002 0.0002 0.0001 0.0002 0.0002 0.0012 0.0023 0.0007 0.0001 0.0009 0.0001
Cytoplasm 0.0034 0 0.0002 0.0032 0.0004 0.0002 0.0001 0 0.0001 0.0004 0.0003 0.0007 0.0044 0 0 0 0.0005 0
Cytoplasmic Foci 0.0451 0.0008 0.0033 0.0082 0.0144 0.001 0.0058 0.0001 0.002 0.0018 0.0102 0.0037 0.0459 0.0001 0.0019 0 0.0062 0
Eisosomes 0.0013 0.0045 0.0007 0.0006 0.0009 0.0002 0.0007 0.0013 0.0004 0.0003 0.0004 0.0003 0.0021 0.0111 0.0134 0.0001 0.001 0.0002
Endoplasmic Reticulum 0.0045 0 0.0001 0.0012 0.0009 0.0008 0 0 0.0001 0.0019 0.0002 0.0015 0.007 0 0 0 0.0022 0
Endosome 0.0102 0.0013 0.0013 0.0053 0.0009 0.0074 0.0007 0.0003 0.0021 0.0093 0.0006 0.0014 0.0278 0.0003 0.0026 0.0001 0.0048 0
Golgi 0.0081 0.0051 0.0025 0.0019 0.0004 0.0041 0.0011 0.0018 0.0014 0.004 0.0015 0.0054 0.0125 0.0004 0.0201 0.0001 0.0075 0.0001
Lipid Particles 0.0661 0.0151 0.0087 0.0021 0.0119 0.0046 0.0135 0.0032 0.0107 0.0055 0.0064 0.0044 0.0526 0.0025 0.0092 0.0007 0.0109 0.0019
Mitochondria 0.5436 0.9218 0.8988 0.9179 0.7925 0.9541 0.9413 0.976 0.9476 0.937 0.9451 0.9666 0.6156 0.9414 0.9001 0.9962 0.8051 0.9925
None 0.0167 0 0.0003 0.0011 0.0012 0.0001 0.0061 0 0.0002 0.001 0.0006 0.0004 0.0125 0 0 0 0.0007 0
Nuclear Periphery 0.0368 0.0002 0.0003 0.0094 0.0557 0.0019 0.0003 0 0.0003 0.0094 0.0001 0.0005 0.0187 0.0001 0.0001 0 0.0009 0
Nucleolus 0.0482 0.0053 0.0062 0.0003 0.0452 0.0002 0.0019 0.0006 0.0014 0.0004 0.0054 0.0023 0.0508 0.002 0.0039 0.0001 0.0628 0.0002
Nucleus 0.0632 0.0005 0.0199 0.0032 0.0196 0.0004 0.0005 0.0001 0.0005 0.0012 0.0003 0.0004 0.008 0.0003 0.0003 0 0.0016 0
Peroxisomes 0.0192 0.0061 0.0049 0.0017 0.006 0.0011 0.0118 0.0019 0.0068 0.0019 0.0019 0.0007 0.0343 0.0025 0.005 0.0003 0.0025 0.0006
Punctate Nuclear 0.0244 0 0.0249 0.0341 0.0013 0.0004 0.0009 0 0.0005 0.0024 0.0002 0.0001 0.0195 0 0 0 0.0004 0
Vacuole 0.0043 0.0051 0.0056 0.0004 0.0055 0.0012 0.0016 0.0011 0.0021 0.0008 0.0005 0.0011 0.008 0.0056 0.0055 0.0003 0.003 0.0004
Vacuole Periphery 0.0108 0.0207 0.0159 0.0018 0.0228 0.0153 0.01 0.01 0.0124 0.0012 0.0022 0.0091 0.0354 0.0279 0.0324 0.0017 0.0173 0.0034

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 168.5757 98.6376 96.5746 171.1733 109.2829 178.4381 170.3762 164.0746 183.0034 157.2073
Translational Efficiency 1.5082 1.8302 1.4466 1.6086 1.4926 2.0086 1.6471 1.445 1.4744 1.3568

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1226 1482 2337 1238 1889 1649 181 433 3115 3131 2518 1671

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 836.64 930.83 1218.52 2614.14 889.27 1062.96 2490.15 2907.65 868.56 1000.42 1309.93 2690.20
Standard Deviation 171.68 234.59 294.78 959.39 173.06 236.64 972.66 1566.27 174.43 244.73 506.49 1155.06
Intensity Change Log 2 — 0.153911 0.542451 1.643658 — 0.257394 1.485539 1.709160 — 0.208156 1.103545 1.677779

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001078 0.009292 0.002372 0.006276 0.000602 0.003767 0.005128 0.009633 0.000789 0.006382 0.002570 0.007146
Bud Neck 0.000920 0.003187 0.012824 0.002145 0.001198 0.000817 0.003208 0.005652 0.001089 0.001939 0.012132 0.003054
Bud Site 0.000695 0.004421 0.035148 0.002694 0.002917 0.001990 0.003093 0.021336 0.002042 0.003141 0.032843 0.007525
Cell Periphery 0.000108 0.000781 0.002138 0.000274 0.000175 0.000142 0.000127 0.002421 0.000149 0.000444 0.001993 0.000830
Cytoplasm 0.000828 0.001016 0.005837 0.000411 0.000884 0.000314 0.000494 0.002065 0.000862 0.000646 0.005453 0.000840
Cytoplasmic Foci 0.014230 0.017507 0.015812 0.012550 0.015222 0.012577 0.033196 0.019789 0.014832 0.014910 0.017061 0.014426
Eisosomes 0.000062 0.000361 0.000242 0.001449 0.000063 0.000206 0.001157 0.001751 0.000063 0.000279 0.000308 0.001527
Endoplasmic Reticulum 0.000184 0.000439 0.000721 0.000452 0.000219 0.000187 0.000118 0.000690 0.000205 0.000306 0.000678 0.000513
Endosome 0.015440 0.021733 0.035119 0.001192 0.020143 0.006787 0.002120 0.008917 0.018292 0.013862 0.032747 0.003194
Golgi 0.015050 0.030960 0.017215 0.021904 0.017687 0.027953 0.028576 0.036700 0.016650 0.029376 0.018031 0.025738
Lipid Particles 0.012529 0.008037 0.006278 0.007648 0.012861 0.004738 0.003209 0.013641 0.012730 0.006300 0.006057 0.009201
Mitochondria 0.905228* 0.859077* 0.777883* 0.897563* 0.896846* 0.921339* 0.878078* 0.779712* 0.900145* 0.891868* 0.785085* 0.867025*
Mitotic Spindle 0.002327 0.001952 0.012655 0.001790 0.002864 0.001038 0.003033 0.004581 0.002653 0.001470 0.011963 0.002514
None 0.000492 0.000979 0.002673 0.005049 0.000418 0.000701 0.003661 0.007073 0.000447 0.000833 0.002744 0.005573
Nuclear Periphery 0.000218 0.000112 0.001716 0.001221 0.000381 0.000114 0.000723 0.002366 0.000317 0.000113 0.001645 0.001518
Nuclear Periphery Foci 0.000326 0.000227 0.001376 0.000342 0.000623 0.000170 0.000274 0.001707 0.000506 0.000197 0.001297 0.000696
Nucleolus 0.000721 0.000528 0.002513 0.000951 0.000684 0.000400 0.001028 0.001786 0.000699 0.000461 0.002406 0.001168
Nucleus 0.000252 0.000392 0.001638 0.000267 0.000311 0.000175 0.000103 0.000561 0.000288 0.000278 0.001528 0.000343
Peroxisomes 0.020254 0.030804 0.010967 0.004579 0.016229 0.010791 0.012287 0.004081 0.017813 0.020263 0.011062 0.004450
Vacuole 0.004086 0.004561 0.034682 0.007259 0.004280 0.002537 0.006278 0.025005 0.004204 0.003495 0.032640 0.011857
Vacuole Periphery 0.004970 0.003633 0.020193 0.023983 0.005391 0.003259 0.014111 0.050534 0.005225 0.003436 0.019756 0.030863

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.16 -3.62 -5.63 1.88 -3.99 -4.58 -4.51 -4.17 -2.59 -1.90 -7.66 -5.57 -7.22 -0.68 -4.87
Bud Neck -2.71 -9.96 -3.22 1.13 8.82 1.51 -2.71 -4.31 -4.71 -2.02 -2.04 -10.09 -5.30 -2.32 7.91
Bud Site -5.37 -13.79 -3.22 1.47 12.42 1.10 -0.13 -3.96 -4.17 -3.82 -1.87 -13.06 -4.15 -3.37 9.28
Cell Periphery -2.96 -7.62 -4.19 2.18 6.92 0.92 1.40 -4.16 -4.22 -4.25 -2.69 -7.45 -4.71 -2.19 4.00
Cytoplasm -0.31 -5.04 0.46 1.46 6.06 1.85 1.20 -1.84 -2.89 -2.58 0.74 -5.56 -0.34 -1.31 5.48
Cytoplasmic Foci -1.41 -0.85 0.71 2.21 1.72 1.62 -2.67 -1.58 -2.45 1.81 -0.05 -1.54 0.14 0.19 1.45
Eisosomes -6.68 -3.75 -12.42 -9.05 -9.93 -6.86 -6.59 -6.26 -5.72 -1.87 -9.04 -5.27 -13.53 -11.27 -10.35
Endoplasmic Reticulum -2.96 -7.05 -1.63 -0.09 1.47 0.74 3.06 -3.20 -3.36 -3.88 -2.16 -6.89 -2.43 -1.57 1.10
Endosome -2.60 -7.70 8.47 11.71 17.41 7.94 11.41 4.71 -1.13 -3.63 3.05 -6.81 12.29 10.08 15.74
Golgi -5.80 -1.16 -2.61 2.91 -1.90 -3.81 -2.33 -3.63 -1.57 -1.20 -6.61 -0.94 -3.95 1.40 -3.26
Lipid Particles 2.25 3.35 2.37 0.25 -1.01 4.71 6.08 -0.27 -2.99 -3.59 4.91 5.15 2.21 -2.23 -2.42
Mitochondria 5.11 13.92 1.09 -4.24 -13.37 -3.53 1.17 7.65 9.31 4.74 1.46 15.27 4.96 3.76 -9.33
Mitotic Spindle 0.64 -7.37 1.00 0.23 7.85 2.58 -0.14 -1.09 -2.21 -0.82 2.46 -7.20 0.18 -1.88 7.07
None -2.84 -4.90 -16.18 -12.49 -4.53 -4.00 -8.29 -8.44 -8.07 -3.88 -4.29 -5.56 -17.56 -15.64 -5.59
Nuclear Periphery 3.53 -3.77 -7.27 -8.17 1.17 1.95 -1.80 -3.98 -4.69 -3.30 2.42 -3.52 -6.66 -8.76 0.31
Nuclear Periphery Foci 1.54 -5.25 -0.22 -2.01 5.24 2.15 1.67 -1.52 -2.20 -2.06 2.39 -3.64 -0.90 -2.66 2.27
Nucleolus 0.52 -3.41 -0.62 -1.94 3.56 0.73 -0.80 -2.59 -4.08 -2.01 0.87 -3.84 -1.69 -3.70 3.09
Nucleus -0.78 -4.32 -1.02 -0.80 0.76 0.94 1.67 -1.35 -2.24 -2.87 0.04 -4.14 -1.10 -1.11 0.99
Peroxisomes -2.89 3.60 6.18 9.12 5.44 2.66 1.14 6.28 3.91 2.51 -1.22 4.18 8.86 9.68 6.28
Vacuole -0.49 -16.10 -2.74 -2.59 13.94 3.16 -1.28 -6.29 -6.83 -5.22 1.35 -17.07 -6.63 -7.35 10.51
Vacuole Periphery 1.54 -11.31 -8.81 -9.85 -1.64 2.76 -2.50 -8.61 -9.04 -5.84 3.11 -12.47 -12.26 -13.32 -4.83
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication
Localization
Cell Percentages mitochondrion (98%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Cit1

Cit1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cit1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available