Standard name
Human Ortholog
Description RNA-dependent DExD/H-box ATPase; required for activation of spliceosome before first transesterification step in RNA splicing; implicated in rearranging and proofreading snRNA structure in catalytic activation of spliceosome; ortholog of human protein DHX16
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0.05 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0.05 0 0 0.07 0.07 0.06 0.07 – 0.05 0.07 0.07 0.06 0.16 0.2 0.05 0.05 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.11 0.33 0.33 0.43 0.68 0.74 0.67 – 0.73 0.77 0.77 0 0 0 0.06 0.05 0.06 0 0 0 0 0 0
Nucleus 0.94 0.88 0.87 0.9 0.73 0.68 0.66 0.65 – 0.62 0.61 0.61 0.9 0.84 0.77 0.9 0.89 0.92 0.92 0.88 0.89 0.79 0.68 0.63
Nuclear Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0.07 0 0 0.05 0 0 0 – 0 0 0 0 0 0 0.07 0.06 0.05 0 0.05 0.05 0.12 0.2 0.21
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Bud 0 0 0 2 5 7 10 8 – 13 9 10 1 0 0 0 0 0 0 2 0 1 0 5
Bud Neck 0 0 0 0 1 1 0 1 – 0 0 0 0 0 1 0 0 0 0 0 0 0 1 1
Bud Site 0 0 0 0 1 22 20 17 – 27 25 28 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 8 7 5 7 29 40 45 52 – 34 34 47 19 57 89 10 9 4 1 2 1 0 3 2
Endoplasmic Reticulum 0 0 0 1 0 0 0 0 – 0 0 0 2 2 1 5 3 5 0 0 0 1 2 4
Endosome 0 0 0 0 1 0 0 1 – 0 0 0 0 0 0 0 1 0 2 0 1 1 3 5
Golgi 0 0 1 0 0 0 0 0 – 0 0 0 0 0 0 1 1 1 2 0 2 0 1 2
Mitochondria 8 15 63 96 171 403 524 481 – 506 399 537 13 2 2 12 9 11 1 1 0 0 7 10
Nucleus 247 117 165 258 290 404 470 469 – 428 317 423 266 307 342 184 146 176 241 121 173 99 210 213
Nuclear Periphery 0 0 1 5 4 2 4 4 – 3 5 9 0 0 0 3 1 0 0 0 0 0 1 1
Nucleolus 1 0 0 1 1 3 7 5 – 4 5 7 0 0 0 1 0 1 0 0 0 1 6 8
Peroxisomes 0 0 0 0 1 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 1 0 1 0 2 0 4 3 – 9 0 5 2 1 1 1 1 1 2 0 3 0 3 4
Vac/Vac Membrane 2 9 2 2 20 7 15 8 – 13 11 13 4 3 12 14 10 10 7 7 9 14 62 71
Unique Cell Count 263 133 189 287 399 592 710 723 691 520 698 294 367 442 205 164 192 261 139 194 127 311 340
Labelled Cell Count 267 148 238 372 526 889 1099 1049 1037 805 1079 307 372 448 231 181 209 261 139 194 127 311 340


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.5 5.3 4.0 3.7 3.8 3.5 3.0 3.3 – 3.0 3.0 2.9 5.9 6.2 6.2 6.9 7.0 7.2 6.6 6.9 7.1
Std Deviation (1e-4) 0.8 1.2 0.8 1.1 1.5 1.0 0.9 1.2 – 0.9 1.2 0.8 1.1 1.7 1.7 1.1 1.6 1.3 1.8 1.9 2.0
Intensity Change (Log2) – – – -0.1 -0.08 -0.2 -0.41 -0.29 – -0.43 -0.4 -0.45 0.56 0.64 0.64 0.79 0.81 0.85 0.71 0.79 0.83


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cytoplasm 0 2.2 2.1 2.0 2.3 – 1.3 2.0 2.1 1.9 4.6 5.7 1.2 1.4 0
Endoplasmic Reticulum 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 – 0 0 0 -8.5 -11.4 -12.4 -6.9 -6.5 -6.8
Nucleus 0.9 -4.0 -5.1 -5.7 -6.0 – -6.6 -6.6 -6.9 1.1 -1.1 -2.9 0.8 0.5 1.4
Nuclear Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Vacuole 0 2.4 0 0 0 – 0 0 0 0 0 0 2.9 2.6 2.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.1414 1.0853 0.7037 0.8089 0.7645 0.961 2.1324 2.9193 2.3982 2.0687 1.7492 2.4698 0.5049 0.5934 0.0829 0.0523 -0.1257 0.0501
Actin 0.0195 0 0.0002 0.0024 0.001 0.0019 0.0061 0 0.0075 0 0.0001 0.0093 0.0026 0.0001 0.0103 0.0177 0 0
Bud 0.0002 0 0.0001 0.0001 0.0009 0 0.0006 0.0002 0.0008 0 0.0006 0.0006 0.0001 0.0001 0.0004 0.0006 0 0.0001
Bud Neck 0.0013 0.0001 0.0001 0.0003 0.004 0.0005 0.001 0.0002 0.0018 0.0002 0.0188 0.0019 0.0001 0.0001 0.0014 0.007 0.0001 0.0024
Bud Periphery 0.0003 0 0.0001 0.0003 0.0019 0 0.0024 0.0001 0.0025 0 0.0006 0.0012 0 0.0002 0.0007 0.0012 0 0.0001
Bud Site 0.0015 0.0001 0 0.0004 0.0139 0 0.0009 0.0001 0.0021 0 0.0352 0.0008 0.0006 0.0001 0.0014 0.0042 0.0001 0.0001
Cell Periphery 0.0001 0 0 0.0001 0.0004 0 0.0002 0 0.0008 0 0.0006 0.0002 0 0 0.0003 0.0006 0 0
Cytoplasm 0.0044 0.0009 0.0011 0.0005 0.0022 0.0001 0.0182 0.0192 0.0034 0.0014 0.0043 0.0014 0.0013 0.0004 0.0017 0.0008 0 0.0001
Cytoplasmic Foci 0.0069 0 0.0009 0.0012 0.0012 0.0002 0.0313 0.0003 0.0043 0.0001 0.0004 0.0013 0.1126 0 0.0051 0.0274 0 0
Eisosomes 0.0002 0 0 0 0 0 0.0001 0 0.0007 0 0 0.0001 0 0 0.0005 0.0004 0 0
Endoplasmic Reticulum 0.0032 0 0.0001 0.0012 0.0001 0.0001 0.0015 0.0004 0.0061 0 0.0001 0.0062 0.0003 0.0003 0.0004 0.0004 0 0
Endosome 0.0122 0.0001 0.0007 0.0138 0.0012 0.0003 0.0054 0.0003 0.0087 0 0.0003 0.0076 0.0083 0.0002 0.0093 0.0359 0 0
Golgi 0.0039 0 0.0003 0.0029 0.0006 0.0001 0.0017 0 0.0019 0 0.0001 0.0076 0.004 0 0.0097 0.0328 0 0
Lipid Particles 0.0118 0 0.0055 0.0051 0.0007 0.0003 0.0048 0.0001 0.0018 0 0 0.0016 0.0229 0 0.0076 0.0452 0 0
Mitochondria 0.0017 0.0001 0.0012 0.0012 0.002 0.0002 0.0097 0.0003 0.0069 0.0002 0.0003 0.0111 0.0004 0.0012 0.0402 0.1132 0 0.0001
None 0.0084 0.0022 0.0031 0.0005 0.0032 0.0002 0.0109 0.0291 0.0067 0.0009 0.0001 0.0007 0.0016 0.0001 0.0282 0.0003 0 0
Nuclear Periphery 0.0211 0.004 0.0094 0.0082 0.0032 0.0078 0.006 0.0034 0.0032 0.0053 0.0014 0.0054 0.0017 0.0175 0.0035 0.0013 0.0001 0.0002
Nucleolus 0.0065 0.0098 0.005 0.0062 0.0171 0.0152 0.0055 0.0299 0.0033 0.0041 0.011 0.0116 0.006 0.0085 0.0035 0.0047 0.0049 0.0274
Nucleus 0.857 0.9749 0.9645 0.9469 0.9159 0.9629 0.8565 0.9094 0.9319 0.9465 0.9233 0.9113 0.7631 0.9682 0.8691 0.6654 0.9947 0.9688
Peroxisomes 0.011 0 0.0024 0.0006 0.0011 0.0039 0.0141 0 0.0012 0 0.0001 0.0007 0.0412 0 0.0034 0.0324 0 0
Punctate Nuclear 0.027 0.0077 0.005 0.0067 0.0277 0.0061 0.0162 0.0059 0.0015 0.0411 0.001 0.0159 0.033 0.0004 0.0009 0.0012 0 0.0001
Vacuole 0.001 0.0001 0.0002 0.0008 0.0015 0.0001 0.0047 0.0009 0.0024 0.0001 0.0017 0.0023 0.0001 0.0009 0.0015 0.0059 0.0001 0.0003
Vacuole Periphery 0.0007 0 0.0002 0.0006 0.0002 0.0001 0.0024 0.0002 0.0006 0.0001 0.0001 0.0009 0.0001 0.0016 0.0008 0.0014 0 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 13.2107 8.2479 13.6316 12.6975 10.6032 7.1256 13.5516 13.3039 11.552 14.4705
Translational Efficiency 0.9154 1.3371 0.6356 0.718 0.9281 1.4006 0.8271 0.7221 0.774 0.6572

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1723 1070 1536 1403 1549 1441 1882 1702 3272 2511 3418 3105

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 696.48 835.11 882.04 901.10 661.20 761.05 868.72 947.51 679.78 792.61 874.71 926.54
Standard Deviation 95.09 119.32 102.69 127.24 88.15 107.94 112.70 137.51 93.54 118.72 108.52 134.96
Intensity Change Log 2 — 0.261884 0.340762 0.371605 — 0.202905 0.393805 0.519054 — 0.233462 0.366838 0.445297

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000062 0.000201 0.000195 0.000961 0.000132 0.000188 0.000301 0.001262 0.000095 0.000194 0.000254 0.001126
Bud Neck 0.000774 0.004353 0.011788 0.013413 0.001455 0.004400 0.008728 0.018876 0.001097 0.004380 0.010103 0.016408
Bud Site 0.000225 0.001430 0.001333 0.008043 0.000560 0.001507 0.001248 0.008924 0.000384 0.001474 0.001286 0.008526
Cell Periphery 0.000090 0.000142 0.000066 0.000138 0.000181 0.000153 0.000065 0.000198 0.000133 0.000148 0.000065 0.000171
Cytoplasm 0.104788* 0.009662 0.003251 0.026096 0.053526 0.013126 0.005432 0.020278 0.080520 0.011650 0.004452 0.022907
Cytoplasmic Foci 0.004080 0.002893 0.000026 0.003551 0.005881 0.001989 0.000060 0.001475 0.004933 0.002374 0.000045 0.002413
Eisosomes 0.000011 0.000014 0.000014 0.000024 0.000017 0.000016 0.000012 0.000023 0.000014 0.000015 0.000013 0.000024
Endoplasmic Reticulum 0.000971 0.003927 0.004063 0.006024 0.001921 0.003532 0.003645 0.006707 0.001421 0.003701 0.003832 0.006399
Endosome 0.000232 0.000590 0.000130 0.004305 0.000797 0.000913 0.000237 0.004274 0.000500 0.000776 0.000189 0.004288
Golgi 0.000043 0.001180 0.000017 0.005557 0.000132 0.000216 0.000037 0.002570 0.000085 0.000627 0.000028 0.003920
Lipid Particles 0.000571 0.000408 0.000029 0.000332 0.001144 0.001455 0.000050 0.000325 0.000842 0.001009 0.000040 0.000328
Mitochondria 0.000303 0.001335 0.000730 0.003793 0.001464 0.002522 0.000800 0.005978 0.000853 0.002017 0.000769 0.004991
Mitotic Spindle 0.000064 0.001877 0.000138 0.029230 0.000994 0.003555 0.001790 0.011068 0.000504 0.002840 0.001048 0.019275
None 0.016760 0.004250 0.000942 0.007206 0.021992 0.005556 0.002048 0.009203 0.019237 0.004999 0.001551 0.008301
Nuclear Periphery 0.000434 0.000834 0.000957 0.002732 0.000565 0.000920 0.000556 0.001796 0.000496 0.000884 0.000736 0.002219
Nuclear Periphery Foci 0.000243 0.000188 0.000024 0.001704 0.000855 0.000555 0.000049 0.000611 0.000533 0.000398 0.000038 0.001105
Nucleolus 0.001767 0.002719 0.000444 0.002290 0.005981 0.004669 0.000869 0.002062 0.003762 0.003838 0.000678 0.002165
Nucleus 0.867214* 0.961091* 0.974856* 0.870809* 0.900525* 0.950613* 0.972505* 0.889122* 0.882984* 0.955078* 0.973562* 0.880847*
Peroxisomes 0.000173 0.000624 0.000022 0.000710 0.000304 0.001464 0.000174 0.000390 0.000235 0.001106 0.000106 0.000535
Vacuole 0.001130 0.002017 0.000931 0.010305 0.001315 0.002033 0.001216 0.010682 0.001218 0.002026 0.001088 0.010512
Vacuole Periphery 0.000063 0.000263 0.000044 0.002776 0.000259 0.000620 0.000178 0.004175 0.000156 0.000468 0.000118 0.003543

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.09 -9.20 -9.73 -8.02 -7.85 -1.58 -6.16 -2.44 -2.29 -1.87 -4.36 -9.89 -4.38 -3.89 -3.41
Bud Neck -4.07 -14.78 -14.82 -8.36 -1.60 -3.58 -10.02 -12.25 -9.06 -5.64 -5.46 -17.17 -17.90 -12.12 -5.63
Bud Site -2.65 -2.32 -6.04 -4.22 -3.74 -2.05 -2.28 -5.91 -4.62 -4.91 -3.36 -3.30 -8.39 -6.23 -6.16
Cell Periphery -1.19 3.25 -1.42 0.81 -3.83 0.62 3.16 0.77 0.09 -4.89 -0.51 3.82 0.14 0.70 -6.09
Cytoplasm 21.00 23.76 17.23 -5.27 -9.67 11.50 14.91 9.08 -3.22 -8.24 23.37 27.57 19.25 -5.85 -12.60
Cytoplasmic Foci 1.35 8.10 3.80 1.22 -3.62 4.27 6.97 5.72 2.25 -3.44 4.14 10.30 7.02 2.20 -4.93
Eisosomes -1.84 -3.66 -13.10 -9.56 -10.82 0.69 3.31 -7.42 -7.56 -12.14 -1.00 -0.04 -14.80 -12.04 -16.16
Endoplasmic Reticulum -11.36 -18.86 -21.24 -9.44 -9.59 -6.46 -11.56 -15.99 -10.12 -9.99 -12.74 -21.83 -25.80 -13.84 -13.77
Endosome -2.24 3.80 -4.29 -3.27 -4.53 -0.26 2.74 -3.10 -2.88 -4.32 -1.37 3.10 -5.00 -4.11 -6.04
Golgi -1.80 5.12 -2.82 -1.08 -2.85 -1.34 3.93 -2.90 -2.71 -3.12 -2.00 4.67 -4.00 -2.36 -4.14
Lipid Particles 1.52 7.43 2.43 0.30 -6.59 -0.57 4.98 3.62 2.40 -8.42 -0.50 7.24 4.32 2.41 -10.46
Mitochondria -3.02 -8.86 -7.71 -3.17 -5.81 -1.19 1.20 -3.32 -1.71 -4.88 -2.30 -0.10 -5.92 -2.63 -6.66
Mitotic Spindle -1.76 -1.93 -7.39 -6.54 -7.35 -1.96 -1.29 -6.06 -4.40 -5.39 -2.73 -1.62 -9.60 -7.76 -9.07
None 7.84 11.71 7.57 -1.07 -6.24 8.31 10.84 7.07 -1.54 -5.48 11.35 15.70 10.01 -1.83 -7.89
Nuclear Periphery -4.16 -7.25 -6.83 -5.66 -4.88 -2.10 -1.18 -10.08 -6.17 -9.89 -3.73 -6.69 -10.91 -8.12 -8.90
Nuclear Periphery Foci 0.76 3.87 -1.97 -2.14 -2.59 1.04 2.89 0.96 -0.28 -4.91 0.95 3.63 -0.94 -1.85 -4.13
Nucleolus -1.50 8.68 -1.62 0.57 -5.82 1.37 7.35 5.38 3.63 -5.95 -0.12 8.90 4.10 3.29 -8.29
Nucleus -14.66 -19.71 -2.12 11.07 14.71 -7.83 -12.90 1.54 9.43 14.66 -15.73 -23.04 -0.67 14.28 20.72
Peroxisomes -1.88 3.84 -1.35 0.70 -2.28 -2.43 1.40 0.47 2.50 -0.87 -2.97 2.29 -1.00 2.55 -2.27
Vacuole -2.65 -0.10 -9.98 -8.79 -9.97 -1.65 -0.12 -9.72 -8.92 -9.61 -3.01 -0.25 -13.88 -12.49 -13.75
Vacuole Periphery -2.50 2.38 -3.14 -2.52 -3.18 -1.20 0.72 -3.15 -2.44 -3.29 -1.80 0.64 -4.18 -3.17 -4.27
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description RNA-dependent DExD/H-box ATPase; required for activation of spliceosome before first transesterification step in RNA splicing; implicated in rearranging and proofreading snRNA structure in catalytic activation of spliceosome; ortholog of human protein DHX16
Localization
Cell Percentages nucleus (83%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Prp2

Prp2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Prp2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available