Standard name
Human Ortholog
Description Putative transmembrane protein involved in the biotin biosynthesis; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.12 0.06 0.09 0.06 0 0.05 0 0 0
Cytoplasm 0.93 0.95 0.91 0.93 0.9 0.89 0.78 0.77 0.65 0.61 0.56 0.56 0.99 0.99 0.99 0.69 0.68 0.67 0.71 0.76 0.35 0.75 0.79 0.73
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.05 0 0 0 0.16 0.25 0.26 0.46 0.56 0.58 0.53 0 0 0 0.14 0.05 0.07 0.09 0.1 0.2 0.16 0.09 0.08
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0.06 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.18 0.21 0.15 0 0 0.17 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 3 1 3 3 2 0 2 2 0 0 0 1 0 1 1 2 1 4 6 3 16 2 4 4
Bud 5 3 5 4 0 5 2 15 17 12 24 10 0 1 0 1 2 2 1 5 9 0 1 6
Bud Neck 1 0 1 1 0 1 0 3 2 1 1 1 12 13 8 0 1 0 4 2 7 1 0 6
Bud Site 0 0 0 1 0 1 0 1 1 3 0 0 0 0 1 1 0 0 – – – – – –
Cell Periphery 5 2 10 11 4 7 4 1 1 2 4 5 17 9 6 21 5 10 9 5 13 2 2 1
Cytoplasm 109 208 249 240 221 383 365 527 298 317 281 287 441 467 475 122 56 72 99 166 96 101 141 140
Endoplasmic Reticulum 1 1 4 0 0 0 0 3 1 0 1 1 3 3 2 4 7 6 1 1 10 0 0 0
Endosome 1 0 2 2 5 5 10 14 7 4 2 6 0 0 0 4 3 1 1 1 7 0 1 1
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 2 0 1 0
Mitochondria 3 11 7 7 6 71 117 177 210 291 287 272 0 0 0 25 4 8 13 22 55 21 16 15
Nucleus 0 0 0 1 0 2 2 5 0 1 2 1 1 1 1 10 3 6 0 0 0 0 0 0
Nuclear Periphery 0 2 0 0 0 0 1 1 0 0 1 2 1 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 1 0 1 0 1 1 1 2 1 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 1 1 2 5 2 9 6 0 1 4 6 0 0 0 1 0 1 0 0 0 0 0 0
SpindlePole 0 0 2 1 1 7 17 16 17 9 12 19 0 0 1 0 1 0 1 2 2 0 2 3
Vac/Vac Membrane 0 0 6 1 10 9 10 8 11 4 4 12 0 0 0 32 17 16 1 5 45 2 5 6
Unique Cell Count 117 220 275 257 245 432 469 686 455 521 499 512 446 472 479 178 82 108 141 221 272 135 179 192
Labelled Cell Count 128 229 290 275 254 494 539 780 566 646 625 624 475 495 495 223 101 126 141 221 272 135 179 192


Cell Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.9 3.6 4.4 4.3 4.0 3.4 3.0 3.4 3.0 2.6 2.9 2.9 4.5 4.9 4.9 6.3 6.1 6.7 4.7 4.9 5.2
Std Deviation (1e-4) 2.1 1.7 2.6 2.4 1.9 2.0 1.3 1.9 1.3 0.8 1.6 0.8 0.7 1.1 0.8 5.8 5.9 5.3 0.7 1.2 1.3
Intensity Change (Log2) – – – -0.04 -0.14 -0.38 -0.57 -0.38 -0.59 -0.79 -0.63 -0.63 0.03 0.13 0.15 0.49 0.47 0.6 0.08 0.14 0.24

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 5.9 6.0 4.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.2571 0.2598 0.0353 0.2372 -0.2257 0.5599 1.9661 2.6208 1.0338 0.7779 0.1134 1.518 0.3694 0.3212 0.3852 0.9224 0.0218 0.6187
Actin 0.0337 0.0006 0.0056 0.007 0.0011 0.0229 0.1338 0.0014 0.0005 0.0001 0.0007 0.0065 0.0674 0.0002 0.0028 0.0372 0 0.0025
Bud 0.0012 0.0075 0.0012 0.0015 0.0011 0.0019 0.0059 0.0085 0.0004 0 0.0217 0.0005 0.0002 0.0007 0.0012 0.002 0 0.0016
Bud Neck 0.0074 0.0003 0.0022 0.0006 0.0003 0.017 0.0014 0.0008 0.0024 0.0001 0.0013 0.0019 0.0002 0.0001 0.0002 0.0016 0 0.0004
Bud Periphery 0.0069 0.012 0.01 0.0021 0.0019 0.0113 0.0381 0.0625 0.0008 0 0.0345 0.004 0.0005 0.0015 0.0019 0.0043 0.0001 0.0143
Bud Site 0.0064 0.0061 0.006 0.0013 0.0006 0.0017 0.0139 0.0339 0.014 0.0001 0.0042 0.0017 0.0004 0.0156 0.0102 0.0209 0 0.0008
Cell Periphery 0.0041 0.0089 0.0013 0.0012 0.0003 0.0037 0.0153 0.068 0.0061 0.0001 0.0011 0.0381 0.0015 0.0011 0.0015 0.0026 0.0001 0.0104
Cytoplasm 0.0294 0.047 0.0523 0.0789 0.0323 0.0668 0.0858 0.0976 0.085 0.1164 0.2706 0.1218 0.146 0.1576 0.0924 0.1566 0.1078 0.1394
Cytoplasmic Foci 0.0192 0.0106 0.0162 0.0222 0.0084 0.0243 0.0373 0.0045 0.0107 0.0024 0.0422 0.004 0.0289 0.0116 0.0258 0.0086 0.0196 0.0199
Eisosomes 0.0011 0.0002 0.0004 0.0002 0.0007 0.0003 0.0048 0.0011 0.0005 0.0001 0.0001 0.0002 0.0012 0.0001 0.0004 0.0012 0.0001 0.0001
Endoplasmic Reticulum 0.0075 0.0013 0.0013 0.0032 0.0009 0.001 0.0526 0.0017 0.0007 0.0005 0.0427 0.0011 0.0083 0.0035 0.0041 0.0169 0.0013 0.0022
Endosome 0.0258 0.0137 0.0089 0.0431 0.0195 0.0214 0.0386 0.0046 0.019 0.0031 0.1021 0.0101 0.0246 0.0078 0.0446 0.0104 0.0373 0.0157
Golgi 0.0047 0.0005 0.0003 0.0042 0.0009 0.002 0.0176 0.0002 0.0009 0 0.0016 0.001 0.0099 0.0003 0.0011 0.0011 0.0003 0.0006
Lipid Particles 0.0078 0.0023 0.0013 0.0073 0.0028 0.0041 0.0485 0.0006 0.003 0.0001 0.0287 0.0033 0.0324 0.0013 0.0028 0.0018 0.0008 0.0064
Mitochondria 0.0095 0.0014 0.0016 0.0027 0.001 0.0005 0.0031 0.0005 0.0017 0.0001 0.0028 0.0069 0.0041 0.0003 0.0035 0.0078 0.0005 0.0003
None 0.7675 0.8456 0.8694 0.7102 0.8401 0.7986 0.398 0.6959 0.7977 0.87 0.4158 0.6949 0.6296 0.7918 0.7543 0.7119 0.8085 0.7507
Nuclear Periphery 0.0137 0.0008 0.0006 0.0098 0.0039 0.0026 0.0029 0.0004 0.0006 0.0003 0.0045 0.0004 0.0031 0.0007 0.0017 0.0024 0.0008 0.0005
Nucleolus 0.0009 0.0009 0.0004 0.0012 0.0016 0.0003 0.0005 0.0003 0.0012 0.0001 0.0005 0.0002 0.0003 0.0003 0.0004 0.0004 0.0002 0.0006
Nucleus 0.0035 0.0018 0.0008 0.0039 0.0041 0.0008 0.0008 0.0006 0.0016 0.0009 0.0013 0.0006 0.001 0.0005 0.001 0.0014 0.0006 0.0006
Peroxisomes 0.0092 0.0004 0.0005 0.0018 0.0005 0.0013 0.0397 0.0001 0.0007 0 0.0007 0.012 0.0257 0.0001 0.0004 0.0004 0.0002 0.0019
Punctate Nuclear 0.0222 0.0014 0.0004 0.0475 0.0404 0.0028 0.0029 0.0001 0.0004 0.0001 0.0009 0.0002 0.0024 0.0006 0.0007 0.0006 0.0004 0.0017
Vacuole 0.0137 0.033 0.0175 0.0432 0.0318 0.0144 0.0568 0.0156 0.0505 0.0051 0.0197 0.0814 0.0116 0.0039 0.0451 0.0088 0.0197 0.0287
Vacuole Periphery 0.0045 0.0037 0.0015 0.007 0.0059 0.0005 0.0018 0.001 0.0018 0.0004 0.0023 0.0091 0.0007 0.0003 0.0037 0.001 0.0017 0.0007

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression – – – – – – – – – –
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression –
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
103 216 157 1099 610 1622 1774 1187 713 1838 1931 2286

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1410.88 758.06 5413.48 819.35 634.90 711.97 940.66 829.62 747.00 717.39 1304.32 824.68
Standard Deviation 490.96 118.52 1166.77 125.45 70.22 93.89 233.07 128.41 336.84 98.24 1286.44 127.10
Intensity Change Log 2 — -0.896211 1.939961 -0.784044 — 0.165287 0.567144 0.385921 — -0.476805 1.635046 -0.311086

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.010662 0.007586 0.000850 0.005869 0.000308 0.003022 0.042760 0.015698 0.001803 0.003558 0.039352 0.010973
Bud Neck 0.014075 0.043815 0.004164 0.018086 0.032114 0.048930 0.083295 0.015574 0.029508 0.048329 0.076861 0.016782
Bud Site 0.177244 0.087130 0.000679 0.065003 0.005971 0.037434 0.325500 0.074995 0.030713 0.043274 0.299090 0.070191
Cell Periphery 0.250330 0.023906 0.651483 0.004924 0.000824 0.006541 0.087953 0.012506 0.036868 0.008582 0.133771 0.008861
Cytoplasm 0.065263 0.317522 0.000009 0.390841 0.335638 0.376117 0.207221 0.384336 0.296579 0.369231 0.190374 0.387463
Cytoplasmic Foci 0.027922 0.257881 0.000064 0.016837 0.377247 0.290490 0.010928 0.039539 0.326783 0.286658 0.010045 0.028625
Eisosomes 0.001514 0.003758 0.218229 0.001099 0.000668 0.001682 0.004366 0.000841 0.000791 0.001926 0.021754 0.000965
Endoplasmic Reticulum 0.027209 0.000844 0.005247 0.002452 0.000612 0.000769 0.020903 0.002204 0.004455 0.000778 0.019630 0.002323
Endosome 0.025764 0.029909 0.000971 0.005303 0.018676 0.024021 0.001958 0.015840 0.019700 0.024713 0.001878 0.010774
Golgi 0.013408 0.003789 0.003956 0.005473 0.002901 0.007397 0.000411 0.006219 0.004419 0.006973 0.000700 0.005861
Lipid Particles 0.006480 0.007166 0.003787 0.001370 0.018960 0.009618 0.002068 0.002543 0.017157 0.009330 0.002208 0.001979
Mitochondria 0.007364 0.005084 0.000417 0.002698 0.010605 0.015481 0.001017 0.014034 0.010137 0.014259 0.000968 0.008584
Mitotic Spindle 0.007160 0.001068 0.002554 0.012521 0.000474 0.003727 0.001047 0.044846 0.001440 0.003414 0.001169 0.029306
None 0.000077 0.001556 0.000082 0.004854 0.001428 0.002248 0.001691 0.002828 0.001233 0.002166 0.001560 0.003802
Nuclear Periphery 0.000350 0.000266 0.008106 0.001404 0.000526 0.000242 0.000462 0.001090 0.000500 0.000245 0.001083 0.001241
Nuclear Periphery Foci 0.001660 0.000548 0.000181 0.000814 0.000175 0.000371 0.001080 0.000868 0.000389 0.000392 0.001007 0.000842
Nucleolus 0.000139 0.001638 0.000094 0.000363 0.000911 0.001371 0.000130 0.000942 0.000799 0.001403 0.000128 0.000664
Nucleus 0.020934 0.087981 0.000242 0.341702 0.125529 0.093864 0.142515 0.212012 0.110419 0.093173 0.130947 0.274361
Peroxisomes 0.001419 0.027811 0.000006 0.002733 0.025274 0.022213 0.001250 0.006765 0.021828 0.022871 0.001149 0.004826
Vacuole 0.321724 0.089432 0.096427 0.114753 0.040165 0.052751 0.063254 0.141379 0.080839 0.057061 0.065951 0.128578
Vacuole Periphery 0.019299 0.001309 0.002453 0.000900 0.000997 0.001712 0.000192 0.004941 0.003641 0.001665 0.000375 0.002998

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.57 1.80 1.47 2.69 -1.90 -4.34 -15.12 -4.70 -2.75 10.27 -1.79 -13.63 -2.89 -1.58 12.03
Bud Neck -4.20 3.38 0.94 4.98 -4.06 -4.11 -8.95 6.36 13.12 17.48 -5.10 -9.20 6.41 14.11 17.30
Bud Site 3.18 6.64 5.50 3.75 -8.14 -8.95 -34.51 -8.15 -0.08 28.24 -2.07 -26.15 -0.58 2.08 28.66
Cell Periphery 6.78 -10.79 7.63 2.74 29.35 -3.40 -16.71 -2.70 0.58 14.99 4.71 -10.91 5.70 2.57 20.51
Cytoplasm -11.65 5.72 -16.27 0.41 -39.41 -3.52 10.45 -0.17 3.72 -11.97 -6.54 9.11 -2.47 5.43 -15.52
Cytoplasmic Foci -12.70 3.11 1.64 15.45 -13.61 7.95 39.50 36.99 41.97 -8.78 3.72 34.16 32.87 46.77 -8.21
Eisosomes -1.42 -10.09 1.23 2.44 10.14 -2.47 -8.23 1.30 3.31 9.64 -2.76 -9.18 1.50 3.80 9.35
Endoplasmic Reticulum 2.48 2.04 2.19 -9.38 1.39 -0.55 -10.03 -9.31 -6.63 8.77 2.30 -6.14 0.61 -9.47 8.65
Endosome -0.60 4.38 3.98 5.54 -4.61 -2.35 8.98 5.02 9.23 -5.45 -2.29 9.95 7.49 13.02 -5.95
Golgi 1.87 1.84 2.26 1.40 1.82 -6.18 7.03 0.45 5.49 -3.70 -2.72 4.80 2.26 6.10 -3.08
Lipid Particles -0.33 0.74 1.70 4.85 0.91 4.18 7.84 7.86 10.76 0.11 3.95 7.84 8.12 12.15 1.53
Mitochondria 0.38 1.24 1.06 1.71 -3.14 -1.85 4.58 1.70 4.24 -3.65 -1.71 4.68 2.95 6.26 -3.86
Mitotic Spindle 1.51 1.25 -0.44 -4.68 -4.25 -3.26 -2.31 -7.77 -6.56 -7.50 -1.84 0.12 -8.37 -7.10 -8.73
None -2.49 -0.05 -13.73 -3.38 -13.75 -1.59 -0.75 -3.55 -1.79 -3.17 -2.08 -1.00 -6.28 -3.35 -5.73
Nuclear Periphery 0.69 -10.77 -15.78 -19.75 7.60 2.26 -1.54 -10.77 -16.54 -13.20 2.33 -6.34 -15.36 -23.93 -9.60
Nuclear Periphery Foci 1.52 3.06 0.71 -1.59 -9.46 -1.19 -6.94 -6.74 -3.49 0.78 -0.14 -4.74 -6.74 -4.63 -0.32
Nucleolus -2.46 1.06 -3.30 2.20 -6.77 -1.48 5.00 1.31 2.59 -4.16 -2.37 5.01 1.97 3.95 -5.53
Nucleus -4.34 2.08 -24.19 -24.96 -45.22 4.61 -6.73 -15.25 -21.89 -9.18 2.75 -7.15 -26.85 -36.07 -19.47
Peroxisomes -4.99 2.38 0.69 5.13 -3.24 0.97 8.34 7.48 11.23 -2.72 -0.31 8.33 7.82 13.35 -2.51
Vacuole 7.36 7.38 3.59 -9.39 -10.12 -3.70 -10.53 -24.86 -23.57 -18.48 3.62 -0.71 -17.94 -28.95 -22.55
Vacuole Periphery 2.78 2.60 2.93 2.79 6.79 -3.30 6.80 -2.37 -0.85 -4.14 1.99 3.40 2.33 1.20 -3.63
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Putative transmembrane protein involved in the biotin biosynthesis; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
Localization
Cell Percentages —
Cell Cycle Regulation No
Subcompartmental Group N/A

Bio5

Bio5


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Bio5-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available