Standard name
Human Ortholog
Description Nucleolar protein involved in pre-25S rRNA processing; also involved in biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.1 0.13 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0.05 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.07 0.06 0.05 0 0 0.1 0.1 0.06 0.13 0.18 0.17 0.18 0.08 0 0 0.12 0.07 0.11 0 0 0 0 0 0
Nucleus 0.26 0.27 0.23 0 0 0 0 0 0.05 0 0.05 0.07 0.07 0 0 0.11 0.14 0.17 0.14 0.25 0.11 0.06 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.76 0.65 0.77 0.93 0.92 0.89 0.87 0.83 0.93 0.84 0.84 0.8 0.87 0.84 0.81 0.88 0.88 0.86 0.76 0.64 0.74 0.82 0.68 0.6
Peroxisomes 0 0 0 0 0 0.07 0.09 0.05 0 0.05 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0.15 0.29 0.32 0.4 0.42 0.25 0.3 0.27 0.3 0 0.06 0.09 0 0 0 0 0 0 0.05 0.17 0.12
Vac/Vac Membrane 0 0.1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud 0 0 0 0 1 1 4 2 4 1 1 4 1 0 0 0 0 0 2 4 1 3 2 6
Bud Neck 0 0 1 15 10 8 13 16 7 4 6 7 4 31 16 0 1 0 0 1 0 0 4 5
Bud Site 0 0 0 1 0 3 13 9 4 19 10 20 0 1 1 1 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
Cytoplasm 6 3 2 6 5 8 5 7 2 13 7 12 19 57 76 13 4 2 2 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 1 0 0 0
Endosome 2 0 1 4 16 8 41 15 10 13 8 8 2 12 23 4 0 1 5 2 4 2 10 32
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 1 4
Mitochondria 35 12 9 6 11 32 55 32 39 59 41 78 22 10 8 40 13 13 1 0 1 3 5 5
Nucleus 121 52 44 10 10 7 15 21 14 12 13 29 19 18 13 37 27 21 76 51 22 15 17 15
Nuclear Periphery 1 0 1 0 1 0 2 2 1 1 1 0 0 0 0 0 0 1 5 0 1 1 2 5
Nucleolus 360 127 146 274 293 281 503 481 273 275 208 354 240 467 464 299 166 104 403 130 152 216 287 258
Peroxisomes 1 0 0 6 9 23 51 29 5 16 10 21 1 12 14 2 0 1 0 0 0 0 3 6
SpindlePole 1 1 1 44 92 100 229 244 74 98 66 133 8 35 51 3 1 2 11 3 6 12 72 53
Vac/Vac Membrane 15 19 5 0 2 1 5 2 1 3 1 1 5 10 7 2 0 1 16 9 8 6 7 26
Unique Cell Count 472 194 190 294 318 317 578 580 293 329 248 445 277 554 570 338 188 121 532 205 206 265 421 432
Labelled Cell Count 542 214 210 366 450 472 936 860 434 514 372 667 321 653 673 404 212 146 532 205 206 265 421 432


Nucleolus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 18.0 19.8 17.0 16.9 13.6 10.2 9.1 9.2 9.2 8.3 8.3 8.5 19.2 18.4 16.7 25.1 29.5 31.5 20.0 18.7 19.5
Std Deviation (1e-4) 4.7 4.6 4.0 4.2 3.3 2.6 2.6 2.4 2.2 2.7 2.5 2.6 5.7 6.6 6.3 8.6 12.0 12.0 4.6 4.3 4.9
Intensity Change (Log2) – – – -0.01 -0.32 -0.74 -0.9 -0.89 -0.89 -1.04 -1.04 -1.0 0.17 0.11 -0.03 0.56 0.79 0.89 0.23 0.14 0.19

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700010203040WT3HU80HU120HU160010203040WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3010203040WT1AF100AF140AF180010203040
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 2.7 0 0 0 0 0 0 0 0 0 3.0 0 0 0 0
Bud Site 0 0 0 0 0 0 3.4 0 3.0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 1.9 0 0 3.0 4.1 4.8 1.9 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 2.7 0 3.5 0 0 2.3 0 0 0 0 2.4 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria -1.7 -0.7 2.1 2.1 0.4 3.1 4.3 3.8 4.3 1.4 0 0 2.7 0.9 2.0
Nucleus -6.7 -7.1 -7.6 -9.2 -8.4 -6.1 -6.9 -5.5 -6.0 -5.1 -8.6 -9.5 -3.7 -2.2 -1.2
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 5.2 4.9 3.5 3.4 1.9 5.2 1.9 1.9 0.8 2.7 2.3 1.4 3.5 2.9 2.0
Peroxisomes 0 0 3.8 4.2 3.1 0 3.1 0 3.0 0 0 0 0 0 0
SpindlePole 5.3 8.0 8.5 10.2 10.7 7.3 8.2 7.5 8.3 0 3.2 4.0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 14.2207 16.7337 15.6223 15.4559 15.0647 15.1152 13.0564 16.1769 13.9097 12.9509 13.6273 13.9746 16.8355 21.4501 19.475 18.0858 18.5624 18.8344
Actin 0.0125 0 0.0007 0 0.0002 0 0.0164 0.0084 0.0168 0.0747 0.0361 0.0018 0.0065 0 0.0022 0.0005 0.0004 0.0077
Bud 0.0001 0 0 0.0001 0 0.0001 0.0002 0.0003 0.0003 0.0001 0.0007 0.0001 0.0002 0 0.0001 0.0001 0.0004 0
Bud Neck 0.0002 0.0003 0.0003 0.0002 0.0001 0.0009 0.0005 0.0002 0.0005 0.0007 0.0005 0.0003 0.0002 0.0002 0.0002 0.0004 0.0017 0.0003
Bud Periphery 0.0001 0.0001 0 0.0001 0.0001 0.0002 0.0004 0.0003 0.0004 0.0002 0.0013 0.0002 0.0003 0.0001 0.0003 0.0002 0.0014 0.0001
Bud Site 0.0003 0.0002 0.0002 0.0001 0.0001 0.0003 0.0008 0.0013 0.0012 0.0005 0.0017 0.0002 0.0011 0.0001 0.0015 0.0003 0.0007 0.0001
Cell Periphery 0.0001 0.0002 0.0001 0.0001 0.0002 0.0002 0.0003 0.0001 0.0002 0.0002 0.0005 0.0002 0.0004 0.0002 0.0003 0.0005 0.0019 0.0002
Cytoplasm 0.0001 0 0.0001 0 0 0 0.0003 0.0016 0.0009 0.0001 0.0002 0.0007 0.0079 0 0.0003 0.0001 0.0003 0
Cytoplasmic Foci 0.0043 0.0012 0.0021 0.0001 0.0013 0.0023 0.0078 0.0025 0.0121 0.023 0.0084 0.0111 0.016 0.0049 0.0068 0.0109 0.0055 0.0008
Eisosomes 0.0001 0 0 0 0.0001 0 0.0003 0.0001 0.0001 0.0001 0.0002 0 0.0002 0 0.0002 0.0001 0.0001 0.0001
Endoplasmic Reticulum 0.0001 0 0 0 0 0 0.0021 0.0022 0.0013 0 0.0003 0.0002 0.0086 0 0.0006 0.0001 0.0001 0
Endosome 0.0011 0.0001 0.0009 0 0.0001 0.0011 0.0038 0.0141 0.0263 0.0007 0.0051 0.008 0.0146 0 0.0023 0.0006 0.001 0.0002
Golgi 0.0016 0.0001 0.0003 0 0.0004 0.0005 0.0026 0.0033 0.0101 0.0028 0.0107 0.0074 0.0052 0 0.0004 0.0004 0.0011 0.0002
Lipid Particles 0.0089 0.0024 0.0057 0.0002 0.029 0.0118 0.0232 0.0049 0.0156 0.068 0.0235 0.0271 0.0085 0.0021 0.0047 0.0154 0.0279 0.0114
Mitochondria 0.0015 0.0001 0.0004 0.0001 0.001 0.0016 0.0032 0.0113 0.012 0.0003 0.0074 0.0017 0.0043 0.0025 0.0058 0.0089 0.0065 0.001
None 0.0007 0 0.0011 0 0.0001 0 0.0011 0.0003 0.001 0.0001 0.0005 0.0006 0.0071 0 0.0008 0.0004 0.0006 0.0001
Nuclear Periphery 0.0113 0.0004 0.0007 0.0002 0.0133 0.0045 0.0055 0.0264 0.0076 0.0001 0.0483 0.0079 0.013 0.0005 0.0028 0.0292 0.0118 0.0096
Nucleolus 0.8514 0.8417 0.9157 0.9026 0.8735 0.8732 0.7774 0.7806 0.8108 0.6695 0.7178 0.8087 0.7963 0.8625 0.8983 0.8353 0.7881 0.8466
Nucleus 0.0866 0.1409 0.0662 0.0946 0.0713 0.0946 0.1366 0.1284 0.0699 0.1488 0.0943 0.1107 0.0811 0.1249 0.0678 0.0828 0.1274 0.1156
Peroxisomes 0.0024 0.0001 0.0018 0 0.0003 0.0004 0.0079 0.0029 0.0054 0.0072 0.0116 0.0032 0.0047 0.0006 0.0004 0.0018 0.0006 0.0001
Punctate Nuclear 0.0155 0.0117 0.0026 0.0011 0.0064 0.0065 0.0073 0.0059 0.0035 0.0024 0.023 0.009 0.0152 0.0008 0.0035 0.0031 0.0113 0.0039
Vacuole 0.0003 0.0004 0.0004 0.0002 0.0003 0.0009 0.001 0.0026 0.0021 0.0003 0.0016 0.0004 0.0025 0.0004 0.0004 0.0031 0.0045 0.0006
Vacuole Periphery 0.0007 0.0001 0.0003 0.0001 0.0022 0.0007 0.0012 0.0023 0.002 0.0001 0.0062 0.0007 0.0061 0.0004 0.0004 0.006 0.0066 0.0014

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 80.7564 60.0403 62.0552 56.8567 71.5306 49.5458 52.9377 43.1679 46.2123 57.3447
Translational Efficiency 2.5596 3.1679 2.4738 2.6443 2.2422 2.5283 1.8904 2.2602 1.7335 2.1892

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1228 613 491 884 79 1100 1546 371 1307 1713 2037 1255

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1262.04 1654.40 2021.53 2419.89 1579.10 1494.14 2221.31 1857.14 1281.20 1551.49 2173.15 2253.53
Standard Deviation 259.57 413.81 393.93 702.18 332.99 367.69 404.32 528.88 275.16 392.43 410.82 704.22
Intensity Change Log 2 — 0.390550 0.679690 0.939184 — -0.079787 0.492308 0.233980 — 0.148213 0.578560 0.590139

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000572 0.000443 0.000481 0.001216 0.000747 0.000462 0.000544 0.001078 0.000583 0.000455 0.000529 0.001175
Bud Neck 0.005764 0.002843 0.005871 0.013567 0.003781 0.002954 0.006143 0.021579 0.005644 0.002914 0.006077 0.015936
Bud Site 0.001799 0.000617 0.000886 0.003347 0.001322 0.000896 0.000726 0.010085 0.001770 0.000796 0.000765 0.005339
Cell Periphery 0.000113 0.000043 0.000038 0.000179 0.000078 0.000054 0.000055 0.000663 0.000111 0.000050 0.000051 0.000322
Cytoplasm 0.001125 0.000540 0.000068 0.001232 0.000426 0.000384 0.000128 0.013554 0.001083 0.000440 0.000114 0.004875
Cytoplasmic Foci 0.012586 0.003291 0.003191 0.010614 0.024294 0.003580 0.001949 0.014964 0.013293 0.003477 0.002248 0.011900
Eisosomes 0.000283 0.000099 0.000095 0.000123 0.000180 0.000114 0.000085 0.000093 0.000276 0.000109 0.000087 0.000114
Endoplasmic Reticulum 0.001417 0.000357 0.000218 0.000675 0.002556 0.000719 0.000191 0.000615 0.001486 0.000589 0.000198 0.000657
Endosome 0.003034 0.000519 0.000217 0.004194 0.000415 0.000801 0.000133 0.007714 0.002875 0.000700 0.000153 0.005234
Golgi 0.001439 0.000680 0.000519 0.002078 0.001992 0.001603 0.000321 0.004722 0.001472 0.001273 0.000369 0.002859
Lipid Particles 0.001095 0.000451 0.000074 0.000407 0.001034 0.000570 0.000095 0.000989 0.001091 0.000527 0.000090 0.000579
Mitochondria 0.003262 0.001458 0.002100 0.004987 0.000772 0.001890 0.002424 0.007500 0.003112 0.001735 0.002346 0.005730
Mitotic Spindle 0.011902 0.005956 0.017080 0.020176 0.009671 0.003899 0.005023 0.011794 0.011767 0.004635 0.007929 0.017698
None 0.001671 0.000806 0.000375 0.001184 0.000701 0.001092 0.000454 0.002464 0.001613 0.000990 0.000435 0.001562
Nuclear Periphery 0.001934 0.002164 0.004130 0.005365 0.000800 0.001176 0.002964 0.001131 0.001865 0.001530 0.003245 0.004113
Nuclear Periphery Foci 0.012348 0.002479 0.003277 0.003224 0.014530 0.003534 0.001793 0.003220 0.012480 0.003156 0.002151 0.003223
Nucleolus 0.692838 0.680828 0.763446 0.626546 0.605637 0.680881 0.725461 0.439776 0.687567 0.680862 0.734617 0.571334
Nucleus 0.187673 0.274395 0.162915 0.265563 0.239388 0.276759 0.234283 0.417645 0.190798 0.275913 0.217080 0.310521
Peroxisomes 0.053300 0.017136 0.032036 0.020332 0.088043 0.012723 0.013285 0.018293 0.055400 0.014302 0.017805 0.019729
Vacuole 0.003583 0.001948 0.001158 0.006417 0.002811 0.002822 0.001272 0.013172 0.003537 0.002509 0.001244 0.008414
Vacuole Periphery 0.002263 0.002945 0.001824 0.008574 0.000822 0.003088 0.002671 0.008949 0.002176 0.003037 0.002467 0.008685

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.48 1.31 -1.99 -2.41 -2.22 2.08 1.48 -3.22 -7.54 -7.13 2.60 1.01 -2.83 -3.43 -3.07
Bud Neck 5.56 -1.53 -8.69 -11.05 -7.27 1.21 -3.95 -10.56 -11.11 -9.54 6.02 -2.19 -12.75 -15.42 -11.85
Bud Site 4.30 2.09 -4.49 -7.63 -6.16 1.19 1.71 -4.50 -4.68 -4.73 3.58 3.61 -5.68 -6.94 -6.89
Cell Periphery 4.23 4.76 -2.92 -6.00 -6.31 1.22 0.99 -2.11 -2.19 -2.18 4.09 3.71 -2.59 -3.29 -3.24
Cytoplasm 1.47 3.06 -0.71 -2.27 -3.93 0.08 2.47 -4.04 -4.04 -4.11 1.90 2.95 -3.79 -4.53 -4.83
Cytoplasmic Foci 5.35 6.69 0.35 -4.11 -4.69 2.01 2.14 0.97 -3.43 -3.95 6.55 7.79 0.38 -5.56 -6.57
Eisosomes 12.55 13.48 11.50 -2.58 -3.31 3.30 4.99 4.50 2.40 -0.65 12.83 15.23 12.75 -0.63 -4.56
Endoplasmic Reticulum 7.89 9.16 2.86 -1.21 -1.77 2.73 3.57 2.38 -1.17 -5.00 6.17 10.13 3.51 -0.76 -3.12
Endosome 2.36 2.78 -0.61 -3.25 -3.72 -1.82 2.43 -2.57 -2.37 -2.70 2.22 2.86 -1.23 -3.94 -4.61
Golgi 1.70 2.56 -0.85 -2.41 -3.19 0.54 3.88 -1.32 -1.54 -2.66 0.42 3.32 -1.67 -1.95 -4.28
Lipid Particles 1.61 4.31 2.64 0.32 -2.71 0.86 1.95 0.15 -0.82 -2.21 1.96 4.40 2.04 -0.01 -3.24
Mitochondria 5.62 3.29 -3.89 -8.61 -6.80 -3.41 -10.50 -5.89 -4.65 -4.27 4.03 2.43 -5.28 -8.37 -7.55
Mitotic Spindle 1.74 -1.43 -2.47 -3.64 -0.66 1.13 0.92 -1.14 -2.79 -2.59 3.10 1.57 -2.60 -5.17 -4.03
None 3.23 5.02 1.22 -2.45 -4.97 -1.57 1.68 -6.17 -4.31 -7.32 2.27 4.86 -0.35 -3.42 -8.00
Nuclear Periphery -0.21 -1.93 -2.81 -1.94 -0.76 -0.78 -2.84 -1.33 -0.65 2.37 0.60 -2.10 -2.59 -2.84 -0.89
Nuclear Periphery Foci 5.81 5.51 5.66 -0.29 0.10 2.18 2.59 2.16 0.20 -0.92 5.90 7.07 5.88 0.24 -1.41
Nucleolus 1.08 -5.86 6.93 4.87 10.85 -2.74 -4.28 6.46 14.64 17.25 0.79 -5.37 12.55 11.97 17.20
Nucleus -7.76 2.23 -8.39 -0.18 -9.03 -1.44 0.09 -6.48 -8.55 -10.93 -11.05 -4.12 -13.40 -4.68 -10.59
Peroxisomes 12.94 5.81 11.22 -1.89 4.81 5.93 5.88 5.57 -1.58 -1.33 15.98 14.62 13.07 -3.62 -0.92
Vacuole 2.37 7.94 -2.25 -3.19 -4.12 -0.13 2.70 -4.76 -4.72 -5.26 1.93 7.76 -4.83 -5.38 -6.56
Vacuole Periphery -0.62 1.91 -5.16 -3.28 -5.64 -4.41 -9.74 -3.40 -2.26 -2.54 -1.63 -1.25 -5.78 -4.45 -5.58
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Nucleolar protein involved in pre-25S rRNA processing; also involved in biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p
Localization
Cell Percentages nucleolus (53%)
Cell Cycle Regulation No
Subcompartmental Group nucleolus-2

Nop12

Nop12


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Nop12-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available