Standard name | |
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Human Ortholog | |
Description | Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 |
Bud | 1 | 1 | 3 | 2 | 7 | 9 | 21 | 17 | 15 | 15 | 12 | 14 | 2 | 1 | 1 | 0 | 2 | 0 | 5 | 1 | 2 | 0 | 3 | 11 |
Bud Neck | 10 | 5 | 5 | 4 | 2 | 8 | 14 | 12 | 19 | 12 | 15 | 21 | 4 | 4 | 6 | 0 | 6 | 0 | 1 | 0 | 0 | 1 | 1 | 5 |
Bud Site | 7 | 0 | 9 | 4 | 8 | 16 | 23 | 20 | 21 | 30 | 26 | 50 | 1 | 4 | 1 | 1 | 1 | 3 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 5 | 2 | 5 | 13 | 12 | 13 | 15 | 11 | 10 | 7 | 4 | 7 | 24 | 54 | 85 | 27 | 17 | 13 | 0 | 0 | 1 | 1 | 5 | 4 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 1 |
Endosome | 4 | 7 | 28 | 7 | 2 | 5 | 3 | 1 | 4 | 2 | 4 | 2 | 15 | 28 | 33 | 54 | 46 | 54 | 8 | 7 | 9 | 14 | 18 | 24 |
Golgi | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 1 | 0 | 3 | 1 | 2 | 1 |
Mitochondria | 27 | 5 | 8 | 6 | 3 | 26 | 22 | 15 | 23 | 35 | 29 | 50 | 1 | 0 | 4 | 12 | 9 | 2 | 2 | 0 | 1 | 1 | 3 | 5 |
Nucleus | 11 | 6 | 9 | 4 | 7 | 17 | 11 | 13 | 5 | 10 | 5 | 17 | 9 | 15 | 30 | 6 | 2 | 5 | 3 | 3 | 0 | 6 | 7 | 8 |
Nuclear Periphery | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 170 | 159 | 97 | 64 | 66 | 100 | 127 | 113 | 124 | 132 | 115 | 156 | 179 | 243 | 216 | 114 | 143 | 106 | 8 | 7 | 8 | 12 | 12 | 19 |
Peroxisomes | 6 | 10 | 34 | 9 | 12 | 38 | 27 | 26 | 8 | 15 | 28 | 31 | 5 | 4 | 12 | 17 | 13 | 19 | 3 | 1 | 3 | 3 | 2 | 4 |
SpindlePole | 190 | 191 | 252 | 139 | 155 | 223 | 301 | 260 | 235 | 247 | 226 | 290 | 269 | 362 | 297 | 153 | 182 | 143 | 245 | 223 | 255 | 252 | 308 | 355 |
Vac/Vac Membrane | 1 | 0 | 2 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 3 | 7 | 11 | 8 | 6 | 1 | 1 | 0 | 1 | 4 | 9 |
Unique Cell Count | 273 | 246 | 291 | 183 | 188 | 295 | 388 | 342 | 304 | 333 | 313 | 398 | 328 | 481 | 465 | 232 | 245 | 192 | 287 | 253 | 290 | 303 | 378 | 462 |
Labelled Cell Count | 433 | 388 | 452 | 255 | 274 | 456 | 565 | 488 | 465 | 509 | 466 | 640 | 510 | 719 | 692 | 399 | 432 | 353 | 287 | 253 | 290 | 303 | 378 | 462 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 5.2 | 7.3 | 5.9 | 5.8 | 5.9 | 5.1 | 5.1 | 5.1 | 4.8 | 4.8 | 4.3 | 4.5 | 6.9 | 7.0 | 6.5 | 9.1 | 9.4 | 9.1 | 7.2 | 7.0 | 7.3 |
Std Deviation (1e-4) | 0.9 | 1.3 | 1.5 | 2.2 | 1.9 | 1.6 | 1.6 | 1.8 | 1.6 | 1.4 | 1.3 | 1.2 | 1.2 | 1.4 | 1.5 | 1.9 | 1.9 | 1.7 | 1.3 | 1.1 | 1.3 |
Intensity Change (Log2) | – | – | – | -0.02 | -0.0 | -0.21 | -0.22 | -0.21 | -0.31 | -0.29 | -0.46 | -0.41 | 0.22 | 0.24 | 0.14 | 0.63 | 0.66 | 0.61 | 0.29 | 0.24 | 0.31 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 1.7 | 3.1 | 2.8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0.8 | 1.5 | 1.4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.6 | 0 |
Bud Site | -0.6 | 0.7 | 1.4 | 1.7 | 1.7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 3.0 | 2.7 | 1.9 | 1.6 | 1.2 | 1.2 | 0.3 | 0 | 0 | 3.3 | 4.8 | 6.8 | 4.7 | 3.0 | 2.9 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | -2.3 | -3.8 | -4.2 | -5.5 | -5.6 | 0 | 0 | 0 | 0 | -2.5 | -2.0 | -1.2 | 4.3 | 3.1 | 5.3 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0.3 | 0 | 3.1 | 1.8 | 1.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.4 | 0.6 | 0 |
Nucleus | -0.6 | 0.4 | 1.6 | -0.2 | 0.5 | -1.2 | -0.1 | -1.2 | 0.8 | -0.3 | 0 | 2.0 | -0.3 | -1.9 | -0.3 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0.4 | 0.4 | 0.1 | -0.2 | -0.1 | 0 | 0 | 0 | 0 | 5.3 | 4.7 | 3.6 | 3.7 | 5.8 | 4.8 |
Peroxisomes | -2.5 | -1.9 | 0.4 | -2.1 | -1.7 | 0 | 0 | 0 | 0 | -5.2 | -6.8 | -5.1 | -1.7 | -2.6 | -0.6 |
SpindlePole | -3.0 | -1.2 | -3.4 | -3.0 | -3.4 | 0 | 0 | 0 | 0 | -1.6 | -3.8 | -6.8 | -5.6 | -3.6 | -3.4 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 3.411 | 3.3191 | 3.2526 | 3.3432 | 2.9935 | 3.4479 | 2.3262 | 1.9833 | 1.9769 | 1.8501 | 2.04 | 2.1515 | 2.0066 | 1.9805 | 1.5941 | 1.9699 | 1.4273 | 1.7395 |
Actin | 0.0075 | 0.0007 | 0.0062 | 0 | 0.0003 | 0.0002 | 0.0065 | 0.0005 | 0.0049 | 0 | 0.0124 | 0.0002 | 0.0023 | 0 | 0 | 0 | 0 | 0.0021 |
Bud | 0 | 0.0001 | 0.0002 | 0 | 0 | 0 | 0.0002 | 0.0007 | 0.0001 | 0 | 0.0001 | 0.0001 | 0 | 0.0002 | 0 | 0 | 0 | 0 |
Bud Neck | 0.0002 | 0.0003 | 0.0004 | 0.011 | 0.0006 | 0.0006 | 0.0012 | 0.0003 | 0.0006 | 0.0011 | 0.0005 | 0.0002 | 0.0001 | 0.0003 | 0.0001 | 0.0036 | 0.0002 | 0.0001 |
Bud Periphery | 0.0001 | 0.0001 | 0.0002 | 0 | 0 | 0 | 0.0004 | 0.0027 | 0.0002 | 0 | 0.0002 | 0.0003 | 0 | 0.0002 | 0 | 0 | 0 | 0 |
Bud Site | 0.0002 | 0.0012 | 0.0017 | 0 | 0.0004 | 0 | 0.0032 | 0.0034 | 0.0008 | 0.0003 | 0.0006 | 0.0001 | 0.0001 | 0.0071 | 0 | 0.0001 | 0 | 0 |
Cell Periphery | 0 | 0 | 0.0002 | 0 | 0 | 0 | 0.0003 | 0.0001 | 0 | 0 | 0.0001 | 0 | 0 | 0.0001 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.0005 | 0.0001 | 0.0006 | 0 | 0.0007 | 0 | 0.0017 | 0 | 0.0007 | 0 | 0.0008 | 0 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0 |
Cytoplasmic Foci | 0.0172 | 0.0058 | 0.0086 | 0.0071 | 0.0364 | 0.0059 | 0.0391 | 0.0072 | 0.012 | 0.0307 | 0.0486 | 0.0039 | 0.0091 | 0.0092 | 0.0039 | 0.0239 | 0.0175 | 0.0011 |
Eisosomes | 0.0002 | 0 | 0.0003 | 0 | 0 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0001 |
Endoplasmic Reticulum | 0.0007 | 0 | 0.0008 | 0 | 0.0002 | 0 | 0.0012 | 0.0001 | 0.0006 | 0 | 0.001 | 0.0003 | 0 | 0 | 0 | 0 | 0 | 0.0001 |
Endosome | 0.0026 | 0.0004 | 0.0032 | 0.0001 | 0.0017 | 0.0004 | 0.0069 | 0.0003 | 0.0063 | 0.0006 | 0.0223 | 0.0014 | 0.0003 | 0.0001 | 0.0001 | 0.0004 | 0.0001 | 0.0004 |
Golgi | 0.0021 | 0.0007 | 0.0028 | 0.0001 | 0.0012 | 0.0008 | 0.0062 | 0.0003 | 0.0023 | 0.001 | 0.0163 | 0.0006 | 0.0003 | 0.0001 | 0.0002 | 0.0005 | 0.0002 | 0.0004 |
Lipid Particles | 0.0144 | 0.0063 | 0.0059 | 0.0006 | 0.0263 | 0.0072 | 0.021 | 0.0013 | 0.0172 | 0.003 | 0.0737 | 0.0075 | 0.002 | 0.0008 | 0.004 | 0.0024 | 0.0079 | 0.0008 |
Mitochondria | 0.0006 | 0.002 | 0.009 | 0 | 0 | 0.0002 | 0.0107 | 0.0016 | 0.0043 | 0.0357 | 0.0362 | 0.013 | 0.0005 | 0.0002 | 0 | 0 | 0 | 0.0012 |
None | 0.0014 | 0.0001 | 0.0018 | 0 | 0.0006 | 0 | 0.0012 | 0.0001 | 0.0025 | 0 | 0.0021 | 0.0001 | 0.0003 | 0.0001 | 0 | 0 | 0 | 0.0002 |
Nuclear Periphery | 0.0022 | 0.0002 | 0.001 | 0.0001 | 0.0012 | 0.0001 | 0.0032 | 0.0008 | 0.0033 | 0.0001 | 0.0022 | 0.0036 | 0.0002 | 0.0002 | 0.0002 | 0.0001 | 0.0001 | 0.0002 |
Nucleolus | 0.0311 | 0.0471 | 0.0709 | 0.0037 | 0.0255 | 0.0204 | 0.0529 | 0.0588 | 0.076 | 0.0017 | 0.0111 | 0.026 | 0.0209 | 0.0535 | 0.0086 | 0.0029 | 0.019 | 0.0119 |
Nucleus | 0.0047 | 0.0233 | 0.0144 | 0.0007 | 0.0031 | 0.0032 | 0.0113 | 0.0107 | 0.0119 | 0.0004 | 0.001 | 0.0038 | 0.0031 | 0.0325 | 0.001 | 0.0007 | 0.0008 | 0.0023 |
Peroxisomes | 0.0034 | 0.0087 | 0.0039 | 0.0001 | 0.0016 | 0.0023 | 0.0099 | 0.0009 | 0.0041 | 0.0025 | 0.0134 | 0.007 | 0.0024 | 0.0002 | 0.0001 | 0.0005 | 0.0002 | 0.0003 |
Punctate Nuclear | 0.9109 | 0.9022 | 0.8669 | 0.9765 | 0.8999 | 0.9587 | 0.8212 | 0.9098 | 0.8506 | 0.9228 | 0.7562 | 0.9313 | 0.9581 | 0.8946 | 0.9816 | 0.9648 | 0.954 | 0.9785 |
Vacuole | 0.0001 | 0.0005 | 0.0009 | 0 | 0.0001 | 0 | 0.001 | 0.0003 | 0.0007 | 0 | 0.0005 | 0.0003 | 0 | 0.0003 | 0 | 0 | 0 | 0 |
Vacuole Periphery | 0.0001 | 0.0001 | 0.0003 | 0 | 0 | 0 | 0.0004 | 0.0002 | 0.0006 | 0 | 0.0006 | 0.0004 | 0 | 0 | 0 | 0 | 0 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 8.1372 | 19.6402 | 16.1932 | 17.8743 | 6.3301 | 4.8796 | 23.3518 | 23.3311 | 22.0252 | 11.6806 |
Translational Efficiency | 0.7184 | 0.7607 | 0.8477 | 0.7853 | 0.8243 | 0.7995 | 0.6989 | 0.6831 | 0.5553 | 0.4977 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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