Standard name
Human Ortholog
Description Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0.05 0.07 0.05 0 0 0 0.07 0 0.08 0.19 0.22 0.09 0.11 0.11 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.06 0 0 0 0 0.14 0.25 0.2 0.4 0.29 0.49 0.26 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.95 0.94 0.94 0.94 0.94 0.88 0.84 0.85 0.82 0.83 0.73 0.81 0.9 0.77 0.67 0.8 0.82 0.84 0.94 0.91 0.93 0.73 0.67 0.64
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0.06 0 0.1 0.08 0.09 0.11 0 0 0.05 0 0 0 0 0 0 0.07 0.06 0.06
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.08 0.05 0 0 0 0 0.11 0.17 0.17
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Bud 0 0 0 1 0 1 6 6 2 1 4 2 1 0 0 1 0 1 3 1 0 2 5 2
Bud Neck 0 0 0 0 1 0 0 2 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
Bud Site 1 0 0 0 2 10 2 8 9 15 10 10 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 3 5 5 7 13 24 18 13 14 13 15 9 12 38 45 21 22 25 0 1 0 4 1 1
Endoplasmic Reticulum 0 0 0 0 1 0 0 0 1 0 0 0 0 0 1 10 0 4 0 0 0 0 0 1
Endosome 1 0 2 0 0 0 0 0 0 0 0 0 0 0 3 4 1 1 0 2 1 0 1 3
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 2 0 1 0 0 1 0
Mitochondria 20 4 3 8 2 47 92 75 138 105 111 55 2 0 0 7 4 9 2 1 2 2 3 5
Nucleus 334 230 163 189 266 294 307 320 280 296 165 174 131 154 134 194 159 194 327 229 158 121 150 138
Nuclear Periphery 8 1 0 1 0 4 2 1 1 3 4 0 1 1 3 2 3 2 0 0 0 1 1 8
Nucleolus 11 1 4 0 3 8 21 13 34 28 20 24 0 3 10 5 3 2 2 3 1 10 12 12
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
SpindlePole 0 0 2 1 1 1 0 3 0 3 1 1 1 1 1 3 0 0 2 1 0 0 2 1
Vac/Vac Membrane 7 6 1 2 1 2 3 3 6 6 1 4 1 3 16 19 9 8 10 8 4 18 37 37
Unique Cell Count 350 245 173 202 282 333 365 378 341 356 225 214 146 199 201 242 195 231 350 253 171 167 225 215
Labelled Cell Count 385 247 180 209 290 391 451 444 485 470 331 279 149 201 213 267 204 248 350 253 171 167 225 215


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.6 9.2 7.2 7.1 7.2 5.5 5.1 5.5 5.0 5.5 4.8 5.1 7.9 8.4 9.0 8.6 9.4 8.9 8.2 8.4 8.6
Std Deviation (1e-4) 1.5 2.0 1.6 1.8 2.0 1.8 1.5 1.4 1.7 1.9 1.9 1.5 2.0 3.2 4.7 2.4 2.4 2.6 2.5 2.9 2.7
Intensity Change (Log2) – – – -0.03 -0.01 -0.38 -0.49 -0.39 -0.53 -0.4 -0.6 -0.52 0.13 0.22 0.32 0.25 0.37 0.3 0.17 0.21 0.25


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.3 0.9 2.0 1.1 0.3 0.7 0.5 1.7 0.7 2.1 4.9 5.5 2.4 3.1 3.0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 1.3 0 4.4 6.7 5.7 9.3 7.4 0 6.6 0 0 0 0 0 1.3
Nucleus -0.3 0 -2.1 -3.3 -3.2 -3.8 -3.5 -5.4 -3.8 -1.5 -4.6 -6.6 -4.1 -3.7 -3.2
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 1.8 0.7 3.1 2.5 0 3.4 0 0 1.4 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 3.4 3.4 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.6987 2.6498 2.4211 2.134 1.3778 2.3895 2.7831 3.2077 2.812 2.0841 2.0031 2.8217 2.9268 2.8437 2.6049 2.0812 2.2334 2.6183
Actin 0.0027 0 0.001 0.0065 0.0196 0.0001 0.0059 0 0.0007 0.0002 0.0001 0.0011 0.0182 0 0.0001 0.0024 0 0
Bud 0.0002 0 0.0001 0.0007 0.0007 0.0001 0.0002 0 0.0001 0 0 0 0.0002 0 0.0003 0.0001 0 0
Bud Neck 0.0016 0.0001 0.0005 0.0008 0.0007 0.0015 0.0044 0.0001 0.0003 0.0002 0.0005 0.0003 0.0013 0.0001 0.0007 0.0003 0.0001 0.0005
Bud Periphery 0.0004 0 0.0003 0.0012 0.002 0.0003 0.0005 0 0.0002 0.0002 0.0001 0.0001 0.0008 0 0.0006 0.0001 0 0
Bud Site 0.0014 0 0.0005 0.0023 0.0022 0.0001 0.0036 0.0001 0.0001 0.0002 0.0001 0 0.0006 0.0001 0.0004 0.0002 0 0
Cell Periphery 0.0003 0 0.0001 0.0003 0.0001 0.0001 0.0004 0 0.0001 0.0002 0 0 0.0005 0 0.0001 0 0 0
Cytoplasm 0.0079 0.0001 0.0004 0.0195 0.004 0.0003 0.0014 0.0007 0.0016 0.001 0.0014 0.0002 0.0012 0.0024 0.0013 0.0029 0.0001 0
Cytoplasmic Foci 0.004 0 0.0073 0.0039 0.0021 0.0002 0.0047 0.0002 0.0005 0.0007 0.0038 0.0001 0.0117 0 0 0.0064 0 0
Eisosomes 0 0 0 0.0001 0.0003 0 0.0001 0 0 0 0 0 0.0001 0 0 0 0 0
Endoplasmic Reticulum 0.0041 0 0.0003 0.002 0.0007 0.0003 0.0015 0.0001 0.0011 0.0009 0.0004 0.0002 0.0024 0.0002 0.0002 0.0011 0 0
Endosome 0.0163 0 0.0069 0.0074 0.0026 0.0009 0.0066 0.0002 0.002 0.0169 0.0146 0.0012 0.0051 0 0.0001 0.0176 0 0
Golgi 0.0015 0 0.0024 0.0044 0.0025 0.0001 0.0013 0 0.0002 0.001 0.0009 0.0003 0.0014 0 0 0.0019 0 0
Lipid Particles 0.0168 0 0.0073 0.0062 0.0139 0.0009 0.0074 0.0002 0.0002 0.0037 0.0041 0.001 0.0059 0 0 0.0088 0 0
Mitochondria 0.0017 0.0001 0.0046 0.0031 0.0034 0.0005 0.0016 0.0002 0.0012 0.0013 0.0003 0.0005 0.0091 0.0001 0.0006 0.0006 0.0005 0.0001
None 0.0025 0 0.0003 0.0304 0.042 0.0006 0.0011 0.0067 0.0008 0.0009 0.0119 0.001 0.001 0.0001 0.0001 0.0219 0 0
Nuclear Periphery 0.0105 0.0015 0.0172 0.0038 0.0255 0.0089 0.0114 0.0049 0.0044 0.0059 0.0043 0.0026 0.005 0.0025 0.0025 0.0204 0.0012 0.0004
Nucleolus 0.0172 0.0143 0.0122 0.0098 0.0353 0.0354 0.014 0.0131 0.0123 0.0159 0.0359 0.0276 0.0155 0.0122 0.0251 0.0084 0.0781 0.035
Nucleus 0.8874 0.9758 0.9175 0.8764 0.7957 0.944 0.9181 0.9584 0.9676 0.9419 0.8994 0.9576 0.9017 0.9714 0.9629 0.8851 0.9148 0.9522
Peroxisomes 0.0019 0 0.0086 0.002 0.0089 0 0.0017 0 0.0001 0.0002 0.0004 0.0001 0.0097 0 0 0.0011 0 0
Punctate Nuclear 0.0126 0.008 0.007 0.0144 0.036 0.0043 0.0114 0.0145 0.005 0.004 0.0206 0.0058 0.0043 0.0107 0.0035 0.0187 0.0049 0.0115
Vacuole 0.0075 0 0.0033 0.004 0.0008 0.0011 0.0016 0.0004 0.0007 0.0032 0.0007 0.0001 0.0025 0.0002 0.0009 0.0012 0.0001 0.0001
Vacuole Periphery 0.0014 0 0.002 0.0008 0.0011 0.0004 0.0012 0.0002 0.0007 0.0015 0.0003 0.0002 0.0016 0 0.0004 0.0007 0.0001 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 32.3529 19.281 20.3315 25.5987 21.3414 26.0949 19.2385 18.0054 20.2433 31.2022
Translational Efficiency 1.5519 1.4607 1.2974 1.1349 1.8092 2.1695 1.6336 1.3949 1.6914 1.4875

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
943 619 1981 1334 1078 1424 191 775 2021 2043 2172 2109

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 817.54 892.65 1003.92 1055.80 841.11 854.20 1097.46 1057.71 830.11 865.85 1012.15 1056.50
Standard Deviation 140.96 155.15 152.54 233.62 125.23 141.72 172.51 224.08 133.32 146.99 156.65 230.16
Intensity Change Log 2 — 0.126805 0.296283 0.368975 — 0.022279 0.383802 0.330578 — 0.074746 0.341328 0.349631

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000427 0.000914 0.000482 0.000672 0.000459 0.000520 0.000759 0.001239 0.000444 0.000639 0.000507 0.000880
Bud Neck 0.002853 0.016858 0.014034 0.021630 0.004798 0.009880 0.007382 0.025469 0.003891 0.011994 0.013449 0.023041
Bud Site 0.000492 0.004192 0.000947 0.004288 0.000772 0.003469 0.000732 0.015471 0.000642 0.003688 0.000928 0.008398
Cell Periphery 0.000167 0.000340 0.000133 0.000215 0.000276 0.000362 0.000059 0.000208 0.000225 0.000355 0.000126 0.000213
Cytoplasm 0.001797 0.018572 0.002008 0.015627 0.001077 0.014520 0.003400 0.031980 0.001413 0.015747 0.002130 0.021637
Cytoplasmic Foci 0.000921 0.004098 0.000019 0.000930 0.000243 0.002389 0.000337 0.006207 0.000559 0.002907 0.000047 0.002869
Eisosomes 0.000025 0.000039 0.000037 0.000028 0.000039 0.000031 0.000046 0.000037 0.000032 0.000033 0.000038 0.000031
Endoplasmic Reticulum 0.005327 0.007650 0.003819 0.003984 0.006798 0.006144 0.004285 0.004982 0.006112 0.006600 0.003860 0.004351
Endosome 0.000174 0.000811 0.000145 0.001354 0.000321 0.001196 0.000168 0.010301 0.000252 0.001080 0.000147 0.004642
Golgi 0.000099 0.000275 0.000036 0.005156 0.000023 0.000684 0.000054 0.013538 0.000058 0.000560 0.000038 0.008236
Lipid Particles 0.000182 0.000667 0.000029 0.000105 0.000120 0.000271 0.000160 0.002177 0.000149 0.000391 0.000041 0.000866
Mitochondria 0.002183 0.001639 0.001166 0.005090 0.000921 0.002795 0.000828 0.016309 0.001509 0.002445 0.001136 0.009213
Mitotic Spindle 0.000448 0.003056 0.002013 0.016935 0.000504 0.008269 0.003085 0.023884 0.000478 0.006690 0.002107 0.019489
None 0.003482 0.004698 0.001684 0.003709 0.001317 0.005165 0.004381 0.007199 0.002327 0.005024 0.001921 0.004992
Nuclear Periphery 0.000173 0.000613 0.000494 0.001862 0.000204 0.000766 0.000261 0.001740 0.000190 0.000720 0.000474 0.001817
Nuclear Periphery Foci 0.000455 0.000800 0.000058 0.000787 0.000041 0.000631 0.000110 0.002688 0.000234 0.000682 0.000063 0.001485
Nucleolus 0.010651 0.011775 0.005743 0.004230 0.009401 0.010165 0.006772 0.005746 0.009984 0.010652 0.005834 0.004787
Nucleus 0.969042* 0.918835* 0.965946* 0.898482* 0.971174* 0.928721* 0.965495* 0.797581* 0.970179* 0.925726* 0.965906* 0.861404*
Peroxisomes 0.000480 0.001486 0.000123 0.000113 0.000420 0.000482 0.000339 0.000660 0.000448 0.000786 0.000142 0.000314
Vacuole 0.000476 0.002353 0.000852 0.007938 0.000941 0.002450 0.001272 0.023220 0.000724 0.002421 0.000889 0.013554
Vacuole Periphery 0.000145 0.000329 0.000232 0.006863 0.000151 0.001089 0.000076 0.009363 0.000148 0.000859 0.000218 0.007782

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.15 -0.58 -2.79 0.83 -5.33 -0.44 -2.50 -4.07 -5.78 -2.52 -1.64 -0.96 -4.47 -3.45 -7.32
Bud Neck -6.08 -13.57 -13.44 -2.23 -4.65 -4.77 -2.55 -10.08 -7.19 -6.30 -8.10 -12.90 -16.43 -7.94 -6.62
Bud Site -4.54 -3.73 -7.15 -0.25 -6.06 -4.28 -1.86 -6.08 -4.43 -5.68 -6.15 -3.13 -8.63 -3.98 -7.97
Cell Periphery -1.96 0.87 -0.37 1.76 -1.30 -0.80 2.87 1.42 2.27 -3.93 -1.74 2.08 0.96 2.64 -1.63
Cytoplasm -5.25 -1.07 -9.56 -1.68 -8.91 -6.46 -2.31 -10.65 -6.33 -9.40 -8.24 -1.94 -14.27 -5.78 -13.01
Cytoplasmic Foci -2.30 1.26 0.07 2.64 -4.26 -3.45 -0.33 -4.52 -1.18 -4.44 -3.62 1.44 -2.85 1.79 -6.21
Eisosomes -4.38 -5.13 -2.72 2.94 3.21 1.98 -2.31 -2.62 -5.85 0.19 -0.67 -2.64 -2.45 -1.91 0.37
Endoplasmic Reticulum -3.38 3.51 1.40 3.98 -0.97 1.10 2.89 0.40 -0.63 -2.44 -1.27 5.80 1.87 2.93 -2.81
Endosome -4.36 0.37 -4.51 -0.58 -4.63 -3.19 0.10 -4.99 -3.97 -5.02 -4.48 1.12 -6.07 -3.47 -6.36
Golgi -1.30 1.56 -2.78 -2.59 -2.85 -2.67 -3.84 -3.51 -3.08 -3.47 -2.80 0.91 -4.42 -3.81 -4.45
Lipid Particles -2.59 2.18 0.07 2.86 -7.17 -1.84 -1.04 -1.73 -1.51 -1.61 -2.93 2.09 -1.75 -0.83 -2.18
Mitochondria 0.47 0.85 -1.49 -2.69 -3.44 -2.08 -0.08 -3.72 -2.64 -3.77 -1.16 0.49 -4.03 -3.11 -4.96
Mitotic Spindle -1.74 -2.64 -7.66 -6.06 -6.61 -3.81 -1.59 -6.50 -4.30 -2.82 -4.22 -2.99 -10.02 -6.59 -8.33
None -1.34 2.56 -1.65 0.06 -4.72 -5.66 -1.99 -5.15 -1.42 -1.37 -4.62 0.79 -5.56 -0.73 -5.59
Nuclear Periphery -6.64 -4.17 -5.89 -4.47 -4.62 -3.54 -2.36 -10.82 -6.52 -8.96 -4.84 -4.15 -9.03 -6.11 -7.07
Nuclear Periphery Foci -0.94 1.21 -0.62 0.47 -2.93 -2.86 -1.80 -3.21 -1.83 -2.80 -1.68 1.07 -2.57 -1.21 -4.23
Nucleolus -1.08 3.49 4.06 5.07 0.96 -0.36 1.90 2.26 2.88 0.29 -0.69 4.10 4.65 5.71 0.63
Nucleus 7.19 2.00 13.92 4.70 13.47 8.33 2.43 17.31 12.60 12.91 10.77 3.43 21.99 12.53 20.20
Peroxisomes -1.39 2.33 2.37 1.93 0.38 -0.35 0.33 -0.16 0.28 -0.95 -1.32 2.34 1.56 2.34 -2.31
Vacuole -4.49 -2.31 -9.28 -7.84 -8.78 -3.40 -1.83 -10.71 -10.36 -9.48 -5.25 -2.38 -13.74 -12.79 -13.27
Vacuole Periphery -2.53 -1.13 -3.31 -3.15 -3.23 -2.24 1.94 -3.68 -2.67 -3.73 -2.44 -1.17 -4.64 -3.65 -4.53
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia
Localization
Cell Percentages nucleus (99%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Rfc4

Rfc4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rfc4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available