Standard name
Human Ortholog
Description Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of TRAMP; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; required for mRNA surveillance and maintenance of genome integrity, serving as a link between RNA and DNA metabolism; overlapping but non-redundant functions with Trf5p; relocalizes to cytosol in response to hypoxia
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 – 0 0 0 0.05 0 0 0 0 0 0.06 0.11 0.2 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.12 0 – 0 0 0 0.07 0.05 0.2 0.12 0.27 0.17 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.94 0.96 – 0.95 0.93 0.96 0.9 0.91 0.89 0.88 0.86 0.82 0.94 0.86 0.71 0.89 0.9 0.88 0.9 0.93 0.84 0.75 0.78 0.65
Nuclear Periphery 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 – 0 0 0 0 0 0.09 0 0.05 0.08 0 0.08 0.05 0.05 0.05 0.06 0 0 0 0 0 0
Peroxisomes 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0.05 0.08 0.11 0.22
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 – 0 0 0 0 1 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0
Bud 1 0 – 0 1 0 0 1 1 3 1 1 0 0 0 0 0 1 0 3 1 0 1 2
Bud Neck 0 0 – 0 0 0 0 1 0 3 0 1 0 0 1 0 0 0 0 0 0 0 0 0
Bud Site 0 0 – 0 0 1 0 2 4 2 7 13 0 1 0 0 0 0 – – – – – –
Cell Periphery 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 4 6 – 9 12 6 22 21 9 17 12 9 3 20 46 10 6 13 1 0 0 1 1 4
Endoplasmic Reticulum 1 1 – 0 0 0 0 0 0 0 0 0 0 0 0 3 2 3 0 1 0 0 1 1
Endosome 0 0 – 0 2 0 2 1 0 0 0 0 0 0 3 1 0 0 1 1 0 0 1 1
Golgi 0 0 – 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 0 0 0 0 2 0
Mitochondria 21 1 – 1 0 11 35 31 50 49 75 64 0 0 1 8 4 13 2 0 0 0 1 3
Nucleus 159 240 – 203 284 254 431 562 223 365 235 300 49 154 165 268 204 287 154 235 32 27 115 120
Nuclear Periphery 0 0 – 1 0 1 7 4 1 4 1 5 0 2 4 1 5 3 0 0 0 0 0 0
Nucleolus 4 1 – 0 3 2 9 13 23 15 13 31 1 14 12 16 11 18 1 2 0 0 5 7
Peroxisomes 0 0 – 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 – 0 0 0 2 5 1 7 0 4 0 0 5 0 0 3 0 0 0 1 1 0
Vac/Vac Membrane 0 5 – 1 9 4 7 17 1 9 4 6 1 2 8 12 7 15 4 5 1 2 15 41
Unique Cell Count 169 251 213 306 265 477 617 250 414 274 366 52 180 231 302 227 327 171 253 39 37 149 185
Labelled Cell Count 190 254 215 311 279 515 659 313 475 348 434 54 193 248 321 240 357 171 253 39 37 149 185


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.7 8.0 – 7.6 7.8 6.5 6.2 6.5 5.2 5.5 5.3 5.4 8.3 8.0 7.9 10.8 11.0 9.7 – 7.5 8.1
Std Deviation (1e-4) 0.8 1.6 – 1.6 1.6 2.6 1.6 1.5 1.1 1.3 1.4 1.6 1.5 1.6 1.8 2.7 2.8 2.6 – 1.4 1.2
Intensity Change (Log2) – – – – – – – – – – – – – – – – – – – – –

RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510HU80HU120HU1600510rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.9512 4.3079 3.802 3.4633 3.4399 3.771 3.5708 4.0713 3.8116 3.4349 3.3925 3.7495 1.669 2.5473 1.8128 1.8388 1.4578 1.5067
Actin 0.0134 0.0001 0.0123 0.0006 0.0423 0.0027 0.0418 0 0.0246 0.0017 0.079 0.017 0.0139 0.0099 0.0069 0.0097 0.0006 0
Bud 0.0008 0.0001 0.0004 0.0006 0.0007 0.0002 0.0007 0 0.0005 0.0002 0.0027 0.0001 0.0004 0.0001 0.0001 0.0002 0.0003 0.0001
Bud Neck 0.0029 0.0003 0.0052 0.0011 0.0011 0.001 0.002 0.0001 0.0014 0.0007 0.0098 0.0026 0.0013 0.0001 0.0002 0.0003 0.0008 0.0008
Bud Periphery 0.0023 0.0003 0.0006 0.0023 0.0008 0.0004 0.0012 0 0.001 0.0002 0.0038 0.0005 0.0012 0.0001 0.0003 0.0003 0.0009 0.0002
Bud Site 0.0029 0.0006 0.0025 0.0007 0.0083 0.0001 0.0102 0.0001 0.0063 0.004 0.0215 0.0003 0.0019 0.0016 0.0004 0.0004 0.001 0.0001
Cell Periphery 0.0013 0.0001 0.0002 0.0005 0.0002 0.0001 0.0006 0.0001 0.001 0.0001 0.0005 0.0004 0.0007 0.0001 0.0002 0.0001 0.0002 0.0001
Cytoplasm 0.0026 0.0001 0.0033 0.0003 0.0006 0.0002 0.002 0.0001 0.0027 0.0001 0.0038 0.0041 0.0028 0 0.0013 0.0003 0.0005 0
Cytoplasmic Foci 0.0092 0.0002 0.0082 0.0003 0.0154 0.0001 0.0079 0 0.0045 0.0103 0.0303 0.0029 0.0121 0 0.0014 0.0142 0.0021 0
Eisosomes 0.0003 0 0.0001 0.0001 0.0003 0 0.0005 0 0.0003 0 0.0005 0.0001 0.0004 0 0.0002 0.0001 0 0
Endoplasmic Reticulum 0.0039 0.0001 0.0032 0.0007 0.0008 0.0009 0.0022 0 0.0023 0 0.0033 0.0009 0.0016 0 0.001 0.0004 0.0006 0
Endosome 0.0282 0.0005 0.0181 0.0023 0.0148 0.0013 0.0134 0 0.0033 0.0019 0.0166 0.0046 0.0066 0 0.0031 0.0282 0.0052 0
Golgi 0.0084 0.0001 0.0086 0.0004 0.0178 0.0007 0.0059 0 0.0036 0.004 0.0153 0.0027 0.0029 0 0.0005 0.0206 0.0009 0
Lipid Particles 0.0154 0.0005 0.0089 0.006 0.0154 0.0001 0.0184 0 0.0044 0.021 0.0103 0.0019 0.0102 0 0.0046 0.018 0.0042 0
Mitochondria 0.0152 0.0039 0.0052 0.018 0.0089 0.0029 0.0127 0.0002 0.0061 0.0012 0.006 0.007 0.006 0.0004 0.0013 0.007 0.0045 0.0002
None 0.0023 0.0001 0.0017 0.0004 0.0005 0.0001 0.0037 0 0.0031 0.0002 0.0065 0.0005 0.0149 0 0.0008 0.0012 0.0005 0
Nuclear Periphery 0.0221 0.0032 0.0223 0.0103 0.0055 0.0053 0.0072 0.0039 0.0064 0.0007 0.0091 0.0034 0.0048 0.0005 0.0097 0.0025 0.0107 0.0042
Nucleolus 0.0894 0.0681 0.0893 0.1508 0.0757 0.1046 0.0743 0.0869 0.0869 0.124 0.0546 0.1382 0.0722 0.0701 0.1244 0.1467 0.0975 0.1138
Nucleus 0.7568 0.9117 0.7856 0.7832 0.7787 0.8757 0.7781 0.9067 0.8287 0.7708 0.6664 0.808 0.8322 0.9153 0.8339 0.7253 0.8453 0.8796
Peroxisomes 0.0029 0.0001 0.0041 0.0003 0.0077 0 0.0088 0 0.0046 0.0443 0.0443 0.0013 0.0071 0 0.0002 0.0157 0.0004 0
Punctate Nuclear 0.0063 0.0081 0.0161 0.0091 0.0029 0.0027 0.0033 0.0014 0.0026 0.014 0.0128 0.0008 0.0035 0.001 0.0063 0.0073 0.0189 0.0003
Vacuole 0.0086 0.0011 0.0026 0.0063 0.0011 0.0004 0.0026 0.0002 0.0044 0.0004 0.002 0.0021 0.0022 0.0004 0.0021 0.0008 0.0031 0.0003
Vacuole Periphery 0.0049 0.0008 0.0016 0.0056 0.0007 0.0004 0.0024 0.0001 0.0014 0.0001 0.0011 0.0008 0.0012 0.0003 0.0012 0.0008 0.0019 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 21.0621 22.4815 21.6869 19.3179 26.4928 26.3916 20.7421 26.273 23.1241 23.7658
Translational Efficiency 0.9802 0.8662 0.8168 0.7052 0.615 0.6466 0.861 0.6247 0.6107 0.6904

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1836 1450 143 148 1498 1828 304 1311 3334 3278 447 1459

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 727.13 792.65 1178.63 1111.87 770.45 814.87 1071.57 987.00 746.59 805.04 1105.82 999.67
Standard Deviation 94.95 129.64 133.44 167.52 108.34 117.17 137.57 149.69 103.46 123.34 145.13 156.21
Intensity Change Log 2 — 0.124471 0.696826 0.612703 — 0.080869 0.475953 0.357349 — 0.102204 0.587420 0.486980

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000127 0.000465 0.001560 0.000903 0.000319 0.000402 0.000967 0.000738 0.000213 0.000430 0.001157 0.000755
Bud Neck 0.002899 0.006139 0.010657 0.032180 0.004833 0.006927 0.014512 0.022563 0.003768 0.006579 0.013279 0.023538
Bud Site 0.002207 0.000753 0.001206 0.001388 0.000500 0.000760 0.001086 0.001407 0.001440 0.000757 0.001124 0.001405
Cell Periphery 0.000136 0.000174 0.000056 0.000072 0.000094 0.000126 0.000049 0.000059 0.000117 0.000147 0.000051 0.000061
Cytoplasm 0.004642 0.002000 0.000411 0.000687 0.002951 0.001234 0.000672 0.000990 0.003882 0.001573 0.000588 0.000959
Cytoplasmic Foci 0.000904 0.000515 0.000046 0.000019 0.000331 0.000390 0.000038 0.000131 0.000647 0.000446 0.000041 0.000120
Eisosomes 0.000013 0.000023 0.000056 0.000034 0.000020 0.000022 0.000040 0.000027 0.000016 0.000023 0.000045 0.000027
Endoplasmic Reticulum 0.003892 0.008198 0.006776 0.003085 0.004155 0.008060 0.005266 0.004372 0.004010 0.008121 0.005749 0.004241
Endosome 0.000380 0.000439 0.000196 0.000143 0.000426 0.000868 0.000116 0.000519 0.000401 0.000678 0.000142 0.000481
Golgi 0.000124 0.000104 0.000096 0.000073 0.000156 0.000502 0.000082 0.000232 0.000139 0.000326 0.000087 0.000216
Lipid Particles 0.000158 0.000198 0.000202 0.000048 0.000175 0.000229 0.000101 0.000055 0.000165 0.000215 0.000133 0.000054
Mitochondria 0.001449 0.001612 0.001423 0.001528 0.001267 0.002125 0.001080 0.001538 0.001367 0.001898 0.001190 0.001537
Mitotic Spindle 0.000787 0.000260 0.000093 0.003451 0.000828 0.002914 0.000561 0.008120 0.000806 0.001740 0.000412 0.007646
None 0.005522 0.003170 0.000577 0.006323 0.005684 0.001487 0.001754 0.001619 0.005595 0.002232 0.001378 0.002096
Nuclear Periphery 0.000681 0.000606 0.000305 0.000350 0.000475 0.001336 0.000220 0.000840 0.000588 0.001013 0.000247 0.000791
Nuclear Periphery Foci 0.000287 0.000238 0.000113 0.000040 0.001026 0.000179 0.000058 0.000434 0.000619 0.000205 0.000076 0.000394
Nucleolus 0.011606 0.017155 0.014740 0.034797 0.047198 0.014507 0.025264 0.026571 0.027598 0.015678 0.021897 0.027406
Nucleus 0.962670 0.956646 0.957393 0.913100 0.927736 0.954335 0.946167 0.925945 0.946973 0.955357 0.949758 0.924642
Peroxisomes 0.000179 0.000394 0.000783 0.000351 0.000324 0.000437 0.000600 0.000250 0.000244 0.000418 0.000659 0.000260
Vacuole 0.001018 0.000694 0.003153 0.001216 0.000855 0.001879 0.001210 0.002009 0.000945 0.001355 0.001832 0.001929
Vacuole Periphery 0.000319 0.000217 0.000158 0.000211 0.000648 0.001279 0.000156 0.001580 0.000467 0.000809 0.000157 0.001441

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -9.90 -10.80 -10.44 -6.95 3.53 -0.58 -10.35 -5.74 -2.85 1.69 -2.71 -15.19 -7.86 -4.09 3.58
Bud Neck -5.29 -5.58 -7.73 -7.08 -5.48 -2.82 -6.11 -15.79 -14.03 -5.66 -5.67 -8.08 -18.17 -16.13 -7.95
Bud Site 1.72 0.77 -0.85 -2.92 -1.97 -1.17 -5.20 -6.06 -4.14 -2.50 1.40 -0.09 -1.71 -5.24 -2.97
Cell Periphery -0.92 3.18 1.88 2.27 -1.23 -0.86 2.29 1.76 1.91 -0.83 -1.08 4.07 3.37 3.31 -0.83
Cytoplasm 2.43 4.61 0.93 -0.32 -1.22 2.54 1.18 2.87 0.22 0.34 3.55 2.92 4.08 0.73 -0.16
Cytoplasmic Foci 0.52 2.55 1.52 1.07 -1.02 -0.17 2.12 1.57 2.01 -1.56 0.59 3.13 2.62 2.56 -1.80
Eisosomes -6.99 -11.45 -8.12 -4.77 3.61 -1.46 -8.76 -7.14 -4.73 5.20 -6.26 -14.42 -12.87 -5.91 7.70
Endoplasmic Reticulum -8.70 -4.63 0.39 8.45 4.72 -7.41 -1.34 -1.10 7.10 0.94 -11.05 -3.27 -1.54 10.46 2.65
Endosome -0.83 1.41 1.41 2.54 -0.09 -1.84 2.74 -0.28 1.51 -2.33 -2.07 3.27 -0.37 1.34 -2.16
Golgi -0.00 0.12 -0.80 -1.08 -1.42 -1.42 1.08 -0.69 1.08 -1.25 -1.41 0.64 -0.95 0.71 -1.34
Lipid Particles -0.88 -1.51 0.42 1.13 1.86 -0.61 1.90 3.06 2.06 1.63 -1.08 0.40 2.98 2.67 3.33
Mitochondria -0.20 -0.26 -1.13 -0.72 -2.45 -1.27 0.14 -1.04 0.70 -4.46 -1.02 0.13 -1.20 0.22 -4.20
Mitotic Spindle 1.64 2.04 -2.05 -2.11 -2.12 -1.81 -1.28 -3.86 -2.78 -2.24 -1.46 -1.15 -4.38 -3.87 -3.25
None 2.29 5.26 0.29 -0.55 -1.50 4.70 2.56 4.46 -0.53 0.84 4.88 4.15 4.76 0.44 -0.17
Nuclear Periphery 0.60 2.58 -0.94 -1.35 -2.47 -3.93 2.71 -3.65 1.50 -5.09 -3.09 3.79 -2.90 0.31 -5.34
Nuclear Periphery Foci -0.44 1.03 1.10 1.35 0.13 2.20 2.37 1.45 -1.44 -1.81 1.83 2.65 0.95 -0.80 -1.74
Nucleolus -3.80 -1.33 -3.86 -3.18 -3.11 12.61 1.97 2.56 -7.86 -0.39 8.45 -0.37 -3.63 -8.23 -1.93
Nucleus 1.87 2.13 5.85 5.44 4.93 -6.24 0.00 4.65 9.72 3.08 -2.95 2.09 9.75 11.63 5.36
Peroxisomes -2.39 -5.98 -3.51 0.19 3.27 -0.64 -2.05 0.04 0.68 2.11 -2.00 -3.67 -2.05 1.10 3.07
Vacuole 1.20 -2.39 -2.19 -2.56 0.54 -2.42 -1.98 -3.41 -1.47 -2.27 -1.56 -2.94 -3.68 -2.79 -0.86
Vacuole Periphery 1.15 1.74 0.55 -0.87 -1.95 -1.35 2.50 -1.08 -0.00 -2.03 -1.32 2.99 -1.41 -0.68 -2.05
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of TRAMP; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; required for mRNA surveillance and maintenance of genome integrity, serving as a link between RNA and DNA metabolism; overlapping but non-redundant functions with Trf5p; relocalizes to cytosol in response to hypoxia
Localization
Cell Percentages nucleus (98%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Pap2

Pap2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pap2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available