Standard name
Human Ortholog
Description Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 – 0 0 0 0 0.08 0.15 0.15 0.1 0.1 0.12 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.06 0 0 0 0.09 0 – 0.15 0.06 0.16 0.1 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.89 0.87 0.89 0.93 0.87 0.82 0.82 – 0.74 0.74 0.74 0.74 0.84 0.75 0.77 0.78 0.84 0.79 0.76 0.84 0.76 0.63 0.6 0.61
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.27 0.13 0.13 0.07 0.11 0.14 0.17 – 0.31 0.32 0.26 0.32 0.19 0.16 0.12 0.12 0.07 0.11 0.17 0.07 0.18 0.29 0.29 0.24
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 1 0 0 0 0 0 1 0 0 1
Bud 0 1 0 0 0 0 1 – 1 2 4 6 0 0 1 0 0 0 3 1 2 1 5 6
Bud Neck 0 0 0 0 0 0 2 – 1 2 1 6 0 0 0 0 0 0 0 0 0 0 1 2
Bud Site 1 0 0 0 4 7 3 – 20 13 20 21 0 2 1 0 0 1 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0
Cytoplasm 5 8 11 14 17 16 18 – 11 16 12 9 28 76 94 18 21 24 0 2 0 0 1 1
Endoplasmic Reticulum 0 0 0 0 1 0 0 – 0 0 0 0 0 0 0 2 0 3 0 0 0 0 2 0
Endosome 2 2 5 0 5 2 4 – 1 6 5 1 1 4 7 1 0 0 1 5 4 4 3 9
Golgi 0 0 0 1 0 0 0 – 0 0 0 0 1 0 1 1 2 0 3 2 2 2 3 4
Mitochondria 1 21 1 5 6 40 10 – 103 38 91 79 0 1 1 7 3 9 0 3 1 1 3 7
Nucleus 312 321 376 387 355 375 556 – 516 510 428 599 291 387 494 141 168 164 282 345 353 256 346 356
Nuclear Periphery 1 0 4 3 1 5 6 – 8 5 3 7 1 3 2 0 1 0 0 0 0 0 2 1
Nucleolus 95 48 55 27 43 64 116 – 217 220 152 258 65 81 75 22 14 22 64 30 82 120 167 142
Peroxisomes 1 0 0 0 0 0 0 – 0 1 0 0 0 5 5 0 0 0 0 0 0 0 0 0
SpindlePole 0 1 3 1 5 4 21 – 2 15 8 9 1 6 15 4 2 2 1 2 3 4 6 12
Vac/Vac Membrane 2 9 2 2 9 11 10 – 3 5 4 6 2 6 5 4 4 2 11 13 7 14 31 36
Unique Cell Count 352 370 421 414 407 455 675 693 689 578 813 346 515 643 181 200 207 373 410 463 409 581 589
Labelled Cell Count 420 411 457 440 446 524 747 883 833 728 1001 390 571 702 201 216 227 373 410 463 409 581 589


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.2 7.6 8.7 8.4 8.3 6.4 7.1 – 6.2 6.6 6.3 6.3 9.1 8.7 9.0 9.2 10.4 8.6 8.0 8.4 8.7
Std Deviation (1e-4) 1.3 1.4 1.7 1.8 1.7 1.8 1.6 – 1.3 1.3 1.4 1.3 2.8 2.5 2.6 2.3 2.1 2.0 2.0 1.9 2.2
Intensity Change (Log2) – – – -0.06 -0.08 -0.44 -0.29 – -0.49 -0.41 -0.47 -0.47 0.07 -0.0 0.04 0.07 0.25 -0.01 -0.12 -0.06 -0.01

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 3.5 0 3.9 3.3 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.7 1.2 0.8 0.1 – -1.2 -0.3 -0.6 -2.0 3.4 6.4 6.4 3.9 4.2 4.6
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 6.0 0 – 8.1 4.6 8.4 6.4 0 0 0 0 0 0
Nucleus 2.1 -0.9 -2.9 -3.1 – -6.0 -6.2 -6.0 -6.4 -2.1 -5.6 -5.2 -3.7 -1.9 -3.4
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus -3.2 -1.1 0.4 1.8 – 6.9 7.1 5.1 7.1 2.2 1.2 -0.7 -0.3 -2.2 -0.9
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 2.6 – 0 1.9 0 0 0 0 2.0 0 0 0
Vacuole 0 2.2 2.4 0 – 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.9677 3.2554 2.9744 2.7698 2.752 2.7359 5.8667 5.3278 4.5961 4.6872 4.4467 5.0203 7.7486 7.5784 7.3528 7.341 7.4434 7.3303
Actin 0.0219 0.0002 0.0035 0.0004 0.0032 0.0012 0.0394 0 0.0073 0.0137 0.0363 0.005 0 0 0 0 0 0
Bud 0.0002 0 0.0003 0.0002 0.0001 0.0001 0.0011 0 0.0003 0.0002 0.001 0.0001 0 0 0 0 0.0001 0
Bud Neck 0.0007 0.0001 0.0002 0.0002 0.0007 0.001 0.0034 0.0001 0.0003 0.0005 0.0016 0.0008 0.0001 0.0001 0.0001 0.0001 0.0004 0.0006
Bud Periphery 0.0004 0 0.0002 0.0008 0.0002 0.0001 0.0019 0 0.0007 0.0002 0.0021 0.0002 0 0 0 0 0.0001 0
Bud Site 0.0005 0.0001 0.0008 0.0004 0.0006 0.0001 0.0038 0 0.001 0.0012 0.0031 0.0002 0 0 0 0 0.0002 0
Cell Periphery 0.0001 0 0.0001 0.0001 0.0001 0 0.0005 0 0.0003 0.0001 0.0003 0.0001 0 0 0 0 0 0
Cytoplasm 0.0011 0.0001 0.0042 0.0002 0.0002 0.0002 0.0175 0 0.0029 0.0008 0.0021 0.0003 0 0 0 0 0.0001 0
Cytoplasmic Foci 0.0021 0.0005 0.0019 0.0007 0.0093 0.0001 0.0075 0 0.0037 0.0102 0.0104 0.0006 0 0 0 0 0 0
Eisosomes 0.0003 0 0 0 0 0 0.0005 0 0.0002 0.0001 0.0005 0.0002 0 0 0 0 0 0
Endoplasmic Reticulum 0.0018 0.0002 0.0004 0.0006 0 0.0004 0.0075 0 0.0029 0.0002 0.0022 0.001 0 0 0 0 0 0
Endosome 0.0098 0.0006 0.0011 0.0024 0.0031 0.0017 0.0216 0 0.0102 0.0027 0.0186 0.0043 0 0 0 0 0 0
Golgi 0.0033 0.0002 0.0005 0.0006 0.0066 0.0002 0.0067 0 0.0023 0.0012 0.0153 0.0018 0 0 0 0 0 0
Lipid Particles 0.0055 0.0038 0.0007 0.0051 0.0034 0.0001 0.0078 0 0.0082 0.0034 0.0487 0.0021 0 0 0 0 0 0
Mitochondria 0.0031 0.0008 0.0068 0.005 0.0014 0.0005 0.0055 0.0001 0.0125 0.0009 0.0137 0.003 0.0003 0 0.0001 0.0001 0.0002 0.0001
None 0.0024 0.0001 0.0009 0.0002 0.0001 0.0001 0.0197 0 0.0019 0.0019 0.0015 0.0004 0 0 0 0 0 0
Nuclear Periphery 0.0091 0.0052 0.0059 0.0073 0.0039 0.0018 0.044 0.0003 0.0121 0.0041 0.0153 0.0109 0.0007 0.0003 0.0009 0.0004 0.0022 0.0001
Nucleolus 0.03 0.0266 0.0206 0.0267 0.1527 0.0908 0.0227 0.0189 0.0198 0.0247 0.1174 0.0564 0.0263 0.0467 0.0264 0.0183 0.1311 0.0737
Nucleus 0.8926 0.9515 0.9473 0.9426 0.781 0.8995 0.7605 0.9801 0.9018 0.9111 0.6594 0.894 0.9717 0.9516 0.9715 0.9808 0.8552 0.9212
Peroxisomes 0.0069 0.0002 0.0003 0.0003 0.013 0 0.003 0 0.0021 0.0091 0.0173 0.0003 0 0 0 0 0 0
Punctate Nuclear 0.0053 0.0087 0.0034 0.0028 0.02 0.0018 0.0187 0.0005 0.0071 0.0128 0.0292 0.0179 0.0007 0.0012 0.0008 0.0004 0.0102 0.004
Vacuole 0.0017 0.0005 0.0006 0.002 0.0003 0.0002 0.0046 0 0.0016 0.0006 0.0021 0.0003 0 0 0 0 0.0001 0
Vacuole Periphery 0.0012 0.0003 0.0005 0.0015 0.0002 0.0001 0.0022 0 0.0009 0.0004 0.0019 0.0004 0 0 0 0 0.0001 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 12.37 14.744 10.9407 17.3368 24.592 18.1326 9.69 16.6018 18.3824 13.9422
Translational Efficiency 2.2456 1.8285 1.9941 1.2275 1.243 1.4693 2.4028 1.5536 1.214 1.8468

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
104 641 332 1948 1901 2263 1437 1909 2005 2904 1769 3857

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 846.57 921.87 1043.04 813.41 878.44 952.58 1070.27 1081.10 876.79 945.80 1065.16 945.90
Standard Deviation 154.62 216.77 138.64 156.63 138.84 151.48 157.32 171.63 139.89 168.57 154.35 211.85
Intensity Change Log 2 — 0.122934 0.301093 -0.057647 — 0.116897 0.284959 0.299484 — 0.119863 0.292900 0.135220

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.003063 0.001229 0.001446 0.000983 0.000335 0.000587 0.000584 0.000932 0.000476 0.000729 0.000746 0.000958
Bud Neck 0.007531 0.013400 0.015569 0.016176 0.009529 0.017058 0.039355 0.046416 0.009426 0.016251 0.034891 0.031143
Bud Site 0.003248 0.002358 0.001892 0.004153 0.000619 0.001692 0.001315 0.003321 0.000755 0.001839 0.001423 0.003741
Cell Periphery 0.000146 0.000171 0.000052 0.000662 0.000089 0.000106 0.000032 0.000084 0.000092 0.000120 0.000035 0.000376
Cytoplasm 0.001173 0.005745 0.000643 0.016125 0.001038 0.001408 0.000206 0.002356 0.001045 0.002365 0.000288 0.009310
Cytoplasmic Foci 0.002449 0.002071 0.000059 0.001833 0.000051 0.000257 0.000016 0.000676 0.000176 0.000657 0.000024 0.001260
Eisosomes 0.000062 0.000047 0.000063 0.000069 0.000029 0.000043 0.000037 0.000032 0.000031 0.000044 0.000042 0.000051
Endoplasmic Reticulum 0.007521 0.003715 0.003434 0.003631 0.002042 0.002878 0.001537 0.002720 0.002327 0.003063 0.001893 0.003180
Endosome 0.001729 0.001624 0.000154 0.001253 0.000205 0.000587 0.000216 0.000642 0.000284 0.000816 0.000204 0.000951
Golgi 0.001201 0.000492 0.000193 0.000652 0.000093 0.000207 0.000143 0.001604 0.000150 0.000269 0.000152 0.001123
Lipid Particles 0.008360 0.001072 0.000098 0.000214 0.000060 0.000374 0.000014 0.000063 0.000491 0.000528 0.000030 0.000139
Mitochondria 0.005465 0.001473 0.002038 0.002129 0.000979 0.001762 0.002481 0.003235 0.001211 0.001698 0.002398 0.002677
Mitotic Spindle 0.005486 0.003147 0.001654 0.006245 0.003492 0.003037 0.003985 0.014774 0.003595 0.003061 0.003547 0.010466
None 0.003392 0.010234 0.001835 0.052422 0.001955 0.003803 0.001015 0.003011 0.002030 0.005222 0.001169 0.027966
Nuclear Periphery 0.001000 0.000202 0.000238 0.001074 0.000252 0.000700 0.000659 0.001879 0.000291 0.000590 0.000580 0.001472
Nuclear Periphery Foci 0.005175 0.002049 0.000175 0.001053 0.000285 0.000658 0.000101 0.000940 0.000538 0.000965 0.000115 0.000997
Nucleolus 0.100942 0.124934 0.090392 0.050758 0.087151 0.112112 0.064222 0.046529 0.087867 0.114942 0.069133 0.048665
Nucleus 0.823096 0.822020 0.876512 0.835858 0.891186 0.850096 0.883080 0.866913 0.887654 0.843899 0.881847 0.851229
Peroxisomes 0.003520 0.002348 0.001965 0.000520 0.000261 0.000655 0.000278 0.000368 0.000430 0.001028 0.000595 0.000445
Vacuole 0.005468 0.001245 0.001357 0.002988 0.000150 0.001205 0.000459 0.001951 0.000426 0.001214 0.000628 0.002474
Vacuole Periphery 0.009973 0.000425 0.000230 0.001204 0.000198 0.000775 0.000265 0.001554 0.000705 0.000698 0.000259 0.001377

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.00 0.75 1.11 1.62 6.53 -6.99 -11.83 -19.82 -12.75 -11.52 -2.42 -3.96 -6.33 -9.16 -6.54
Bud Neck -2.96 -4.93 -5.57 -3.59 -0.19 -9.11 -19.73 -25.07 -19.93 -3.68 -9.44 -20.13 -24.46 -17.02 2.17
Bud Site 0.47 0.43 -0.36 -2.47 -2.90 -5.94 -6.97 -9.98 -6.01 -6.22 -5.17 -6.21 -10.67 -6.50 -6.98
Cell Periphery -0.27 1.43 -4.46 -4.98 -7.32 -0.76 2.83 0.15 1.46 -10.98 -1.29 2.80 -6.05 -5.58 -8.35
Cytoplasm -2.09 0.86 -8.73 -3.19 -9.37 -0.69 2.33 -3.47 -2.30 -9.28 -1.97 2.18 -9.09 -6.40 -11.06
Cytoplasmic Foci 0.21 2.01 0.72 0.54 -4.16 -1.89 1.81 -1.47 -0.20 -1.65 -2.10 2.33 -3.61 -0.82 -4.51
Eisosomes 1.46 -0.81 -0.13 -0.97 0.31 -7.79 -5.72 -5.12 4.04 1.28 -7.75 -8.09 -2.54 -0.81 -0.84
Endoplasmic Reticulum 1.61 1.55 1.65 0.15 0.58 -3.98 2.86 -8.16 -1.44 -12.38 -3.52 1.04 -6.64 -2.04 -10.89
Endosome 0.09 2.00 0.79 0.55 -4.15 -2.85 0.05 -3.22 0.52 -2.69 -2.29 0.97 -4.05 0.04 -4.58
Golgi 1.27 1.83 1.15 -0.15 -1.58 -3.04 -3.61 -1.81 -1.55 -1.64 -2.77 -1.09 -2.38 -1.84 -2.25
Lipid Particles 1.35 1.57 1.56 1.37 -2.24 -1.36 2.22 -2.06 1.16 -5.29 -0.21 1.63 1.20 1.65 -7.26
Mitochondria 2.67 2.22 2.17 -2.61 -0.28 -2.79 -3.10 -9.17 -6.21 -1.84 -1.94 -2.89 -6.46 -5.09 -0.84
Mitotic Spindle 0.47 0.57 -0.67 -2.50 -3.23 0.13 -1.22 -6.17 -6.65 -4.84 0.20 -1.01 -6.05 -7.23 -4.66
None -2.76 0.93 -11.61 -8.45 -12.70 -2.96 3.00 -5.51 0.00 -11.18 -4.54 2.56 -12.92 -10.37 -13.42
Nuclear Periphery 1.23 1.07 -0.14 -2.15 -1.89 -2.65 -2.17 -7.65 -4.63 -4.07 -2.20 -1.98 -5.20 -3.53 -3.03
Nuclear Periphery Foci 0.93 1.86 1.57 2.19 -4.79 -1.68 1.68 -2.34 -0.27 -3.63 -1.97 2.40 -1.62 0.90 -6.19
Nucleolus -1.99 0.23 3.87 12.75 5.77 -6.32 3.40 7.59 13.68 3.48 -7.49 2.63 9.95 19.01 6.24
Nucleus 0.17 -1.67 -0.66 -2.17 2.66 8.95 5.11 9.72 1.85 4.22 10.05 4.84 10.64 0.89 5.13
Peroxisomes 0.84 1.35 2.98 3.37 6.66 -2.92 -2.08 -5.35 1.53 -3.95 -3.64 -3.04 -1.01 3.45 3.12
Vacuole 1.44 1.22 0.81 -3.01 -2.01 -3.47 -2.54 -5.36 -2.49 -3.95 -2.70 -1.98 -6.90 -3.97 -5.47
Vacuole Periphery 1.32 1.34 1.23 -1.94 -2.54 -3.39 -1.56 -2.33 -0.47 -2.06 0.01 1.13 -0.66 -1.14 -3.19
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
Localization
Cell Percentages nucleus (99%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Med7

Med7


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Med7-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available