Standard name
Human Ortholog
Description Hsp90 cochaperone; regulates spatial organization of amyloid-like proteins in the cytosol, thereby buffering the proteotoxicity caused by amyloid-like proteins; interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0.06 0.08 0.07 0.09 0.05 0.08 0 0 0 0.05 0.06 0 0 0 0 0 0 0
Cytoplasm 1.0 0.98 0.98 1.0 0.95 0.94 0.85 0.81 0.79 0.79 0.81 0.83 1.0 1.0 0.97 0.99 0.99 0.99 0.99 0.95 0.91 0.94 1.0 0.96
Endoplasmic Reticulum 0 0 0 0 0 0 0.12 0.14 0.15 0.12 0.15 0.13 0 0 0 0 0.09 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 2 0 4 1 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 1 1 0 1 2 0 1 0 3 0 0 0 0 0 0 0 2 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 7 4 3 7 7 17 25 14 22 6 15 0 0 0 14 14 10 0 0 0 0 0 0
Cytoplasm 184 309 98 181 225 187 241 258 149 198 93 151 16 36 30 288 245 278 180 304 89 6 14 61
Endoplasmic Reticulum 0 3 0 0 10 8 33 44 28 31 17 24 0 0 1 8 21 14 0 2 2 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 2 3 2 2 0 1 0 0 0 0 0 1 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 1 1 0 1 0 1 0 1 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 1 1 1 2 0 0 0 0 0 1 1 0 0 4 1 0 0 0
Unique Cell Count 184 314 100 181 238 198 282 319 189 250 115 183 16 36 31 292 247 280 183 319 99 7 15 64
Labelled Cell Count 185 320 102 185 243 202 295 333 196 256 122 196 16 37 31 312 281 304 183 319 99 7 15 64


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 91.3 113.3 105.3 97.6 93.1 89.5 84.8 89.1 79.9 82.1 69.5 73.4 162.2 146.4 145.3 173.6 177.3 159.8 – – 149.7
Std Deviation (1e-4) 15.1 29.3 24.1 22.3 22.5 24.9 26.3 25.4 29.6 28.0 27.9 24.3 37.1 48.6 41.4 72.6 75.5 66.8 – – 43.6
Intensity Change (Log2) – – – -0.11 -0.18 -0.24 -0.31 -0.24 -0.4 -0.36 -0.6 -0.52 0.62 0.47 0.46 0.72 0.75 0.6 – – 0.51

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000100200WT3HU80HU120HU1600100200WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30100200WT1AF1800100200
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0.8 1.3 1.1 1.5 0 1.3 0 0 0 0 0.6 0
Cytoplasm 1.9 -1.4 -1.4 -3.4 -4.2 -4.4 -4.4 -4.0 -3.8 0.6 0.9 -0.4 0.4 0.9 1.1
Endoplasmic Reticulum 0 0 0 3.6 3.9 4.1 3.7 4.0 3.8 0 0 0 0 3.0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 68.9322 99.0109 86.8093 90.536 74.5962 88.9856 68.6892 101.115 89.5774 70.6537 75.9139 90.1067 50.3815 84.4747 75.5309 75.6799 72.7706 80.9573
Actin 0.0011 0.0001 0.0015 0 0.0003 0.0001 0.005 0.0003 0.0064 0.0034 0.0003 0.0012 0.0456 0.0003 0.0143 0.0001 0.061 0.0087
Bud 0.0009 0.0001 0.0005 0.0001 0.0004 0.0001 0.001 0 0.0018 0.0006 0.0002 0.0007 0.0055 0.0003 0.0004 0.0001 0.0009 0.0002
Bud Neck 0.0003 0.0004 0.001 0.0005 0.0006 0.0013 0.0009 0.0001 0.0005 0.0254 0.0003 0.0013 0.0033 0.0002 0.0005 0.0001 0.0007 0.0006
Bud Periphery 0.0007 0 0.0004 0 0.0003 0 0.0013 0 0.0015 0.0006 0.0001 0.0004 0.0035 0.0001 0.0002 0 0.002 0.0002
Bud Site 0.0006 0.0001 0.0024 0 0.0002 0 0.0019 0 0.0036 0.0017 0.0003 0.0001 0.0044 0.0002 0.0023 0.0001 0.0016 0.0001
Cell Periphery 0.004 0.0022 0.0038 0.0009 0.0019 0.0003 0.0037 0.0004 0.0008 0.0014 0.0008 0.0021 0.0011 0.0017 0.0002 0 0.0001 0.0001
Cytoplasm 0.879 0.9797 0.9253 0.9612 0.8577 0.9676 0.8396 0.995 0.9364 0.8229 0.8473 0.979 0.7587 0.9774 0.8914 0.9588 0.8532 0.9099
Cytoplasmic Foci 0.0121 0.0033 0.0054 0.0003 0.0225 0.0008 0.0256 0.0002 0.0055 0.0242 0.0267 0.0014 0.0377 0.0029 0.0371 0.0016 0.0065 0.0028
Eisosomes 0.0004 0 0.0004 0 0.0005 0 0.0003 0 0.0002 0.0007 0.0004 0 0.0003 0 0.0001 0 0.0003 0.0001
Endoplasmic Reticulum 0.0168 0.0053 0.0026 0.0031 0.0099 0.0169 0.0178 0.0015 0.0007 0.0011 0.0137 0.0027 0.0102 0.0004 0.0009 0.0032 0.0014 0.0009
Endosome 0.0027 0.0002 0.0027 0.0005 0.0036 0.0012 0.0168 0.0001 0.0018 0.0045 0.0015 0.0023 0.0189 0.0003 0.0059 0.0125 0.0153 0.0358
Golgi 0.0014 0.0001 0.0013 0 0.0004 0.0001 0.0028 0 0.0026 0.0022 0.0003 0.0005 0.0096 0 0.0049 0.0002 0.0111 0.0171
Lipid Particles 0.0042 0.0003 0.0036 0.0002 0.0044 0.0001 0.0084 0.0001 0.0027 0.0231 0.007 0.0002 0.0163 0.0003 0.0052 0.0002 0.0211 0.0041
Mitochondria 0.0123 0.0001 0.0086 0 0.0213 0.0001 0.0069 0 0.0122 0.0366 0.0047 0.0005 0.03 0.0004 0.0051 0.0001 0.0049 0.006
None 0.0034 0.0004 0.0025 0 0.0067 0.0001 0.0153 0.0001 0.0022 0.0068 0.0251 0.0002 0.0104 0.001 0.0031 0.0079 0.0024 0.0003
Nuclear Periphery 0.0053 0.0012 0.0028 0.0021 0.0026 0.0027 0.01 0.0006 0.0009 0.0019 0.0052 0.0013 0.0083 0.001 0.0018 0.006 0.0052 0.0043
Nucleolus 0.0133 0.0001 0.0063 0 0.0209 0 0.0035 0 0.0037 0.0145 0.0242 0.0001 0.0012 0.0025 0.0019 0.0001 0.0001 0
Nucleus 0.0073 0.0009 0.0038 0.0015 0.0079 0.0019 0.0076 0.0005 0.0021 0.006 0.0105 0.002 0.0063 0.0041 0.0024 0.0045 0.0014 0.0035
Peroxisomes 0.0035 0 0.0014 0 0.0005 0 0.0036 0 0.0016 0.0044 0.0007 0 0.006 0 0.0052 0 0.0058 0.0003
Punctate Nuclear 0.0006 0.0002 0.0007 0 0.015 0 0.0033 0 0.0006 0.0012 0.024 0.0001 0.0082 0.0019 0.0077 0.0007 0.003 0.0002
Vacuole 0.0256 0.0048 0.0185 0.0284 0.0156 0.006 0.0185 0.0008 0.0075 0.0104 0.0042 0.0034 0.0111 0.0034 0.0066 0.0029 0.0013 0.0029
Vacuole Periphery 0.0046 0.0002 0.0046 0.001 0.0066 0.0008 0.0064 0.0001 0.0047 0.0064 0.0025 0.0005 0.0033 0.0012 0.0028 0.0006 0.0008 0.0019

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 181.0955 333.8075 324.6147 370.7057 267.1284 248.5958 401.606 476.893 453.6003 282.0439
Translational Efficiency 3.2301 3.0304 2.8116 2.9244 3.1937 2.5238 2.3695 2.428 2.3902 2.6422

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2149 1492 137 1575 1315 1507 131 1725 3464 2999 268 3300

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 6231.95 5434.65 6501.62 14208.63 5229.73 5960.04 10063.54 15511.82 5851.49 5698.66 8242.71 14889.84
Standard Deviation 1248.69 1633.72 3175.69 3732.02 1108.90 1832.49 2955.43 4114.95 1292.55 1756.20 3548.96 3990.29
Intensity Change Log 2 — -0.197497 0.061116 1.189012 — 0.188586 0.944330 1.568560 — -0.008457 0.531334 1.374637

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000016 0.000098 0.000242 0.000145 0.000102 0.000084 0.000161 0.000119 0.000049 0.000091 0.000202 0.000132
Bud Neck 0.000111 0.000402 0.005168 0.001110 0.000453 0.000400 0.003456 0.000709 0.000241 0.000401 0.004331 0.000900
Bud Site 0.000593 0.003551 0.004347 0.005505 0.001600 0.002331 0.006485 0.004093 0.000975 0.002938 0.005392 0.004767
Cell Periphery 0.001589 0.006140 0.062099 0.016537 0.013038 0.005687 0.031081 0.028866 0.005936 0.005913 0.046937 0.022982
Cytoplasm 0.916873 0.820994 0.452991 0.797519 0.804161 0.895517 0.620628 0.808335 0.874085 0.858442 0.534933 0.803173
Cytoplasmic Foci 0.004656 0.012255 0.026971 0.004720 0.009333 0.006665 0.023374 0.003845 0.006432 0.009446 0.025213 0.004263
Eisosomes 0.000000 0.000001 0.000013 0.000003 0.000002 0.000002 0.000005 0.000003 0.000001 0.000001 0.000009 0.000003
Endoplasmic Reticulum 0.000075 0.000372 0.000203 0.000108 0.000418 0.000155 0.000161 0.000143 0.000205 0.000263 0.000182 0.000126
Endosome 0.000104 0.000489 0.000803 0.000355 0.000539 0.000232 0.000587 0.000146 0.000269 0.000360 0.000697 0.000246
Golgi 0.016562 0.044160 0.038325 0.004844 0.048168 0.014521 0.024724 0.005025 0.028561 0.029266 0.031677 0.004939
Lipid Particles 0.000799 0.007529 0.030975 0.011492 0.010730 0.004013 0.026107 0.016494 0.004569 0.005762 0.028595 0.014107
Mitochondria 0.000092 0.000239 0.000116 0.000208 0.000130 0.000146 0.000104 0.000198 0.000106 0.000193 0.000110 0.000203
Mitotic Spindle 0.000551 0.001438 0.001729 0.001072 0.000991 0.000595 0.001700 0.000461 0.000718 0.001015 0.001715 0.000752
None 0.002917 0.006544 0.001838 0.004265 0.004154 0.007924 0.002742 0.002398 0.003386 0.007238 0.002280 0.003289
Nuclear Periphery 0.000171 0.000365 0.002906 0.000238 0.000739 0.000204 0.001627 0.000306 0.000386 0.000284 0.002281 0.000273
Nuclear Periphery Foci 0.003372 0.009686 0.017242 0.002410 0.019686 0.003993 0.012230 0.002975 0.009565 0.006825 0.014792 0.002705
Nucleolus 0.000039 0.000507 0.000128 0.000152 0.000149 0.000331 0.000133 0.000090 0.000080 0.000419 0.000130 0.000120
Nucleus 0.012642 0.016242 0.053868 0.024190 0.015862 0.019678 0.053320 0.019909 0.013865 0.017968 0.053600 0.021953
Peroxisomes 0.000004 0.000030 0.000018 0.000070 0.000030 0.000015 0.000038 0.000050 0.000014 0.000022 0.000028 0.000059
Vacuole 0.009871 0.035736 0.261581 0.117844 0.036135 0.026170 0.171880 0.098886 0.019842 0.030929 0.217735 0.107934
Vacuole Periphery 0.028964 0.033220 0.038439 0.007214 0.033581 0.011336 0.019456 0.006949 0.030717 0.022223 0.029160 0.007076

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.50 -7.73 -6.42 -2.15 2.32 0.56 -2.14 -0.65 -1.78 2.02 -2.81 -7.45 -5.60 -2.76 3.14
Bud Neck -5.25 -7.54 -8.14 -6.13 5.44 -0.09 -7.29 -4.15 -3.62 6.64 -4.47 -10.50 -9.67 -7.12 8.40
Bud Site -5.80 -5.89 -7.63 -2.71 -1.45 -2.16 -5.03 -5.52 -3.45 2.53 -6.44 -7.55 -9.94 -4.09 1.05
Cell Periphery -8.69 -8.33 -11.67 -7.34 6.19 6.04 -3.44 -8.00 -13.07 -0.03 -0.19 -9.01 -14.81 -14.86 5.01
Cytoplasm 12.84 16.57 18.18 4.52 -11.39 -9.86 7.37 0.50 11.77 -7.27 3.26 17.31 14.39 10.90 -13.04
Cytoplasmic Foci -8.28 -5.91 -1.33 5.03 5.50 2.65 -4.08 5.74 3.75 4.94 -5.14 -6.95 2.24 6.34 7.29
Eisosomes -6.87 -5.06 -8.10 -4.95 3.87 0.20 -4.28 -2.39 -2.20 3.54 -2.26 -6.37 -8.80 -4.80 4.86
Endoplasmic Reticulum -4.29 -3.40 -1.61 3.80 2.43 3.81 3.38 3.81 0.37 0.13 -1.24 0.89 2.52 3.32 1.35
Endosome -9.42 -5.88 -2.10 1.19 2.82 3.35 -0.37 4.44 2.44 3.50 -2.30 -4.69 0.45 2.02 4.50
Golgi -10.93 -5.14 11.27 16.89 8.58 13.10 5.65 17.93 9.51 3.84 -0.37 -0.03 20.59 18.87 8.51
Lipid Particles -8.47 -9.55 -11.89 -3.41 5.89 5.70 -3.17 -3.84 -10.08 1.88 -2.12 -8.64 -11.58 -9.63 4.99
Mitochondria -2.67 -1.81 -2.65 0.03 -2.15 -0.62 0.22 -1.40 -1.07 -1.54 -2.84 -1.04 -3.00 -0.58 -2.61
Mitotic Spindle -4.08 -3.88 -1.15 0.76 1.11 1.46 -1.91 1.49 0.50 2.58 -2.27 -3.89 -0.20 0.96 2.69
None -2.74 3.30 -1.31 1.70 -2.76 -2.59 2.08 2.71 4.00 0.24 -3.97 3.10 0.49 4.01 -1.95
Nuclear Periphery -5.54 -7.93 -3.53 2.46 7.63 10.11 -3.50 7.84 -3.40 4.97 3.33 -8.58 3.14 -0.37 8.97
Nuclear Periphery Foci -8.08 -6.77 2.42 9.53 7.23 11.92 3.73 13.08 2.25 4.49 4.05 -3.16 12.40 9.23 8.31
Nucleolus -1.17 -8.16 -5.74 0.79 -2.03 -0.74 0.01 1.33 1.10 2.81 -1.46 -2.48 -2.07 1.24 0.52
Nucleus -2.54 -6.89 -9.22 -5.71 4.34 -2.41 -6.50 -3.58 -0.92 5.75 -3.91 -9.50 -9.60 -4.86 7.23
Peroxisomes -2.80 -4.94 -6.83 -2.89 -4.92 0.90 0.09 -0.07 -4.56 -0.39 -0.17 -0.73 -2.63 -4.75 -3.02
Vacuole -10.98 -11.66 -23.26 -16.94 5.94 2.67 -6.96 -14.43 -16.76 3.60 -6.71 -13.34 -28.28 -23.68 6.80
Vacuole Periphery -1.36 -0.92 10.22 11.75 4.67 8.71 4.39 11.26 3.73 3.39 4.37 1.23 14.84 11.95 5.62
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Hsp90 cochaperone; regulates spatial organization of amyloid-like proteins in the cytosol, thereby buffering the proteotoxicity caused by amyloid-like proteins; interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-2

Sti1

Sti1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sti1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available