Standard name
Human Ortholog
Description Nuclear 5' to 3' single-stranded RNA exonuclease; involved in RNA metabolism, including rRNA and snoRNA processing, as well as poly (A+) dependent and independent mRNA transcription termination; required for cotranscriptional pre-rRNA cleavage; displaces Cdk1p from elongating transcripts, especially as RNAPII reaches the poly(A) site, negatively regulates phosphorylation of the CTD of RNAPII, and inhibits RNAPII transcriptional elongation
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 – 0 0 0.07 0.15 0.15 0.1 0.05 0.06 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0.07 0.06 0.05 0.16 0.15 0.23 0.34 – 0.33 0.38 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.95 0.96 0.95 0.96 0.93 0.87 0.87 0.82 0.78 – 0.8 0.76 0.92 0.8 0.78 0.79 0.88 0.86 0.94 0.93 0.94 0.87 0.75 0.57
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0.05 0.11 0.12 0.15 0.19 – 0.24 0.23 0 0.05 0.06 0.05 0 0 0 0 0 0 0.07 0.11
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.05 0.05 0 0 0 0 0.07 0.14 0.24
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 1 0 0 0 0
Bud 0 0 0 0 1 0 2 3 4 – 4 3 0 0 0 0 0 0 0 2 1 0 0 3
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 5 1 8 13 9 21 – 11 19 0 0 4 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 6 2 7 4 7 10 12 13 15 – 6 11 16 51 54 15 4 6 1 0 1 1 0 1
Endoplasmic Reticulum 0 0 0 1 0 0 0 0 0 – 0 0 0 1 0 2 3 3 0 0 0 0 1 1
Endosome 0 2 0 0 1 0 0 0 0 – 0 0 0 4 2 1 0 0 3 1 0 2 1 2
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 1 0 0 0 0 0 0 2 0
Mitochondria 2 6 30 19 22 65 87 137 188 – 145 184 0 1 6 6 1 4 3 1 2 1 1 8
Nucleus 251 326 401 304 390 353 490 490 427 – 348 363 202 276 280 116 76 82 259 333 406 190 230 186
Nuclear Periphery 2 2 0 1 4 5 8 5 12 – 6 11 0 0 2 1 0 0 0 0 0 0 0 1
Nucleolus 3 2 2 8 20 43 69 88 106 – 104 111 9 19 23 7 1 0 0 0 1 4 20 35
Peroxisomes 0 0 1 0 0 0 0 0 0 – 0 0 0 2 4 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 1 2 1 2 – 0 1 1 4 8 1 1 0 3 2 0 0 1 2
Vac/Vac Membrane 8 7 3 1 5 2 2 3 0 – 2 3 1 3 5 8 4 3 2 11 13 14 42 79
Unique Cell Count 265 341 421 318 419 406 562 597 548 435 480 220 346 361 147 86 95 275 357 431 220 307 326
Labelled Cell Count 272 347 444 343 451 487 685 749 775 626 706 229 361 388 158 90 98 275 357 431 220 307 326


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 12.2 8.5 6.6 6.7 6.9 6.1 5.7 5.6 5.0 – 4.9 4.6 9.7 9.0 7.7 12.1 13.4 14.0 10.0 10.1 9.9
Std Deviation (1e-4) 3.2 1.6 1.4 1.3 1.3 1.4 1.2 1.3 1.3 – 1.2 1.4 3.1 2.7 2.3 3.7 3.7 4.0 2.7 2.0 2.3
Intensity Change (Log2) – – – 0.03 0.06 -0.11 -0.2 -0.25 -0.4 – -0.43 -0.53 0.55 0.44 0.22 0.88 1.02 1.09 0.6 0.61 0.59


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 3.1 0 4.1 – 3.3 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0.8 0.5 0.6 1.1 – -0.3 0.7 3.6 6.8 6.9 4.6 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria -0.6 -1.1 4.0 4.0 6.7 10.0 – 9.5 0 -4.1 -4.8 -3.6 -1.3 -2.1 -1.0
Nucleus 0.2 -1.3 -4.2 -4.3 -6.3 -7.6 – -6.7 -8.2 -1.7 -6.6 -7.4 -6.0 -2.5 -3.2
Nuclear Periphery 0 0 0 0 0 3.1 – 0 0 0 0 0 0 0 0
Nucleolus 0 3.9 6.4 7.1 7.9 9.3 – 10.4 0 0 4.2 4.7 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 8.2352 8.847 7.9187 7.0997 7.6862 8.0104 6.0714 6.6095 6.4032 5.3749 5.8367 6.0888 10.8881 10.521 9.5963 9.504 9.4939 9.9044
Actin 0.0265 0.0009 0.0158 0.0281 0.0002 0.0003 0.0049 0 0.0092 0.0002 0.001 0.0016 0.0001 0 0 0 0 0
Bud 0.0006 0.0004 0.0006 0.0001 0.0001 0.0001 0.0003 0 0.0002 0.0001 0.0002 0.0007 0.0001 0.0002 0.0002 0 0.0001 0
Bud Neck 0.0015 0.0001 0.0005 0.0001 0.0005 0.0005 0.0006 0.0001 0.0007 0.0003 0.0002 0.0004 0.0002 0.0001 0.0001 0 0.0002 0.0003
Bud Periphery 0.0013 0.0005 0.0019 0.0001 0.0002 0.0002 0.0006 0 0.0003 0.0004 0.0005 0.001 0.0004 0.0001 0.0004 0 0.0001 0
Bud Site 0.0039 0.0037 0.0057 0.0009 0.0001 0.0001 0.0006 0 0.0014 0.0002 0.0002 0.0011 0.0001 0.0001 0.0001 0 0 0
Cell Periphery 0.0003 0.0002 0.0015 0.0001 0.0001 0.0001 0.0003 0 0.0001 0.0003 0.0003 0.0001 0.0002 0 0.0001 0 0 0
Cytoplasm 0.0036 0.0035 0.0074 0.0105 0 0 0.0065 0 0.0002 0.0002 0.0019 0.0004 0.0001 0.0179 0.0003 0 0.0001 0
Cytoplasmic Foci 0.0065 0.0012 0.0022 0.0091 0.0019 0.0001 0.0034 0 0.0008 0.0001 0.0005 0.0002 0 0.0001 0 0 0 0
Eisosomes 0.0002 0 0.0002 0.0001 0 0 0.0001 0 0.0001 0.0001 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.0064 0.0016 0.0011 0.0113 0.0001 0 0.0044 0 0.0003 0.0002 0.0005 0.0007 0.0001 0.0001 0.0002 0 0 0
Endosome 0.0215 0.0023 0.0036 0.0027 0.0019 0.0002 0.0141 0 0.0021 0.0003 0.0019 0.0037 0.0002 0.0002 0.0001 0 0.0001 0
Golgi 0.0055 0.0009 0.0027 0.003 0.0017 0.0002 0.0027 0 0.0012 0.0001 0.0002 0.0011 0 0 0 0 0 0
Lipid Particles 0.0139 0.0015 0.005 0.005 0.037 0.0002 0.0054 0 0.0011 0.0012 0.0003 0.0008 0.0001 0 0 0 0 0
Mitochondria 0.0148 0.0062 0.0201 0.0011 0.003 0.0066 0.0106 0.0002 0.0016 0.0108 0.0065 0.002 0.003 0.0001 0.0006 0 0.0004 0.0001
None 0.0021 0.0004 0.0013 0.0036 0.0001 0 0.0013 0 0.0001 0.0001 0.0006 0.0001 0.0001 0 0 0 0 0
Nuclear Periphery 0.0301 0.0042 0.007 0.0071 0.0018 0.0004 0.0262 0.0035 0.0024 0.0037 0.0138 0.0056 0.0016 0.0007 0.0015 0.0006 0.0021 0.0005
Nucleolus 0.0091 0.0087 0.0064 0.0061 0.0715 0.0387 0.0195 0.0087 0.0056 0.0176 0.0442 0.0314 0.0144 0.0065 0.0065 0.0076 0.0262 0.0261
Nucleus 0.8355 0.9599 0.9039 0.8894 0.8757 0.9495 0.8783 0.9868 0.9709 0.9598 0.9114 0.9464 0.9763 0.972 0.9885 0.9916 0.9693 0.9726
Peroxisomes 0.002 0.0005 0.0016 0.0164 0.0016 0.0002 0.0014 0 0.0003 0.0001 0.0001 0.0001 0 0 0 0 0 0
Punctate Nuclear 0.0089 0.0009 0.0087 0.0045 0.0009 0.0018 0.0122 0.0004 0.0008 0.0002 0.01 0.0004 0.0002 0 0.0001 0.0002 0.0003 0.0003
Vacuole 0.003 0.002 0.0017 0.0004 0.0005 0.0004 0.0031 0.0001 0.0003 0.0013 0.0017 0.0014 0.0014 0.0016 0.0009 0 0.0005 0.0001
Vacuole Periphery 0.0029 0.0005 0.0012 0.0003 0.0009 0.0002 0.0036 0.0001 0.0004 0.0029 0.0041 0.0009 0.0011 0.0003 0.0004 0 0.0003 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 56.7956 60.7302 50.1524 48.614 45.2246 41.6149 52.9034 50.3564 48.4423 53.7691
Translational Efficiency 0.904 0.744 0.8042 0.7435 0.7985 0.7987 0.6781 0.601 0.5842 0.6475

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
142 168 658 468 1169 1253 226 19 1311 1421 884 487

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 826.65 1093.55 1220.61 1251.49 871.91 1021.75 1355.31 1570.74 867.01 1030.24 1255.05 1263.95
Standard Deviation 127.49 156.97 169.68 244.76 153.80 161.17 172.95 273.01 151.82 162.35 180.36 253.58
Intensity Change Log 2 — 0.403671 0.562254 0.598298 — 0.228791 0.636372 0.849193 — 0.316550 0.600776 0.732523

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000392 0.000285 0.000515 0.001123 0.000351 0.000495 0.000563 0.000639 0.000356 0.000470 0.000528 0.001104
Bud Neck 0.002569 0.006709 0.010222 0.017652 0.003893 0.005194 0.007333 0.009145 0.003749 0.005373 0.009483 0.017320
Bud Site 0.000611 0.000595 0.000610 0.003210 0.000366 0.000993 0.000414 0.000482 0.000392 0.000946 0.000560 0.003104
Cell Periphery 0.000073 0.000048 0.000040 0.000217 0.000200 0.000220 0.000020 0.000029 0.000186 0.000200 0.000035 0.000209
Cytoplasm 0.000418 0.000079 0.000107 0.004399 0.000536 0.000514 0.000059 0.000344 0.000524 0.000463 0.000094 0.004241
Cytoplasmic Foci 0.000135 0.000076 0.000009 0.006380 0.000055 0.000860 0.000013 0.000015 0.000064 0.000768 0.000010 0.006131
Eisosomes 0.000027 0.000029 0.000045 0.000051 0.000046 0.000053 0.000046 0.000042 0.000044 0.000050 0.000045 0.000051
Endoplasmic Reticulum 0.004034 0.002220 0.002036 0.002064 0.005503 0.004968 0.001494 0.000973 0.005344 0.004643 0.001898 0.002021
Endosome 0.000076 0.000166 0.000033 0.006320 0.000116 0.000480 0.000019 0.000018 0.000112 0.000443 0.000029 0.006074
Golgi 0.000045 0.000035 0.000027 0.005129 0.000039 0.000684 0.000026 0.000030 0.000039 0.000608 0.000026 0.004930
Lipid Particles 0.000133 0.000038 0.000016 0.001154 0.000066 0.000963 0.000014 0.000008 0.000073 0.000854 0.000015 0.001109
Mitochondria 0.002709 0.003139 0.000859 0.004959 0.000542 0.001751 0.000942 0.001898 0.000777 0.001915 0.000880 0.004839
Mitotic Spindle 0.000657 0.002855 0.000012 0.012978 0.000119 0.005382 0.000011 0.000007 0.000177 0.005083 0.000012 0.012471
None 0.002301 0.000613 0.000556 0.004435 0.003540 0.001468 0.000497 0.000684 0.003406 0.001367 0.000541 0.004288
Nuclear Periphery 0.000173 0.000059 0.000087 0.001063 0.000143 0.000224 0.000066 0.000142 0.000146 0.000204 0.000082 0.001027
Nuclear Periphery Foci 0.000293 0.000013 0.000007 0.001672 0.000171 0.000428 0.000002 0.000002 0.000184 0.000379 0.000006 0.001607
Nucleolus 0.011788 0.005484 0.004381 0.012269 0.009905 0.007314 0.004750 0.002944 0.010109 0.007098 0.004475 0.011905
Nucleus 0.972317* 0.976861* 0.979741* 0.905158* 0.973571* 0.965445* 0.982771* 0.981850* 0.973435* 0.966795* 0.980515* 0.908151*
Peroxisomes 0.000399 0.000218 0.000228 0.001043 0.000255 0.000911 0.000477 0.000306 0.000271 0.000829 0.000292 0.001014
Vacuole 0.000451 0.000332 0.000415 0.005980 0.000463 0.001024 0.000430 0.000372 0.000462 0.000942 0.000419 0.005761
Vacuole Periphery 0.000397 0.000147 0.000056 0.002746 0.000123 0.000629 0.000052 0.000071 0.000153 0.000572 0.000055 0.002642

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.93 -1.24 -4.77 -6.26 -4.80 -2.61 -5.82 -2.99 -1.53 -0.98 -2.29 -5.89 -5.94 -5.09 -4.79
Bud Neck -1.06 -6.59 -6.31 -2.89 -3.45 -2.24 -4.82 -1.98 -1.65 -0.97 -2.39 -11.07 -6.51 -5.64 -3.78
Bud Site 0.03 -0.08 -3.87 -3.94 -4.45 -2.56 -1.67 -0.98 1.00 -0.54 -2.48 -3.12 -4.84 -3.65 -4.51
Cell Periphery 1.01 1.67 -2.46 -3.05 -3.40 -0.26 5.46 4.96 2.59 -0.73 -0.20 5.15 -0.10 0.11 -3.50
Cytoplasm 1.45 1.33 -2.20 -2.41 -2.39 -0.09 4.05 1.06 0.94 -1.42 0.12 4.05 -2.16 -2.16 -2.40
Cytoplasmic Foci 0.54 1.40 -2.37 -2.40 -2.44 -2.53 2.00 1.94 2.68 -0.14 -2.50 2.53 -2.41 -1.94 -2.44
Eisosomes -0.26 -2.81 -4.08 -5.50 -1.82 -0.77 -0.13 0.14 0.85 0.29 -0.76 -0.27 -1.20 -0.56 -1.89
Endoplasmic Reticulum 3.41 3.66 3.18 -0.06 -0.43 1.36 12.98 12.22 11.11 1.69 1.97 11.48 8.55 6.90 -0.88
Endosome -0.85 1.82 -2.68 -2.62 -2.71 -3.44 6.10 5.92 4.35 0.14 -3.51 5.59 -2.65 -2.42 -2.71
Golgi 0.36 0.75 -2.12 -2.13 -2.13 -2.86 0.79 0.97 2.93 0.41 -2.85 1.11 -2.12 -1.72 -2.13
Lipid Particles 1.12 1.41 -1.46 -1.70 -1.74 -1.35 1.80 1.95 1.44 1.64 -1.33 2.08 -1.61 0.06 -1.74
Mitochondria -0.12 1.08 -0.85 -0.43 -3.61 -2.19 -4.18 -4.40 -0.43 -3.19 -1.86 -0.80 -3.78 -2.18 -3.66
Mitotic Spindle -0.75 0.99 -4.00 -2.96 -4.19 -3.43 0.74 1.21 3.52 1.13 -3.51 1.40 -4.14 -2.75 -4.19
None 2.16 2.26 -1.74 -4.66 -4.79 2.68 4.38 4.18 1.98 -0.33 2.95 4.77 -0.80 -3.37 -4.78
Nuclear Periphery 0.93 0.57 -2.61 -3.15 -3.01 -1.59 3.22 0.00 1.42 -1.87 -1.27 2.03 -2.87 -2.64 -3.04
Nuclear Periphery Foci 1.32 1.34 -2.04 -2.64 -2.65 -1.22 2.03 2.04 2.56 1.14 -1.03 2.28 -2.26 -1.91 -2.65
Nucleolus 1.84 2.30 -0.81 -3.59 -4.52 2.12 4.44 5.88 3.76 2.02 2.62 5.72 -1.86 -3.22 -4.46
Nucleus -0.46 -0.92 5.69 5.91 7.71 2.21 -3.82 -0.88 -2.14 0.63 1.93 -3.39 7.05 6.07 7.77
Peroxisomes 1.15 1.12 -2.45 -4.27 -4.47 -2.12 -2.77 -0.24 2.01 1.89 -2.04 -0.23 -4.01 -0.20 -4.07
Vacuole 0.43 -0.02 -2.59 -2.66 -2.60 -2.58 0.36 0.62 2.74 0.41 -2.48 0.10 -2.60 -2.35 -2.60
Vacuole Periphery 0.95 1.31 -1.72 -2.11 -2.22 -2.36 5.21 2.78 2.59 -1.42 -2.19 3.14 -2.10 -1.51 -2.22
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Nuclear 5' to 3' single-stranded RNA exonuclease; involved in RNA metabolism, including rRNA and snoRNA processing, as well as poly (A+) dependent and independent mRNA transcription termination; required for cotranscriptional pre-rRNA cleavage; displaces Cdk1p from elongating transcripts, especially as RNAPII reaches the poly(A) site, negatively regulates phosphorylation of the CTD of RNAPII, and inhibits RNAPII transcriptional elongation
Localization
Cell Percentages nucleus (100%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Rat1

Rat1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rat1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available