Standard name
Human Ortholog
Description AN1-type zinc finger protein, effector of proteotoxic stress response; stress-inducible transcriptional target of Rpn4p; induced by nitrogen limitation, weak acid, misfolded proteins; short-lived protein, degraded by proteasome; may protect cells from trivalent metalloid induced proteotoxicity; contains PACE promoter element; ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases under DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.07 0.05 0.27 0.08 0.09 0.12 0.09 0.19 0.17 0.24 0.2 0.27 0.08 0.17 0.27 0.18 0.18 0.14 0 0 0.13 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.14 0.05 0.63 0.42 0.09 0.54 0.61 0.62 0.81 0.71 0.8 0.76 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.83 0.78 0.33 0.74 0.83 0.67 0.57 0.41 0.28 0.27 0.28 0.2 0.85 0.7 0.56 0.55 0.55 0.63 0.78 0.81 0.54 0.74 0.72 0.65
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.13 0.17 0 0.07 0.06 0.09 0.11 0.08 0.1 0.07 0.06 0.07 0.11 0.18 0.27 0.3 0.34 0.3 0.13 0.14 0.23 0.13 0.14 0.22
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2
Bud 0 0 0 0 0 1 6 11 4 8 4 9 0 0 0 1 0 0 4 1 0 5 9 13
Bud Neck 0 0 0 0 0 0 0 1 0 2 0 0 0 0 0 0 0 0 0 0 0 0 1 1
Bud Site 0 0 0 0 0 4 3 2 8 10 4 5 1 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 27 3 14 12 20 31 44 98 56 116 96 156 36 82 138 23 18 17 16 1 10 9 13 7
Endoplasmic Reticulum 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 4 3 6 0 0 0 0 0 2
Endosome 0 0 0 0 1 0 2 1 0 0 0 1 2 1 2 5 2 1 2 0 0 2 4 2
Golgi 0 0 0 0 1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1 1 1
Mitochondria 53 3 32 64 20 140 306 322 269 340 393 444 15 9 6 4 2 3 1 0 2 1 6 3
Nucleus 308 51 17 112 191 174 287 211 95 128 139 117 381 332 284 71 55 76 323 67 43 159 295 276
Nuclear Periphery 0 0 0 1 0 4 7 6 4 1 4 4 0 0 0 0 0 1 0 0 0 0 0 1
Nucleolus 0 0 0 0 0 0 1 1 1 0 1 0 0 0 0 0 0 0 0 0 0 0 3 7
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 0 6 0 1 5 8 6
Vac/Vac Membrane 48 11 1 11 14 23 56 41 32 31 30 38 50 88 137 38 34 36 54 11 18 29 58 93
Unique Cell Count 372 65 51 151 230 261 500 519 334 476 490 583 447 477 510 128 100 121 414 84 81 216 409 426
Labelled Cell Count 436 69 64 200 247 377 712 694 469 638 673 775 485 512 568 146 115 140 414 84 81 216 409 426


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.4 5.0 3.3 4.4 5.4 4.1 3.6 3.5 2.9 3.2 2.9 2.9 5.6 5.8 5.6 8.9 9.2 8.9 5.2 6.1 6.4
Std Deviation (1e-4) 0.6 0.7 0.7 1.6 1.4 1.6 1.1 0.9 0.8 1.0 1.2 1.0 1.0 1.3 1.2 3.0 3.2 3.8 1.3 1.5 1.5
Intensity Change (Log2) – – – 0.42 0.72 0.33 0.12 0.08 -0.18 -0.06 -0.18 -0.2 0.76 0.83 0.78 1.45 1.49 1.44 0.66 0.9 0.96


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -3.6 -3.7 -2.9 -4.1 -1.5 -1.8 -0.5 -1.3 -0.1 -4.4 -1.8 -0.1 -1.4 -1.3 -2.1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 -9.0 0 0 0 0 0 0 0 0 0 0 -9.0 -8.5 -9.0
Nucleus 5.2 7.3 4.5 3.3 1.0 -0.7 -1.0 -0.7 -2.2 8.8 5.2 3.1 2.7 2.5 3.5
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 2.1 0 0 0 0 0 2.1 3.0 3.9 4.1 4.4 4.1

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.742 1.6189 1.2146 1.0878 0.7577 1.1142 0.8349 1.4031 1.0989 0.8476 1.3564 1.2049 2.058 2.7595 2.2363 2.3788 1.8911 2.4609
Actin 0.01 0 0.0019 0 0.0035 0.0011 0.0334 0.0003 0.002 0 0.0007 0.0014 0.0181 0.0001 0.0052 0.0142 0.0352 0.0009
Bud 0.0002 0 0 0 0.0006 0.0001 0.0006 0 0.0005 0 0 0.0003 0.0002 0 0.0001 0.0006 0.0001 0.0001
Bud Neck 0.0004 0.0001 0.0001 0.0002 0.0005 0.0018 0.0014 0.0001 0.0003 0.0001 0.0009 0.0049 0.0015 0.0001 0.0001 0.0044 0.0004 0.0034
Bud Periphery 0.0008 0 0 0 0.0047 0.0001 0.0006 0 0.0007 0 0.0001 0.0009 0.0002 0 0.0001 0.0014 0.0003 0.0001
Bud Site 0.0003 0 0.0001 0 0.0007 0.0001 0.0046 0.0001 0.004 0 0.0001 0.0011 0.0006 0.0001 0.0001 0.0019 0.0005 0.0001
Cell Periphery 0.0001 0 0 0 0.0003 0 0.0002 0 0.0001 0 0 0.0002 0.0001 0 0 0.0002 0.0001 0
Cytoplasm 0.0093 0.0077 0.0075 0.0004 0.0077 0.0085 0.0248 0.0189 0.0084 0.0011 0.0018 0.0029 0.0121 0.0189 0.0132 0.001 0.0019 0.0064
Cytoplasmic Foci 0.0057 0 0.0031 0 0.0023 0.0004 0.0235 0.0008 0.0112 0 0.0023 0.0019 0.0097 0.0002 0.0006 0.0019 0.0054 0.0003
Eisosomes 0.0001 0 0 0 0.0001 0 0.0005 0 0 0 0 0 0.0002 0 0 0.0002 0.0005 0
Endoplasmic Reticulum 0.0012 0.0003 0.0002 0 0.0083 0.0007 0.0042 0.0029 0.0002 0.0001 0.0007 0.0004 0.0019 0.001 0.0003 0.0009 0.0006 0.0006
Endosome 0.0037 0.0001 0.0012 0 0.0362 0.0022 0.0434 0.0036 0.0055 0 0.0126 0.0041 0.0099 0.001 0.0004 0.0087 0.0073 0.0009
Golgi 0.0019 0 0.0008 0 0.0032 0.0006 0.0166 0.0002 0.0042 0 0.0051 0.002 0.0032 0 0.0005 0.0034 0.0053 0.0001
Lipid Particles 0.0086 0 0.0038 0 0.0088 0.0016 0.0199 0.0002 0.005 0 0.034 0.0029 0.0063 0 0.0003 0.0062 0.0207 0
Mitochondria 0.0104 0.0002 0.0004 0.0001 0.0191 0.0007 0.0113 0.0002 0.0046 0.0001 0.0016 0.0083 0.001 0.0004 0.0003 0.0096 0.0027 0.0002
None 0.0045 0.0056 0.0095 0 0.0016 0.0066 0.0101 0.0066 0.0083 0.0001 0.0003 0.0007 0.0154 0.0034 0.0223 0.0011 0.002 0.0101
Nuclear Periphery 0.0197 0.0299 0.0096 0.0009 0.0378 0.0234 0.0212 0.0179 0.0088 0.0047 0.0095 0.0111 0.0121 0.015 0.0069 0.0086 0.0089 0.0055
Nucleolus 0.0035 0.002 0.002 0.0029 0.005 0.0065 0.0039 0.0022 0.0018 0.0013 0.0418 0.0131 0.0061 0.0019 0.0021 0.0042 0.0042 0.0044
Nucleus 0.8944 0.9518 0.9546 0.9948 0.8484 0.9351 0.7426 0.9358 0.9271 0.9915 0.8819 0.9316 0.8821 0.953 0.9432 0.9171 0.8848 0.9621
Peroxisomes 0.0121 0 0.0033 0 0.0004 0.0002 0.0199 0 0.0047 0 0.0015 0.0014 0.0087 0 0.0014 0.003 0.0059 0
Punctate Nuclear 0.0107 0.0012 0.0016 0.0005 0.0014 0.0087 0.0124 0.0091 0.0014 0.0008 0.0035 0.0062 0.0095 0.002 0.0023 0.0093 0.0121 0.0043
Vacuole 0.0015 0.0004 0.0002 0 0.0048 0.001 0.0029 0.0006 0.0008 0.0001 0.0008 0.0029 0.0008 0.0025 0.0005 0.0013 0.0005 0.0003
Vacuole Periphery 0.0009 0.0004 0.0001 0 0.0045 0.0006 0.0021 0.0002 0.0003 0 0.0007 0.0015 0.0003 0.0003 0.0002 0.0008 0.0005 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 40.1902 43.5486 40.3937 56.3494 36.318 73.0327 65.4975 79.4973 82.9939 45.1947
Translational Efficiency 2.6961 3.2405 2.8705 2.817 2.8977 2.3595 1.9798 2.6601 2.4948 2.3111

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
320 1422 2412 1265 1928 145 1644 1341 2248 1567 4056 2606

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 663.13 765.96 964.88 857.64 687.64 839.15 884.69 861.60 684.15 772.73 932.38 859.68
Standard Deviation 77.27 110.02 121.80 126.94 79.19 110.95 117.88 127.82 79.38 112.13 126.51 127.41
Intensity Change Log 2 — 0.207977 0.541058 0.371080 — 0.287275 0.363519 0.325365 — 0.248890 0.453408 0.347989

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000314 0.000168 0.000082 0.004712 0.000045 0.001840 0.000291 0.000995 0.000084 0.000323 0.000167 0.002799
Bud Neck 0.002048 0.007888 0.007185 0.012699 0.002822 0.013272 0.009691 0.012162 0.002712 0.008386 0.008201 0.012423
Bud Site 0.000451 0.002275 0.004406 0.025173 0.000933 0.005968 0.005556 0.023196 0.000864 0.002617 0.004872 0.024156
Cell Periphery 0.000135 0.000110 0.000081 0.000368 0.000125 0.000224 0.000103 0.000199 0.000126 0.000120 0.000090 0.000281
Cytoplasm 0.146321* 0.123329* 0.073013 0.207866* 0.220182* 0.151127* 0.068636 0.270992* 0.209668* 0.125901* 0.071239 0.240349*
Cytoplasmic Foci 0.050990 0.018576 0.000152 0.006417 0.032246 0.076562 0.000464 0.008900 0.034914 0.023941 0.000279 0.007695
Eisosomes 0.000067 0.000029 0.000006 0.000045 0.000037 0.000122 0.000017 0.000048 0.000041 0.000037 0.000011 0.000046
Endoplasmic Reticulum 0.001114 0.002664 0.001332 0.009251 0.000852 0.003725 0.005365 0.003714 0.000889 0.002763 0.002967 0.006402
Endosome 0.001061 0.002220 0.000147 0.005222 0.000800 0.007510 0.000488 0.010255 0.000838 0.002710 0.000285 0.007812
Golgi 0.000149 0.000493 0.000014 0.002155 0.000759 0.008756 0.000029 0.003386 0.000672 0.001258 0.000021 0.002789
Lipid Particles 0.004918 0.002068 0.000052 0.001485 0.003194 0.015430 0.000291 0.001393 0.003439 0.003305 0.000149 0.001437
Mitochondria 0.005654 0.004165 0.000613 0.008365 0.002154 0.030405 0.001562 0.005602 0.002652 0.006593 0.000997 0.006944
Mitotic Spindle 0.000067 0.007454 0.000616 0.027342 0.001265 0.006927 0.006474 0.049546 0.001094 0.007405 0.002990 0.038767
None 0.013217 0.008616 0.003457 0.005905 0.006709 0.002862 0.004925 0.007607 0.007635 0.008084 0.004052 0.006781
Nuclear Periphery 0.001081 0.001758 0.001272 0.002413 0.001226 0.001452 0.001718 0.002427 0.001206 0.001729 0.001453 0.002420
Nuclear Periphery Foci 0.000261 0.000529 0.000041 0.001029 0.000276 0.001194 0.000208 0.001142 0.000274 0.000591 0.000109 0.001087
Nucleolus 0.002881 0.004573 0.000182 0.000682 0.001790 0.004056 0.000387 0.001023 0.001946 0.004525 0.000265 0.000858
Nucleus 0.760989* 0.800144* 0.903404* 0.616878* 0.716845* 0.607292* 0.882712* 0.533901* 0.723129* 0.782299* 0.895017* 0.574179*
Peroxisomes 0.002905 0.002147 0.000009 0.001919 0.001733 0.026461 0.000138 0.001373 0.001900 0.004397 0.000061 0.001638
Vacuole 0.005236 0.010238 0.003853 0.057400 0.005823 0.033013 0.010835 0.060376 0.005740 0.012346 0.006683 0.058931
Vacuole Periphery 0.000141 0.000555 0.000083 0.002673 0.000184 0.001802 0.000110 0.001764 0.000178 0.000670 0.000094 0.002205

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.49 0.80 -2.41 -2.74 -2.86 -2.48 -14.69 -6.55 1.42 -3.34 -3.23 -3.72 -3.87 -3.10 -3.48
Bud Neck -5.80 -6.55 -8.20 -2.96 -3.53 -2.12 -5.95 -7.43 0.51 -0.14 -5.76 -8.35 -10.66 -2.45 -2.79
Bud Site -3.31 -4.22 -7.65 -6.46 -5.32 -2.28 -3.89 -7.47 -3.01 -4.76 -3.19 -5.28 -10.52 -8.59 -7.19
Cell Periphery 1.47 3.52 -1.68 -2.29 -3.07 -3.55 2.45 -2.26 2.65 -4.59 0.49 4.78 -2.38 -2.54 -4.11
Cytoplasm 1.95 7.03 -0.81 -4.59 -15.21 3.74 27.00 0.88 -3.27 -21.78 12.35 28.59 3.68 -9.31 -26.31
Cytoplasmic Foci 5.11 8.48 7.84 8.85 -7.85 -4.16 17.58 14.10 6.88 -10.90 4.23 19.52 16.63 10.50 -13.44
Eisosomes 3.98 6.54 1.33 -8.60 -20.45 -5.58 5.88 -7.20 4.18 -13.96 0.74 12.30 -5.78 -6.51 -25.35
Endoplasmic Reticulum -6.25 -3.64 -12.87 -10.60 -12.15 -4.09 -14.40 -17.74 -1.60 2.47 -8.88 -14.00 -18.70 -12.72 -10.14
Endosome -3.49 4.71 -3.29 -0.57 -5.85 -3.71 2.87 -4.44 1.44 -4.74 -6.04 7.48 -5.76 -1.37 -6.93
Golgi -2.11 3.30 -2.17 -0.75 -2.70 -2.18 1.99 -0.81 2.04 -2.83 -1.15 2.08 -0.77 0.53 -3.83
Lipid Particles 3.37 6.04 4.28 2.78 -9.46 -2.87 9.27 5.73 3.35 -9.90 0.39 11.39 6.88 4.38 -13.94
Mitochondria 0.39 1.44 0.48 0.26 -2.99 -2.52 1.13 -0.83 2.45 -1.91 -2.68 2.48 -0.76 2.23 -3.73
Mitotic Spindle -4.14 -2.50 -6.62 -2.88 -6.08 -1.90 -3.55 -7.55 -4.81 -5.44 -3.74 -3.05 -9.66 -5.30 -8.32
None 1.45 3.33 2.59 2.57 -5.18 3.87 2.76 0.37 -3.98 -2.73 -0.38 4.77 1.93 1.97 -5.20
Nuclear Periphery -4.27 -3.58 -14.83 -11.87 -15.15 -1.44 -9.98 -12.03 -7.65 -6.68 -4.88 -9.35 -19.26 -13.20 -14.94
Nuclear Periphery Foci -2.47 3.64 -9.05 -4.72 -11.74 -2.49 -0.71 -6.36 0.08 -6.38 -2.94 2.07 -10.18 -4.21 -12.87
Nucleolus -2.84 7.25 5.63 6.21 -5.31 -2.05 3.95 2.89 3.25 -3.98 -4.29 5.49 3.90 6.60 -7.04
Nucleus -2.29 -9.52 6.38 14.02 30.29 3.88 -21.54 13.93 1.10 32.45 -6.17 -27.77 13.96 18.65 45.04
Peroxisomes 0.70 3.19 2.30 3.58 -3.21 -3.00 5.18 3.13 3.16 -3.38 -2.76 6.19 3.71 4.55 -4.68
Vacuole -3.85 0.29 -20.78 -19.61 -21.07 -4.98 -9.13 -22.94 -10.24 -19.68 -6.46 -6.80 -31.02 -27.64 -29.24
Vacuole Periphery -4.56 2.45 -1.93 -0.93 -2.08 -2.23 1.47 -2.54 1.40 -2.97 -4.38 1.98 -2.80 -0.67 -3.23
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description AN1-type zinc finger protein, effector of proteotoxic stress response; stress-inducible transcriptional target of Rpn4p; induced by nitrogen limitation, weak acid, misfolded proteins; short-lived protein, degraded by proteasome; may protect cells from trivalent metalloid induced proteotoxicity; contains PACE promoter element; ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases under DNA replication stress
Localization
Cell Percentages nucleus (51%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Tmc1

Tmc1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Tmc1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available