Standard name
Human Ortholog
Description Cis-golgi GTPase-activating protein (GAP) for yeast Rabs; the Rab family members are Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0.07 0 0 0.05 0 – 0.06 0.05 0 0.05 0 0 0 0 0 0 0.06 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0.05 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0.07 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.7 0.85 0.85 0.84 0.77 0.62 0.56 – 0.46 0.47 0.39 0.4 0.95 0.86 0.88 0.8 0.79 0.87 0.39 0.56 0.46 0.68 0.79 0.77
Endoplasmic Reticulum 0.05 0.07 0 0.05 0.06 0.09 0 – 0.07 0.08 0.07 0.09 0.05 0.05 0 0 0 0 0 0 0 0 0 0
Endosome 0.16 0 0 0.06 0.11 0.12 0.17 – 0.12 0.13 0 0.1 0 0.05 0.08 0.1 0.1 0.05 0.25 0.1 0.06 0.05 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0
Mitochondria 0.06 0 0 0 0 0.15 0.18 – 0.32 0.28 0.6 0.36 0 0 0 0 0 0 0.12 0.14 0.25 0.12 0.06 0.07
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0.06 – 0.05 0.06 0 0.06 0 0 0 0.12 0.15 0.09 0 0.07 0.06 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 8 9 11 5 10 12 13 – 11 16 9 17 1 7 2 3 5 2 12 11 6 2 5 7
Bud 3 2 0 1 0 4 13 – 9 9 12 16 1 1 0 0 0 0 1 1 1 0 0 4
Bud Neck 0 0 1 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 3 3 3 2 4 4
Bud Site 0 0 0 0 0 0 1 – 0 0 2 2 0 0 0 0 0 0 – – – – – –
Cell Periphery 2 1 2 1 3 2 3 – 4 12 4 8 4 2 0 7 1 3 0 0 1 0 0 0
Cytoplasm 133 217 143 144 188 139 193 – 90 141 111 134 58 204 220 138 108 113 87 166 96 92 277 246
Endoplasmic Reticulum 10 17 5 9 15 19 6 – 14 24 19 30 3 11 2 7 3 5 5 6 9 0 2 4
Endosome 31 9 7 10 26 26 58 – 24 38 12 32 0 13 20 18 13 6 57 30 11 7 11 12
Golgi 0 1 0 0 2 1 3 – 1 1 0 2 0 0 0 2 0 2 11 5 4 0 1 1
Mitochondria 11 4 0 7 3 33 61 – 63 84 172 118 0 0 0 3 1 2 27 40 51 16 19 22
Nucleus 0 2 1 1 1 4 1 – 0 0 2 4 0 1 0 2 1 0 0 0 0 2 0 0
Nuclear Periphery 0 1 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0
Peroxisomes 0 0 0 1 0 0 8 – 0 3 1 1 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 1 0 2 4 6 4 14 – 6 4 3 20 0 5 3 2 0 1 5 5 2 2 3 3
Vac/Vac Membrane 8 5 6 1 7 6 20 – 9 18 8 21 0 4 10 21 20 12 9 19 12 4 11 5
Unique Cell Count 191 255 168 172 245 223 345 194 299 288 331 61 237 251 172 136 130 226 296 209 135 349 319
Labelled Cell Count 207 268 178 184 261 250 394 231 350 355 405 67 248 257 203 153 146 226 296 209 135 349 319


Cytoplasm, Punctate Nuclear

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.2 6.6 7.2 6.7 7.5 6.4 6.6 – 6.0 6.5 5.5 5.9 6.9 6.9 6.9 9.6 9.7 9.1 6.3 6.7 7.0
Std Deviation (1e-4) 0.7 0.9 1.1 1.9 1.5 1.1 1.4 – 1.2 1.7 1.0 1.3 0.9 0.9 1.2 2.4 2.4 2.1 0.9 1.0 1.6
Intensity Change (Log2) – – – -0.1 0.04 -0.18 -0.13 – -0.26 -0.16 -0.4 -0.3 -0.06 -0.06 -0.08 0.41 0.42 0.33 -0.2 -0.12 -0.05

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -1.6 -1.1 -0.5 -1.4 – -0.3 -0.5 -1.7 -0.6 0 -1.7 -3.3 -2.2 -1.1 -2.1
Bud 0 0 0 0 – 0 0 0 2.9 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 1.7 0 0 0 0 0 0 0 0
Cytoplasm -0.4 -2.1 -5.0 -6.5 – -7.7 -8.1 -9.7 -9.5 2.0 0.3 0.7 -1.2 -1.3 0.4
Endoplasmic Reticulum 1.0 1.5 2.3 0 – 1.8 2.2 1.7 2.5 0 0.8 0 0.5 0 0
Endosome 0.7 2.4 2.6 4.0 – 2.8 3.0 0 2.2 0 0.6 1.6 2.2 1.9 0.2
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 5.2 5.8 – 8.1 7.6 12.7 8.9 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 1.8 – 0 0 0 2.5 0 0 0 0 0 0
Vacuole 0 -0.4 -0.5 1.1 – 0.5 1.2 -0.5 1.3 0 0 0.2 2.9 3.5 2.0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.3521 0.6112 0.3857 0.1421 -0.9705 0.3404 1.7031 2.1432 1.9442 1.8845 1.8172 1.8335 0.7684 0.6781 0.2492 1.0332 0.4227 0.6462
Actin 0.0083 0.0085 0.0085 0.002 0.0024 0.0008 0.0228 0.0045 0.0412 0.0131 0.027 0.0108 0.0745 0.0012 0.0016 0.0508 0.0783 0.0144
Bud 0.0006 0.002 0.0007 0.0003 0.0004 0.0001 0.0041 0.0009 0.0045 0.001 0.0008 0.0057 0.0006 0.0004 0.0004 0.0002 0.0005 0.0002
Bud Neck 0.0052 0.0037 0.0061 0.0013 0.0002 0.0006 0.0021 0.0013 0.0032 0.0006 0.0007 0.0041 0.0007 0.0002 0.0002 0.0003 0.001 0.0009
Bud Periphery 0.0008 0.0016 0.001 0.0006 0.0005 0.0001 0.0084 0.0008 0.0048 0.0012 0.0007 0.0028 0.0006 0.0002 0.0002 0.0002 0.0009 0.0003
Bud Site 0.0084 0.0228 0.0028 0.0013 0.0015 0.0001 0.0125 0.0107 0.007 0.0021 0.0013 0.0005 0.002 0.0097 0.0006 0.0014 0.0015 0.0003
Cell Periphery 0.0013 0.0006 0.0005 0.0012 0.0003 0.0001 0.0008 0.0003 0.0003 0.0004 0.0001 0.0002 0.0002 0.0003 0.0002 0.0002 0.0003 0.0001
Cytoplasm 0.2304 0.4443 0.4136 0.4076 0.2054 0.409 0.3244 0.5635 0.4544 0.3283 0.3788 0.5107 0.3209 0.6096 0.4725 0.2472 0.254 0.5203
Cytoplasmic Foci 0.1419 0.0967 0.0707 0.1439 0.0848 0.1636 0.121 0.0818 0.1174 0.1561 0.1451 0.1191 0.072 0.0797 0.0908 0.0576 0.1469 0.1087
Eisosomes 0.0015 0.0004 0.0011 0.0005 0.0003 0 0.0005 0.0001 0.0002 0.0001 0.0001 0.0001 0.0008 0.0001 0.0001 0.0003 0.0013 0.0002
Endoplasmic Reticulum 0.0095 0.0067 0.0076 0.0064 0.0087 0.0056 0.0141 0.0088 0.0067 0.0069 0.0088 0.009 0.0112 0.0062 0.0122 0.0176 0.0094 0.006
Endosome 0.137 0.1222 0.1594 0.069 0.1297 0.1948 0.1318 0.0906 0.1394 0.2087 0.1861 0.1356 0.1594 0.1043 0.2221 0.1591 0.2141 0.1559
Golgi 0.029 0.0115 0.0148 0.0067 0.0044 0.0162 0.0235 0.015 0.0244 0.0241 0.0444 0.0179 0.0177 0.0105 0.0132 0.0158 0.0535 0.0229
Lipid Particles 0.042 0.0033 0.0105 0.0025 0.003 0.0072 0.0208 0.0059 0.0066 0.004 0.0097 0.003 0.015 0.0014 0.0022 0.0357 0.0889 0.0081
Mitochondria 0.0119 0.0211 0.0095 0.0024 0.0025 0.003 0.0171 0.0149 0.0079 0.0075 0.0182 0.0148 0.0099 0.0041 0.0068 0.0036 0.0203 0.0057
None 0.3127 0.2343 0.2643 0.3416 0.5435 0.1812 0.2181 0.1856 0.1455 0.2053 0.1459 0.151 0.2566 0.1588 0.1596 0.3795 0.0122 0.1437
Nuclear Periphery 0.0031 0.0014 0.002 0.001 0.0011 0.0007 0.0184 0.0012 0.003 0.0038 0.002 0.0035 0.0162 0.0014 0.0024 0.0052 0.0152 0.0021
Nucleolus 0.0048 0.0002 0.0004 0.0002 0.0003 0.0001 0.0012 0.0002 0.0014 0.0007 0.0001 0.0001 0.0013 0.0001 0.0001 0.0002 0.001 0.0001
Nucleus 0.0028 0.001 0.0009 0.0013 0.0009 0.0006 0.017 0.0011 0.0092 0.0131 0.0011 0.0011 0.0063 0.0011 0.0008 0.0009 0.0022 0.0007
Peroxisomes 0.0155 0.0077 0.0108 0.0018 0.0008 0.0059 0.0263 0.002 0.0103 0.0043 0.0176 0.0036 0.0088 0.0012 0.0009 0.0097 0.0453 0.0028
Punctate Nuclear 0.0094 0.0012 0.0027 0.0014 0.0011 0.0009 0.0039 0.0007 0.0031 0.0052 0.0012 0.0009 0.0179 0.0008 0.0006 0.0028 0.0132 0.0012
Vacuole 0.021 0.0067 0.0098 0.006 0.007 0.0074 0.0088 0.0086 0.0075 0.0112 0.0082 0.0039 0.0051 0.0071 0.0095 0.009 0.0347 0.0036
Vacuole Periphery 0.0029 0.0022 0.0023 0.0008 0.0011 0.0021 0.0027 0.0015 0.0021 0.0024 0.0022 0.0016 0.0023 0.0013 0.003 0.0028 0.0058 0.0017

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 13.2593 11.3377 7.6482 11.8605 12.7066 12.6758 12.7662 12.8365 12.3915 14.3745
Translational Efficiency 0.5576 0.8589 0.8923 0.6162 0.5806 0.9885 0.8873 0.8904 0.9307 0.6755

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
107 1015 2657 89 2565 1403 3163 190 2672 2418 5820 279

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 694.08 754.57 886.50 1005.37 797.15 768.59 974.64 926.48 793.02 762.70 934.40 951.65
Standard Deviation 94.07 130.50 102.69 115.74 85.46 106.93 116.68 99.97 88.17 117.60 118.91 111.49
Intensity Change Log 2 — 0.120553 0.353019 0.534553 — -0.052637 0.290018 0.216909 — 0.030565 0.319684 0.373480

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001624 0.000905 0.000425 0.001676 0.000364 0.000836 0.000342 0.003330 0.000414 0.000865 0.000380 0.002802
Bud Neck 0.023879 0.012182 0.014466 0.004771 0.012092 0.014993 0.009025 0.006279 0.012564 0.013813 0.011509 0.005798
Bud Site 0.028607 0.028291 0.015530 0.039358 0.008767 0.023087 0.018348 0.030829 0.009562 0.025271 0.017061 0.033550
Cell Periphery 0.000230 0.000107 0.000042 0.000167 0.000069 0.000109 0.000033 0.000117 0.000075 0.000108 0.000037 0.000133
Cytoplasm 0.155394 0.157209 0.570846 0.169023 0.224340 0.173598 0.600851 0.196764 0.221579 0.166719 0.587153 0.187915
Cytoplasmic Foci 0.495458 0.457739 0.141859 0.183017 0.452872 0.390542 0.097256 0.270044 0.454577 0.418749 0.117618 0.242283
Eisosomes 0.000484 0.000128 0.000024 0.000096 0.000190 0.000117 0.000018 0.000094 0.000201 0.000122 0.000021 0.000095
Endoplasmic Reticulum 0.002885 0.001723 0.000950 0.003524 0.003193 0.001140 0.000339 0.002450 0.003181 0.001385 0.000618 0.002792
Endosome 0.083746 0.123740 0.018031 0.032350 0.072482 0.148359 0.018139 0.099873 0.072933 0.138025 0.018090 0.078333
Golgi 0.051649 0.068971 0.002925 0.007355 0.064924 0.058240 0.001388 0.005403 0.064392 0.062745 0.002090 0.006025
Lipid Particles 0.025763 0.013271 0.002831 0.003210 0.018238 0.009402 0.002069 0.008787 0.018540 0.011026 0.002417 0.007008
Mitochondria 0.029351 0.016925 0.003019 0.000051 0.018530 0.021772 0.002001 0.000198 0.018963 0.019738 0.002465 0.000151
Mitotic Spindle 0.000901 0.012495 0.047609 0.013915 0.002565 0.013771 0.040841 0.067257 0.002498 0.013235 0.043931 0.050241
None 0.000177 0.002195 0.002434 0.000204 0.000555 0.001246 0.000959 0.000272 0.000540 0.001645 0.001632 0.000250
Nuclear Periphery 0.000132 0.000325 0.001018 0.000402 0.000173 0.000251 0.000561 0.000732 0.000171 0.000282 0.000770 0.000627
Nuclear Periphery Foci 0.000517 0.001453 0.001372 0.003816 0.000484 0.000459 0.000457 0.008753 0.000485 0.000876 0.000875 0.007178
Nucleolus 0.000230 0.001616 0.001404 0.000092 0.000520 0.001405 0.000555 0.000700 0.000508 0.001493 0.000943 0.000506
Nucleus 0.008331 0.007277 0.086571 0.040557 0.012151 0.007193 0.027190 0.019661 0.011998 0.007228 0.054299 0.026327
Peroxisomes 0.024919 0.019797 0.008704 0.031090 0.009048 0.016379 0.005996 0.047779 0.009684 0.017814 0.007232 0.042455
Vacuole 0.058467 0.064553 0.078884 0.465091 0.089793 0.104017 0.172352 0.229810 0.088539 0.087452 0.129681 0.304864
Vacuole Periphery 0.007260 0.009097 0.001057 0.000234 0.008651 0.013082 0.001279 0.000867 0.008595 0.011409 0.001178 0.000665

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.75 1.27 0.81 0.26 -1.33 -2.58 1.35 -5.33 -4.04 -5.48 -3.73 0.97 -5.30 -3.79 -5.50
Bud Neck 1.75 1.32 3.19 8.59 12.75 -2.33 5.76 6.24 6.42 1.83 -1.28 1.75 9.14 9.20 8.94
Bud Site 0.02 1.45 1.37 3.47 -0.04 -8.71 -4.14 -5.43 -1.37 -4.36 -11.32 -4.51 -5.28 0.38 -3.86
Cell Periphery 2.34 3.72 3.16 2.22 -1.44 -2.61 15.46 -4.55 -0.66 -8.10 -3.07 12.56 -2.89 0.37 -7.36
Cytoplasm -0.20 -24.11 -1.81 -1.94 14.03 6.67 -47.83 1.15 -1.56 19.43 8.73 -56.52 1.16 -2.48 23.96
Cytoplasmic Foci 1.70 17.14 18.16 28.27 5.95 8.54 77.48 15.93 10.91 -10.40 5.97 74.50 23.88 20.35 -5.94
Eisosomes 3.11 4.02 3.80 7.70 -3.54 5.48 19.67 7.76 1.46 -9.90 6.86 18.79 10.50 4.33 -10.08
Endoplasmic Reticulum 0.82 1.30 1.23 1.15 0.02 5.23 8.64 0.31 -4.28 -6.91 4.98 7.78 1.74 -2.91 -5.52
Endosome -4.06 7.29 7.74 21.65 2.33 -15.61 30.32 -0.32 7.15 -6.87 -17.64 30.45 2.68 11.43 -6.09
Golgi -1.89 5.77 5.94 18.94 2.00 2.24 31.75 25.06 18.27 -1.93 0.82 31.87 28.07 25.57 -1.08
Lipid Particles 2.05 3.91 4.01 8.59 1.58 7.52 17.87 7.98 0.77 -7.87 6.62 17.84 11.16 5.01 -6.77
Mitochondria 1.81 4.02 4.45 9.26 13.84 -1.48 16.66 18.27 11.94 4.99 -0.37 16.74 18.84 15.08 11.93
Mitotic Spindle -6.20 -17.31 -1.67 -0.54 2.86 -5.93 -15.05 -5.64 -4.59 -2.58 -7.77 -22.15 -5.72 -4.41 -1.05
None -2.93 -11.36 -2.43 2.24 6.81 -1.72 -2.72 1.65 2.35 4.78 -2.90 -6.84 0.86 3.30 9.20
Nuclear Periphery -2.23 -13.92 -6.34 -3.52 3.44 -2.34 -14.87 -6.97 -6.33 -0.64 -2.68 -19.81 -8.43 -6.97 0.69
Nuclear Periphery Foci -2.36 -4.05 -4.86 -2.39 -2.46 0.13 -0.40 -5.15 -5.17 -5.13 -1.86 -3.16 -5.54 -5.27 -5.18
Nucleolus -3.06 -11.79 2.00 3.21 13.07 -3.34 -2.64 -1.95 1.83 -0.65 -3.92 -7.91 -0.92 3.40 4.48
Nucleus 0.28 -25.07 -2.15 -2.37 10.92 4.05 -23.01 -2.69 -3.69 3.82 5.02 -36.39 -3.18 -4.39 10.79
Peroxisomes 1.12 3.80 2.26 1.91 -0.29 -7.04 7.83 -4.43 -3.15 -5.24 -8.93 5.75 -3.99 -2.10 -4.78
Vacuole -0.04 -2.19 -18.15 -19.76 -18.83 -3.24 -30.58 -10.90 -9.93 -3.22 0.04 -22.58 -17.09 -17.05 -12.63
Vacuole Periphery -1.26 4.82 5.50 13.21 12.31 -4.59 18.01 18.91 14.37 0.44 -3.92 19.06 20.13 18.84 3.11
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Cis-golgi GTPase-activating protein (GAP) for yeast Rabs; the Rab family members are Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion
Localization
Cell Percentages cytoplasm (54%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-3

Gyp1

Gyp1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Gyp1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available