Standard name
Human Ortholog
Description Exomer-dependent cargo protein; induces appearance of [PIN+] prion when overproduced; prion-like domain serves as a retention signal in the trans-Golgi network; predicted to be palmitoylated
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.46 0.24 0.35 0.3 0.12 0.12 0.09 0.11 0.09 0.07 0.11 0.1 0.27 0.19 0.15 0.07 0.15 0.11 0.19 0.14 0.2 0.11 0.14 0.09
Bud 0.12 0.17 0.13 0.12 0 0.06 0.07 0.07 0.1 0.07 0.08 0.08 0.09 0 0.05 0 0 0 0.11 0.11 0.09 0.12 0.11 0.06
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.12 0.15 0.12 0.06
Bud Site 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.23 0.38 0.32 0.49 0.55 0.58 0.63 0.55 0.61 0.64 0.61 0.59 0.39 0.65 0.64 0.22 0.11 0.21 0 0.07 0 0.12 0.12 0.16
Endoplasmic Reticulum 0.35 0.18 0.2 0.06 0.06 0.08 0 0 0 0.05 0.09 0 0.36 0.19 0.16 0 0.05 0.07 0.15 0.09 0.12 0.08 0.15 0.17
Endosome 0 0 0 0 0.08 0.11 0.11 0.12 0.06 0.09 0.05 0.12 0 0 0 0.22 0.21 0.12 0.05 0.06 0.06 0.07 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.21 0.15 0.05 0 0 0 0 0
Mitochondria 0 0.21 0 0 0 0 0 0 0.07 0 0.06 0.08 0.07 0 0 0.09 0.05 0.05 0.05 0.09 0.06 0.06 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0.09 0.07 0 0 0 0 0 0 0 0 0 0 0 0.07 0.07 0.12 0 0 0 0 0 0
Vac/Vac Membrane 0.12 0.05 0.1 0.05 0.27 0.17 0.17 0.21 0.16 0.15 0.13 0.16 0 0 0 0.37 0.37 0.4 0.29 0.31 0.24 0.22 0.29 0.35
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 12 37 108 95 46 58 59 80 43 47 46 57 12 25 24 12 23 17 16 28 93 10 29 17
Bud 3 26 39 39 16 28 45 56 47 48 32 47 4 6 8 1 1 3 9 23 41 11 22 11
Bud Neck 0 0 7 1 1 0 0 1 0 0 0 0 0 1 0 0 0 0 3 16 54 13 24 10
Bud Site 0 3 5 17 0 6 6 0 4 4 1 3 0 1 0 0 0 0 – – – – – –
Cell Periphery 0 1 6 6 3 3 6 7 6 5 9 5 1 8 5 3 3 4 0 0 3 0 1 0
Cytoplasm 6 59 98 157 211 283 434 416 301 430 256 345 17 88 105 38 17 31 3 15 17 11 24 31
Endoplasmic Reticulum 9 28 62 19 22 38 20 30 22 31 37 24 16 26 26 7 7 11 13 19 57 7 30 32
Endosome 0 0 4 14 31 54 75 87 31 64 22 68 1 2 7 37 31 18 4 12 27 6 5 6
Golgi 0 1 2 1 2 1 1 0 0 2 0 0 0 0 0 15 32 22 4 4 12 2 0 2
Mitochondria 1 33 0 6 0 2 5 6 36 28 24 47 3 0 2 16 8 7 4 18 26 5 5 7
Nucleus 0 1 3 0 0 5 5 4 3 3 5 5 0 0 0 0 1 1 0 1 0 0 0 1
Nuclear Periphery 0 0 0 0 0 0 1 3 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 1
Nucleolus 0 0 0 1 0 1 2 4 1 1 3 4 0 0 1 3 2 4 0 0 0 0 0 0
Peroxisomes 0 0 4 10 1 6 14 4 0 5 1 2 0 2 2 1 0 1 0 0 3 0 0 0
SpindlePole 0 0 28 23 12 11 13 20 6 13 5 11 0 3 7 12 10 18 0 0 2 0 0 0
Vac/Vac Membrane 3 8 30 15 103 81 120 159 77 104 53 94 0 0 0 62 55 60 25 64 112 20 60 68
Unique Cell Count 26 156 311 319 386 488 689 750 490 674 422 584 44 135 165 169 150 150 87 210 465 94 208 196
Labelled Cell Count 34 197 396 404 448 577 806 877 577 785 494 712 54 162 187 207 190 197 87 210 465 94 208 196


Cell Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.9 5.7 8.3 7.7 8.4 7.5 7.7 7.9 6.6 7.4 7.3 7.3 6.8 7.4 6.4 8.4 10.4 11.6 10.6 10.8 10.6
Std Deviation (1e-4) 1.4 0.9 1.4 1.5 1.4 1.4 1.4 1.2 1.2 1.2 1.2 1.3 1.2 3.1 1.4 1.4 1.8 2.6 8.1 8.4 7.8
Intensity Change (Log2) – – – -0.1 0.03 -0.14 -0.11 -0.08 -0.32 -0.16 -0.19 -0.18 -0.3 -0.17 -0.37 0.02 0.33 0.48 0.35 0.39 0.36


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -1.3 -7.2 -7.8 -10.3 -9.3 -9.2 -11.1 -7.8 -9.2 -1.0 -3.4 -4.7 -6.7 -4.3 -5.3
Bud -0.1 -4.1 -3.4 -3.2 -2.6 -1.3 -2.8 -2.2 -2.2 -0.7 -2.6 -2.7 -4.5 -4.2 -3.7
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 2.5 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0.2 0 0 0 0 0 0 0
Cytoplasm 4.5 6.1 7.3 9.2 7.1 8.3 9.4 7.8 7.9 0.9 6.6 6.7 -2.1 -4.7 -2.4
Endoplasmic Reticulum -5.2 -5.7 -5.1 -9.1 -8.4 -7.0 -7.7 -4.4 -7.6 2.5 -0.2 -1.1 -4.7 -4.3 -3.5
Endosome 2.3 4.1 5.2 5.2 5.5 3.4 4.7 2.8 5.4 0 0 0 7.7 7.4 5.1
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 4.7 8.0 6.4
Mitochondria 0 0 0 0 0 4.9 3.6 4.3 5.1 0 0 0 5.5 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 1.6 0 0 0.8 0 0 0 0 0 0 0 0 0 0 0
SpindlePole -0.8 -3.3 -4.3 -5.3 -4.5 -5.3 -5.2 -5.0 -5.0 0 -2.6 -1.9 -0.7 -0.9 1.0
Vacuole -2.4 5.7 2.8 3.2 4.5 2.5 2.5 1.2 2.7 0 -3.7 -4.1 7.2 7.0 7.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.4634 6.1182 5.5416 5.4354 5.0954 6.0426 5.481 6.9288 6.011 6.2296 5.5214 6.6209 3.3537 3.9002 3.8501 3.7583 4.0424 4.1797
Actin 0.122 0.0117 0.0826 0.0923 0.0464 0.0259 0.0612 0.0655 0.0699 0.093 0.1755 0.0374 0.0823 0.0123 0.0381 0.0479 0.0383 0.0238
Bud 0.0289 0.0119 0.1687 0.0604 0.0301 0.0065 0.0154 0.0167 0.1056 0.0693 0.0468 0.0067 0.0448 0.0215 0.188 0.0868 0.0155 0.0035
Bud Neck 0.0305 0.0075 0.0094 0.0132 0.0595 0.5829 0.0716 0.0169 0.0033 0.0059 0.0105 0.4514 0.0218 0.009 0.0049 0.0065 0.1525 0.4386
Bud Periphery 0.0901 0.013 0.3865 0.3111 0.0962 0.0174 0.0533 0.0132 0.2092 0.2411 0.1526 0.0233 0.101 0.0445 0.3594 0.2387 0.1066 0.0096
Bud Site 0.0997 0.3028 0.0498 0.0069 0.0172 0.0105 0.144 0.3257 0.0459 0.0105 0.0234 0.0098 0.0779 0.2235 0.0367 0.0245 0.0042 0.0042
Cell Periphery 0.0404 0.0114 0.0059 0.0085 0.0068 0.0089 0.026 0.0073 0.0115 0.0094 0.018 0.0111 0.0171 0.0171 0.0055 0.0058 0.0115 0.0069
Cytoplasm 0.298 0.3681 0.1177 0.247 0.1969 0.1526 0.1831 0.2757 0.1849 0.0997 0.2058 0.2738 0.3513 0.3139 0.1765 0.2049 0.316 0.2614
Cytoplasmic Foci 0.0425 0.0556 0.0178 0.0131 0.0397 0.0364 0.0496 0.062 0.0496 0.0277 0.0535 0.0367 0.0309 0.0458 0.0178 0.0205 0.0592 0.0515
Eisosomes 0.0014 0.0003 0.0002 0.0002 0.0011 0.0001 0.0035 0.0004 0.0005 0.0003 0.0007 0.0003 0.0007 0.0002 0.0001 0.0002 0.0001 0.0001
Endoplasmic Reticulum 0.026 0.0076 0.0039 0.0077 0.0108 0.0053 0.0141 0.0122 0.0069 0.0138 0.0071 0.0068 0.0229 0.0117 0.0045 0.0223 0.0052 0.015
Endosome 0.0466 0.0987 0.0529 0.098 0.1262 0.0557 0.0954 0.1317 0.1612 0.1758 0.203 0.0692 0.0889 0.1213 0.0537 0.1311 0.149 0.0885
Golgi 0.0281 0.0177 0.0203 0.0206 0.0894 0.054 0.0411 0.0427 0.0395 0.0498 0.042 0.0349 0.0276 0.0265 0.0088 0.0225 0.0253 0.0271
Lipid Particles 0.0165 0.0059 0.0024 0.0034 0.0604 0.0058 0.0424 0.0026 0.0043 0.0352 0.0164 0.002 0.0137 0.0076 0.0017 0.0019 0.0285 0.0051
Mitochondria 0.0115 0.0014 0.0077 0.0046 0.0412 0.0072 0.0588 0.0038 0.0271 0.017 0.0154 0.0045 0.0034 0.0027 0.0032 0.0067 0.0071 0.0042
None 0.0499 0.0341 0.0044 0.0129 0.0572 0.0017 0.0677 0.0012 0.0238 0.0348 0.002 0.0043 0.0443 0.033 0.0109 0.0014 0.036 0.0129
Nuclear Periphery 0.0076 0.0013 0.0015 0.0019 0.0039 0.0068 0.0107 0.0008 0.0019 0.0023 0.0012 0.0006 0.0115 0.0029 0.0018 0.0034 0.0008 0.0047
Nucleolus 0.0009 0.0008 0.0005 0.0002 0.0011 0.0003 0.0016 0.0003 0.0008 0.001 0.0002 0.0002 0.0006 0.0014 0.0004 0.0005 0.0003 0.0002
Nucleus 0.0027 0.0025 0.0014 0.0013 0.0014 0.0013 0.003 0.001 0.0017 0.0016 0.0007 0.0009 0.0051 0.0032 0.0024 0.0024 0.0013 0.0009
Peroxisomes 0.0074 0.0015 0.0033 0.0003 0.0322 0.0018 0.0236 0.0026 0.0027 0.0047 0.0031 0.0013 0.0016 0.0017 0.0008 0.0013 0.0066 0.002
Punctate Nuclear 0.0184 0.001 0.0009 0.0002 0.0081 0.0034 0.0059 0.0005 0.0009 0.0005 0.0007 0.0003 0.0015 0.0011 0.0013 0.0005 0.0006 0.0005
Vacuole 0.0287 0.0419 0.0489 0.0763 0.0641 0.0131 0.0218 0.0152 0.0404 0.0927 0.0173 0.022 0.0472 0.0923 0.0725 0.1457 0.0308 0.0362
Vacuole Periphery 0.0022 0.0031 0.0133 0.02 0.0101 0.0025 0.0061 0.0019 0.0088 0.0139 0.0041 0.0024 0.0039 0.007 0.0111 0.0247 0.0047 0.0031

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 14.2962 9.2945 18.1044 15.7045 11.7954 9.0925 20.851 22.5961 17.7959 16.0303
Translational Efficiency 0.8347 1.935 1.0766 1.0672 1.0459 1.6672 0.8008 0.9265 1.2766 1.1218

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2116 493 1696 1376 1669 2403 2099 1584 3785 2896 3795 2960

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 859.25 923.95 1109.17 1185.13 793.24 1034.32 1105.74 1277.14 830.14 1015.53 1107.27 1234.37
Standard Deviation 104.13 191.33 143.79 212.47 102.34 125.61 150.56 196.34 108.42 145.06 147.58 209.09
Intensity Change Log 2 — 0.104737 0.368331 0.463895 — 0.382853 0.479183 0.687087 — 0.244938 0.422607 0.575347

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.012642 0.034050 0.122804* 0.085927 0.016109 0.030175 0.071717 0.070138 0.014171 0.030834 0.094548 0.077478
Bud Neck 0.073797 0.038937 0.057549 0.056470 0.063125 0.070587 0.087750 0.048528 0.069091 0.065199 0.074253 0.052220
Bud Site 0.241781* 0.315434* 0.523491* 0.436752* 0.189333* 0.358474* 0.574108* 0.502679* 0.218654* 0.351147* 0.551487* 0.472032*
Cell Periphery 0.002598 0.010822 0.010277 0.172000* 0.002555 0.004825 0.025262 0.122738* 0.002579 0.005846 0.018565 0.145638*
Cytoplasm 0.206901* 0.157566* 0.095616 0.101122* 0.213073* 0.159963* 0.115603* 0.095770 0.209623* 0.159555* 0.106670* 0.098258
Cytoplasmic Foci 0.139756 0.184303* 0.049378 0.015007 0.234273* 0.117403 0.026945 0.019432 0.181433* 0.128792 0.036971 0.017375
Eisosomes 0.001215 0.000779 0.000947 0.004468 0.002329 0.001751 0.001089 0.002195 0.001706 0.001586 0.001026 0.003251
Endoplasmic Reticulum 0.004936 0.005279 0.019200 0.007080 0.004959 0.003408 0.006508 0.007029 0.004946 0.003726 0.012180 0.007053
Endosome 0.114721 0.105298 0.028215 0.027611 0.076247 0.079360 0.018091 0.032718 0.097756 0.083776 0.022616 0.030344
Golgi 0.061557 0.061180 0.021555 0.016351 0.099386 0.083826 0.004207 0.020881 0.078238 0.079971 0.011960 0.018775
Lipid Particles 0.008147 0.008927 0.015414 0.031386 0.017127 0.005920 0.008911 0.025283 0.012107 0.006432 0.011817 0.028120
Mitochondria 0.019466 0.005703 0.004039 0.003033 0.020395 0.031852 0.001705 0.003134 0.019875 0.027400 0.002748 0.003087
Mitotic Spindle 0.000276 0.000717 0.004359 0.001940 0.001593 0.000952 0.002485 0.003596 0.000857 0.000912 0.003323 0.002826
None 0.000068 0.002035 0.000056 0.000189 0.000364 0.000107 0.000166 0.000052 0.000199 0.000435 0.000117 0.000116
Nuclear Periphery 0.000021 0.000158 0.000054 0.000071 0.000041 0.000031 0.000060 0.000080 0.000030 0.000053 0.000057 0.000076
Nuclear Periphery Foci 0.000108 0.000443 0.001046 0.000475 0.000267 0.000193 0.000749 0.000543 0.000178 0.000235 0.000881 0.000511
Nucleolus 0.000163 0.000618 0.000040 0.000054 0.000337 0.000338 0.000046 0.000045 0.000239 0.000386 0.000043 0.000049
Nucleus 0.001344 0.004093 0.003459 0.003981 0.003482 0.001158 0.003388 0.000958 0.002286 0.001658 0.003420 0.002363
Peroxisomes 0.012599 0.011757 0.009842 0.005652 0.017109 0.014508 0.006468 0.004667 0.014588 0.014039 0.007976 0.005125
Vacuole 0.083725 0.043058 0.030760 0.026563 0.031360 0.025731 0.043874 0.034530 0.060634 0.028681 0.038014 0.030827
Vacuole Periphery 0.014180 0.008844 0.001898 0.003865 0.006538 0.009438 0.000867 0.005005 0.010810 0.009337 0.001328 0.004475

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.70 -21.87 -16.32 -8.22 5.52 -6.58 -15.84 -14.74 -10.38 0.12 -9.30 -26.91 -22.16 -14.56 4.09
Bud Neck 5.96 4.04 4.06 -3.00 0.14 -1.57 -4.58 3.40 5.54 8.88 1.05 -1.08 5.60 3.98 7.02
Bud Site -4.84 -28.11* -17.80 -7.20 6.81 -18.87 -39.83* -29.73* -13.54 5.70 -18.25 -47.76 -33.27 -14.05 8.89
Cell Periphery -4.19 -8.54 -21.95 -20.23 -20.85 -4.21 -12.99 -20.32 -19.91 -15.95 -6.26 -15.22 -29.79 -28.97 -25.96
Cytoplasm 5.09 17.47 15.52 5.53 -0.74 7.91 13.79 17.16 11.30 3.97 9.98 21.72 23.33 12.68 2.45
Cytoplasmic Foci -4.58 20.92 33.00 18.33 12.01 20.00 39.05 41.29 28.60 3.88 12.32 42.47 51.06 34.79 11.26
Eisosomes 2.75 2.17 -6.11 -6.97 -6.77 2.07 5.15 0.48 -1.71 -5.23 0.69 5.34 -5.24 -5.64 -8.33
Endoplasmic Reticulum -0.31 -8.64 -2.48 -1.49 7.11 2.18 -2.03 -2.20 -4.48 -0.42 2.34 -8.46 -3.31 -5.42 5.72
Endosome 1.24 24.60 22.06 10.72 0.27 -0.85 18.94 12.40 13.85 -5.55 4.29 31.23 24.95 18.47 -4.01
Golgi 0.07 14.25 15.16 9.23 2.08 3.29 26.28 19.26 17.54 -8.37 -0.53 29.95 24.03 20.75 -4.47
Lipid Particles -0.51 -4.97 -7.02 -6.08 -4.29 8.51 5.13 -2.99 -7.66 -6.05 6.88 -0.17 -7.61 -10.40 -7.26
Mitochondria 11.03 13.67 14.23 2.91 1.26 -5.87 14.77 12.45 17.74 -2.26 -5.05 20.69 18.85 18.25 -0.74
Mitotic Spindle -3.44 -6.21 -2.21 -1.61 2.63 1.80 -1.81 -2.16 -2.99 -0.71 -0.26 -5.75 -3.28 -3.22 1.09
None -1.02 0.66 -3.18 0.93 -3.36 2.33 1.29 2.95 1.73 1.14 -0.71 1.02 1.23 0.91 -0.19
Nuclear Periphery -1.90 -6.36 -4.91 1.12 -0.87 1.12 -1.93 -2.01 -2.46 -0.35 -1.68 -4.23 -4.20 -1.45 -0.66
Nuclear Periphery Foci -3.26 -9.13 -3.62 -0.18 4.77 0.90 -6.07 -3.80 -3.58 2.86 -0.89 -10.94 -5.46 -3.24 5.42
Nucleolus -1.23 2.17 1.86 1.51 -1.45 -0.07 1.37 1.39 1.62 0.85 -0.83 1.98 1.93 2.04 -0.70
Nucleus -1.38 -5.12 -4.11 -0.60 -0.42 4.81 -0.63 6.40 0.60 7.33 1.34 -4.88 -1.54 -2.22 2.14
Peroxisomes 0.71 3.02 9.25 5.51 5.08 2.52 10.99 13.88 12.77 2.66 0.73 10.07 16.44 13.87 5.43
Vacuole 7.64 12.85 14.26 3.22 2.41 2.73 -6.22 -1.61 -3.96 4.32 13.44 6.20 11.04 -1.78 5.00
Vacuole Periphery 4.35 19.79 11.48 3.93 -2.83 -4.17 14.69 1.93 4.81 -5.74 2.26 24.35 10.26 6.76 -6.25
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Exomer-dependent cargo protein; induces appearance of [PIN+] prion when overproduced; prion-like domain serves as a retention signal in the trans-Golgi network; predicted to be palmitoylated
Localization
Cell Percentages vacuole (28%), ER (11%), mixed (21%)
Cell Cycle Regulation Yes
vacuole - S/G2 (0.0002)
Subcompartmental Group N/A

Pin2

Pin2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pin2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available