Standard name
Human Ortholog
Description Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.42 0.44 0.52 0.43 0.45 0.18 0.23 0.21 0.14 – 0.14 0.15 0.44 0.34 0.29 0.39 0.43 0.39 0.31 0.26 0.24 0.32 0.48 0.48
Bud 0.16 0.07 0.18 0.14 0.16 0.07 0.05 0.07 0.09 – 0 0.08 0.14 0.1 0.07 0.16 0.15 0.12 0 0 0 0.09 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 – – – – – –
Cell Periphery 0 0.12 0.06 0.05 0.13 0.07 0.09 0.09 0 – 0 0.05 0.16 0.23 0.23 0.14 0.13 0.08 0 0 0.07 0.1 0.13 0.12
Cytoplasm 0.07 0.07 0 0.08 0.12 0.15 0.2 0.19 0.18 – 0.16 0.16 0.12 0.1 0.13 0.15 0.07 0.15 0 0 0 0 0 0
Endoplasmic Reticulum 0.17 0.37 0.21 0.19 0.29 0.46 0.45 0.44 0.29 – 0.24 0.29 0.36 0.46 0.48 0.05 0 0 0.4 0.45 0.36 0.21 0.19 0.17
Endosome 0 0 0.06 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0.18 0 0.08 0.06 0 0 0 0 – 0 0 0 0.05 0 0.17 0.22 0.2 0 0.05 0 0 0 0
Mitochondria 0.42 0.07 0.22 0.62 0.12 0.33 0.31 0.15 0.56 – 0.54 0.5 0.3 0.07 0.1 0.08 0.07 0.09 0.05 0 0.11 0.05 0.07 0.06
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.14 0.14 0.14 0 0 0 0 0 0
Vac/Vac Membrane 0.09 0.1 0.12 0 0.09 0.05 0.06 0.11 0.06 – 0.08 0.08 0 0 0 0.14 0.17 0.15 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 56 72 35 16 57 19 40 31 20 – 13 16 52 44 44 131 126 77 59 61 27 13 77 75
Bud 21 11 12 5 20 8 8 11 13 – 3 8 16 13 11 54 44 24 8 9 3 3 2 1
Bud Neck 0 0 0 0 0 0 0 1 0 – 0 0 0 0 0 0 5 0 7 8 4 2 3 2
Bud Site 2 1 1 0 0 1 1 1 0 – 0 0 0 1 0 3 3 10 – – – – – –
Cell Periphery 4 19 4 2 17 7 15 13 6 – 1 5 19 30 34 47 39 15 2 9 7 4 21 18
Cytoplasm 10 11 3 3 15 16 34 28 26 – 15 17 14 13 20 52 21 29 1 1 0 0 0 0
Endoplasmic Reticulum 23 61 14 7 36 49 78 66 42 – 22 30 42 59 72 16 10 8 77 105 41 9 30 27
Endosome 5 2 4 0 4 2 7 4 1 – 1 0 4 2 0 10 8 5 6 6 4 0 2 5
Golgi 6 30 1 3 7 0 0 0 0 – 0 0 5 6 4 57 63 39 3 10 3 0 3 6
Mitochondria 56 12 15 23 15 35 54 23 80 – 50 53 35 9 15 28 21 17 8 6 12 2 11 8
Nucleus 0 2 3 0 0 0 2 3 1 – 1 0 0 0 2 4 1 3 0 0 0 0 0 0
Nuclear Periphery 0 0 1 0 0 1 0 0 2 – 1 2 0 0 1 0 0 0 0 0 2 0 0 0
Nucleolus 4 3 1 0 0 1 0 0 0 – 2 0 1 0 0 10 10 4 0 0 0 0 0 0
Peroxisomes 3 2 2 0 2 0 0 0 0 – 0 0 6 5 3 6 9 6 2 0 3 0 4 5
SpindlePole 6 0 1 0 5 0 0 0 0 – 1 1 1 1 1 49 42 27 6 1 1 1 1 0
Vac/Vac Membrane 12 17 8 0 11 5 10 16 8 – 7 8 0 1 3 49 50 30 6 10 2 0 1 1
Unique Cell Count 134 165 67 37 126 107 174 150 144 92 105 118 128 150 340 291 196 192 236 116 43 163 158
Labelled Cell Count 208 243 105 59 189 144 249 197 199 117 140 195 184 210 516 452 294 192 236 116 43 163 158


Punctate Nuclear

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 10.1 12.8 8.1 7.9 9.2 7.2 7.4 7.4 6.5 – 6.0 6.4 10.0 10.2 10.1 13.2 14.1 13.1 – 9.5 10.2
Std Deviation (1e-4) 2.3 2.6 1.7 1.2 1.3 1.2 1.3 1.1 1.1 – 1.0 1.2 1.6 2.0 2.0 3.0 3.0 3.3 – 1.5 1.9
Intensity Change (Log2) – – – -0.05 0.19 -0.18 -0.13 -0.13 -0.33 – -0.44 -0.34 0.3 0.33 0.32 0.7 0.8 0.7 – 0.23 0.33


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -0.9 -0.9 -4.8 -4.4 -4.7 -5.9 – -5.2 -5.2 -1.1 -2.4 -3.2 -2.1 -1.3 -1.9
Bud -0.6 -0.4 -2.1 -3.4 -2.3 -1.9 – -3.1 -2.1 -0.8 -1.5 -2.3 -0.4 -0.6 -1.2
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 0 1.6 0 0.7 0.7 0 – 0 0 2.0 3.1 3.0 1.8 1.7 0
Cytoplasm 0 1.7 2.2 2.9 2.8 2.7 – 2.3 2.3 1.7 1.4 2.0 2.4 0 2.2
Endoplasmic Reticulum -0.2 1.2 3.3 3.4 3.3 1.3 – 0.4 1.1 2.1 3.5 3.8 0 0 -4.3
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 3.3 3.9 3.6
Mitochondria 4.0 -1.9 1.5 1.3 -1.3 4.5 – 4.0 3.7 1.1 -3.1 -2.4 -3.4 -3.7 -3.0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 2.9 2.9 2.8
Vacuole 0 -0.7 -1.8 -1.6 -0.3 -1.6 – -0.9 -1.0 0 0 0 0.5 1.0 0.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.7705 6.0946 5.9176 6.2924 5.9857 6.2256 7.9191 8.356 7.9895 7.7378 8.19 8.2358 7.6999 7.4976 7.3234 7.0956 7.0198 7.6572
Actin 0.1954 0.1421 0.2691 0.1418 0.1785 0.1622 0.1802 0.1201 0.2187 0.0634 0.1284 0.1238 0.1632 0.1485 0.178 0.1037 0.104 0.0994
Bud 0.006 0.0052 0.0255 0.0048 0.0033 0.003 0.0037 0.0068 0.0289 0.0139 0.0019 0.0023 0.0087 0.0074 0.0335 0.0072 0.0042 0.0021
Bud Neck 0.0145 0.0159 0.0164 0.05 0.011 0.1191 0.0153 0.0144 0.0149 0.0392 0.0255 0.0969 0.0132 0.0124 0.0115 0.0573 0.0435 0.0983
Bud Periphery 0.0294 0.0149 0.1237 0.0373 0.0128 0.0174 0.0124 0.0194 0.1188 0.0544 0.0118 0.0152 0.0335 0.0185 0.1419 0.0458 0.0324 0.0141
Bud Site 0.0237 0.1686 0.042 0.0051 0.0102 0.0053 0.0294 0.1464 0.0699 0.0232 0.0071 0.0029 0.0283 0.1528 0.0775 0.0053 0.0039 0.0045
Cell Periphery 0.0712 0.0764 0.0779 0.0846 0.036 0.0659 0.0732 0.0935 0.1022 0.1538 0.0809 0.0847 0.0766 0.083 0.0973 0.0903 0.1023 0.0815
Cytoplasm 0.042 0.0662 0.0287 0.0497 0.0331 0.0267 0.0552 0.0614 0.0289 0.0636 0.0318 0.0443 0.0476 0.0949 0.0308 0.0352 0.042 0.0431
Cytoplasmic Foci 0.0269 0.0153 0.0139 0.0142 0.0112 0.0191 0.0243 0.0202 0.0116 0.0073 0.0097 0.0144 0.0299 0.0363 0.0107 0.0108 0.0198 0.0174
Eisosomes 0.0205 0.0104 0.0347 0.0196 0.0642 0.0121 0.0231 0.0243 0.0176 0.0247 0.0351 0.0127 0.0225 0.0107 0.0124 0.0341 0.0308 0.0266
Endoplasmic Reticulum 0.2546 0.2673 0.1711 0.3482 0.2107 0.277 0.3096 0.3036 0.2324 0.3495 0.3561 0.3749 0.2777 0.213 0.2192 0.4332 0.2325 0.3262
Endosome 0.0566 0.0403 0.0366 0.0535 0.058 0.0554 0.0645 0.034 0.0282 0.0661 0.0455 0.0397 0.0499 0.0414 0.0266 0.0294 0.0549 0.045
Golgi 0.0906 0.0641 0.0716 0.0934 0.189 0.1369 0.0724 0.0749 0.0485 0.0349 0.1547 0.097 0.0803 0.0681 0.0566 0.0804 0.1267 0.1159
Lipid Particles 0.0804 0.0578 0.0294 0.0304 0.0483 0.0334 0.0483 0.0373 0.0138 0.0093 0.0543 0.0257 0.0781 0.0595 0.0367 0.0156 0.0308 0.0497
Mitochondria 0.0364 0.0188 0.0367 0.029 0.088 0.0343 0.0133 0.0184 0.0344 0.0532 0.0245 0.0432 0.0381 0.0211 0.0432 0.0306 0.1102 0.0419
None 0.0115 0.0031 0.0019 0.0019 0.0023 0.0017 0.0047 0.0016 0.0034 0.0048 0.0017 0.0013 0.009 0.0021 0.0018 0.0018 0.0077 0.0019
Nuclear Periphery 0.01 0.0084 0.0054 0.0074 0.0187 0.0069 0.0337 0.0062 0.0067 0.0085 0.0105 0.0045 0.0097 0.0071 0.0059 0.0042 0.01 0.0076
Nucleolus 0.0008 0.0008 0.0004 0.0004 0.0009 0.0022 0.0009 0.0005 0.0006 0.0005 0.0004 0.0003 0.001 0.0015 0.0005 0.0004 0.0008 0.0044
Nucleus 0.0021 0.0017 0.001 0.0015 0.0029 0.0023 0.0065 0.0011 0.0017 0.0015 0.0035 0.001 0.0018 0.0024 0.0013 0.0009 0.0025 0.0019
Peroxisomes 0.006 0.001 0.0014 0.0014 0.0009 0.0033 0.0043 0.0012 0.0058 0.0005 0.0006 0.0024 0.0064 0.0018 0.0012 0.0009 0.0243 0.0016
Punctate Nuclear 0.0015 0.0011 0.0005 0.0004 0.0013 0.0017 0.0061 0.0009 0.0006 0.0003 0.0005 0.0003 0.0038 0.001 0.0006 0.0003 0.0016 0.0016
Vacuole 0.0164 0.0172 0.0097 0.0201 0.0123 0.0097 0.0136 0.012 0.0097 0.0188 0.0121 0.0091 0.0172 0.0148 0.0107 0.0103 0.011 0.0112
Vacuole Periphery 0.0036 0.0033 0.0024 0.0053 0.0062 0.0044 0.0054 0.0016 0.0026 0.0087 0.0034 0.0031 0.0031 0.0018 0.0023 0.0026 0.0042 0.0039

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 55.6199 53.7408 47.1 49.2679 50.3261 53.4602 66.638 60.7864 55.0188 56.9763
Translational Efficiency 1.1683 1.1473 1.0424 1.1602 0.9513 1.0437 0.9203 0.8372 0.9239 0.8829

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1588 1826 449 1511 1047 1559 1584 1492 2635 3385 2033 3003

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 937.22 1012.25 1474.54 1273.51 922.95 1025.95 1319.64 1319.36 931.55 1018.56 1353.85 1296.29
Standard Deviation 143.65 154.53 194.11 188.39 210.70 165.54 171.18 204.42 173.56 159.84 187.83 197.85
Intensity Change Log 2 — 0.111106 0.653805 0.442351 — 0.152636 0.515820 0.515514 — 0.131861 0.586990 0.479115

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.065258 0.132532* 0.221311* 0.231079* 0.121993* 0.179108* 0.228404* 0.104285* 0.087802 0.153983* 0.226838* 0.168083*
Bud Neck 0.039989 0.009110 0.066594 0.031866 0.014138 0.024468 0.049463 0.054222 0.029717 0.016183 0.053247 0.042973
Bud Site 0.160806* 0.102277* 0.104430* 0.289167* 0.089789 0.112190* 0.281358* 0.210834* 0.132588* 0.106843* 0.242283* 0.250249*
Cell Periphery 0.008166 0.049911 0.040826 0.014226 0.051319 0.069594 0.018703 0.012659 0.025313 0.058977 0.023589 0.013447
Cytoplasm 0.011418 0.021614 0.002032 0.019853 0.013105 0.018660 0.013764 0.035313 0.012088 0.020254 0.011173 0.027534
Cytoplasmic Foci 0.421372* 0.065777 0.010280 0.228623* 0.056447 0.044605 0.194163* 0.393274* 0.276371* 0.056026 0.153552 0.310427*
Eisosomes 0.001469 0.006918 0.019298 0.002646 0.009669 0.013610 0.005394 0.002311 0.004727 0.010000 0.008465 0.002479
Endoplasmic Reticulum 0.014770 0.364578* 0.360575* 0.038920 0.314143* 0.252583* 0.066997 0.005136 0.133724* 0.312997* 0.131836* 0.022135
Endosome 0.039991 0.057824 0.041790 0.015943 0.103076 0.063216 0.025195 0.014510 0.065057 0.060307 0.028860 0.015231
Golgi 0.026674 0.042162 0.018660 0.009877 0.070012 0.037218 0.008438 0.010922 0.043894 0.039885 0.010695 0.010396
Lipid Particles 0.052147 0.048801 0.083528 0.038337 0.085835 0.078520 0.042661 0.021003 0.065533 0.062489 0.051687 0.029725
Mitochondria 0.007455 0.031914 0.002760 0.004307 0.021230 0.022696 0.003815 0.018628 0.012928 0.027669 0.003582 0.011422
Mitotic Spindle 0.002936 0.000880 0.002168 0.007987 0.001104 0.000696 0.009819 0.002876 0.002208 0.000795 0.008129 0.005448
None 0.000677 0.000294 0.000220 0.000116 0.001005 0.000459 0.000091 0.000316 0.000807 0.000370 0.000120 0.000215
Nuclear Periphery 0.000064 0.000104 0.000473 0.000087 0.000559 0.000132 0.000117 0.000031 0.000261 0.000117 0.000196 0.000059
Nuclear Periphery Foci 0.003586 0.000732 0.001969 0.000953 0.004270 0.000784 0.001250 0.000299 0.003858 0.000756 0.001409 0.000628
Nucleolus 0.000268 0.000363 0.000023 0.000042 0.000265 0.000051 0.000037 0.000057 0.000266 0.000219 0.000034 0.000050
Nucleus 0.000482 0.000645 0.006033 0.000226 0.000911 0.000678 0.000262 0.003067 0.000652 0.000660 0.001536 0.001637
Peroxisomes 0.139267* 0.055843 0.002373 0.062189 0.029302 0.074861 0.046512 0.108900* 0.095573 0.064602 0.036764 0.085397
Vacuole 0.002317 0.002886 0.013590 0.002865 0.006103 0.002776 0.003196 0.001084 0.003821 0.002835 0.005491 0.001980
Vacuole Periphery 0.000889 0.004837 0.001067 0.000692 0.005724 0.003095 0.000360 0.000273 0.002811 0.004035 0.000517 0.000484

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -11.09 -11.27 -18.74 -10.49 -0.63 -6.50 -10.78 2.08 8.85 13.00 -12.87 -18.77 -13.00 -2.04 7.10
Bud Neck 13.57 -4.74 2.99 -14.13 6.43 -4.54 -14.07 -11.64 -8.02 -1.20 7.87 -9.46 -5.83 -13.41 3.82
Bud Site 8.46 6.00 -14.08 -22.82 -17.93 -3.31 -22.62* -14.40 -12.06 7.37 5.11 -15.60 -18.43 -24.65 -1.01
Cell Periphery -15.55 -8.59 -3.44 12.29 6.70 -4.13 9.25 11.01 16.90 2.89 -13.80 0.93 6.71 20.61 5.72
Cytoplasm -8.56 5.99 -5.62 0.75 -9.12 -3.78 -0.67 -9.65 -7.19 -9.49 -8.85 0.74 -11.32 -5.24 -11.15
Cytoplasmic Foci 38.71* 43.72 16.15 -20.12 -26.12 3.09 -17.30 -33.50 -35.34 -16.28 32.86 13.72 -3.82 -38.82 -17.83
Eisosomes -12.89 -6.12 -3.62 9.49 5.71 -3.18 3.88 7.37 13.44 4.75 -9.02 -4.13 5.06 16.32 7.33
Endoplasmic Reticulum -44.39* -21.15 -5.81 38.56* 19.34 4.98 22.57 30.85 33.81* 13.13 -24.36 0.39 20.81 50.90* 18.11
Endosome -5.53 -0.42 8.31 18.44 7.68 8.08 16.79 19.24 17.02 4.61 1.64 12.76 19.10 24.91 7.58
Golgi -6.06 2.99 8.19 14.59 3.65 7.99 16.67 16.00 12.52 -2.24 1.75 16.84 17.26 19.30 0.27
Lipid Particles 0.88 -3.82 2.93 2.60 5.61 1.23 7.50 11.75 13.44 5.68 0.92 3.47 10.15 11.28 6.29
Mitochondria -11.61 3.76 2.52 13.19 -1.23 -0.55 8.05 0.90 1.56 -7.15 -9.09 8.27 1.01 9.68 -6.50
Mitotic Spindle 5.18 1.24 -3.80 -5.47 -4.25 1.66 -7.02 -2.34 -2.91 4.63 5.49 -5.99 -4.20 -6.17 2.06
None 1.46 1.38 2.10 4.75 0.73 1.85 3.60 2.66 0.85 -4.86 2.18 3.53 3.08 1.93 -2.02
Nuclear Periphery -6.27 -11.21 -3.01 1.58 10.43 1.78 1.83 2.19 11.10 8.32 1.52 0.64 2.09 9.23 11.52
Nuclear Periphery Foci 8.03 4.18 6.65 -1.39 3.70 4.04 2.93 4.60 5.57 2.34 7.74 4.37 7.84 1.05 2.32
Nucleolus -0.28 4.32 4.12 0.96 -0.70 2.79 2.93 2.63 -0.38 -0.94 0.24 5.16 4.78 0.94 -1.08
Nucleus -1.03 -2.46 2.00 4.30 2.51 1.18 3.46 -2.61 -2.88 -3.29 -0.00 -2.11 -2.44 -2.47 0.82
Peroxisomes 14.03 25.44 12.02 -1.29 -16.03 -10.95 -4.64 -14.47 -5.52 -10.75 7.54 14.08 2.25 -5.38 -12.46
Vacuole -1.52 -4.64 -1.62 -0.22 4.38 4.26 3.77 6.96 3.76 6.02 2.58 -2.68 4.85 2.67 5.70
Vacuole Periphery -10.05 -0.67 0.71 11.56 1.75 3.45 7.61 7.74 9.54 1.50 -3.20 7.21 7.15 15.10 0.37
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
Localization
Cell Percentages ER (39%), peroxisome (21%), mixed (6%)
Cell Cycle Regulation Yes
peroxisome - MA (4.4e-10)
Subcompartmental Group N/A

Sey1

Sey1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sey1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available