Standard name
Human Ortholog
Description Kinetochore-associated protein; required for chromosome segregation and kinetochore clustering; required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0.06 0.05 – 0.08 0.07 0 0 0 0 0 0 0 0 0 0 0 0.06
Bud Neck 0 0 0 0 0 0 0 0.05 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0.05 0.06 0 0.08 0 0 0.13 – 0.19 0.1 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.05 0.05 0.06 0.05 0.11 0.08 – 0.06 0.06 0.05 0.09 0.11 0.08 0.07 0.08 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0.06 0 0 0 0 0 0 0 – 0 0 0.11 0.21 0.1 0.18 0.25 0.28 0.08 0.11 0.1 0.07 0.05 0.07
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.05 0.16 0.05 0 0 0.1 0.11 0.08 0.24 – 0.17 0.13 0.1 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.05 0.05 0 0.06 0.05 0.05 0.07 0.07 0.09 – 0.08 0.09 0 0.1 0.14 0.13 0.15 0.1 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.67 0.4 0.25 0.28 0.38 0.35 0.33 0.26 0.31 – 0.29 0.29 0.63 0.46 0.43 0.55 0.59 0.56 0 0.07 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0.12 0.09 0 0.05 0 0 0 0 0.05 0 0
SpindlePole 0.82 0.65 0.87 0.81 0.82 0.79 0.75 0.7 0.6 – 0.69 0.71 0.6 0.53 0.45 0.51 0.59 0.5 0.81 0.65 0.76 0.73 0.74 0.64
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 2 1 0 0 0 4 0 – 0 1 0 0 0 0 0 0 0 0 1 0 1 2
Bud 0 6 3 2 7 7 10 24 14 – 28 20 2 0 0 1 1 0 0 5 1 5 11 15
Bud Neck 1 7 10 4 4 6 14 18 7 – 15 12 0 1 0 0 0 0 1 4 1 3 2 5
Bud Site 1 10 14 13 13 20 18 14 33 – 65 30 9 2 6 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 1 2 0 – 0 1 0 0 1 0 0 1 0 0 0 0 0 0
Cytoplasm 0 12 9 11 14 15 21 45 20 – 19 18 14 39 36 18 15 11 0 2 0 1 2 5
Endoplasmic Reticulum 0 1 0 0 1 0 1 0 0 – 0 0 0 0 1 2 3 3 0 0 0 0 3 1
Endosome 2 23 5 6 3 3 2 1 0 – 0 0 31 94 33 38 55 39 7 41 31 14 16 20
Golgi 0 0 1 0 0 0 0 0 0 – 0 0 0 0 0 3 0 1 0 7 1 0 2 2
Mitochondria 3 56 14 7 7 26 47 32 62 – 57 38 27 6 7 8 6 6 0 12 3 1 5 9
Nucleus 3 17 12 12 16 12 28 29 23 – 26 27 10 44 46 29 32 14 1 6 4 2 11 7
Nuclear Periphery 0 4 0 0 0 0 1 0 1 – 1 0 0 0 0 2 0 0 0 1 0 0 1 0
Nucleolus 40 143 70 57 117 89 139 104 82 – 96 87 173 203 146 119 130 78 2 26 10 4 5 3
Peroxisomes 2 11 4 1 1 4 2 4 2 – 3 0 7 54 29 4 10 5 0 6 2 10 7 9
SpindlePole 49 232 247 163 254 200 310 278 157 – 232 209 164 234 154 109 130 70 73 258 234 149 270 178
Vac/Vac Membrane 0 5 0 0 1 0 0 2 0 – 0 0 0 4 1 6 6 4 0 4 3 1 8 11
Unique Cell Count 60 357 283 201 309 252 415 395 262 336 295 273 442 340 215 219 140 91 395 308 206 365 280
Labelled Cell Count 101 528 391 277 438 382 594 557 401 542 443 437 681 460 339 388 232 91 395 308 206 365 280


SpindlePole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.3 5.1 5.6 5.3 6.0 4.7 4.9 5.3 4.1 – 3.8 4.4 5.1 5.4 5.4 8.9 9.2 8.8 4.7 4.8 4.8
Std Deviation (1e-4) 1.3 1.0 1.1 1.4 1.5 1.2 1.3 1.8 1.3 – 1.2 1.3 1.3 1.3 1.7 1.9 2.5 1.9 1.3 1.7 1.5
Intensity Change (Log2) – – – -0.07 0.1 -0.26 -0.19 -0.07 -0.45 – -0.55 -0.35 -0.12 -0.06 -0.06 0.68 0.72 0.66 -0.24 -0.2 -0.21

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 1.3 3.3 0 – 0 0 0 0 0 0 0 0
Bud Neck -1.0 -1.8 0 -0.1 0.7 0 – 0 0 0 0 0 0 0 0
Bud Site 0.7 -0.4 0 -0.4 -0.9 0 – 0 0 -1.0 -4.0 -2.2 -3.3 -3.3 0
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cytoplasm 1.2 0.8 1.5 1.2 3.9 2.3 – 1.5 1.7 1.2 3.0 3.6 2.5 1.9 2.1
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 4.6 7.5 4.1 6.3 8.0 8.3
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria -0.8 -1.8 0 2.9 1.6 0 – 0 0 2.2 -2.9 -2.0 -0.7 -1.3 -0.3
Nucleus 0.9 0.5 0.3 1.4 1.7 2.2 – 1.8 2.4 -0.3 2.8 4.0 3.7 4.1 2.3
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0.9 3.4 0 2.5 0.5 0 – 0 0 9.2 5.7 4.8 7.0 7.9 6.3
Peroxisomes 0 0 0 0 0 0 – 0 0 1.0 5.2 3.9 0 2.1 0
SpindlePole -1.9 -1.7 0 -4.1 -5.2 0 – 0 0 -7.3 -9.5 -10.9 -9.0 -7.2 -8.3
Vacuole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.8115 3.7413 3.373 2.7924 2.8384 2.585 0.5621 2.1828 1.7958 1.4923 1.4337 1.1088 -0.8091 0.4858 0.5091 0.7243 0.2324 -0.3977
Actin 0.0181 0 0.0166 0.0143 0.0002 0.0007 0.0127 0 0.0012 0.0001 0.0003 0.0044 0.0062 0 0.0002 0 0.0017 0.0002
Bud 0.0005 0 0.0002 0.0001 0 0 0.0001 0 0 0 0 0 0.0006 0.0001 0.0011 0 0.0001 0.0003
Bud Neck 0.0022 0.0003 0.0014 0.0002 0.0001 0.0045 0.001 0.0004 0.0002 0.0001 0.0002 0.0001 0.0006 0.0004 0.0009 0 0.0016 0.0069
Bud Periphery 0.0013 0 0.0005 0.0001 0 0.0001 0.0001 0 0.0001 0 0 0 0.0014 0.0003 0.0018 0 0.0003 0.0012
Bud Site 0.0046 0.0001 0.002 0.0005 0 0.0001 0.0019 0.0008 0.0002 0.0001 0.0001 0 0.0013 0.0013 0.0068 0 0.0005 0.0002
Cell Periphery 0.0004 0 0.0002 0 0 0 0.0001 0 0 0 0 0 0.0004 0.0002 0.0006 0 0.0003 0.0011
Cytoplasm 0.0017 0 0.0007 0.0001 0.0001 0.0004 0.0009 0 0.0039 0 0.0002 0 0.0053 0.0004 0.0007 0.0004 0.0004 0.001
Cytoplasmic Foci 0.0538 0.0022 0.0159 0.0138 0.0307 0.0058 0.0377 0.0067 0.0107 0.0195 0.0297 0.0027 0.0438 0.0588 0.0139 0.0387 0.0223 0.0331
Eisosomes 0.0012 0 0.0015 0.0001 0 0.0002 0.0002 0 0 0 0 0.0008 0.0033 0.0002 0.001 0 0.0004 0.0001
Endoplasmic Reticulum 0.0005 0 0.0006 0.0001 0 0.0002 0.0004 0 0.0006 0 0.0001 0 0.0004 0 0.0001 0 0.0006 0
Endosome 0.0063 0.0001 0.0057 0.0009 0.0005 0.0022 0.0052 0.0002 0.0071 0.0002 0.0047 0.0007 0.0037 0.0029 0.0002 0.0001 0.0061 0.0008
Golgi 0.0051 0.0001 0.0026 0.0013 0.0015 0.0007 0.0025 0.0003 0.002 0.0004 0.0035 0.0011 0.0013 0.0008 0.0002 0.0001 0.0058 0.0005
Lipid Particles 0.0331 0.0012 0.0148 0.0149 0.0323 0.0077 0.0228 0.0061 0.0183 0.0052 0.0469 0.0029 0.011 0.0194 0.0029 0.0034 0.1739 0.0151
Mitochondria 0.0128 0 0.0187 0.0067 0 0.0021 0.0011 0 0.0055 0 0.0008 0.0025 0.0017 0.0015 0.0011 0 0.0021 0.0006
None 0.0388 0 0.0087 0.0003 0.0001 0.0088 0.0069 0 0.0012 0 0.0002 0.0001 0.069 0.0961 0.0589 0.0024 0.0018 0.1069
Nuclear Periphery 0.0023 0.0002 0.0038 0.0006 0.0031 0.0019 0.0011 0.0024 0.0018 0.0009 0.0044 0.0021 0.0035 0.0002 0.0004 0.0002 0.0082 0.0005
Nucleolus 0.0124 0.0572 0.0223 0.0241 0.0041 0.0158 0.0145 0.036 0.0142 0.0028 0.0033 0.0064 0.0131 0.0496 0.0399 0.0019 0.037 0.0162
Nucleus 0.0166 0.0191 0.0045 0.0024 0.0005 0.0067 0.0053 0.0177 0.0043 0.0006 0.0008 0.0022 0.0229 0.0095 0.0171 0.0008 0.006 0.005
Peroxisomes 0.0136 0.0001 0.0063 0.023 0.0105 0.0019 0.0121 0.0016 0.0033 0.0005 0.0191 0.0015 0.0042 0.011 0.0018 0.0003 0.012 0.0126
Punctate Nuclear 0.7727 0.9193 0.8709 0.8963 0.9162 0.9397 0.8724 0.9276 0.925 0.9696 0.8855 0.9722 0.8055 0.7452 0.8503 0.9516 0.7174 0.7971
Vacuole 0.0013 0 0.0011 0 0 0.0002 0.0008 0 0.0003 0 0.0001 0 0.0006 0.0018 0.0003 0 0.001 0.0004
Vacuole Periphery 0.0006 0 0.001 0.0001 0 0.0003 0.0002 0 0.0002 0 0.0001 0 0.0002 0.0003 0 0 0.0007 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 38.9279 27.9993 6.233 12.0196 32.4875 32.1984 19.3115 12.5563 11.47 33.2088
Translational Efficiency 2.7733 1.7276 1.9458 1.6981 1.9715 2.6093 1.6548 1.3601 1.2989 1.6825

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2006 1360 306 160 1849 1943 161 2631 3855 3303 467 2791

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 684.96 817.19 1103.71 1143.42 700.28 799.05 996.22 1090.50 692.31 806.52 1066.65 1093.53
Standard Deviation 84.43 119.67 151.15 188.04 101.18 104.20 116.46 208.98 93.16 111.19 149.19 208.20
Intensity Change Log 2 — 0.254652 0.688270 0.739264 — 0.190354 0.508532 0.638986 — 0.222505 0.600205 0.689442

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000295 0.000404 0.000270 0.000291 0.000543 0.000355 0.000516 0.000332 0.000414 0.000375 0.000355 0.000329
Bud Neck 0.004807 0.004444 0.001805 0.003923 0.003345 0.004196 0.002087 0.003573 0.004105 0.004298 0.001902 0.003593
Bud Site 0.004606 0.004289 0.001730 0.002838 0.003800 0.002977 0.001361 0.003123 0.004219 0.003517 0.001602 0.003107
Cell Periphery 0.000312 0.000128 0.000021 0.000051 0.000266 0.000103 0.000135 0.000069 0.000290 0.000113 0.000060 0.000068
Cytoplasm 0.021793 0.011037 0.000274 0.000446 0.026335 0.002638 0.006291 0.001401 0.023972 0.006096 0.002348 0.001346
Cytoplasmic Foci 0.062913 0.023011 0.001630 0.008598 0.055365 0.022263 0.006105 0.005760 0.059292 0.022571 0.003173 0.005923
Eisosomes 0.000103 0.000082 0.000017 0.000019 0.000093 0.000079 0.000067 0.000027 0.000098 0.000080 0.000034 0.000027
Endoplasmic Reticulum 0.001437 0.001634 0.000825 0.000256 0.001879 0.001388 0.002035 0.000432 0.001649 0.001489 0.001242 0.000422
Endosome 0.003876 0.005314 0.000309 0.002572 0.005730 0.005835 0.001541 0.000566 0.004765 0.005621 0.000734 0.000681
Golgi 0.006475 0.004718 0.000347 0.002503 0.009654 0.005375 0.000619 0.000833 0.008000 0.005105 0.000441 0.000928
Lipid Particles 0.015230 0.011702 0.000310 0.000218 0.011910 0.013495 0.003069 0.000281 0.013638 0.012757 0.001261 0.000277
Mitochondria 0.003343 0.002008 0.000180 0.001381 0.002324 0.005227 0.001249 0.001339 0.002854 0.003902 0.000549 0.001341
Mitotic Spindle 0.530255 0.639873 0.937284 0.898290 0.544842 0.749871 0.657414 0.888612 0.537252 0.704580 0.840798 0.889167
None 0.025763 0.007887 0.000112 0.000494 0.025755 0.002530 0.009073 0.001430 0.025759 0.004735 0.003202 0.001377
Nuclear Periphery 0.000694 0.000970 0.000279 0.000407 0.000602 0.000709 0.000651 0.000744 0.000650 0.000817 0.000407 0.000725
Nuclear Periphery Foci 0.092830 0.087264 0.004786 0.000906 0.108865 0.072602 0.013133 0.006728 0.100521 0.078639 0.007664 0.006394
Nucleolus 0.143849 0.107675 0.020690 0.041494 0.122429 0.063001 0.046238 0.048077 0.133575 0.081396 0.029498 0.047700
Nucleus 0.055912 0.069902 0.024009 0.018657 0.055451 0.031335 0.238432 0.027365 0.055691 0.047215 0.097932 0.026865
Peroxisomes 0.024563 0.015136 0.003384 0.008543 0.019311 0.014368 0.003798 0.008551 0.022044 0.014684 0.003527 0.008551
Vacuole 0.000654 0.002035 0.001656 0.005119 0.001213 0.001084 0.005907 0.000562 0.000922 0.001476 0.003121 0.000823
Vacuole Periphery 0.000289 0.000487 0.000083 0.002993 0.000289 0.000570 0.000278 0.000196 0.000289 0.000536 0.000150 0.000356

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.95 -5.62 -2.87 -1.96 1.54 0.99 -4.94 -2.81 -4.10 4.16 -2.29 -7.07 -5.86 -3.95 5.33
Bud Neck -2.04 -4.34 -3.01 -2.57 -1.14 -1.95 -3.18 -7.35 -5.02 -0.98 -2.52 -5.47 -7.31 -5.35 0.05
Bud Site -0.41 -1.90 -1.67 -1.48 -0.28 1.08 -1.56 -2.19 -2.85 0.31 0.71 -2.50 -1.75 -2.08 1.36
Cell Periphery 5.33 9.02 2.52 0.46 -1.14 6.11 1.39 7.44 2.52 2.46 8.31 7.39 9.86 3.64 1.11
Cytoplasm 1.92 8.21 8.92 5.08 0.42 7.42 4.25 7.75 1.27 2.31 7.14 9.06 11.03 4.43 1.01
Cytoplasmic Foci 12.05 20.86 11.46 2.87 -2.55 9.92 13.95 16.28 9.02 -0.47 15.75 25.83 24.00 11.07 -3.52
Eisosomes 7.12 16.00 17.18 11.38 1.71 5.46 1.57 24.90 17.58 7.06 9.17 12.09 32.09 22.43 6.92
Endoplasmic Reticulum -4.24 -2.95 0.91 1.95 3.00 2.11 -4.23 10.13 8.15 6.14 -1.13 -4.36 10.45 10.60 6.27
Endosome -0.05 11.59 2.30 2.16 -0.94 2.03 6.29 13.65 10.06 3.40 1.31 12.59 18.26 12.18 3.55
Golgi 8.70 21.80 9.25 4.28 -0.97 8.30 15.78 18.75 14.38 3.93 12.00 26.95 26.81 17.41 1.89
Lipid Particles 2.41 11.38 11.79 7.30 2.58 -0.22 7.66 12.33 11.45 3.89 1.49 14.41 16.99 13.52 4.90
Mitochondria 0.58 3.38 -0.31 -0.57 -1.63 -2.04 0.45 -1.43 1.58 -1.43 -1.74 3.02 -1.05 1.23 -4.06
Mitotic Spindle -10.29 -17.86 -14.89 -9.06 -0.41 -17.37 -3.46 -35.87 -16.94 -7.92 -20.44 -15.06 -47.63 -24.18 -6.18
None 6.35 12.74 12.24 6.09 -1.89 9.66 3.33 10.89 3.64 2.06 11.88 10.33 15.54 5.98 1.33
Nuclear Periphery -1.54 -2.02 -1.41 -0.37 -0.09 -2.43 -2.39 -4.27 -3.09 -0.89 -2.40 -3.00 -4.20 -2.52 -1.06
Nuclear Periphery Foci 3.68 26.12 29.28 20.63 2.35 8.51 11.02 29.41 23.11 4.52 8.87 26.40 41.34 30.50 4.21
Nucleolus 5.86 11.98 8.47 4.91 -0.22 9.87 2.16 13.97 3.76 3.51 11.80 10.19 20.16 8.07 1.44
Nucleus -4.67 -4.24 -1.90 -0.39 1.63 2.47 -6.39 -3.08 -5.52 5.98 -1.54 -7.40 -4.13 -2.56 6.36
Peroxisomes 3.22 12.22 4.49 2.45 -2.08 2.95 6.55 8.87 6.24 0.10 4.60 13.76 12.83 8.00 -2.35
Vacuole -2.74 -4.27 -2.61 -2.09 0.94 -0.61 -2.75 -1.94 -0.92 2.61 -2.74 -5.06 -3.82 -0.68 4.57
Vacuole Periphery -1.64 -3.21 -1.57 -1.45 -1.47 -1.38 -2.48 -2.70 0.62 1.21 -1.99 -4.06 -2.60 -0.35 -0.64
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Kinetochore-associated protein; required for chromosome segregation and kinetochore clustering; required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate
Localization
Cell Percentages spindle pole (77%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Slk19

Slk19


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Slk19-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available