Standard name
Human Ortholog
Description Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; master regulator of cellular acetylation balance; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy; human ortholog TIP60/KAT5 is implicated in cancer and other diseases, functionally complements lethality of the esa1 null mutation
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0.05 0.06 0.09 0.12 0.07 0.06 0.06 0.06 0.08 0.07 0.05 0 0 0 0.11 0.14 0.11 0 0 0.05 0 0 0
Bud 0 0 0 0.07 0 0 0 0 0.06 0.05 0.09 0.05 0 0 0 0 0 0 0 0 0 0 0 0.05
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.07 0.09 0.06 0.05 0.07 0.09 0.06 0.09 0.1 0.13 0.06 0.05 0.09 0.32 0.35 0.37 0 0 0 0 0 0
Cytoplasm 0.41 0.57 0.34 0.44 0.46 0.22 0.19 0.22 0.28 0.24 0.38 0.33 0.5 0.66 0.76 0.46 0.49 0.38 0.09 0.16 0.05 0.21 0.29 0.31
Endoplasmic Reticulum 0.48 0.41 0.6 0.33 0.31 0.62 0.56 0.53 0.4 0.38 0.19 0.3 0.44 0.33 0.22 0 0 0 0.73 0.6 0.78 0.54 0.46 0.45
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.08 0.11 0 0 0 0 0 0
Mitochondria 0.15 0 0 0.27 0.19 0.26 0.31 0.24 0.25 0.33 0.37 0.34 0 0 0 0 0 0 0.05 0 0 0.07 0.05 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.07 0 0 0 0.06 0 0 0.07 0.09 0.08 0.09 0.06 0 0 0 0.12 0.06 0.14 0 0.07 0 0.07 0.06 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 5 2 12 12 20 16 22 18 18 31 18 20 6 5 1 19 20 15 8 3 11 3 12 17
Bud 5 1 4 9 7 2 14 10 18 21 24 20 1 2 1 5 6 1 10 3 4 2 7 19
Bud Neck 0 0 1 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 2 0 2 2 3 4
Bud Site 0 0 0 0 0 0 1 0 0 1 2 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 3 0 15 12 11 11 26 28 19 35 27 47 16 17 35 54 52 49 2 0 5 3 9 7
Cytoplasm 94 25 75 58 79 52 68 65 87 92 99 124 133 210 301 78 72 51 23 12 13 34 109 127
Endoplasmic Reticulum 110 18 131 44 53 146 198 158 124 145 50 111 117 106 88 4 4 4 196 48 196 89 172 186
Endosome 1 0 1 2 6 0 5 0 3 0 1 2 3 0 0 1 1 0 0 0 1 1 5 2
Golgi 1 0 1 0 5 0 0 0 0 0 0 0 0 0 0 8 12 14 2 0 1 0 0 1
Mitochondria 34 1 8 35 32 62 110 72 77 128 97 129 0 0 0 3 5 5 14 3 8 11 19 14
Nucleus 0 0 1 0 0 0 2 0 1 0 2 1 0 4 0 1 0 1 0 0 0 2 1 1
Nuclear Periphery 0 0 1 2 1 2 8 6 3 6 0 9 0 0 0 0 0 0 0 2 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 1 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 1 0 1 1 0 0 1 1 1 0 2 0 0 2 0 0 0 0 0 1 0 0
Vac/Vac Membrane 16 1 7 4 10 6 10 21 29 29 24 23 11 8 15 21 9 18 4 5 3 11 21 21
Unique Cell Count 229 44 218 132 172 237 354 299 308 384 262 374 265 319 394 170 147 133 271 80 251 166 373 410
Labelled Cell Count 269 48 258 179 226 299 464 378 381 489 346 487 289 352 442 196 181 158 271 80 251 166 373 410


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.0 7.9 6.6 6.7 8.2 8.8 8.3 8.0 7.9 7.5 7.1 7.0 8.5 7.5 6.8 18.3 19.4 20.6 8.3 8.2 8.1
Std Deviation (1e-4) 1.6 2.5 1.6 2.1 3.4 2.5 2.5 2.3 2.4 2.5 2.8 2.5 2.6 1.8 1.6 9.4 9.5 11.1 2.0 1.7 1.9
Intensity Change (Log2) – – – 0.02 0.3 0.41 0.34 0.28 0.26 0.18 0.11 0.09 0.37 0.19 0.04 1.47 1.55 1.64 0.33 0.3 0.29

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000102030WT3HU80HU120HU1600102030WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30102030WT1AF100AF140AF1800102030
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 1.3 2.2 0.6 0.3 0.2 0.2 1.2 0.6 -0.1 -1.9 -2.6 0 2.0 2.7 2.0
Bud 0 0 0 1.4 1.0 2.3 2.1 3.4 2.1 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0.8 -0.2 -1.0 0.2 1.0 -0.3 1.0 1.3 2.2 -0.4 -0.7 0.9 6.4 6.9 7.1
Cytoplasm 1.8 2.3 -3.0 -4.1 -3.2 -1.5 -2.8 0.8 -0.3 3.5 7.2 10.2 2.3 2.8 0.7
Endoplasmic Reticulum -4.9 -5.8 0.3 -1.0 -1.6 -4.5 -5.3 -9.2 -7.3 -3.5 -6.2 -9.3 -11.8 -11.1 -10.7
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 3.9 4.5
Mitochondria 6.3 4.8 6.6 7.9 6.3 6.5 8.4 8.8 8.6 0 0 0 0 -0.1 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 1.3 -0.4 -0.3 1.9 2.8 2.2 2.6 1.6 0.5 -0.5 0.4 3.5 1.3 3.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.2277 6.5775 4.7226 4.9375 3.705 7.0321 5.204 6.1648 4.3377 3.5555 2.7209 5.6702 4.8794 5.7095 3.2798 2.478 0.6044 5.0466
Actin 0.003 0.0043 0.006 0.0088 0.0088 0.0067 0.038 0.0063 0.0088 0.0224 0.0221 0.001 0.0235 0.002 0.0231 0.0513 0.0173 0.003
Bud 0.0002 0.0064 0.0014 0.0074 0.0029 0.0002 0.001 0.002 0.0018 0.0006 0.0049 0.0002 0.0004 0.0002 0.0004 0.0051 0.0017 0.0002
Bud Neck 0.0002 0.0006 0.0007 0.0024 0.0022 0.0021 0.0012 0.0007 0.0012 0.0012 0.0012 0.0093 0.0028 0.0002 0.0007 0.0035 0.0007 0.0033
Bud Periphery 0.0016 0.0161 0.0056 0.0088 0.0139 0.0008 0.004 0.0037 0.0083 0.001 0.0545 0.0008 0.0013 0.0009 0.0009 0.0089 0.0145 0.001
Bud Site 0.0011 0.0132 0.0036 0.006 0.0007 0.0026 0.0027 0.0207 0.013 0.0014 0.0023 0.0002 0.002 0.0012 0.0038 0.0043 0.0006 0.0002
Cell Periphery 0.0028 0.0133 0.0059 0.0093 0.0077 0.0025 0.0067 0.0075 0.005 0.0018 0.0026 0.0014 0.0023 0.0083 0.0033 0.005 0.0056 0.0019
Cytoplasm 0.1666 0.1775 0.2324 0.2117 0.3273 0.1431 0.1187 0.2565 0.2402 0.2269 0.2661 0.2328 0.09 0.161 0.1863 0.261 0.4732 0.1758
Cytoplasmic Foci 0.0136 0.0033 0.011 0.0083 0.0137 0.0065 0.013 0.0042 0.0097 0.0135 0.0117 0.0068 0.013 0.0029 0.0126 0.0257 0.0127 0.0071
Eisosomes 0.0002 0.0004 0.0004 0.0007 0.0008 0.0002 0.0019 0.0002 0.0002 0.0003 0.0003 0 0.0003 0.0001 0.0002 0.0007 0.0004 0
Endoplasmic Reticulum 0.6756 0.6554 0.5961 0.551 0.4791 0.7622 0.6279 0.602 0.583 0.6122 0.4061 0.689 0.7159 0.7772 0.6729 0.4552 0.2791 0.7453
Endosome 0.0183 0.005 0.0092 0.02 0.007 0.0119 0.059 0.0109 0.02 0.0227 0.0407 0.0097 0.0345 0.0051 0.0186 0.0237 0.0445 0.0147
Golgi 0.0035 0.0011 0.0024 0.0082 0.0029 0.004 0.0208 0.0013 0.0066 0.016 0.011 0.0008 0.0086 0.003 0.0036 0.0072 0.0067 0.0028
Lipid Particles 0.0271 0.0061 0.012 0.0107 0.0068 0.0054 0.03 0.0103 0.0129 0.0125 0.0437 0.0058 0.0192 0.012 0.0095 0.0116 0.0596 0.0098
Mitochondria 0.0039 0.0038 0.0009 0.0098 0.0028 0.0017 0.0254 0.0007 0.0083 0.006 0.0344 0.0006 0.0135 0.0046 0.002 0.0033 0.0073 0.0007
None 0.0618 0.0706 0.0893 0.0883 0.0862 0.0367 0.0066 0.0411 0.0402 0.0137 0.0161 0.0195 0.0199 0.0023 0.0329 0.0841 0.0376 0.0174
Nuclear Periphery 0.0107 0.0097 0.0103 0.0109 0.0051 0.0072 0.0166 0.0149 0.0137 0.0225 0.0154 0.0089 0.0258 0.0109 0.011 0.0154 0.0146 0.0073
Nucleolus 0.0002 0.0006 0.0002 0.0013 0.0005 0.0001 0.0005 0.0002 0.0003 0.0002 0.002 0.0001 0.0007 0 0.0002 0.0017 0.0005 0.0001
Nucleus 0.0015 0.0031 0.0021 0.0077 0.0026 0.0014 0.0034 0.0032 0.0061 0.0061 0.0254 0.0024 0.0036 0.0012 0.0019 0.0043 0.0023 0.0015
Peroxisomes 0.0029 0.0002 0.0005 0.0003 0.0164 0.0002 0.0056 0.0001 0.0058 0.0076 0.0104 0.0031 0.0103 0.0001 0.0021 0.0036 0.0071 0.0012
Punctate Nuclear 0.0013 0.0017 0.0016 0.016 0.0046 0.0005 0.0038 0.0012 0.0025 0.005 0.0091 0.0009 0.0041 0.0003 0.0066 0.0141 0.0076 0.001
Vacuole 0.0037 0.0071 0.0076 0.0099 0.0074 0.0036 0.0104 0.0098 0.0109 0.0052 0.0133 0.0061 0.006 0.006 0.0065 0.0089 0.0051 0.0052
Vacuole Periphery 0.0005 0.0006 0.0008 0.0026 0.0005 0.0005 0.0028 0.0023 0.0014 0.001 0.0069 0.0006 0.0023 0.0005 0.0008 0.0014 0.0014 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 14.844 13.2696 10.3937 16.7812 7.4845 9.8905 18.2619 16.6018 16.019 19.2911
Translational Efficiency 1.0241 1.0471 1.1689 0.9158 2.0703 1.6649 0.8871 0.8508 0.999 0.9484

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
71 255 173 763 1139 1001 228 2320 1210 1256 401 3083

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 806.56 913.97 1334.65 1084.15 809.23 884.61 1275.15 1281.26 809.07 890.57 1300.82 1232.48
Standard Deviation 166.13 146.46 223.43 324.34 138.03 127.94 241.46 332.77 139.84 132.44 235.70 341.47
Intensity Change Log 2 — 0.180365 0.726608 0.426711 — 0.128492 0.656045 0.662942 — 0.154619 0.691700 0.549851

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.004978 0.006884 0.002067 0.007950 0.001601 0.001721 0.001817 0.009234 0.001799 0.002769 0.001925 0.008916
Bud Neck 0.046384 0.007004 0.002426 0.016210 0.005002 0.007622 0.005045 0.023366 0.007430 0.007497 0.003915 0.021595
Bud Site 0.096555 0.030800 0.017711 0.085553 0.016501 0.013225 0.006724 0.071039 0.021198 0.016793 0.011464 0.074631
Cell Periphery 0.008518 0.002255 0.005193 0.003918 0.004264 0.002554 0.002493 0.008271 0.004514 0.002493 0.003658 0.007194
Cytoplasm 0.196577 0.201572 0.024947 0.254067 0.278058 0.271697 0.109800 0.292310 0.273277 0.257459 0.073192 0.282845
Cytoplasmic Foci 0.132970 0.100590 0.004084 0.079474 0.065715 0.099505 0.041095 0.037491 0.069661 0.099726 0.025127 0.047881
Eisosomes 0.000814 0.002430 0.000192 0.000440 0.001484 0.001298 0.000348 0.001069 0.001444 0.001528 0.000281 0.000914
Endoplasmic Reticulum 0.152303 0.426566 0.842457 0.191844 0.481298 0.388014 0.527378 0.242574 0.461993 0.395841 0.663310 0.230019
Endosome 0.039735 0.024287 0.010357 0.035473 0.008523 0.022379 0.015711 0.020659 0.010355 0.022766 0.013401 0.024325
Golgi 0.023814 0.015158 0.000916 0.014181 0.010921 0.018286 0.001304 0.008123 0.011678 0.017651 0.001137 0.009622
Lipid Particles 0.038202 0.035439 0.012703 0.048597 0.034293 0.047738 0.036468 0.055262 0.034522 0.045241 0.026216 0.053613
Mitochondria 0.044029 0.004846 0.000403 0.003781 0.005747 0.008508 0.000615 0.007056 0.007994 0.007764 0.000524 0.006246
Mitotic Spindle 0.011153 0.004249 0.001285 0.020371 0.000486 0.002569 0.000221 0.019083 0.001112 0.002910 0.000680 0.019402
None 0.010395 0.008373 0.000182 0.004583 0.005595 0.001574 0.001425 0.004003 0.005877 0.002955 0.000889 0.004147
Nuclear Periphery 0.003070 0.002705 0.005616 0.002367 0.002270 0.002378 0.011196 0.004580 0.002317 0.002445 0.008788 0.004032
Nuclear Periphery Foci 0.011667 0.020613 0.034502 0.036171 0.005520 0.006094 0.074033 0.019968 0.005880 0.009042 0.056978 0.023978
Nucleolus 0.017000 0.000309 0.000025 0.000773 0.000508 0.000486 0.000702 0.000517 0.001476 0.000450 0.000410 0.000580
Nucleus 0.078168 0.021417 0.007030 0.034936 0.040452 0.035313 0.070602 0.051796 0.042665 0.032492 0.043176 0.047623
Peroxisomes 0.016856 0.006383 0.000134 0.003144 0.004771 0.005040 0.002189 0.002452 0.005480 0.005313 0.001302 0.002623
Vacuole 0.051670 0.073124 0.027532 0.152130 0.025414 0.061263 0.090529 0.117702 0.026955 0.063671 0.063350 0.126222
Vacuole Periphery 0.015142 0.004995 0.000241 0.004039 0.001577 0.002735 0.000305 0.003443 0.002373 0.003194 0.000278 0.003591

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.69 1.41 -1.43 -0.39 -3.69 -0.27 -0.19 -10.05 -9.02 -5.53 -1.62 -0.32 -10.74 -7.34 -6.96
Bud Neck 2.46 2.75 1.88 -4.64 -7.99 -2.50 -0.01 -13.91 -11.07 -7.24 -0.06 2.02 -9.37 -11.87 -10.96
Bud Site 2.99 3.46 0.62 -6.36 -6.85 1.12 3.07 -13.95 -15.66 -16.48 1.40 2.21 -13.87 -16.82 -13.99
Cell Periphery 1.73 0.86 1.31 -1.54 1.01 2.63 1.78 -3.94 -6.60 -4.53 3.24 0.95 -2.67 -6.57 -3.06
Cytoplasm -0.20 5.58 -1.90 -3.03 -20.02 0.56 11.04 -2.32 -2.95 -13.47 1.50 17.94 -1.79 -3.69 -22.82
Cytoplasmic Foci 1.46 6.50 2.67 2.35 -16.80 -5.92 3.51 7.12 12.67 0.77 -5.68 9.07 5.50 11.86 -6.06
Eisosomes -1.11 2.42 1.57 1.41 -2.22 0.68 4.72 2.25 2.08 -5.41 -0.21 5.24 2.83 2.25 -6.44
Endoplasmic Reticulum -6.39 -17.35 -0.55 9.21 29.29 5.46 -0.95 20.03 12.84 10.73 4.20 -8.31 20.35 15.75 22.23
Endosome 2.25 4.44 0.94 -2.66 -8.21 -8.39 -4.58 -8.54 1.77 -1.70 -8.11 -2.44 -10.10 0.04 -5.98
Golgi 1.02 2.79 1.35 0.84 -6.11 -3.74 10.31 3.50 5.98 -7.08 -3.36 10.74 2.82 5.67 -9.57
Lipid Particles 0.31 2.59 -0.92 -2.22 -7.15 -3.96 -0.36 -5.23 -1.16 -2.52 -3.45 1.99 -5.39 -1.85 -6.00
Mitochondria 2.85 3.19 2.97 0.79 -2.63 -1.66 6.73 -0.40 1.42 -7.18 0.14 6.91 2.10 1.67 -7.84
Mitotic Spindle 0.80 1.52 -1.45 -3.68 -5.49 -2.88 1.02 -10.16 -8.73 -10.44 -2.39 0.68 -11.14 -9.50 -11.36
None 0.33 2.26 1.31 0.81 -2.51 4.27 3.60 1.71 -2.57 -2.09 2.20 5.07 1.91 -0.67 -3.56
Nuclear Periphery 0.23 -1.26 0.49 0.33 2.10 -0.12 -4.74 -2.47 -2.51 3.49 -0.15 -4.81 -2.15 -2.25 3.63
Nuclear Periphery Foci -1.23 -3.06 -4.02 -2.53 -0.18 -0.45 -8.21 -9.92 -8.37 6.39 -2.12 -9.45 -12.65 -8.12 5.97
Nucleolus 2.82 2.87 2.75 -1.95 -3.49 0.25 -0.74 -0.08 -0.50 0.77 2.69 2.67 2.32 -1.46 -1.20
Nucleus 3.05 3.82 2.24 -3.88 -7.69 1.68 -3.25 -5.04 -7.13 1.79 3.40 -0.34 -2.79 -7.69 -0.96
Peroxisomes 2.48 4.43 3.64 2.12 -7.22 -0.38 1.92 4.20 4.32 -0.10 0.09 4.62 4.99 4.70 -1.66
Vacuole -1.42 1.63 -8.30 -8.60 -14.55 -8.68 -6.94 -27.13 -15.51 -4.45 -9.43 -6.04 -30.98 -17.94 -11.31
Vacuole Periphery 1.98 3.00 2.31 0.97 -4.93 -3.02 4.99 -2.54 -0.37 -5.50 -1.58 5.44 -1.32 0.18 -7.10
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; master regulator of cellular acetylation balance; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy; human ortholog TIP60/KAT5 is implicated in cancer and other diseases, functionally complements lethality of the esa1 null mutation
Localization
Cell Percentages ER (85%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Esa1

Esa1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Esa1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available