| Standard name | |
|---|---|
| Human Ortholog | |
| Description | ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization |
Micrographs
Sub-cellular Localization
Yeast GFP Assignment
Protein Abundance
Localization Change
External localization resources
| ensLOC | DeepLoc | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
| Cortical Patches | 0 | – | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | – | – | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Bud | 0 | – | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 2 | 0 | 0 | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 |
| Bud Neck | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Bud Site | 0 | – | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 2 | 0 | – | – | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
| Cell Periphery | 0 | – | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | – | – | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cytoplasm | 2 | – | 2 | 2 | 5 | 3 | 22 | 9 | 4 | 6 | 2 | 2 | – | – | 7 | 45 | 39 | 31 | 1 | 0 | 0 | 0 | 0 | 3 |
| Endoplasmic Reticulum | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | 0 | 5 | 9 | 4 | 0 | 0 | 1 | 0 | 0 | 0 |
| Endosome | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | – | – | 0 | 1 | 4 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Golgi | 0 | – | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | – | – | 1 | 3 | 5 | 10 | 0 | 0 | 0 | 0 | 0 | 0 |
| Mitochondria | 0 | – | 0 | 0 | 0 | 1 | 1 | 0 | 4 | 3 | 1 | 4 | – | – | 0 | 8 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| Nucleus | 12 | – | 47 | 21 | 29 | 64 | 106 | 118 | 44 | 90 | 15 | 30 | – | – | 10 | 186 | 232 | 96 | 30 | 13 | 69 | 1 | 20 | 24 |
| Nuclear Periphery | 0 | – | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Nucleolus | 2 | – | 2 | 4 | 2 | 10 | 14 | 11 | 15 | 23 | 4 | 18 | – | – | 0 | 5 | 21 | 8 | 3 | 0 | 5 | 0 | 1 | 3 |
| Peroxisomes | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| SpindlePole | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Vac/Vac Membrane | 3 | – | 3 | 0 | 1 | 4 | 24 | 34 | 13 | 15 | 1 | 7 | – | – | 1 | 22 | 32 | 27 | 1 | 0 | 5 | 0 | 1 | 1 |
| Unique Cell Count | 16 | 52 | 27 | 36 | 77 | 163 | 164 | 75 | 131 | 23 | 54 | 19 | 261 | 325 | 162 | 40 | 15 | 85 | 2 | 25 | 35 | |||
| Labelled Cell Count | 19 | 54 | 28 | 37 | 82 | 170 | 176 | 83 | 139 | 26 | 61 | 19 | 277 | 344 | 179 | 40 | 15 | 85 | 2 | 25 | 35 | |||
Yeast GFP Assignment
Protein Abundance
| Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean Cell GFP Intensity (1e-4) | 19.3 | – | 27.4 | 25.4 | 26.4 | 23.1 | 23.4 | 24.1 | 21.7 | 21.8 | 21.9 | 19.1 | – | – | 26.1 | 33.5 | 32.9 | 33.8 | – | – | – |
| Std Deviation (1e-4) | 10.3 | – | 7.8 | 6.1 | 7.5 | 5.7 | 7.2 | 7.2 | 6.4 | 6.7 | 7.6 | 6.6 | – | – | 11.9 | 15.1 | 14.0 | 15.8 | – | – | – |
| Intensity Change (Log2) | – | – | – | -0.11 | -0.05 | -0.24 | -0.23 | -0.18 | -0.34 | -0.33 | -0.32 | -0.52 | – | – | -0.07 | 0.29 | 0.27 | 0.3 | – | – | – |
Localization Change
| Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 |
| Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 |
| Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 |
| Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 |
| Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 |
| Cytoplasm | 0 | 0 | 0 | 1.9 | 0 | 0 | 0 | 0 | 0 | – | – | 0 | 2.5 | 1.8 | 2.7 |
| Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 |
| Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 |
| Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 |
| Mitochondria | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 |
| Nucleus | -1.5 | -1.3 | -1.2 | -3.5 | -2.7 | -3.9 | -3.0 | -2.7 | -4.0 | – | – | -3.5 | -2.9 | -2.9 | -4.1 |
| Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 |
| Nucleolus | 0 | 0 | 0 | 0 | 0 | 2.6 | 2.4 | 0 | 3.9 | – | – | 0 | 0 | 0 | 0 |
| Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 |
| SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 |
| Vacuole | 0 | 0 | 0 | 1.7 | 2.5 | 1.9 | 1.2 | 0 | 0 | – | – | 0 | 0 | 0 | 2.0 |
External localization resources
Images
Protein Concentration and Protein Localization Data
| R1 | R2 | R3 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
| Concentration | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cytoplasmic Foci | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Eisosomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Lipid Particles | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| None | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Punctate Nuclear | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Vacuole Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Sequencing Data
| R1 | R2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
| Gene Expression | 91.9504 | 86.3267 | 97.4798 | 115.8793 | 91.4547 | 88.1228 | 102.4648 | 122.1771 | 125.8127 | 96.8333 |
| Translational Efficiency | 2.257 | 1.9746 | 2.0216 | 1.7808 | 1.8324 | 2.4987 | 1.9521 | 1.559 | 1.5909 | 1.7786 |
Hit Data
| Dataset | Hit |
|---|---|
| Protein Concentration | – |
| Protein Localization | – |
| Gene Expression | ✔ |
| Translational Efficiency | ✘ |
Micrographs
Cell Count
| R1 | R2 | R1 & R2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 |
| 33 | 123 | 1588 | 747 | 1079 | 97 | 1214 | 180 | 1112 | 220 | 2802 | 927 |
Protein Abundance
| R1 | R2 | R1 & R2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | |
| Mean | 1354.09 | 2333.90 | 2229.75 | 2215.34 | 1838.27 | 2120.12 | 2448.45 | 2356.11 | 1823.90 | 2239.64 | 2324.50 | 2242.67 |
| Standard Deviation | 623.90 | 558.97 | 528.92 | 604.15 | 461.29 | 443.88 | 554.97 | 673.87 | 474.11 | 522.33 | 551.12 | 620.81 |
| Intensity Change Log 2 | — | 0.785419 | 0.719558 | 0.710205 | — | 0.205797 | 0.413520 | 0.358058 | — | 0.480485 | 0.551330 | 0.518028 |
Localization Score (DeepLoc)
| R1 | R2 | R1 & R2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | |
| Actin | 0.000940 | 0.000640 | 0.000599 | 0.003866 | 0.000634 | 0.001554 | 0.000743 | 0.007169 | 0.000643 | 0.001043 | 0.000661 | 0.004508 |
| Bud Neck | 0.004746 | 0.004810 | 0.017594 | 0.030999 | 0.004064 | 0.014190 | 0.018679 | 0.027072 | 0.004084 | 0.008946 | 0.018064 | 0.030237 |
| Bud Site | 0.002487 | 0.000549 | 0.001441 | 0.007926 | 0.000237 | 0.002565 | 0.002030 | 0.014555 | 0.000303 | 0.001438 | 0.001697 | 0.009213 |
| Cell Periphery | 0.000690 | 0.000043 | 0.000116 | 0.001201 | 0.000090 | 0.000213 | 0.000184 | 0.001940 | 0.000108 | 0.000118 | 0.000145 | 0.001344 |
| Cytoplasm | 0.171273* | 0.000441 | 0.001029 | 0.004959 | 0.000349 | 0.000480 | 0.002540 | 0.004388 | 0.005422 | 0.000458 | 0.001684 | 0.004848 |
| Cytoplasmic Foci | 0.015733 | 0.003253 | 0.001058 | 0.003875 | 0.000089 | 0.000254 | 0.002054 | 0.006443 | 0.000553 | 0.001931 | 0.001489 | 0.004374 |
| Eisosomes | 0.000059 | 0.000043 | 0.000046 | 0.000039 | 0.000053 | 0.000051 | 0.000046 | 0.000334 | 0.000053 | 0.000047 | 0.000046 | 0.000096 |
| Endoplasmic Reticulum | 0.026166 | 0.000498 | 0.000762 | 0.001354 | 0.000762 | 0.002599 | 0.000668 | 0.002664 | 0.001516 | 0.001424 | 0.000721 | 0.001609 |
| Endosome | 0.006345 | 0.000565 | 0.001494 | 0.008434 | 0.000018 | 0.000627 | 0.001222 | 0.005833 | 0.000206 | 0.000592 | 0.001377 | 0.007929 |
| Golgi | 0.001759 | 0.001935 | 0.000543 | 0.009095 | 0.000032 | 0.000302 | 0.001449 | 0.006565 | 0.000083 | 0.001215 | 0.000935 | 0.008604 |
| Lipid Particles | 0.008036 | 0.000118 | 0.000105 | 0.000394 | 0.000008 | 0.000426 | 0.000187 | 0.004587 | 0.000247 | 0.000254 | 0.000141 | 0.001208 |
| Mitochondria | 0.005332 | 0.001395 | 0.002353 | 0.008313 | 0.001424 | 0.002248 | 0.003821 | 0.004829 | 0.001540 | 0.001771 | 0.002989 | 0.007636 |
| Mitotic Spindle | 0.000591 | 0.000998 | 0.002818 | 0.031248 | 0.000094 | 0.052299 | 0.002284 | 0.014539 | 0.000109 | 0.023617 | 0.002587 | 0.028004 |
| None | 0.005747 | 0.000616 | 0.001426 | 0.006054 | 0.002416 | 0.001093 | 0.002131 | 0.003376 | 0.002515 | 0.000827 | 0.001732 | 0.005534 |
| Nuclear Periphery | 0.008251 | 0.000534 | 0.000319 | 0.004709 | 0.000144 | 0.001249 | 0.000734 | 0.002129 | 0.000384 | 0.000849 | 0.000499 | 0.004208 |
| Nuclear Periphery Foci | 0.028881 | 0.000317 | 0.000184 | 0.002389 | 0.000029 | 0.002832 | 0.000439 | 0.003489 | 0.000885 | 0.001426 | 0.000294 | 0.002603 |
| Nucleolus | 0.037718 | 0.015264 | 0.008879 | 0.028820 | 0.023434 | 0.022397 | 0.013185 | 0.020085 | 0.023858 | 0.018409 | 0.010745 | 0.027124 |
| Nucleus | 0.537921* | 0.965742* | 0.957740* | 0.831099* | 0.964611* | 0.889771* | 0.945290* | 0.859469* | 0.951949* | 0.932246* | 0.952346* | 0.836608* |
| Peroxisomes | 0.003382 | 0.001134 | 0.000418 | 0.001276 | 0.000896 | 0.001355 | 0.000569 | 0.001273 | 0.000970 | 0.001232 | 0.000484 | 0.001276 |
| Vacuole | 0.121153 | 0.000867 | 0.000660 | 0.008740 | 0.000402 | 0.002931 | 0.001106 | 0.008462 | 0.003985 | 0.001777 | 0.000853 | 0.008686 |
| Vacuole Periphery | 0.012791 | 0.000236 | 0.000416 | 0.005207 | 0.000214 | 0.000564 | 0.000639 | 0.000797 | 0.000587 | 0.000381 | 0.000513 | 0.004351 |
Localization Changes (T-score)
| R1 | R2 | R1 & R2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | |
| Actin | 1.54 | 1.45 | -1.48 | -1.72 | -1.68 | -2.21 | -4.35 | -1.43 | -0.87 | -1.36 | -2.14 | -3.33 | -2.18 | -1.58 | -2.09 |
| Bud Neck | -0.10 | -8.58 | -11.61 | -12.99 | -6.65 | -3.34 | -16.51 | -8.13 | -3.71 | -3.29 | -3.46 | -21.33 | -15.62 | -10.47 | -7.36 |
| Bud Site | 2.80 | 1.05 | -3.55 | -5.14 | -4.31 | -2.16 | -5.97 | -2.99 | -1.82 | -2.40 | -2.25 | -8.30 | -6.18 | -4.27 | -4.84 |
| Cell Periphery | 1.72 | 1.51 | -0.33 | -1.92 | -1.74 | -1.39 | -2.17 | -1.32 | -1.14 | -1.19 | -0.36 | -1.31 | -2.14 | -2.08 | -2.03 |
| Cytoplasm | 3.43 | 3.41 | 3.33 | -6.03 | -4.78 | -1.11 | -3.08 | -4.73 | -4.34 | -1.46 | 2.86 | 2.00 | 0.15 | -6.95 | -4.25 |
| Cytoplasmic Foci | 1.81 | 2.54 | 2.14 | 0.09 | -2.41 | -2.01 | -3.85 | -1.86 | -1.72 | -0.95 | -0.81 | -2.40 | -3.37 | -0.58 | -2.29 |
| Eisosomes | 1.04 | 0.69 | 1.28 | 0.56 | 2.19 | -0.21 | 0.61 | -0.97 | -0.96 | -0.99 | 0.82 | 0.75 | -0.57 | -0.75 | -0.71 |
| Endoplasmic Reticulum | 3.78 | 3.74 | 3.67 | -2.94 | -1.99 | -1.61 | 0.83 | -1.55 | 0.80 | -1.65 | -0.40 | 3.11 | 0.28 | 0.52 | -2.70 |
| Endosome | 3.03 | 2.75 | 0.62 | -2.96 | -2.61 | -2.02 | -3.05 | -1.82 | -1.33 | -1.27 | -1.35 | -2.55 | -3.86 | -3.26 | -2.98 |
| Golgi | -0.15 | 1.63 | -1.83 | -1.23 | -2.64 | -2.45 | -1.95 | -1.20 | -1.05 | -0.81 | -1.12 | -2.42 | -3.08 | -1.89 | -2.63 |
| Lipid Particles | 2.01 | 2.02 | 1.96 | -1.37 | -2.30 | -1.85 | -2.40 | -1.38 | -1.07 | -1.29 | -0.46 | 0.88 | -1.35 | -1.09 | -1.69 |
| Mitochondria | 1.26 | 0.86 | -0.99 | -6.56 | -5.36 | -2.43 | -3.76 | -7.43 | -4.73 | -2.44 | -1.52 | -4.86 | -7.51 | -6.89 | -5.26 |
| Mitotic Spindle | -0.77 | -2.28 | -6.58 | -6.22 | -6.10 | -2.95 | -2.58 | -3.08 | 1.49 | -2.80 | -2.96 | -3.85 | -7.35 | -0.40 | -6.73 |
| None | 2.25 | 1.77 | -0.03 | -3.96 | -3.12 | 1.29 | 0.40 | -1.61 | -4.55 | -3.32 | 1.73 | 0.73 | -1.98 | -4.41 | -3.44 |
| Nuclear Periphery | 2.15 | 2.39 | 0.69 | -4.30 | -7.03 | -2.05 | -3.38 | -3.47 | -1.84 | -2.68 | -1.44 | -1.66 | -7.61 | -4.94 | -7.25 |
| Nuclear Periphery Foci | 2.39 | 2.42 | 2.25 | -2.93 | -4.53 | -1.31 | -2.50 | -1.62 | 0.11 | -1.41 | -0.81 | 1.52 | -2.30 | -0.27 | -3.83 |
| Nucleolus | 1.16 | 1.40 | 0.05 | -3.68 | -6.93 | -0.27 | 2.63 | -0.85 | -0.32 | -2.04 | 0.85 | 4.33 | -2.91 | -2.82 | -6.83 |
| Nucleus | -6.68 | -6.54 | -4.53 | 9.95 | 12.22 | 3.41 | 6.14 | 6.36 | 0.65 | 4.85 | 2.11 | 1.64 | 12.92 | 5.52 | 12.81 |
| Peroxisomes | 0.84 | 1.10 | 0.78 | -0.34 | -3.67 | -1.55 | 1.72 | -1.47 | 0.81 | -2.17 | -1.23 | 3.20 | -1.61 | 0.34 | -3.88 |
| Vacuole | 4.05 | 4.05 | 3.87 | -3.87 | -4.35 | -1.83 | -2.96 | -2.10 | -0.69 | -1.69 | 1.49 | 2.78 | -1.23 | -2.87 | -4.48 |
| Vacuole Periphery | 2.76 | 2.74 | 1.98 | -2.82 | -2.72 | -1.84 | -1.50 | -3.25 | 0.05 | -0.43 | 0.74 | 0.74 | -2.53 | -2.69 | -2.69 |
| Standard name | |
|---|---|
| Human Ortholog | |
| Description | ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization |
| Localization | |
| Cell Percentages | nucleus (95%) |
| Cell Cycle Regulation | No |
| Subcompartmental Group | nucleus-5 |
Rpt4
Rpt4
Nearest neighbours ( genes)
correlation threshold
0.80
Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)
Endocytosis
| Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
|---|---|---|---|---|
| 37℃ | ||||
| RT |
Cell Cycle Omics
CYCLoPs (Rpt4-GFP)
| Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
|---|
| Gene | Images |
|---|
| Gene | Images |
|---|
Images are not yet available
Images are not yet available
