Standard name
Human Ortholog
Description Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.95 0.99 1.0 0.97 0.98 0.98 0.93 0.95 0.88 0.89 0.84 0.83 1.0 1.0 1.0 0.6 0.57 0.74 0.65 0.67 0.68 0.79 0.76 0.72
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.1 0 0 0 0 0 0.08 0.05 0.17 0.11 0.21 0.09 0 0 0 0 0.05 0 0.15 0.07 0.12 0.07 0.07 0.08
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.09 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0.05 0.08 0.1 0 0 0 0.47 0.51 0.32 0.1 0.2 0.1 0.06 0 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 3 1 1 3 9 6
Bud 2 0 0 0 0 1 9 5 9 8 7 4 0 0 0 0 0 0 1 0 1 1 10 11
Bud Neck 0 0 3 1 5 9 11 12 2 4 1 2 2 2 1 0 0 0 3 1 1 2 1 4
Bud Site 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 2 0 2 1 0 2 0 1 1 0 1 0 4 1 1 0 0 1 1 0 0 1 6 7
Cytoplasm 212 172 146 146 307 277 356 367 247 298 244 235 369 537 557 150 93 148 158 117 97 191 328 298
Endoplasmic Reticulum 1 0 0 0 0 0 0 0 0 0 0 2 0 0 0 10 2 8 2 0 0 0 2 3
Endosome 0 0 0 1 0 0 0 1 0 2 0 0 0 0 0 9 9 6 2 1 2 0 2 5
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 2
Mitochondria 23 3 2 4 1 9 30 19 48 37 60 25 0 0 0 4 8 6 37 13 16 16 31 32
Nucleus 0 1 0 1 3 2 3 8 4 5 5 9 1 0 2 20 14 9 0 0 0 1 0 0
Nuclear Periphery 0 0 0 1 1 0 0 0 0 1 1 1 0 0 0 0 0 0 0 0 0 0 1 1
Nucleolus 0 0 0 1 0 0 1 1 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1
SpindlePole 2 0 1 0 3 3 4 2 1 2 0 1 0 0 1 0 2 0 2 0 0 3 8 8
Vac/Vac Membrane 1 2 0 0 0 3 5 5 10 16 23 29 1 0 0 118 83 65 23 35 14 13 18 24
Unique Cell Count 223 173 146 151 312 283 381 386 282 333 289 283 370 537 559 251 163 201 244 176 143 243 433 417
Labelled Cell Count 243 178 154 156 320 307 419 421 324 373 342 308 377 540 562 312 211 244 244 176 143 243 433 417


Vacuole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 2.9 4.1 4.0 4.3 4.7 4.0 3.7 4.2 3.6 3.7 3.5 4.2 4.6 4.9 4.9 6.6 6.7 6.3 4.3 4.9 5.4
Std Deviation (1e-4) 0.4 0.9 0.9 1.9 1.7 1.6 1.3 1.5 1.5 1.1 1.0 1.2 0.9 1.3 1.2 1.7 1.8 1.7 1.1 1.6 1.9
Intensity Change (Log2) – – – 0.11 0.24 -0.01 -0.11 0.07 -0.14 -0.1 -0.2 0.07 0.2 0.29 0.3 0.74 0.74 0.66 0.12 0.29 0.43


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 9.9 10.1 7.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -1.2604 -0.6704 -0.9287 -0.9608 -0.9975 -0.7999 -0.8054 -0.6657 -0.6924 -0.9621 -0.8077 -0.7144 -1.3947 -1.1561 -1.2463 -0.7297 -0.8577 -1.3267
Actin 0.0037 0.0003 0.0001 0.0001 0.0003 0.0001 0.0225 0.0001 0.0095 0.0003 0.0027 0.0013 0.0181 0.0021 0.0066 0.0423 0.0296 0.0004
Bud 0.0065 0.0094 0.0044 0 0.0185 0.0017 0.0048 0.0002 0.0015 0.0002 0.0009 0.0029 0.0018 0.0068 0.0055 0.0074 0.0379 0.0016
Bud Neck 0.0012 0.0001 0.0001 0 0.0001 0.0003 0.0025 0.0004 0.0012 0.0005 0.0004 0.0023 0.0114 0.0004 0.0009 0.0014 0.0008 0.0007
Bud Periphery 0.0039 0.0022 0.0005 0 0.0046 0.0016 0.0105 0.0004 0.0029 0.0003 0.0015 0.0026 0.0042 0.0041 0.0023 0.0137 0.0158 0.0015
Bud Site 0.0051 0.0106 0.0019 0 0.0052 0.0001 0.0025 0.0011 0.0046 0.0055 0.0004 0.0005 0.0054 0.0105 0.0083 0.0067 0.0106 0.0004
Cell Periphery 0.0005 0.0004 0.0001 0 0.0004 0 0.0005 0.0002 0.0003 0.0001 0.0002 0.0004 0.0005 0.0004 0.0003 0.0006 0.002 0.0002
Cytoplasm 0.0164 0.0364 0.0438 0.0109 0.0311 0.0299 0.0332 0.058 0.0376 0.026 0.0489 0.0605 0.0699 0.1405 0.1031 0.0342 0.109 0.1082
Cytoplasmic Foci 0.0065 0.0043 0.006 0.0034 0.0056 0.0114 0.0131 0.0148 0.0179 0.0338 0.0237 0.0113 0.0233 0.0272 0.0178 0.0446 0.0517 0.0297
Eisosomes 0.0002 0.0001 0.0002 0.0001 0.0001 0.0001 0.0004 0.0001 0.0003 0.0001 0.0001 0.0001 0.0004 0.0001 0.0003 0.0005 0.0002 0.0001
Endoplasmic Reticulum 0.0009 0.0005 0.001 0.0002 0.0002 0.0003 0.0012 0.0005 0.0012 0.0005 0.0016 0.0007 0.0029 0.0017 0.0021 0.0032 0.0032 0.0009
Endosome 0.004 0.0042 0.0048 0.0002 0.0002 0.002 0.0097 0.0038 0.0206 0.0135 0.0345 0.0083 0.0182 0.0354 0.0187 0.0576 0.1097 0.0225
Golgi 0.0011 0.0001 0.0001 0 0 0.0001 0.0036 0.0002 0.0014 0.0005 0.002 0.0007 0.005 0.0008 0.0044 0.006 0.0141 0.0003
Lipid Particles 0.0014 0.0007 0.0004 0.0002 0.0002 0.0003 0.0079 0.0003 0.0024 0.001 0.0234 0.0012 0.0085 0.0017 0.0042 0.0163 0.0776 0.0022
Mitochondria 0.0009 0.0005 0.0007 0.0003 0.0013 0.0003 0.0029 0.0006 0.0077 0.0006 0.0021 0.0016 0.0052 0.001 0.0063 0.0221 0.007 0.001
None 0.9357 0.9122 0.927 0.9832 0.9273 0.9475 0.85 0.9121 0.8722 0.9083 0.8128 0.8718 0.7874 0.7078 0.7805 0.6227 0.3922 0.7923
Nuclear Periphery 0.0022 0.0009 0.0004 0.0001 0.0002 0.0003 0.0043 0.0002 0.0028 0.0004 0.0049 0.0016 0.0058 0.0013 0.0056 0.0203 0.0087 0.0034
Nucleolus 0.001 0.0004 0.0006 0.0002 0.0008 0.0003 0.0027 0.0009 0.0007 0.0006 0.0015 0.0009 0.0012 0.0016 0.0013 0.0042 0.0013 0.0013
Nucleus 0.0022 0.0034 0.0028 0.0002 0.0014 0.0016 0.0046 0.0018 0.0017 0.0012 0.0058 0.0034 0.007 0.0041 0.0038 0.0106 0.0032 0.0026
Peroxisomes 0.0004 0.0002 0.0002 0.0002 0.0002 0.0004 0.0122 0.0002 0.0029 0.001 0.0044 0.0005 0.0059 0.001 0.0009 0.0045 0.0119 0.0007
Punctate Nuclear 0.0031 0.0007 0.0008 0.0002 0.0016 0.001 0.0078 0.0008 0.0026 0.001 0.0071 0.0082 0.0019 0.006 0.0035 0.034 0.0075 0.01
Vacuole 0.0025 0.0115 0.0038 0.0002 0.0006 0.0006 0.0026 0.0032 0.0064 0.0042 0.0191 0.0188 0.0148 0.0436 0.0206 0.0373 0.096 0.0183
Vacuole Periphery 0.0003 0.0009 0.0004 0 0.0001 0.0001 0.0006 0.0002 0.0016 0.0005 0.0021 0.0006 0.0014 0.0019 0.0028 0.0096 0.0099 0.0016

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 21.3302 18.5525 7.6482 19.5258 32.1402 19.5899 14.5899 14.7708 16.1548 26.6648
Translational Efficiency 1.9715 0.9266 1.6913 1.0237 0.8817 2.2633 1.1889 1.029 1.2179 1.2614

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1420 493 1815 1167 268 1912 222 1252 1688 2405 2037 2419

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 670.58 733.71 820.95 779.01 679.82 712.94 875.75 858.05 672.05 717.20 826.92 819.92
Standard Deviation 69.85 90.44 96.93 109.58 71.54 84.77 98.22 128.99 70.20 86.37 98.56 126.35
Intensity Change Log 2 — 0.129800 0.291885 0.216232 — 0.068628 0.365366 0.335909 — 0.099329 0.329345 0.277720

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000114 0.000457 0.000145 0.000700 0.000054 0.000177 0.000253 0.001791 0.000104 0.000234 0.000156 0.001265
Bud Neck 0.023924 0.045949 0.003596 0.005413 0.008284 0.046404 0.001604 0.006170 0.021441 0.046311 0.003379 0.005805
Bud Site 0.003286 0.017160 0.004529 0.024627 0.001468 0.012543 0.003312 0.042138 0.002997 0.013489 0.004396 0.033690
Cell Periphery 0.000139 0.000126 0.000128 0.000363 0.000183 0.000158 0.000350 0.000237 0.000146 0.000151 0.000152 0.000298
Cytoplasm 0.426105* 0.310251* 0.310705* 0.475835* 0.436642* 0.393566* 0.264088* 0.469970* 0.427778* 0.376487* 0.305624* 0.472799*
Cytoplasmic Foci 0.288646* 0.306661* 0.006510 0.040922 0.270020* 0.252276* 0.053005 0.036019 0.285689* 0.263425* 0.011577 0.038384
Eisosomes 0.000256 0.000162 0.000027 0.000099 0.000191 0.000157 0.000193 0.000075 0.000246 0.000158 0.000045 0.000087
Endoplasmic Reticulum 0.000602 0.000846 0.002907 0.004484 0.000449 0.000574 0.001874 0.002425 0.000578 0.000630 0.002795 0.003419
Endosome 0.014715 0.035411 0.001237 0.004771 0.011267 0.023989 0.003931 0.009385 0.014167 0.026331 0.001531 0.007159
Golgi 0.002646 0.007907 0.000047 0.002378 0.001104 0.004654 0.000713 0.007984 0.002401 0.005321 0.000120 0.005280
Lipid Particles 0.013608 0.007305 0.000933 0.002591 0.009728 0.008463 0.003881 0.002667 0.012992 0.008226 0.001254 0.002630
Mitochondria 0.006960 0.014930 0.000441 0.001003 0.000855 0.013897 0.004412 0.007733 0.005991 0.014109 0.000874 0.004486
Mitotic Spindle 0.001213 0.006391 0.002272 0.008563 0.000035 0.006951 0.000586 0.025991 0.001026 0.006837 0.002088 0.017583
None 0.002744 0.001354 0.004260 0.006273 0.001543 0.002553 0.012367 0.002821 0.002554 0.002307 0.005144 0.004486
Nuclear Periphery 0.000453 0.000524 0.002143 0.001026 0.000448 0.000412 0.001024 0.001303 0.000452 0.000435 0.002021 0.001169
Nuclear Periphery Foci 0.000180 0.000713 0.000917 0.003798 0.000365 0.000263 0.001116 0.002697 0.000210 0.000355 0.000938 0.003228
Nucleolus 0.000992 0.002735 0.000414 0.000355 0.000655 0.002355 0.000977 0.000311 0.000939 0.002433 0.000476 0.000332
Nucleus 0.160075* 0.104373 0.626353* 0.215627* 0.206871* 0.144321* 0.563854* 0.183343* 0.167505* 0.136132* 0.619542* 0.198918*
Peroxisomes 0.011052 0.034059 0.000124 0.001387 0.004999 0.014649 0.001231 0.002028 0.010091 0.018628 0.000244 0.001719
Vacuole 0.041277 0.100532 0.032214 0.198881 0.044387 0.069209 0.080555 0.190106 0.041771 0.075630 0.037482 0.194339
Vacuole Periphery 0.001013 0.002153 0.000097 0.000905 0.000452 0.002429 0.000674 0.004806 0.000924 0.002372 0.000160 0.002924

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.30 -4.46 -7.68 -2.11 -6.44 -7.39 -2.82 -3.79 -3.27 -2.00 -6.13 -5.45 -5.48 -4.46 -4.52
Bud Neck -4.42 10.59 9.74 9.00 -1.51 -13.34 4.01 1.80 16.33 -5.86 -9.28 10.95 10.05 18.62 -2.82
Bud Site -6.90 -1.48 -6.17 -0.45 -5.24 -9.70 -1.69 -8.01 -3.52 -5.63 -10.07 -1.92 -9.63 -3.46 -7.95
Cell Periphery 1.22 0.66 -5.91 -6.27 -6.08 1.69 -4.47 1.40 -0.20 5.34 -0.54 -1.00 -5.23 -4.81 -4.21
Cytoplasm 8.65 16.03 2.63 -6.33 -11.82 2.64 9.34 3.37 1.40 -8.35 6.18 18.14 4.67 -1.58 -14.20
Cytoplasmic Foci -1.19 47.04 41.38 26.81 -14.57 1.24 16.25 18.45 42.54 4.66 3.23 50.09 46.23 49.70 -14.23
Eisosomes 2.33 5.55 4.00 6.69 -13.50 2.40 -0.32 8.16 13.06 8.41 2.60 5.74 4.77 13.83 -8.95
Endoplasmic Reticulum -1.50 -14.59 -14.37 -14.23 -1.99 -1.07 -6.71 -12.55 -12.85 1.56 -0.44 -16.05 -16.54 -19.69 1.29
Endosome -5.93 11.38 9.13 9.78 -5.06 -4.63 2.60 2.47 14.02 -0.35 -7.71 11.68 8.86 17.94 -6.52
Golgi -2.01 9.55 1.82 2.51 -1.48 -5.76 1.20 -1.83 1.64 -2.44 -4.16 9.64 0.51 3.60 -3.26
Lipid Particles 5.01 12.18 10.84 6.32 -9.28 0.79 3.36 4.82 11.55 4.50 4.81 12.82 11.79 13.34 -5.75
Mitochondria -2.34 5.77 5.50 4.65 -1.66 -10.27 -0.87 -2.13 6.77 0.02 -5.36 5.28 3.73 9.48 -1.95
Mitotic Spindle -1.96 -1.15 -3.07 -0.09 -2.43 -5.40 -1.49 -6.99 -4.00 -6.72 -4.56 -1.33 -7.03 -3.12 -6.32
None 1.99 -1.30 -1.30 -3.14 -0.53 -2.50 -1.80 -3.50 0.31 1.56 0.27 -2.23 -1.08 -1.80 1.39
Nuclear Periphery -0.88 -24.52 -11.69 -8.00 8.23 0.43 -8.04 -9.82 -10.63 -3.61 0.17 -25.62 -14.33 -14.55 4.79
Nuclear Periphery Foci -2.53 -7.83 -5.88 -4.60 -4.10 1.33 -4.11 -8.48 -9.01 -0.25 -2.91 -8.71 -8.84 -8.18 -4.97
Nucleolus -2.86 7.16 9.29 3.93 1.67 -5.37 -1.67 4.03 6.63 5.22 -5.37 6.66 10.06 7.71 2.97
Nucleus 6.45 -60.75 -10.12 -13.96 42.54 4.78 -14.06 -0.56 -9.41 15.61 5.62 -61.04 -9.58 -15.71 51.62
Peroxisomes -6.35 11.80 10.32 9.56 -2.13 -6.75 3.21 3.48 13.79 0.27 -6.45 12.29 10.98 16.66 -2.85
Vacuole -9.58 -3.19 -29.81 -16.29 -27.86 -3.74 -6.62 -25.67 -27.53 -9.76 -12.13 -5.97 -42.30 -34.75 -36.60
Vacuole Periphery -3.28 4.16 1.71 4.93 -1.81 -6.71 -0.18 -2.26 0.87 -1.87 -4.90 4.11 -0.70 2.90 -3.12
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation
Localization
Cell Percentages —
Cell Cycle Regulation No
Subcompartmental Group N/A

Mpd1

Mpd1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mpd1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available