Standard name
Human Ortholog
Description Cytoplasmic NAD(+)-dependent protein deacetylase; deacetylation targets are primarily cytoplasmic proteins; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0.11 0.1 0.11 0 0 0 0 0 0
Cytoplasm 0.99 0.97 0.96 0.96 0.94 0.88 0.76 0.76 0.75 0.77 0.6 0.72 0.99 0.99 0.99 0.91 0.94 0.95 0.95 0.95 0.91 0.97 0.9 0.91
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0.05 0.14 0.28 0.26 0.33 0.26 0.5 0.32 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0.05 0.06 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 3 7 4 1 2 0 0 0 0 0 0 1 0 0 0 0 1
Bud 1 1 2 0 0 0 4 7 11 11 12 8 0 0 0 0 0 0 0 0 0 0 3 1
Bud Neck 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 5 5 4 9 19 9 6 8 11 12 12 0 8 5 24 33 27 0 0 0 0 0 0
Cytoplasm 386 393 230 204 322 300 336 270 254 337 210 207 183 198 239 201 304 232 380 385 227 127 244 205
Endoplasmic Reticulum 2 9 5 3 6 4 5 5 10 5 3 5 0 1 1 5 9 9 5 7 6 1 7 4
Endosome 0 0 0 1 0 0 2 4 2 1 0 1 0 0 0 0 2 1 3 0 1 0 3 6
Golgi 0 2 1 0 0 0 0 0 0 0 0 0 0 0 0 3 2 3 0 2 1 0 1 1
Mitochondria 1 1 2 1 17 49 124 91 111 113 176 91 2 0 0 2 3 2 0 2 6 0 3 0
Nucleus 0 1 2 0 1 3 6 3 3 3 4 0 0 0 1 0 2 0 0 1 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 1
Vac/Vac Membrane 0 0 0 6 12 10 20 13 11 11 13 11 0 0 0 12 18 5 0 3 5 0 3 0
Unique Cell Count 389 404 239 213 344 339 441 355 337 439 350 288 184 200 241 221 322 243 399 406 251 131 270 226
Labelled Cell Count 391 412 247 219 367 385 506 404 417 498 431 338 185 207 246 248 374 279 399 406 251 131 270 226


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.6 10.9 8.4 8.5 7.8 6.6 6.2 6.6 5.9 6.3 5.4 6.0 9.2 9.7 9.4 14.6 15.2 15.4 9.1 9.4 10.0
Std Deviation (1e-4) 1.0 1.5 1.1 1.7 1.3 1.2 1.2 1.2 1.2 1.1 1.0 0.9 1.6 1.3 1.3 2.2 2.1 2.2 1.4 1.6 1.7
Intensity Change (Log2) – – – 0.02 -0.1 -0.34 -0.44 -0.35 -0.51 -0.42 -0.62 -0.48 0.13 0.21 0.17 0.8 0.86 0.88 0.11 0.17 0.25


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 1.9 0 2.0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0.4 2.1 0 0 0.2 0.3 1.0 1.3 0 1.2 0 3.9 3.8 4.0
Cytoplasm -0.2 -1.4 -3.3 -6.7 -6.6 -6.7 -6.5 -9.9 -7.4 2.2 1.8 2.1 -2.3 -1.0 -0.4
Endoplasmic Reticulum 0 0 0 0 0 0.6 0 0 0 0 0 0 0 0.5 1.1
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 2.7 5.7 8.7 8.2 9.6 8.3 12.8 9.2 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 3.3 3.0 0 0 3.0 0 0 0 0 3.7 3.7 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.7078 7.6124 7.035 6.9873 5.9979 7.3069 5.3884 7.0437 6.4214 6.2024 6.3673 6.4094 4.9996 6.3129 5.9185 5.4103 5.3801 6.1636
Actin 0.0193 0.0001 0.0128 0.0028 0.0014 0.0004 0.0033 0.0012 0.0006 0.0002 0.0023 0.0009 0.0208 0.0002 0.0068 0.0043 0.0423 0.0008
Bud 0.0005 0.0002 0.0006 0.0004 0.0005 0.0001 0.0008 0.0016 0.0023 0.0016 0.0007 0.0013 0.0006 0.0002 0.0003 0.0004 0.0016 0.0002
Bud Neck 0.0044 0.0002 0.002 0.0006 0.0006 0.0008 0.001 0.0003 0.0006 0.001 0.0006 0.003 0.0005 0.0003 0.0003 0.0004 0.0037 0.0009
Bud Periphery 0.0007 0 0.0006 0.0003 0.0005 0.0001 0.0006 0.0004 0.0015 0.001 0.0009 0.001 0.0008 0.0001 0.0006 0.0002 0.0012 0.0001
Bud Site 0.0075 0.0015 0.0017 0.0007 0.0007 0.0001 0.0096 0.0085 0.0074 0.0003 0.0001 0.0011 0.0031 0.004 0.0012 0.0005 0.0054 0.0001
Cell Periphery 0.0007 0.0001 0.0003 0.0001 0.0001 0.0001 0.0003 0.0003 0.0002 0.0001 0 0.0002 0.0004 0.0001 0.0002 0.0001 0.0001 0.0001
Cytoplasm 0.7901 0.9697 0.8993 0.8496 0.7996 0.9487 0.8813 0.9402 0.9266 0.931 0.9128 0.9259 0.7213 0.9595 0.8925 0.7589 0.7372 0.9025
Cytoplasmic Foci 0.0302 0.0084 0.0155 0.0163 0.0397 0.0112 0.0142 0.0132 0.0149 0.0137 0.0097 0.0149 0.0409 0.0059 0.0169 0.0577 0.0415 0.0079
Eisosomes 0.0004 0 0.0002 0.0001 0 0 0 0 0 0 0 0 0.0003 0 0.0001 0 0.0001 0
Endoplasmic Reticulum 0.0303 0.0051 0.0098 0.0106 0.005 0.0135 0.0257 0.0054 0.0062 0.0083 0.004 0.0134 0.0488 0.0031 0.0125 0.008 0.009 0.0436
Endosome 0.0527 0.0082 0.0261 0.0356 0.0582 0.0152 0.035 0.0137 0.0195 0.0164 0.0129 0.0208 0.0459 0.0132 0.0261 0.0664 0.083 0.0243
Golgi 0.0084 0.0007 0.0051 0.0038 0.0236 0.004 0.0024 0.0009 0.0009 0.0005 0.0059 0.0014 0.0104 0.001 0.0049 0.0604 0.0243 0.003
Lipid Particles 0.0092 0.0001 0.0039 0.001 0.0016 0.0002 0.001 0.0001 0.0002 0 0.0001 0.0002 0.0115 0.0001 0.0007 0.0047 0.0103 0.0058
Mitochondria 0.0081 0.0004 0.0035 0.039 0.0293 0.0011 0.0014 0.0005 0.0006 0.0003 0.0166 0.0021 0.0211 0.0002 0.0122 0.0051 0.0044 0.0023
None 0.0156 0.0017 0.0064 0.008 0.0255 0.0012 0.0108 0.0045 0.0068 0.0165 0.0021 0.005 0.0191 0.0068 0.0056 0.0014 0.0023 0.001
Nuclear Periphery 0.0029 0.0004 0.0018 0.0032 0.0013 0.0005 0.0024 0.0005 0.0012 0.0009 0.0189 0.0011 0.018 0.0006 0.0032 0.0015 0.0083 0.0012
Nucleolus 0.0005 0 0.0001 0.0001 0.0001 0 0.0001 0.0001 0.0002 0 0.0002 0.0001 0.0018 0 0.0001 0 0.0001 0
Nucleus 0.0011 0.0007 0.001 0.0014 0.0021 0.0007 0.0018 0.0018 0.0022 0.0017 0.0079 0.0023 0.007 0.0007 0.001 0.001 0.0034 0.0009
Peroxisomes 0.0086 0.0001 0.0026 0.0008 0.0022 0.0002 0.0003 0.0001 0.0002 0.0001 0.0006 0.0002 0.0095 0 0.0013 0.0139 0.0107 0.0006
Punctate Nuclear 0.0009 0.0001 0.0009 0.0003 0.0006 0.0001 0.0007 0.0018 0.0012 0.0002 0.0003 0.0006 0.0085 0.0001 0.0002 0.0014 0.004 0.0001
Vacuole 0.006 0.0018 0.0047 0.0222 0.0057 0.0016 0.0063 0.0046 0.0057 0.0052 0.0023 0.0037 0.0069 0.0035 0.0108 0.0113 0.0052 0.0031
Vacuole Periphery 0.0018 0.0003 0.001 0.003 0.0017 0.0004 0.0009 0.0005 0.0009 0.0011 0.0011 0.0008 0.0028 0.0004 0.0023 0.0025 0.002 0.0013

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 54.9647 38.5734 70.1948 53.3961 59.2758 57.5013 46.4304 55.7805 67.5579 52.7088
Translational Efficiency 0.4444 0.4278 0.3795 0.5466 0.2909 0.4685 0.496 0.6048 0.4573 0.4684

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2412 1394 2044 1477 1953 1883 1050 1306 4365 3277 3094 2783

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 960.86 994.73 1086.70 1073.96 917.56 990.98 1144.92 1111.88 941.49 992.58 1106.46 1091.76
Standard Deviation 127.32 130.84 140.16 148.43 119.51 130.16 165.03 153.13 125.74 130.46 151.59 151.84
Intensity Change Log 2 — 0.049979 0.177556 0.160542 — 0.111053 0.319372 0.277127 — 0.080135 0.248572 0.218668

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000162 0.000192 0.000436 0.001112 0.000171 0.000196 0.000127 0.001770 0.000166 0.000194 0.000331 0.001421
Bud Neck 0.001669 0.001549 0.001018 0.002040 0.002139 0.001524 0.001394 0.002790 0.001879 0.001535 0.001146 0.002392
Bud Site 0.013256 0.024179 0.014506 0.033864 0.018359 0.018831 0.010031 0.042163 0.015539 0.021106 0.012988 0.037758
Cell Periphery 0.000154 0.000124 0.000116 0.000142 0.000222 0.000093 0.000070 0.000100 0.000184 0.000106 0.000100 0.000122
Cytoplasm 0.708712* 0.750041* 0.891229* 0.782752* 0.681136* 0.739612* 0.658471* 0.738799* 0.696374* 0.744048* 0.812239* 0.762126*
Cytoplasmic Foci 0.182575* 0.151584 0.033922 0.050877 0.201804* 0.154314 0.063168 0.064696 0.191179* 0.153152 0.043847 0.057362
Eisosomes 0.000025 0.000012 0.000006 0.000013 0.000032 0.000014 0.000014 0.000014 0.000028 0.000013 0.000009 0.000013
Endoplasmic Reticulum 0.004055 0.002221 0.000143 0.000798 0.007001 0.001179 0.000631 0.000210 0.005373 0.001622 0.000309 0.000522
Endosome 0.012336 0.011043 0.001835 0.004846 0.013560 0.012181 0.006127 0.011265 0.012884 0.011697 0.003292 0.007858
Golgi 0.011914 0.008104 0.001537 0.003538 0.013251 0.009958 0.000234 0.012227 0.012512 0.009169 0.001095 0.007616
Lipid Particles 0.001614 0.001080 0.000898 0.000919 0.001986 0.000980 0.000831 0.000655 0.001781 0.001023 0.000875 0.000795
Mitochondria 0.001175 0.000346 0.000107 0.002332 0.001735 0.000777 0.000030 0.005248 0.001425 0.000594 0.000081 0.003700
Mitotic Spindle 0.002819 0.000470 0.003742 0.010152 0.001653 0.004973 0.001127 0.032673 0.002298 0.003057 0.002854 0.020720
None 0.001075 0.000468 0.000930 0.000427 0.000931 0.000692 0.001266 0.000443 0.001011 0.000597 0.001044 0.000434
Nuclear Periphery 0.000032 0.000026 0.000025 0.000076 0.000059 0.000168 0.000137 0.000087 0.000044 0.000108 0.000063 0.000081
Nuclear Periphery Foci 0.000278 0.000412 0.000897 0.001236 0.000537 0.000663 0.003031 0.000949 0.000394 0.000556 0.001621 0.001101
Nucleolus 0.000119 0.000083 0.000122 0.000136 0.000104 0.000329 0.000161 0.000125 0.000113 0.000224 0.000135 0.000131
Nucleus 0.006175 0.004399 0.009128 0.008883 0.004797 0.005040 0.017743 0.005432 0.005558 0.004767 0.012052 0.007263
Peroxisomes 0.000708 0.000961 0.001078 0.002053 0.000722 0.001197 0.000482 0.005629 0.000715 0.001097 0.000876 0.003731
Vacuole 0.044253 0.038366 0.037897 0.092285 0.041186 0.043275 0.234569* 0.070952 0.042880 0.041186 0.104641 0.082274
Vacuole Periphery 0.006892 0.004340 0.000428 0.001520 0.008616 0.004005 0.000355 0.003773 0.007664 0.004148 0.000404 0.002577

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.89 -2.67 -3.67 -3.55 -2.04 -1.11 3.00 -3.64 -3.53 -3.77 -1.28 -2.49 -5.11 -4.95 -3.89
Bud Neck 0.65 5.59 -1.67 -1.78 -5.96 2.66 2.90 -0.82 -4.15 -4.41 2.51 5.77 -1.66 -4.26 -7.64
Bud Site -8.85 -0.77 -5.98 -0.75 -5.23 -0.35 6.70 -5.52 -5.17 -8.89 -6.39 3.47 -8.21 -4.37 -9.51
Cell Periphery 1.49 2.05 1.93 1.07 -0.16 10.26 12.52 10.11 1.22 -2.27 6.32 7.08 6.58 1.11 -0.57
Cytoplasm -5.13 -29.43 -4.77 0.39 19.52 -7.16 4.40 -3.23 2.87 -6.68 -8.35 -18.56 -5.52 2.10 10.90
Cytoplasmic Foci 5.39 37.09 32.01 20.65 -5.37 8.08 29.24 27.81 19.15 -0.84 9.32 47.95 42.09 28.51 -5.51
Eisosomes 8.56 13.63 8.14 0.05 -6.41 9.28 9.48 9.63 0.32 0.66 12.30 17.00 12.54 0.45 -5.87
Endoplasmic Reticulum 3.08 8.90 7.08 3.63 -1.59 6.02 6.86 7.23 5.74 4.89 7.09 10.44 9.95 5.41 -0.67
Endosome 1.44 18.58 11.16 8.02 -3.02 1.33 11.83 6.28 4.48 -1.89 1.71 22.43 11.93 8.66 -4.17
Golgi 7.00 22.77 12.73 7.65 -1.10 3.26 28.25 5.06 2.37 -4.39 5.41 33.66 10.92 5.65 -4.07
Lipid Particles 4.33 6.86 5.68 0.61 -0.54 7.28 11.74 9.56 0.62 -1.58 8.11 12.29 10.57 0.75 -0.99
Mitochondria 6.04 8.25 -0.35 -1.71 -2.12 2.64 5.11 -0.95 -2.12 -3.03 4.50 8.13 -0.99 -2.63 -3.67
Mitotic Spindle 3.48 -0.53 -2.97 -4.60 -2.41 -2.70 0.80 -5.87 -4.48 -6.15 -1.01 -0.44 -6.48 -5.80 -6.01
None 4.51 0.51 6.22 0.65 1.03 0.85 -0.06 1.87 1.43 1.59 2.71 0.39 4.54 1.66 1.49
Nuclear Periphery 1.11 0.68 -4.53 -4.83 -4.65 -1.00 -4.09 -1.99 0.59 3.99 -1.01 -2.56 -4.28 0.16 -2.92
Nuclear Periphery Foci -2.33 -8.80 -10.86 -9.31 -2.01 -0.48 -9.58 -3.50 -2.17 8.62 -1.06 -11.20 -8.30 -4.48 4.84
Nucleolus 2.89 -0.28 -1.83 -4.04 -1.13 -2.41 -3.58 -1.18 1.85 0.11 -2.10 -1.98 -1.72 1.47 -0.57
Nucleus 3.14 -7.83 -12.38 -11.30 -3.09 -0.63 -14.30 -8.28 -5.66 10.02 1.94 -15.93 -14.61 -12.21 5.22
Peroxisomes -2.83 -1.09 -2.60 -1.77 -1.34 -2.90 3.91 -5.02 -4.07 -5.53 -3.76 -0.46 -5.63 -4.27 -4.77
Vacuole 2.14 0.21 -19.75 -20.06 -20.01 -1.06 -28.81 -19.27 -18.71 13.50 0.75 -21.54 -27.57 -27.40 -5.11
Vacuole Periphery 5.13 17.30 12.46 7.48 -1.80 5.96 12.54 8.18 3.35 -3.37 7.83 20.09 13.77 7.08 -3.71
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Cytoplasmic NAD(+)-dependent protein deacetylase; deacetylation targets are primarily cytoplasmic proteins; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-4

Hst2

Hst2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Hst2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available