Standard name
Human Ortholog
Description Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex; stimulates superhelical relaxing, DNA catenation/decatenation and ssDNA binding activities of Top3p; involved in response to DNA damage; functions in S phase-mediated cohesion establishment via a pathway involving the Ctf18-RFC complex and Mrc1p; stimulates Top3p DNA catenation/decatenation activity; null mutants display increased rates of recombination and delayed S phase
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.26 0.25 0.46 0.45 0.44 0.15 0.32 – 0.19 0.33 0.12 0.2 0.45 0.54 0.56 0.19 0.19 0.2 0.15 0.15 0.21 0.33 0.5 0.46
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0 0.07 0 0 0 0 0 0
Endosome 0.11 0 0.07 0 0.05 0 0 – 0 0 0 0 0.16 0.12 0.09 0.07 0.05 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.14 0.1 0.06 0.07 0 0.57 0.25 – 0.63 0.54 0.68 0.63 0 0 0 0 0 0.05 0 0 0.06 0.09 0.08 0.06
Nucleus 0.26 0.29 0.36 0.35 0.26 0.41 0.39 – 0.34 0.31 0.41 0.39 0.14 0.1 0.11 0.53 0.52 0.51 0.32 0.35 0.31 0.09 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0.06 0 0.05 – 0 0 0 0 0 0 0 0 0 0 0.07 0.06 0.05 0.06 0.07 0.05
Vac/Vac Membrane 0.41 0.44 0.15 0.15 0.2 0 0.09 – 0 0 0.05 0 0.35 0.34 0.38 0.22 0.27 0.26 0.26 0.29 0.25 0.24 0.14 0.19
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 4 1 0 2 3 4
Bud 0 0 0 1 0 1 0 – 6 2 0 3 0 0 0 0 1 0 12 5 3 5 12 19
Bud Neck 0 1 2 0 4 0 3 – 2 2 2 0 0 0 0 0 0 0 3 3 1 4 5 8
Bud Site 0 0 0 0 0 2 2 – 1 1 2 3 0 0 0 1 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0
Cytoplasm 85 82 66 40 65 7 52 – 28 57 12 20 119 248 230 38 43 34 64 62 47 71 200 177
Endoplasmic Reticulum 0 5 0 0 0 0 0 – 0 0 0 0 0 1 0 10 5 12 1 0 1 1 6 3
Endosome 35 11 10 4 8 0 3 – 0 0 0 0 42 55 38 14 12 4 17 16 6 8 17 16
Golgi 0 0 0 0 1 0 0 – 0 0 0 0 0 1 2 5 5 1 6 2 0 4 2 4
Mitochondria 46 33 8 6 6 26 41 – 93 93 66 64 4 3 0 9 5 8 13 16 12 20 31 22
Nucleus 84 96 52 31 39 19 63 – 51 53 40 40 38 48 47 106 115 87 141 148 68 19 17 17
Nuclear Periphery 0 0 0 0 1 0 0 – 0 1 0 1 0 0 0 1 2 0 4 1 0 2 0 2
Nucleolus 2 0 0 0 0 0 0 – 2 1 1 0 0 2 0 3 1 1 10 4 2 1 1 3
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0
SpindlePole 3 2 0 3 9 0 8 – 4 4 3 0 1 2 0 5 2 3 32 25 10 13 29 19
Vac/Vac Membrane 136 145 22 13 30 1 15 – 3 5 5 3 92 159 157 44 61 45 112 120 55 51 58 74
Unique Cell Count 329 328 145 89 149 46 162 148 171 97 102 263 463 412 200 222 170 439 419 222 218 401 391
Labelled Cell Count 391 375 160 98 163 56 187 190 219 131 134 296 519 475 236 252 196 439 419 222 218 401 391


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.4 4.5 5.2 4.8 5.3 3.5 4.3 – 3.7 4.1 3.5 4.0 5.5 5.5 5.6 7.1 7.6 7.0 4.8 4.7 4.9
Std Deviation (1e-4) 1.1 0.7 1.2 0.8 1.7 0.7 1.1 – 1.2 1.7 0.7 1.5 1.5 1.6 1.9 1.7 2.0 1.9 1.8 1.6 1.9
Intensity Change (Log2) – – – -0.11 0.04 -0.57 -0.27 – -0.47 -0.33 -0.55 -0.37 0.08 0.09 0.12 0.46 0.55 0.44 -0.12 -0.13 -0.08


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 1.6 2.8 2.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -1.3395 -0.9479 -1.2177 -1.5875 -1.4289 -1.2398 0.7818 0.8977 0.6643 1.4862 0.2004 1.2091 2.6555 3.2192 3.3157 2.876 3.0606 3.4961
Actin 0.0158 0.0005 0.0031 0.0011 0.0051 0.0009 0.0159 0.0009 0.0015 0.0049 0.0006 0.0022 0.0003 0.0004 0.0003 0.0003 0.0004 0.0003
Bud 0.0003 0.0001 0.0004 0.0001 0.0003 0.0001 0.0004 0.0042 0.0053 0.0009 0.0006 0.0007 0.0001 0.0001 0.0001 0.0001 0 0.0006
Bud Neck 0.0014 0.0019 0.0013 0.0146 0.0073 0.0029 0.0022 0.0012 0.0007 0.0085 0.0013 0.0055 0.0018 0.0007 0.0009 0.0017 0.0009 0.0043
Bud Periphery 0.0004 0.0001 0.0022 0.0001 0.0006 0.0001 0.0005 0.0014 0.0015 0.001 0.0008 0.0023 0.0001 0.0001 0.0001 0.0002 0 0.0002
Bud Site 0.0009 0.0045 0.0011 0.0007 0.0016 0.0003 0.0049 0.0067 0.0036 0.0126 0.0006 0.0037 0.0021 0.0016 0.0006 0.0008 0.0001 0.0002
Cell Periphery 0.0001 0.0001 0.0002 0.0001 0.0002 0 0.0003 0.0002 0.0001 0.0004 0 0.0003 0.0001 0.0001 0.0001 0.0001 0 0
Cytoplasm 0.1609 0.1771 0.113 0.0698 0.0765 0.1061 0.1207 0.2429 0.2132 0.1902 0.3902 0.1191 0.1634 0.135 0.0945 0.0766 0.1355 0.0966
Cytoplasmic Foci 0.0207 0.0091 0.0113 0.0087 0.0072 0.0126 0.0656 0.0137 0.0203 0.0412 0.0226 0.0066 0.0116 0.0035 0.0117 0.0034 0.0058 0.0042
Eisosomes 0.0002 0.0001 0.0001 0.0001 0.0003 0 0.0003 0 0.0001 0.0001 0 0.0001 0 0.0001 0.0001 0.0001 0.0001 0
Endoplasmic Reticulum 0.0056 0.0075 0.0053 0.0015 0.006 0.003 0.0059 0.0062 0.0071 0.0018 0.0039 0.0049 0.0039 0.0041 0.0033 0.0058 0.0028 0.0018
Endosome 0.0149 0.0093 0.0209 0.0057 0.0345 0.0091 0.0375 0.0073 0.0227 0.08 0.0073 0.0092 0.0068 0.0037 0.0088 0.005 0.0026 0.003
Golgi 0.0031 0.0003 0.0033 0.0036 0.0032 0.0009 0.0115 0.0003 0.003 0.0323 0.0003 0.0008 0.0002 0.0001 0.0003 0.0001 0.0001 0.0001
Lipid Particles 0.0053 0.0017 0.0109 0.0109 0.0204 0.0042 0.0444 0.001 0.0022 0.0191 0.0005 0.0043 0.0009 0.0003 0.0025 0.0005 0.0006 0.0003
Mitochondria 0.0028 0.001 0.0046 0.0173 0.003 0.0016 0.0107 0.0011 0.0027 0.0096 0.0009 0.0027 0.0008 0.0005 0.0081 0.0012 0.0005 0.0005
None 0.1893 0.2249 0.1605 0.1927 0.1253 0.1328 0.2804 0.2943 0.2734 0.2697 0.1697 0.1981 0.246 0.2716 0.2369 0.2826 0.3208 0.2201
Nuclear Periphery 0.0436 0.0542 0.0562 0.0191 0.0948 0.0231 0.02 0.0272 0.0351 0.0072 0.0119 0.0263 0.0174 0.0156 0.0213 0.0363 0.0113 0.0091
Nucleolus 0.0064 0.0075 0.0097 0.0095 0.0302 0.0124 0.0045 0.0055 0.0051 0.0031 0.0032 0.0108 0.0061 0.0058 0.0088 0.013 0.0041 0.0092
Nucleus 0.4255 0.4271 0.5117 0.4769 0.4915 0.6057 0.2916 0.3442 0.3216 0.2865 0.2911 0.5386 0.4692 0.5298 0.516 0.493 0.4677 0.6032
Peroxisomes 0.0032 0.0002 0.0064 0.0066 0.0039 0.0006 0.0312 0.0005 0.0076 0.014 0.003 0.001 0.0004 0.0001 0.0003 0.0001 0.0002 0.0001
Punctate Nuclear 0.0948 0.0674 0.0701 0.1592 0.0794 0.0807 0.0417 0.0344 0.0673 0.0116 0.0865 0.057 0.0653 0.0243 0.0823 0.0749 0.0452 0.0443
Vacuole 0.0036 0.0041 0.0053 0.0013 0.0056 0.002 0.0085 0.0059 0.0048 0.0041 0.0044 0.0046 0.0029 0.0024 0.0025 0.0031 0.0011 0.0014
Vacuole Periphery 0.0014 0.0011 0.0023 0.0006 0.0031 0.0006 0.0014 0.0008 0.0011 0.0013 0.0004 0.0012 0.0005 0.0003 0.0005 0.0011 0.0002 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 13.6786 16.3037 19.1553 20.7547 9.8527 28.861 16.4847 19.4706 24.9248 17.8573
Translational Efficiency 0.4012 0.4782 0.4497 0.5707 0.7501 0.3746 0.3013 0.4119 0.4516 0.4536

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1438 1670 1552 1646 858 1389 2736 1656 2296 3059 4288 3302

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 620.02 763.97 783.83 825.21 620.87 758.96 796.12 818.57 620.34 761.70 791.67 821.88
Standard Deviation 69.88 91.50 93.29 122.16 66.41 536.09 100.00 110.21 68.61 367.52 97.80 116.37
Intensity Change Log 2 — 0.301201 0.338226 0.412447 — 0.289733 0.358695 0.398815 — 0.295474 0.348504 0.405642

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000080 0.000320 0.000172 0.001013 0.001047 0.000150 0.000164 0.000192 0.000442 0.000243 0.000167 0.000601
Bud Neck 0.005114 0.015039 0.004368 0.022535 0.002275 0.027376 0.008519 0.004707 0.004053 0.020641 0.007016 0.013594
Bud Site 0.000820 0.006244 0.003652 0.035750 0.000669 0.014560 0.004474 0.003957 0.000764 0.010020 0.004176 0.019805
Cell Periphery 0.000146 0.000156 0.000075 0.000440 0.000153 0.000228 0.000089 0.000113 0.000149 0.000188 0.000084 0.000276
Cytoplasm 0.305229* 0.322083* 0.042670 0.169107* 0.300339* 0.341431* 0.112866* 0.143923* 0.303402* 0.330868* 0.087459 0.156477*
Cytoplasmic Foci 0.120181 0.094517 0.000610 0.006685 0.073660 0.040234 0.000822 0.001853 0.102796 0.069869 0.000745 0.004262
Eisosomes 0.000088 0.000071 0.000014 0.000031 0.000063 0.000044 0.000013 0.000019 0.000079 0.000059 0.000013 0.000025
Endoplasmic Reticulum 0.001120 0.002706 0.003045 0.004567 0.000772 0.000962 0.002697 0.002623 0.000990 0.001914 0.002823 0.003592
Endosome 0.003155 0.005881 0.000467 0.005717 0.001667 0.004046 0.000517 0.000794 0.002599 0.005048 0.000499 0.003248
Golgi 0.000982 0.001497 0.000029 0.007898 0.000212 0.001177 0.000032 0.000583 0.000694 0.001352 0.000031 0.004230
Lipid Particles 0.012236 0.007302 0.000269 0.000750 0.006109 0.003158 0.000298 0.000476 0.009946 0.005420 0.000288 0.000613
Mitochondria 0.004956 0.006425 0.000722 0.007067 0.002792 0.007636 0.001197 0.000941 0.004147 0.006975 0.001025 0.003995
Mitotic Spindle 0.001407 0.007226 0.006803 0.077165 0.000106 0.012578 0.006871 0.010269 0.000921 0.009656 0.006846 0.043616
None 0.008945 0.007960 0.002904 0.010399 0.009587 0.013458 0.004274 0.015011 0.009185 0.010457 0.003778 0.012712
Nuclear Periphery 0.001660 0.002277 0.001619 0.003669 0.001169 0.001543 0.003115 0.001960 0.001477 0.001944 0.002574 0.002812
Nuclear Periphery Foci 0.000657 0.001247 0.000277 0.001031 0.000638 0.000507 0.000671 0.000446 0.000650 0.000911 0.000529 0.000738
Nucleolus 0.003797 0.005359 0.000722 0.001785 0.002550 0.006035 0.000791 0.001900 0.003331 0.005666 0.000766 0.001843
Nucleus 0.513181* 0.476080* 0.926057* 0.602377* 0.585863* 0.505123* 0.844655* 0.799375* 0.540342* 0.489267* 0.874118* 0.701174*
Peroxisomes 0.004976 0.006661 0.000084 0.000684 0.001842 0.002586 0.000070 0.000093 0.003805 0.004811 0.000075 0.000388
Vacuole 0.010861 0.029697 0.005297 0.036352 0.008121 0.016067 0.007732 0.010527 0.009837 0.023508 0.006851 0.023400
Vacuole Periphery 0.000409 0.001251 0.000144 0.004977 0.000366 0.001100 0.000134 0.000238 0.000393 0.001183 0.000137 0.002600

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.49 -7.24 -9.17 -4.78 -6.91 0.91 0.82 0.67 -7.60 -5.12 0.49 0.52 -0.56 -6.20 -8.22
Bud Neck -7.22 -0.89 -11.01 -2.48 -10.24 -10.83 -10.48 -9.69 8.38 3.96 -12.73 -8.25 -13.08 4.98 -5.00
Bud Site -7.49 -3.20 -10.21 -6.96 -7.58 -7.53 -5.60 -5.20 4.83 -0.02 -9.95 -6.36 -11.32 -1.89 -6.71
Cell Periphery -0.82 5.06 -3.61 -3.36 -5.31 -1.90 2.33 1.83 4.40 -1.57 -2.24 5.11 -1.87 -0.02 -5.53
Cytoplasm -1.83 36.93 20.57 23.30 -18.05 -3.82 21.33 18.64 26.16 -2.58 -4.00 38.58 28.24 35.02 -11.69
Cytoplasmic Foci 4.60 27.56 26.79 24.34 -5.56 7.34 18.08 17.83 16.38 -3.70 8.59 32.52 31.85 28.58 -6.55
Eisosomes 3.65 16.80 10.04 6.63 -11.73 4.33 11.32 6.79 2.62 -8.85 6.03 20.83 12.63 7.08 -15.46
Endoplasmic Reticulum -8.64 -12.83 -21.12 -14.91 -9.07 -1.19 -19.96 -16.64 -13.86 -5.01 -7.09 -22.37 -26.38 -19.88 -10.85
Endosome -4.63 6.58 0.69 5.34 -5.96 -5.24 5.93 3.64 7.14 -2.39 -6.11 7.92 2.38 8.65 -6.41
Golgi -1.12 3.97 -1.45 -1.01 -2.70 -2.19 4.00 -0.49 1.69 -1.19 -2.02 4.32 -1.26 -0.04 -2.91
Lipid Particles 5.09 14.53 13.75 12.03 -9.27 4.45 9.63 9.22 7.73 -4.54 7.04 17.07 16.29 14.20 -10.17
Mitochondria -1.37 4.95 0.36 2.02 -5.97 -3.09 1.07 1.30 6.51 2.03 -3.15 4.20 1.69 6.31 -5.13
Mitotic Spindle -3.50 -3.72 -11.85 -9.77 -8.85 -6.00 -7.37 -7.81 -2.08 -3.21 -6.54 -7.30 -13.93 -9.11 -9.24
None 1.01 6.96 0.63 -0.46 -7.54 -2.39 4.30 -1.76 0.97 -7.33 -1.35 7.56 -1.15 0.34 -9.95
Nuclear Periphery -2.14 -2.79 -13.61 -10.60 -12.48 -2.18 -13.97 -12.46 -11.06 2.98 -2.67 -13.25 -17.35 -13.64 -7.09
Nuclear Periphery Foci -2.54 -0.90 -3.64 -1.58 -1.45 1.05 -1.81 -3.17 -3.83 -0.75 -1.80 -1.92 -4.76 -3.30 -1.63
Nucleolus -1.84 4.74 1.82 3.72 -3.12 -4.59 0.76 -1.78 2.48 -2.36 -4.02 4.07 0.35 4.21 -3.46
Nucleus 3.34 -44.84 -12.02 -15.60 29.56 6.25 -22.90 -16.91 -26.60 6.40 6.09 -46.43 -21.78 -29.66 24.13
Peroxisomes -1.72 9.52 9.10 8.88 -3.45 -1.69 5.75 5.58 10.16 -2.49 -1.64 10.91 10.50 11.30 -4.54
Vacuole -10.61 0.30 -17.60 -12.07 -17.29 -5.31 -5.23 -9.95 -6.28 -6.40 -11.51 -3.86 -19.73 -13.03 -17.42
Vacuole Periphery -6.36 4.39 -2.83 -1.00 -3.39 -3.02 1.59 1.22 4.66 -0.74 -6.22 4.04 -2.29 0.89 -3.47
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex; stimulates superhelical relaxing, DNA catenation/decatenation and ssDNA binding activities of Top3p; involved in response to DNA damage; functions in S phase-mediated cohesion establishment via a pathway involving the Ctf18-RFC complex and Mrc1p; stimulates Top3p DNA catenation/decatenation activity; null mutants display increased rates of recombination and delayed S phase
Localization
Cell Percentages nucleus (34%), cytoplasm (5%), mixed (42%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Rmi1

Rmi1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rmi1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available