Standard name
Human Ortholog
Description Zinc-finger DNA-binding transcription factor; targets strong transcriptional activator Met4p to promoters of sulfur metabolic genes; involved in transcriptional regulation of the methionine biosynthetic genes; feedforward loop controlling expression of MET32 and the lack of such a loop for MET31 may account for the differential actions of Met31p and Met32p; MET31 has a paralog, MET32, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.37 0.3 0.46 0.5 0.66 0.61 0.7 0.69 0.67 0.72 0.5 0.59 0.38 0.36 0.43 0.15 0.14 0.16 0.28 0.21 0.18 0.23 0.24 0.2
Endoplasmic Reticulum 0.08 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.05 0 0 0 0 0 0 0
Endosome 0 0 0 0.09 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.39 0.12 0 0.09 0.05 0.41 0.17 0.25 0.34 0.32 0.58 0.41 0.06 0 0 0.05 0.08 0.06 0.1 0 0.14 0.06 0.05 0.05
Nucleus 0.18 0.48 0.3 0.26 0.16 0.09 0.08 0.05 0 0 0.05 0.07 0.49 0.51 0.4 0.73 0.68 0.72 0.23 0.39 0.28 0.36 0.34 0.33
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.07 0.07 0.08
Vac/Vac Membrane 0.18 0.2 0.23 0.12 0.15 0 0.1 0 0 0 0.06 0 0.09 0.11 0.14 0.11 0.13 0.1 0.24 0.25 0.18 0.19 0.2 0.22
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0
Bud 0 0 0 1 0 2 2 3 1 2 2 1 0 0 0 1 0 0 0 3 2 8 12 18
Bud Neck 0 0 2 0 2 2 2 9 1 3 0 0 0 0 1 0 0 0 1 0 0 1 3 7
Bud Site 0 0 0 0 0 5 0 3 0 0 0 4 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
Cytoplasm 14 48 28 89 132 117 229 353 91 141 79 98 151 194 314 54 35 42 28 45 17 92 150 130
Endoplasmic Reticulum 3 0 1 0 0 0 0 0 0 0 0 0 2 0 1 21 12 11 0 0 1 1 3 2
Endosome 0 0 1 16 11 2 7 10 2 1 1 2 9 24 30 8 10 6 2 3 2 5 10 14
Golgi 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 3 0 1 1 1 0 0 1
Mitochondria 15 20 0 17 9 79 54 128 46 63 91 68 23 13 18 19 21 16 10 8 13 22 32 35
Nucleus 7 78 18 46 32 18 25 25 6 5 8 12 195 273 293 254 169 187 23 82 27 146 213 220
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 1 1 1
Nucleolus 0 0 0 0 0 0 0 4 1 0 2 2 0 0 0 0 1 0 0 1 0 12 14 15
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 2 4 5 1 11 8 1 8 5 4 4 2 2 1 2 1 3 9 5 27 42 49
Vac/Vac Membrane 7 33 14 22 30 2 34 22 6 6 10 6 36 61 102 40 33 26 24 52 17 76 125 142
Unique Cell Count 38 161 61 179 199 191 327 508 135 197 157 166 399 537 729 349 250 260 103 212 98 408 624 658
Labelled Cell Count 46 179 66 195 221 228 364 566 155 229 198 198 421 567 761 400 286 289 103 212 98 408 624 658


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.5 4.2 5.1 5.2 5.5 3.6 4.3 4.2 3.9 4.1 3.9 4.3 4.6 4.7 4.7 6.1 6.1 6.3 4.1 4.2 4.2
Std Deviation (1e-4) 0.5 0.6 0.9 1.7 1.9 1.4 1.2 1.4 1.5 1.7 1.6 2.2 1.0 1.1 0.9 1.4 1.5 1.4 0.8 1.1 1.1
Intensity Change (Log2) – – – 0.03 0.12 -0.48 -0.23 -0.27 -0.37 -0.3 -0.36 -0.24 -0.12 -0.1 -0.09 0.28 0.27 0.31 -0.31 -0.27 -0.25

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000246WT3HU80HU120HU1600246WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30246WT1AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – -2.4 -1.9 -2.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.0405 -0.1291 -0.2738 -0.619 -0.7225 -0.37 0.5473 0.7786 0.796 0.4467 0.6323 0.6827 3.1902 2.612 2.4744 2.4275 2.6875 2.7622
Actin 0.0112 0.0003 0.0002 0.0002 0.0001 0.0002 0.0002 0.0001 0.0001 0.0001 0.0001 0.0001 0.0381 0.0009 0.002 0.006 0.0044 0.0097
Bud 0.0003 0.0001 0 0 0 0 0 0 0 0 0 0 0.0004 0.0013 0.0002 0.0005 0.0001 0.0001
Bud Neck 0.0043 0.0007 0.0004 0.0004 0.0008 0.0017 0.0004 0.0003 0.0002 0.0005 0.0004 0.0013 0.0085 0.001 0.0012 0.0067 0.0072 0.0023
Bud Periphery 0.0007 0.0001 0 0 0 0 0.0001 0 0 0 0 0 0.0007 0.0006 0.0003 0.0019 0.0001 0.0001
Bud Site 0.001 0.0009 0.0001 0.0001 0.0001 0 0.0001 0.0004 0.0002 0 0.0001 0.0001 0.002 0.0034 0.0018 0.0039 0.0007 0.0002
Cell Periphery 0.0001 0 0 0 0 0 0 0 0 0 0 0 0.0002 0.0001 0.0001 0.0031 0 0
Cytoplasm 0.0257 0.0481 0.0229 0.0318 0.0252 0.0083 0.0175 0.03 0.0103 0.0249 0.0184 0.0115 0.0458 0.0676 0.0459 0.0565 0.0246 0.0253
Cytoplasmic Foci 0.0038 0.001 0.0006 0.0009 0.0009 0.0004 0.0006 0.0008 0.0002 0.0009 0.0003 0.0018 0.0064 0.0045 0.0063 0.0089 0.0161 0.0032
Eisosomes 0.0002 0.0001 0 0 0 0.0001 0 0 0 0 0 0 0.0003 0.0002 0.0002 0.0006 0.0001 0.0002
Endoplasmic Reticulum 0.0037 0.0022 0.0009 0.0008 0.0006 0.0003 0.0005 0.0008 0.0002 0.0004 0.0005 0.0002 0.0031 0.0028 0.0011 0.0013 0.001 0.0009
Endosome 0.0065 0.0021 0.001 0.0014 0.0012 0.0004 0.0013 0.0014 0.0003 0.0007 0.0006 0.0022 0.0106 0.0031 0.0055 0.005 0.0046 0.004
Golgi 0.0008 0.0001 0 0 0 0 0 0 0 0 0 0.0001 0.0053 0.0002 0.0019 0.0029 0.0023 0.0016
Lipid Particles 0.0035 0.0012 0.0002 0.0001 0.0001 0 0.0001 0.0002 0 0.0001 0.0001 0.0004 0.0038 0.0005 0.0043 0.0082 0.005 0.0022
Mitochondria 0.0031 0.0047 0.0003 0.0004 0.0004 0.0001 0.0005 0.0003 0.0002 0.0002 0.0004 0.0001 0.0017 0.0009 0.0015 0.0103 0.0005 0.0008
None 0.056 0.0922 0.0781 0.0332 0.101 0.0332 0.0597 0.0536 0.0244 0.033 0.0614 0.0185 0.0679 0.2175 0.1195 0.0753 0.2065 0.0495
Nuclear Periphery 0.0246 0.0288 0.0173 0.0102 0.0333 0.0059 0.0086 0.0126 0.0062 0.0074 0.0143 0.0034 0.0166 0.0136 0.0104 0.0193 0.0086 0.0062
Nucleolus 0.009 0.0081 0.0076 0.0082 0.019 0.0122 0.0072 0.0063 0.0055 0.0049 0.0079 0.0132 0.0127 0.0097 0.0092 0.009 0.0154 0.0152
Nucleus 0.7919 0.7515 0.8281 0.8105 0.7434 0.8842 0.8773 0.8607 0.9271 0.8998 0.8738 0.9067 0.74 0.6257 0.7248 0.7022 0.6113 0.8279
Peroxisomes 0.0013 0.0002 0 0 0 0 0.0001 0 0 0 0 0.0001 0.0028 0.0017 0.0058 0.0125 0.0038 0.0069
Punctate Nuclear 0.0491 0.0554 0.0413 0.1012 0.0731 0.0524 0.025 0.0316 0.0249 0.0265 0.0208 0.0399 0.0305 0.0422 0.0473 0.0616 0.086 0.0428
Vacuole 0.002 0.0016 0.0006 0.0003 0.0005 0.0002 0.0004 0.0008 0.0002 0.0004 0.0004 0.0003 0.0018 0.0022 0.0098 0.0032 0.0014 0.0006
Vacuole Periphery 0.001 0.0006 0.0002 0.0002 0.0003 0.0001 0.0002 0.0002 0.0001 0.0002 0.0003 0.0001 0.0008 0.0003 0.0007 0.001 0.0003 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 16.5304 35.0958 19.1893 16.7075 17.4138 6.1955 19.6103 17.6475 14.1468 18.895
Translational Efficiency 0.9439 0.5649 0.9112 0.9488 0.9628 2.6206 0.7907 1.2553 1.3563 0.8336

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1176 1035 161 549 1746 1734 1118 1544 2922 2769 1279 2093

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 638.30 707.04 893.87 833.46 655.02 766.14 841.57 825.24 648.29 744.05 848.15 827.40
Standard Deviation 75.97 109.49 99.00 96.94 69.61 90.26 99.36 102.27 72.70 101.98 100.82 100.96
Intensity Change Log 2 — 0.147557 0.485830 0.384878 — 0.226069 0.361544 0.333275 — 0.187854 0.424222 0.358974

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000077 0.000358 0.000999 0.000423 0.000130 0.000230 0.000437 0.000661 0.000109 0.000278 0.000508 0.000598
Bud Neck 0.006458 0.019166 0.004013 0.002740 0.003210 0.013467 0.003711 0.009140 0.004517 0.015597 0.003749 0.007462
Bud Site 0.000780 0.007488 0.001183 0.006497 0.000818 0.006607 0.002594 0.007255 0.000803 0.006936 0.002417 0.007056
Cell Periphery 0.000160 0.000186 0.000125 0.000202 0.000129 0.000253 0.000116 0.000147 0.000141 0.000228 0.000117 0.000162
Cytoplasm 0.293996 0.324513 0.009706 0.221533 0.317784 0.268518 0.105330 0.225442 0.308210 0.289448 0.093293 0.224417
Cytoplasmic Foci 0.135060 0.106343 0.000407 0.018023 0.068790 0.055574 0.002629 0.005048 0.095462 0.074550 0.002349 0.008451
Eisosomes 0.000112 0.000079 0.000052 0.000080 0.000053 0.000056 0.000031 0.000027 0.000077 0.000064 0.000033 0.000040
Endoplasmic Reticulum 0.000791 0.002834 0.010370 0.003268 0.000741 0.001151 0.004791 0.004044 0.000761 0.001780 0.005493 0.003840
Endosome 0.002913 0.008175 0.000618 0.002842 0.001467 0.004841 0.001076 0.001438 0.002049 0.006088 0.001018 0.001806
Golgi 0.000746 0.003238 0.000071 0.000094 0.000316 0.001789 0.000063 0.000575 0.000489 0.002331 0.000064 0.000449
Lipid Particles 0.015294 0.007825 0.000789 0.002330 0.006930 0.006037 0.000846 0.000688 0.010296 0.006705 0.000839 0.001119
Mitochondria 0.006533 0.008898 0.000719 0.000881 0.003380 0.008091 0.000835 0.001340 0.004649 0.008393 0.000820 0.001220
Mitotic Spindle 0.000279 0.005192 0.000202 0.005020 0.002501 0.005745 0.001013 0.006146 0.001607 0.005538 0.000911 0.005851
None 0.010011 0.012747 0.003425 0.013957 0.008662 0.009239 0.008534 0.009252 0.009205 0.010550 0.007891 0.010486
Nuclear Periphery 0.001182 0.002057 0.001011 0.001816 0.001527 0.001880 0.001409 0.001898 0.001388 0.001946 0.001359 0.001876
Nuclear Periphery Foci 0.000387 0.001302 0.000404 0.000989 0.000842 0.000517 0.000754 0.000631 0.000659 0.000811 0.000710 0.000725
Nucleolus 0.003410 0.008088 0.002637 0.001585 0.002369 0.004482 0.001731 0.001067 0.002788 0.005830 0.001845 0.001203
Nucleus 0.506423 0.448189 0.954964 0.648900 0.570501 0.589677 0.852245 0.703817 0.544712 0.536791 0.865175 0.689412
Peroxisomes 0.006072 0.007339 0.000241 0.000495 0.003511 0.005733 0.000245 0.000381 0.004542 0.006334 0.000245 0.000411
Vacuole 0.008882 0.024233 0.007933 0.067929 0.006015 0.014675 0.011463 0.020788 0.007169 0.018247 0.011018 0.033153
Vacuole Periphery 0.000432 0.001750 0.000132 0.000396 0.000324 0.001437 0.000147 0.000216 0.000368 0.001554 0.000145 0.000263

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.00 -7.76 -3.04 -1.45 2.79 -1.37 -6.80 -2.09 -1.49 0.25 -3.10 -10.93 -2.96 -1.80 0.74
Bud Neck -5.58 0.82 2.15 7.57 1.92 -7.61 -2.28 -6.57 2.25 -4.62 -9.18 -0.58 -4.43 5.62 -3.94
Bud Site -5.73 -3.48 -3.25 0.70 -2.59 -5.73 -2.21 -5.53 0.09 -2.92 -7.96 -2.41 -6.43 0.48 -3.39
Cell Periphery -1.30 1.18 -2.04 -0.22 -2.17 -2.58 1.11 -0.15 2.48 -0.96 -2.78 2.60 -0.44 2.52 -2.31
Cytoplasm -2.61 37.59 9.25 11.02 -17.26 5.58 28.11 13.58 8.07 -13.73 2.76 34.69 16.16 13.17 -16.63
Cytoplasmic Foci 3.52 25.56 21.66 16.86 -8.83 3.38 23.09 21.94 19.44 -4.31 5.22 33.34 30.83 25.60 -8.36
Eisosomes 4.21 5.95 1.03 -3.06 -4.93 -1.11 3.28 6.14 7.26 2.44 3.08 9.20 6.89 3.94 -2.82
Endoplasmic Reticulum -8.88 -9.86 -12.43 -6.62 5.44 -2.62 -16.24 -15.00 -13.74 3.31 -7.85 -18.97 -19.18 -14.28 5.02
Endosome -6.91 6.43 -0.83 6.61 -8.23 -6.59 1.24 0.51 6.60 -0.64 -9.38 4.13 0.99 9.74 -3.02
Golgi -3.13 6.34 6.31 3.98 -0.37 -3.64 4.56 -0.13 3.09 -1.19 -4.70 7.91 1.14 4.82 -1.22
Lipid Particles 5.00 11.02 9.33 7.21 -5.75 1.04 8.54 8.76 8.80 1.52 4.37 13.87 13.22 12.01 -3.53
Mitochondria -1.40 4.32 4.13 6.75 -0.71 -4.12 4.04 3.50 7.07 -1.99 -3.85 5.83 5.36 9.66 -1.98
Mitotic Spindle -3.55 -1.37 -2.93 0.03 -2.50 -2.17 0.44 -3.54 -1.72 -4.07 -3.74 -0.48 -4.60 -1.66 -4.52
None -1.45 6.01 0.38 1.30 -2.71 -0.47 1.43 1.03 1.33 -0.32 -1.23 2.96 1.24 2.17 -1.26
Nuclear Periphery -4.25 -1.61 -9.07 -2.88 -4.56 -1.25 -1.96 -4.37 -2.87 -4.24 -2.93 -3.50 -7.77 -3.82 -5.77
Nuclear Periphery Foci -4.20 -1.74 -6.08 -0.06 -1.03 1.10 -1.22 -0.27 -2.60 1.47 -0.70 -2.19 -1.97 -1.60 0.98
Nucleolus -5.61 0.94 6.01 8.90 2.66 -3.61 1.75 5.81 6.54 2.96 -6.34 2.92 8.47 10.82 3.52
Nucleus 4.50 -41.28 -8.15 -11.62 21.38 -1.77 -29.08 -13.05 -10.95 15.07 1.06 -39.71 -16.56 -16.99 20.47
Peroxisomes -1.48 9.21 8.45 8.78 -1.77 -2.07 5.96 5.78 6.46 -0.66 -2.44 10.30 9.85 10.02 -1.52
Vacuole -8.87 -1.96 -13.37 -11.17 -12.58 -7.16 -8.39 -13.48 -9.74 -5.80 -11.15 -8.19 -18.28 -13.99 -11.67
Vacuole Periphery -5.06 5.22 1.23 5.36 -2.08 -3.55 1.88 1.47 4.22 -1.40 -5.42 3.57 2.29 6.34 -2.46
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Zinc-finger DNA-binding transcription factor; targets strong transcriptional activator Met4p to promoters of sulfur metabolic genes; involved in transcriptional regulation of the methionine biosynthetic genes; feedforward loop controlling expression of MET32 and the lack of such a loop for MET31 may account for the differential actions of Met31p and Met32p; MET31 has a paralog, MET32, that arose from the whole genome duplication
Localization
Cell Percentages nucleus (55%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Met31

Met31


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Met31-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available