Standard name
Human Ortholog
Description Subunit of the HOPS and the CORVET complexes; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0.06 0.09 0.06 0.08 0.07 0.1 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0.05 0.05 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0.05 0 0 0 0 0 0
Endosome 0.4 0.3 0.47 0.52 0.54 0.48 0.42 0.4 0.16 0.1 0.11 0.22 0.45 0.67 0.69 – 0.56 0.54 0.67 0.69 0.71 0.77 0.79 0.82
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0.07 0.06 0 0 0 0 0 0
Mitochondria 0.44 0.49 0.28 0.33 0.22 0.39 0.39 0.28 0.7 0.71 0.76 0.58 0.42 0.14 0.17 – 0.1 0.13 0.06 0.05 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 – 0 0.07 0.08 0 0 0 0.05 0
Nucleolus 0.27 0.18 0.09 0.1 0.06 0.07 0.06 0 0.06 0.07 0.06 0 0.24 0.21 0.19 – 0.21 0.18 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0.06 0.06 0.13 0.11 0 0 0 0.06 0 0 0.06 – 0 0 0 0 0 0 0 0
SpindlePole 0.14 0.05 0.32 0.25 0.35 0.24 0.33 0.39 0.21 0.25 0.15 0.3 0.13 0.11 0.09 – 0.18 0.16 0 0 0 0 0 0
Vac/Vac Membrane 0.22 0.32 0.28 0.18 0.14 0.11 0.07 0.07 0 0.05 0.05 0.08 0.28 0.31 0.17 – 0.4 0.43 0.09 0.13 0.1 0.08 0.07 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 0 1 0 1 0 0 5 2 2 1 2 1 0 1 – 0 1 0 3 2 0 1 3
Bud 1 2 11 6 2 13 28 38 16 28 13 27 3 2 2 – 1 2 0 1 0 1 0 1
Bud Neck 0 0 0 0 2 0 2 3 1 2 1 1 0 0 0 – 0 1 0 0 0 0 0 0
Bud Site 1 0 1 0 1 1 6 2 3 4 4 0 0 0 0 – 0 0 – – – – – –
Cell Periphery 0 0 0 0 1 1 1 1 0 0 0 0 0 0 0 – 0 1 0 0 0 0 0 0
Cytoplasm 4 9 2 6 12 5 22 23 8 10 9 5 5 11 14 – 15 12 2 2 3 1 0 0
Endoplasmic Reticulum 4 0 1 0 0 1 0 0 1 4 3 2 2 2 4 – 12 16 0 1 1 1 0 0
Endosome 79 70 120 112 162 175 199 176 42 34 22 59 91 253 266 – 232 176 136 180 207 137 261 305
Golgi 1 1 1 0 0 1 1 0 0 0 0 0 1 1 0 – 28 19 6 4 6 0 2 9
Mitochondria 88 114 72 70 65 143 186 121 182 244 151 157 85 52 64 – 40 41 11 13 11 3 5 4
Nucleus 2 2 5 2 0 4 5 2 3 0 3 0 1 1 0 – 2 0 0 2 1 0 0 0
Nuclear Periphery 12 8 3 0 0 1 2 1 2 3 1 1 6 17 10 – 9 24 17 5 11 6 16 11
Nucleolus 54 42 24 22 17 27 29 15 15 24 12 9 49 77 75 – 86 59 0 2 1 1 0 2
Peroxisomes 3 1 8 6 19 23 63 49 9 15 7 16 5 9 22 – 1 1 1 1 5 0 2 6
SpindlePole 27 11 81 53 104 87 157 170 54 86 30 82 26 42 35 – 73 52 7 5 6 7 11 3
Vac/Vac Membrane 43 74 72 38 43 39 31 30 10 16 10 23 56 118 64 – 164 140 19 33 29 13 23 22
Unique Cell Count 198 233 254 215 301 365 473 437 261 345 200 271 203 375 386 415 326 205 260 291 179 331 374
Labelled Cell Count 320 334 402 315 429 521 732 636 348 472 267 384 331 585 557 663 545 205 260 291 179 331 374


Vacuole Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.5 6.0 6.3 5.7 6.6 5.2 5.4 5.7 4.9 4.6 4.5 5.1 6.4 6.8 6.7 – 10.3 9.4 5.9 6.1 6.7
Std Deviation (1e-4) 1.0 1.3 0.9 0.7 1.3 0.6 1.2 1.0 1.0 0.9 0.8 1.0 1.1 0.9 1.1 – 2.1 1.7 1.1 0.9 1.2
Intensity Change (Log2) – – – -0.15 0.07 -0.27 -0.22 -0.13 -0.37 -0.46 -0.47 -0.29 0.02 0.1 0.1 – 0.71 0.58 -0.09 -0.06 0.09


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Bud -0.9 -2.8 -0.5 0.9 2.2 0.9 0 0 2.5 -1.8 -3.3 -3.3 – 0 -3.0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Cytoplasm 0 2.4 0 2.8 3.0 0 1.8 0 0 0 1.9 2.3 – 2.3 2.3
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 – 0 3.2
Endosome 1.0 1.5 0.2 -1.3 -1.8 -7.6 0 0 -6.2 -0.5 5.1 5.5 – 2.2 1.6
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 – 3.9 3.6
Mitochondria 1.0 -1.8 2.8 2.9 -0.2 9.4 0 0 6.8 3.0 -4.5 -3.6 – -6.3 -4.8
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 2.4 1.2 – 0 3.5
Nucleolus 0.3 -1.7 -0.9 -1.6 -3.3 -1.6 0 0 -2.9 4.3 3.7 3.4 – 3.8 3.0
Peroxisomes -0.2 1.7 1.8 4.4 3.7 0.2 0 0 1.5 -0.4 -0.6 1.5 – 0 0
SpindlePole -1.7 0.7 -2.2 0.4 1.8 -2.9 0 0 -0.4 -4.8 -6.4 -7.3 – -4.3 -4.5
Vacuole -2.7 -4.1 -5.6 -8.0 -7.7 -7.6 -8.1 -6.4 -5.9 -0.2 0.8 -3.6 – 2.9 3.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.5068 1.3247 1.4958 2.0342 1.7808 1.4231 -0.5196 -0.407 -0.421 -0.2113 -0.398 -0.5169 -1.2784 -1.0281 -1.1938 -0.9429 -1.4256 -1.2656
Actin 0.0311 0.0008 0.0053 0.0017 0.0153 0.0028 0.0304 0.0027 0.0172 0.0025 0.0074 0.007 0.0156 0.0012 0.0089 0.0017 0.0668 0.0102
Bud 0.0005 0.0001 0.0003 0.0018 0.0003 0.0004 0.0006 0.0003 0.0003 0.0013 0.0004 0.0002 0.0004 0.0003 0.0016 0.0002 0.0003 0.0002
Bud Neck 0.0033 0.0015 0.0033 0.005 0.0075 0.0077 0.0042 0.0006 0.001 0.0078 0.0014 0.005 0.0024 0.0007 0.0006 0.0011 0.0009 0.004
Bud Periphery 0.001 0.0002 0.0014 0.0054 0.0005 0.001 0.0014 0.0005 0.0006 0.0038 0.0007 0.0002 0.0006 0.0003 0.0016 0.0001 0.0003 0.0006
Bud Site 0.0042 0.0023 0.0039 0.0212 0.0046 0.0015 0.0091 0.0007 0.0019 0.0108 0.0011 0.0005 0.006 0.0025 0.0063 0.0022 0.0009 0.0003
Cell Periphery 0.0005 0.0007 0.0026 0.0019 0.0005 0.0002 0.0005 0.0001 0.0001 0.0003 0.0001 0 0.0003 0.0001 0.0001 0 0 0.0001
Cytoplasm 0.0574 0.0699 0.0627 0.0356 0.0537 0.0451 0.0404 0.0976 0.051 0.0253 0.0584 0.0624 0.0629 0.0755 0.0556 0.0501 0.0236 0.041
Cytoplasmic Foci 0.0251 0.0033 0.0108 0.0253 0.0133 0.0128 0.0097 0.0073 0.0108 0.0165 0.0308 0.0065 0.0234 0.0032 0.0049 0.01 0.0009 0.0125
Eisosomes 0.0006 0.0003 0.0005 0.0002 0.001 0.0001 0.0006 0 0.0001 0.0001 0.0002 0 0.0004 0.0001 0.0001 0.0001 0.0001 0.0001
Endoplasmic Reticulum 0.014 0.0041 0.0064 0.0019 0.0013 0.0016 0.0059 0.0079 0.0022 0.0014 0.0041 0.0015 0.005 0.0047 0.004 0.0018 0.0009 0.0017
Endosome 0.0267 0.0028 0.0088 0.0394 0.0062 0.0044 0.0258 0.0108 0.0199 0.0213 0.0319 0.0043 0.0199 0.0056 0.0071 0.0023 0.0018 0.0054
Golgi 0.0139 0.0003 0.0025 0.0096 0.0051 0.001 0.009 0.0006 0.0076 0.0081 0.0218 0.0023 0.0039 0.0004 0.0042 0.0011 0.0019 0.006
Lipid Particles 0.0236 0.002 0.0068 0.0176 0.011 0.0092 0.0109 0.0024 0.0063 0.0314 0.0523 0.0067 0.0196 0.0014 0.0037 0.0043 0.0002 0.0043
Mitochondria 0.0167 0.001 0.0029 0.0193 0.0742 0.002 0.0182 0.0028 0.0153 0.0117 0.0311 0.0052 0.0038 0.0011 0.0045 0.0059 0.001 0.011
None 0.143 0.2754 0.2071 0.1652 0.2966 0.1291 0.1012 0.1268 0.1027 0.0679 0.176 0.0626 0.083 0.1865 0.1654 0.2373 0.0585 0.1038
Nuclear Periphery 0.017 0.0194 0.0193 0.0143 0.0121 0.0136 0.0284 0.0228 0.031 0.0514 0.0184 0.0125 0.0364 0.0264 0.0469 0.0363 0.026 0.0173
Nucleolus 0.0142 0.0144 0.0156 0.0137 0.0341 0.0193 0.0115 0.0098 0.0116 0.0237 0.0116 0.0174 0.0094 0.0071 0.0065 0.0062 0.0098 0.0125
Nucleus 0.5178 0.5557 0.5738 0.5582 0.3235 0.668 0.6169 0.6566 0.6366 0.6622 0.4429 0.7068 0.6233 0.6164 0.6404 0.5239 0.7864 0.6913
Peroxisomes 0.0256 0.0003 0.0035 0.0039 0.0217 0.0052 0.0086 0.001 0.0062 0.0083 0.0245 0.0037 0.0152 0.0003 0.0021 0.0304 0.0002 0.004
Punctate Nuclear 0.0569 0.0424 0.0587 0.0404 0.1149 0.0728 0.0591 0.0439 0.0748 0.0324 0.0817 0.0939 0.0617 0.0632 0.0333 0.084 0.0184 0.0723
Vacuole 0.0051 0.003 0.0029 0.0153 0.002 0.0017 0.0056 0.0037 0.0019 0.008 0.0022 0.0009 0.0047 0.0024 0.0013 0.0005 0.0007 0.001
Vacuole Periphery 0.002 0.0003 0.001 0.0031 0.0005 0.0005 0.0021 0.0013 0.001 0.0039 0.0011 0.0002 0.0021 0.0006 0.0008 0.0004 0.0003 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 8.7462 10.2876 11.9088 14.0818 11.6383 12.882 14.5625 13.6198 13.5592 17.2047
Translational Efficiency 0.9551 0.6615 0.5996 0.4794 0.5246 0.5059 0.5581 0.4164 0.4481 0.3899

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1969 539 560 1014 1127 793 221 2638 3096 1332 781 3652

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 651.87 725.48 933.00 863.66 685.09 749.21 922.08 934.87 663.96 739.61 929.91 915.10
Standard Deviation 64.71 102.01 147.32 145.26 80.25 112.48 91.04 135.43 72.55 108.99 133.91 141.86
Intensity Change Log 2 — 0.154352 0.517293 0.405879 — 0.129077 0.428598 0.448472 — 0.141455 0.472525 0.427862

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000040 0.000367 0.001186 0.002667 0.000195 0.000527 0.000540 0.000299 0.000097 0.000462 0.001003 0.000957
Bud Neck 0.005204 0.007670 0.008422 0.021437 0.002630 0.014046 0.002532 0.036954 0.004267 0.011466 0.006755 0.032646
Bud Site 0.001150 0.002298 0.003502 0.043195 0.000956 0.007739 0.000884 0.012111 0.001079 0.005537 0.002761 0.020742
Cell Periphery 0.000095 0.000157 0.000102 0.001663 0.000123 0.000219 0.000095 0.000141 0.000105 0.000194 0.000100 0.000563
Cytoplasm 0.305754* 0.200924* 0.013112 0.077945 0.299764* 0.181666* 0.031101 0.128927* 0.303574* 0.189459* 0.018202 0.114772*
Cytoplasmic Foci 0.055774 0.074626 0.000968 0.026576 0.062067 0.083859 0.003314 0.000412 0.058065 0.080123 0.001632 0.007677
Eisosomes 0.000045 0.000082 0.000036 0.000072 0.000052 0.000089 0.000061 0.000015 0.000047 0.000086 0.000043 0.000031
Endoplasmic Reticulum 0.001219 0.002784 0.010108 0.009387 0.001732 0.002509 0.007664 0.002498 0.001406 0.002620 0.009416 0.004411
Endosome 0.001305 0.005190 0.000781 0.027800 0.002523 0.006316 0.001078 0.000705 0.001748 0.005861 0.000865 0.008228
Golgi 0.000371 0.002733 0.005659 0.021070 0.001804 0.004020 0.000062 0.000078 0.000893 0.003499 0.004075 0.005907
Lipid Particles 0.008917 0.012925 0.000417 0.002435 0.008087 0.016043 0.001419 0.000253 0.008615 0.014781 0.000701 0.000859
Mitochondria 0.005626 0.012885 0.001370 0.017380 0.002921 0.021071 0.000515 0.007384 0.004641 0.017759 0.001128 0.010160
Mitotic Spindle 0.002082 0.010327 0.001892 0.079655 0.003599 0.025265 0.000177 0.022089 0.002634 0.019220 0.001407 0.038073
None 0.009558 0.012441 0.004272 0.007959 0.014264 0.010212 0.004315 0.008728 0.011271 0.011114 0.004284 0.008514
Nuclear Periphery 0.003321 0.003061 0.001099 0.006249 0.002082 0.003921 0.001529 0.003632 0.002870 0.003573 0.001221 0.004358
Nuclear Periphery Foci 0.000876 0.002350 0.000496 0.002566 0.001501 0.002790 0.000697 0.000132 0.001104 0.002612 0.000553 0.000807
Nucleolus 0.005572 0.009978 0.003640 0.004597 0.004910 0.011770 0.002112 0.001603 0.005331 0.011045 0.003208 0.002434
Nucleus 0.585120* 0.616589* 0.935222* 0.556927* 0.581499* 0.582124* 0.925721* 0.761704* 0.583802* 0.596070* 0.932533* 0.704846*
Peroxisomes 0.002786 0.009489 0.000225 0.003231 0.003142 0.009553 0.000255 0.000114 0.002916 0.009527 0.000234 0.000980
Vacuole 0.004861 0.011910 0.006895 0.063009 0.005729 0.014698 0.015809 0.011368 0.005177 0.013570 0.009417 0.025706
Vacuole Periphery 0.000323 0.001215 0.000596 0.024181 0.000419 0.001564 0.000123 0.000853 0.000358 0.001423 0.000462 0.007330

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.83 -10.82 -6.31 -5.10 -1.16 -3.33 -5.58 -2.17 2.16 4.84 -6.47 -11.78 -7.62 -3.15 4.25
Bud Neck -1.72 -6.76 -8.51 -5.98 -3.40 -6.85 -3.53 -18.59 -8.39 -17.13 -6.15 -7.60 -19.32 -10.88 -12.69
Bud Site -2.22 -2.66 -8.01 -7.57 -6.60 -4.51 -3.11 -8.57 -0.69 -7.52 -4.80 -3.01 -11.33 -5.69 -7.42
Cell Periphery -4.48 -1.60 -1.22 -1.10 -1.19 -4.10 -0.11 2.81 5.23 1.87 -6.13 -1.12 -1.18 -0.54 -1.12
Cytoplasm 9.46 52.84 34.52 12.09 -14.15 10.87 29.78 24.44 10.18 -12.32 15.27 60.43 42.15 15.10 -25.22
Cytoplasmic Foci -3.39 22.19 15.51 11.51 -6.35 -3.53 16.19 17.60 17.72 2.41 -5.49 27.62 26.46 21.53 -3.50
Eisosomes -4.75 0.44 -3.93 0.93 -4.02 -5.21 -3.39 12.61 11.18 7.53 -7.60 -2.05 5.18 9.79 5.48
Endoplasmic Reticulum -4.55 -15.92 -20.62 -16.50 -2.51 -2.64 -8.79 -7.50 -4.38 7.15 -5.74 -18.10 -21.34 -14.24 8.70
Endosome -4.87 2.67 -7.65 -3.95 -8.00 -4.64 3.01 7.45 7.68 4.91 -7.25 4.38 -4.47 3.52 -6.40
Golgi -2.33 -1.27 -4.92 -2.86 -1.98 -1.67 2.72 2.73 3.58 0.59 -3.17 -0.83 -2.69 1.37 -0.07
Lipid Particles -2.72 9.83 7.90 8.13 -6.87 -4.16 7.69 10.23 9.51 5.23 -4.84 12.60 12.91 12.48 1.15
Mitochondria -3.25 4.90 -1.52 1.69 -4.25 -6.63 3.93 -3.19 5.60 -7.95 -6.92 5.84 -2.00 5.93 -7.89
Mitotic Spindle -2.43 -0.58 -9.02 -6.18 -8.82 -4.74 2.24 -7.15 0.83 -10.06 -5.49 0.45 -11.97 -2.60 -12.21
None -1.49 8.40 3.42 3.51 -2.64 2.09 7.26 4.43 1.84 -6.20 0.25 10.96 5.48 3.59 -7.62
Nuclear Periphery 0.52 3.70 -4.28 -4.59 -7.11 -2.23 -0.28 -9.60 -2.77 -13.31 -1.14 3.34 -8.43 -5.08 -15.83
Nuclear Periphery Foci -2.13 0.09 -4.01 -0.11 -3.37 -1.10 2.25 6.63 2.56 4.55 -2.16 1.01 2.15 2.68 0.35
Nucleolus -2.79 3.64 4.00 4.98 0.63 -4.52 4.86 5.20 7.04 -0.18 -5.05 5.04 7.65 8.85 2.17
Nucleus -1.74 -43.50 -7.32 -3.66 21.90 0.13 -25.35 -21.24 -17.48 10.57 -0.77 -50.20 -26.23 -17.25 25.10
Peroxisomes -4.84 5.69 1.61 5.55 -2.83 -5.39 5.36 5.79 8.54 4.65 -7.33 7.71 6.40 10.50 -1.85
Vacuole -4.55 -4.41 -16.55 -13.56 -14.68 -4.98 -5.10 -8.89 0.07 3.07 -6.93 -6.52 -18.39 -9.07 -7.47
Vacuole Periphery -4.05 -0.53 -5.38 -4.82 -5.31 -4.44 2.42 -0.09 4.25 -2.23 -6.21 0.15 -5.30 -2.98 -5.22
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the HOPS and the CORVET complexes; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages
Localization
Cell Percentages nucleus (66%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Vps16

Vps16


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Vps16-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available