Standard name
Human Ortholog
Description Essential component of the TIM23 complex; acts as receptor for the translocase of the inner mitochondrial membrane (TIM23) complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 – – – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Cytoplasm 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Golgi 0 0.11 0 0 0 0 0 0 0 0 0 0 0.14 0.1 0.2 – – – 0 0.06 0.06 0.08 0.1 0.07
Mitochondria 0.91 0.91 0.87 0.92 0.91 0.86 0.89 0.87 0.92 0.93 0.95 0.94 0.89 0.9 0.87 – – – 0.82 0.8 0.75 0.73 0.71 0.7
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0.07 0.08 0.07 0.1 0.07 0.09 0 0 0 – – – 0 0 0 0 0 0
Nucleolus 0.1 0 0.09 0 0.11 0.14 0.12 0.17 0.18 0.11 0.07 0.13 0 0 0 – – – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0.07 0.05 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Vac/Vac Membrane 0.13 0.16 0 0 0.06 0 0 0 0 0 0 0 0.11 0.09 0.11 – – – 0 0.08 0 0 0 0.07
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 0 0 0 0 0 1 1 0 1 1 2 2 3 – – – 3 3 4 5 5 11
Bud 0 0 4 2 1 1 3 8 4 8 9 0 2 1 0 – – – 1 0 0 1 1 2
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 1 0 0 0 0 0
Bud Site 1 0 0 0 0 0 1 2 1 1 0 1 0 0 0 – – – – – – – – –
Cell Periphery 1 6 2 3 0 0 1 0 1 1 0 1 3 5 5 – – – 0 0 0 0 0 0
Cytoplasm 5 0 3 5 2 5 3 9 6 6 5 2 9 6 3 – – – 1 0 0 0 0 0
Endoplasmic Reticulum 0 2 0 0 1 1 0 1 2 2 0 0 5 5 1 – – – 0 0 0 0 1 1
Endosome 0 0 0 0 0 0 2 0 0 1 0 0 0 1 1 – – – 3 0 1 1 7 5
Golgi 2 21 1 3 4 1 0 0 0 0 0 0 39 34 67 – – – 8 13 6 11 26 22
Mitochondria 188 168 80 101 106 144 200 209 132 172 140 137 254 316 289 – – – 170 170 76 101 182 219
Nucleus 1 1 1 0 1 1 1 1 0 0 0 1 1 0 0 – – – 2 0 0 0 0 1
Nuclear Periphery 4 3 3 0 5 7 15 18 10 19 10 13 2 5 7 – – – 0 1 0 1 2 3
Nucleolus 21 6 8 4 13 24 28 40 26 20 10 19 7 10 3 – – – 3 1 2 1 4 2
Peroxisomes 2 0 4 0 1 1 2 3 0 0 1 0 1 7 5 – – – 1 2 7 6 10 12
SpindlePole 1 0 0 0 0 1 1 2 0 1 0 0 0 0 0 – – – 1 0 0 1 0 0
Vac/Vac Membrane 26 29 3 2 7 6 10 5 0 6 1 4 31 30 38 – – – 6 17 0 2 8 22
Unique Cell Count 207 185 92 110 117 167 224 239 143 184 147 145 285 352 334 207 213 101 140 257 312
Labelled Cell Count 252 237 109 120 141 192 267 299 183 237 177 179 356 422 422 207 213 101 140 257 312


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 13.2 17.6 15.0 16.1 14.9 13.9 13.1 11.5 12.0 11.1 10.4 11.6 17.8 17.9 17.4 – – – 14.5 15.4 16.1
Std Deviation (1e-4) 3.0 3.3 3.5 3.9 4.0 3.9 3.5 3.0 3.6 2.9 2.8 3.3 3.5 4.1 3.5 – – – 3.4 3.3 3.3
Intensity Change (Log2) – – – 0.11 -0.01 -0.1 -0.19 -0.38 -0.31 -0.43 -0.53 -0.37 0.25 0.26 0.22 – – – -0.05 0.05 0.11

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70005101520WT3HU80HU120HU16005101520WT305101520WT1AF100AF140AF18005101520
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Bud 0 0 0 0 0 0 0 0.6 0 0 0 0 – – –
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Golgi 0 0 0 0 0 0 0 0 0 3.4 2.7 4.4 – – –
Mitochondria 1.1 0.8 -0.2 0.6 0.1 1.3 1.8 2.3 2.0 0.6 0.8 -0.1 – – –
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Nuclear Periphery 0 0 0 1.2 1.4 1.2 2.0 1.2 1.7 0 0 0 – – –
Nucleolus -1.5 0.6 1.3 1.0 1.9 2.0 0.6 -0.5 1.0 0 0 0 – – –
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 – – –
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Vacuole 0 0 0 0 0 0 0 0 0 2.2 1.7 2.3 – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 15.8962 16.417 16.4297 15.2402 14.6916 16.9901 19.3456 18.7628 18.3358 19.0969 17.3087 18.7716 22.3302 21.5178 20.9603 19.1646 21.0447 21.1898
Actin 0.0075 0.0036 0.0075 0.0065 0.0004 0.0002 0.0143 0.0048 0.0162 0.0046 0.0007 0.0067 0.0039 0.0016 0.0024 0.0208 0.0002 0.0004
Bud 0.0004 0.0002 0.0004 0.0131 0.0001 0 0.0003 0.0002 0.0004 0.0001 0.0001 0 0.0001 0.0001 0.0017 0.0006 0 0
Bud Neck 0.0017 0.0001 0.0005 0 0 0 0.0002 0.0001 0.0002 0.0001 0 0 0.0002 0.0001 0 0.0008 0 0
Bud Periphery 0.0006 0.0004 0.0008 0.0178 0.0005 0 0.0005 0.0005 0.001 0.0004 0.0002 0.0001 0.0001 0.0002 0.0028 0.0009 0 0
Bud Site 0.0121 0.0004 0.001 0.0032 0.0001 0 0.0012 0.0038 0.0026 0.0001 0.0001 0 0.0005 0.0003 0.0009 0.0101 0 0
Cell Periphery 0.0011 0.0005 0.0007 0.0002 0.0004 0.0001 0.0003 0.0003 0.0009 0.0001 0.0001 0.0001 0.0003 0.0005 0.0002 0.0008 0 0.0001
Cytoplasm 0.0013 0 0.0001 0 0.0001 0 0.0008 0 0.0007 0.0002 0.0074 0.0001 0.0014 0 0.0001 0.0021 0 0.0002
Cytoplasmic Foci 0.0136 0.0008 0.0022 0.0002 0.0003 0 0.0139 0.0002 0.0029 0.0044 0.0019 0.0024 0.0035 0.0009 0.0054 0.0293 0.0076 0.0005
Eisosomes 0.0006 0.0005 0.0007 0.0002 0.0001 0.0001 0.0005 0.001 0.0003 0.0004 0.0001 0.0001 0.0003 0.0001 0.0002 0.002 0 0.0001
Endoplasmic Reticulum 0.0013 0 0.0004 0.0001 0.0001 0 0.0008 0.0002 0.0004 0.0006 0.0003 0.0002 0.0028 0 0.0001 0.0006 0 0.0001
Endosome 0.012 0.0031 0.004 0.0046 0.0024 0.0003 0.0073 0.0014 0.003 0.0049 0.0062 0.0028 0.0079 0.0035 0.0019 0.0018 0.0002 0.0013
Golgi 0.0132 0.0138 0.01 0.0017 0.0009 0.001 0.0058 0.0033 0.0058 0.0041 0.0006 0.0083 0.0017 0.0131 0.0014 0.0014 0.0003 0.0065
Lipid Particles 0.0155 0.0046 0.0039 0.0021 0.0025 0.0018 0.017 0.0009 0.0074 0.0136 0.0003 0.0082 0.0043 0.0102 0.0092 0.018 0.0195 0.0013
Mitochondria 0.8934 0.9513 0.9445 0.9358 0.9449 0.9908 0.9074 0.9702 0.9431 0.9463 0.9601 0.9624 0.9389 0.9482 0.9515 0.8727 0.9653 0.9789
None 0.0013 0 0.0001 0.0001 0.0001 0 0.0049 0 0.0008 0.0003 0.0003 0.0001 0.0042 0 0.0004 0.0082 0 0.0001
Nuclear Periphery 0.0041 0.0001 0.0045 0.0002 0.0002 0 0.0017 0.0013 0.0003 0.005 0.0034 0.0004 0.0077 0 0.0007 0.0013 0 0.0016
Nucleolus 0.0025 0.0001 0.0002 0.0001 0.0021 0 0.0012 0.0001 0.0018 0.0001 0.0008 0.0001 0.002 0.0028 0.0003 0.0114 0.0044 0.0014
Nucleus 0.001 0.0001 0.0003 0.0001 0.0016 0 0.0006 0.0001 0.0003 0.0002 0.0055 0 0.0017 0.0005 0.0002 0.003 0.0002 0.0022
Peroxisomes 0.0066 0.009 0.0025 0.0014 0.0005 0.0002 0.0054 0.0021 0.0026 0.0023 0.0011 0.0013 0.0024 0.0017 0.0024 0.0043 0.0008 0.0005
Punctate Nuclear 0.0006 0 0.0002 0 0 0 0.0048 0 0.0003 0.0061 0.0018 0.0002 0.0021 0 0.0024 0.0026 0.0005 0.0018
Vacuole 0.0044 0.0026 0.0025 0.0023 0.0124 0.0003 0.0026 0.0017 0.0053 0.0016 0.0045 0.0004 0.0041 0.0056 0.0046 0.0031 0.0001 0.0004
Vacuole Periphery 0.0052 0.0088 0.0131 0.0102 0.0302 0.0052 0.0086 0.0078 0.0039 0.0044 0.0044 0.0062 0.01 0.0106 0.0115 0.0041 0.0007 0.0027

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 58.987 57.9005 56.2632 67.1612 61.9832 77.0645 67.4291 64.9137 70.9608 72.5185
Translational Efficiency 1.8692 1.6884 1.8273 1.541 1.5062 1.2727 1.2885 1.2817 1.23 1.2582

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1529 856 568 1473 400 2287 492 156 1929 3143 1060 1629

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1005.13 1381.70 1587.00 1441.99 1246.89 1327.01 1376.19 1452.29 1055.26 1341.90 1489.15 1442.98
Standard Deviation 164.70 276.39 312.22 253.86 211.26 271.28 275.32 231.02 200.91 273.77 313.80 251.78
Intensity Change Log 2 — 0.459062 0.658920 0.520679 — 0.089845 0.142345 0.219995 — 0.266386 0.395931 0.361985

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001006 0.002449 0.002684 0.002736 0.000870 0.000620 0.002897 0.002986 0.000978 0.001118 0.002783 0.002760
Bud Neck 0.000629 0.001283 0.004725 0.001762 0.001942 0.000530 0.013415 0.006611 0.000901 0.000735 0.008759 0.002227
Bud Site 0.001564 0.001483 0.004111 0.007197 0.001241 0.000607 0.018532 0.011878 0.001497 0.000846 0.010805 0.007645
Cell Periphery 0.000317 0.000163 0.000143 0.000682 0.000233 0.000134 0.000540 0.000347 0.000300 0.000142 0.000327 0.000650
Cytoplasm 0.000228 0.000288 0.000641 0.000664 0.000209 0.000109 0.001906 0.000713 0.000224 0.000158 0.001228 0.000669
Cytoplasmic Foci 0.009922 0.014600 0.038487 0.008897 0.023872 0.006076 0.029058 0.013654 0.012815 0.008398 0.034111 0.009352
Eisosomes 0.000101 0.000276 0.000260 0.000120 0.000205 0.000150 0.000188 0.000153 0.000123 0.000184 0.000227 0.000124
Endoplasmic Reticulum 0.000229 0.000170 0.000213 0.001215 0.000178 0.000066 0.000712 0.000308 0.000219 0.000094 0.000445 0.001128
Endosome 0.005316 0.004975 0.006412 0.007789 0.007338 0.002748 0.023511 0.015345 0.005735 0.003354 0.014349 0.008513
Golgi 0.012507 0.023346 0.039582 0.061306 0.016936 0.010331 0.031019 0.054481 0.013425 0.013876 0.035608 0.060653
Lipid Particles 0.005282 0.003783 0.008168 0.002413 0.007617 0.001895 0.009042 0.000511 0.005766 0.002409 0.008574 0.002230
Mitochondria 0.936393 0.919523 0.803936 0.825474 0.902171 0.956922 0.746893 0.816008 0.929296 0.946737 0.777460 0.824568
Mitotic Spindle 0.000938 0.001166 0.009139 0.006135 0.003629 0.000252 0.016057 0.006444 0.001496 0.000501 0.012350 0.006165
None 0.000972 0.001479 0.002905 0.001742 0.001788 0.001289 0.001495 0.001107 0.001141 0.001341 0.002251 0.001681
Nuclear Periphery 0.000203 0.000188 0.004523 0.000912 0.001348 0.000212 0.004957 0.000342 0.000441 0.000205 0.004724 0.000858
Nuclear Periphery Foci 0.000251 0.000256 0.001948 0.001016 0.001079 0.000225 0.004984 0.000301 0.000423 0.000233 0.003357 0.000948
Nucleolus 0.000286 0.000976 0.002189 0.000393 0.000991 0.000309 0.004132 0.000344 0.000432 0.000491 0.003091 0.000389
Nucleus 0.000124 0.000150 0.000274 0.000136 0.000221 0.000071 0.001460 0.000137 0.000144 0.000093 0.000824 0.000136
Peroxisomes 0.006843 0.009370 0.011843 0.002085 0.009046 0.002831 0.018089 0.008137 0.007300 0.004612 0.014742 0.002665
Vacuole 0.008030 0.007315 0.019718 0.019996 0.008605 0.007284 0.034546 0.033602 0.008150 0.007292 0.026600 0.021299
Vacuole Periphery 0.008859 0.006760 0.038097 0.047329 0.010482 0.007338 0.036565 0.026592 0.009195 0.007181 0.037386 0.045343

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.07 -3.64 -3.56 -0.41 -0.13 0.80 -2.97 -2.26 -2.55 -0.06 -0.45 -4.35 -4.07 -3.65 0.02
Bud Neck -2.06 -6.61 -3.81 -1.18 4.39 2.92 -6.20 -1.65 -2.16 2.01 0.94 -8.63 -3.39 -3.79 6.68
Bud Site 0.10 -2.29 -4.38 -4.52 -1.98 1.28 -5.50 -2.36 -2.51 1.20 1.31 -5.78 -5.05 -5.95 1.67
Cell Periphery 1.69 2.50 -2.46 -3.54 -4.01 0.63 -1.82 -0.70 -3.62 2.20 2.37 -0.43 -2.60 -4.14 -2.56
Cytoplasm -0.63 -1.82 -3.34 -2.81 -0.03 3.03 -1.94 -2.70 -3.27 1.41 1.17 -2.33 -3.83 -4.80 1.38
Cytoplasmic Foci -2.43 -7.72 0.70 3.11 8.10 5.12 -1.16 2.02 -2.02 3.20 3.41 -8.09 2.38 -0.89 9.70
Eisosomes -7.18 -6.72 -1.24 5.86 5.40 1.65 0.45 1.37 -0.14 1.40 -4.58 -6.26 -0.07 3.87 5.59
Endoplasmic Reticulum 1.21 0.38 -3.15 -3.33 -3.20 3.45 -4.83 -1.84 -3.83 3.30 4.23 -3.85 -3.21 -3.67 -2.38
Endosome 0.33 -1.15 -2.60 -2.58 -1.27 2.38 -5.01 -1.95 -3.46 1.83 3.38 -5.98 -2.85 -6.23 3.86
Golgi -3.43 -6.16 -11.65 -7.67 -3.74 2.07 -2.71 -3.33 -4.05 -2.01 -0.28 -6.91 -11.98 -11.94 -5.21
Lipid Particles 1.25 -1.99 2.73 1.48 4.66 3.10 -0.56 3.89 4.56 4.67 3.86 -2.13 3.76 0.30 5.58
Mitochondria 2.19 10.88 13.38 9.74 -1.61 -5.29 8.61 3.46 6.12 -2.55 -3.68 15.01 13.29 16.63 -4.11
Mitotic Spindle -0.49 -5.30 -4.83 -4.57 1.65 2.22 -3.66 -1.06 -2.91 2.61 2.44 -6.48 -4.51 -5.90 3.28
None -2.98 -6.91 -7.77 -1.44 4.07 2.56 1.28 3.04 1.38 2.15 -2.40 -6.47 -5.65 -3.61 3.21
Nuclear Periphery 0.30 -3.32 -4.64 -4.72 2.75 1.92 -2.82 1.67 -1.02 4.05 1.78 -4.86 -2.27 -4.61 4.37
Nuclear Periphery Foci -0.08 -3.15 -1.53 -1.52 1.25 2.82 -2.80 2.54 -0.87 3.43 2.32 -4.19 -1.16 -1.58 2.89
Nucleolus -1.32 -3.50 -0.96 1.10 3.26 1.49 -2.50 1.38 -0.32 3.18 -0.32 -4.20 0.31 0.58 4.28
Nucleus -0.40 -2.72 -0.31 0.21 2.51 2.34 -2.83 1.11 -1.50 3.04 1.53 -3.32 0.20 -1.32 3.36
Peroxisomes -1.34 -2.22 4.28 4.49 4.78 3.60 -2.86 0.26 -1.63 2.40 2.52 -3.97 4.60 2.61 6.97
Vacuole 0.39 -5.64 -6.46 -5.82 -0.11 0.82 -7.14 -3.15 -3.35 0.10 0.77 -9.07 -7.28 -7.99 2.15
Vacuole Periphery 1.59 -7.46 -13.93 -14.20 -1.98 1.25 -5.44 -2.30 -2.92 1.28 2.06 -9.64 -13.88 -14.99 -2.13
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Essential component of the TIM23 complex; acts as receptor for the translocase of the inner mitochondrial membrane (TIM23) complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel
Localization
Cell Percentages mitochondrion (99%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Tim50

Tim50


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Tim50-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available