Standard name
Human Ortholog
Description Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0.07 0.05 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0.05 0 0 0.05 0.09 0.13 0.1 0.09 0.1 0.06 0.06 0.07 0.15 0.14 0.11 0.11 0.11 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.07 0.5 0 0.05 0 0.28 0.51 0.14 0.69 0.45 0.42 0.55 0 0 0 0.06 0.08 0 0 0 0 0 0 0
Nucleus 0.93 0.79 0.94 0.93 0.92 0.85 0.63 0.77 0.68 0.79 0.78 0.72 0.91 0.82 0.84 0.83 0.76 0.8 0.91 0.8 0.91 0.82 0.77 0.62
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0 0.09 0.11 0.07 0 0.11 0.08 0.1 0.12 0.22
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 1 5 0 4 5 3 4 0 0 0 1 0 0 2 1 0 1 0 2
Bud Neck 0 0 0 0 0 0 1 3 1 1 0 3 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 1 3 2 12 8 6 14 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 9 19 4 3 8 4 18 17 16 15 16 19 9 34 35 29 19 22 4 5 0 6 2 7
Endoplasmic Reticulum 0 2 0 0 0 0 0 2 0 0 0 0 0 1 2 9 10 5 0 0 0 0 0 0
Endosome 0 1 0 1 0 1 0 1 0 0 0 1 0 1 0 3 0 2 0 7 0 0 1 2
Golgi 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 1 0
Mitochondria 20 207 3 6 4 13 69 22 122 69 114 175 5 4 2 15 14 8 2 11 0 1 2 7
Nucleus 262 328 92 113 153 39 85 124 120 122 211 231 116 182 205 222 133 160 254 355 101 172 132 129
Nuclear Periphery 0 0 0 0 0 0 2 1 0 1 0 0 0 0 1 2 0 2 0 0 0 0 0 0
Nucleolus 0 0 1 1 1 0 1 0 1 2 3 4 0 0 1 1 0 1 0 0 0 0 4 6
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 1 1 1 1 2 0 2 0 3 1 7 0 2 3 0 1 1 0 7 0 2 3 3
Vac/Vac Membrane 10 7 1 2 3 0 1 11 4 1 5 9 1 9 3 23 20 15 12 49 9 21 20 44
Unique Cell Count 282 415 98 121 167 46 134 162 177 155 270 320 128 223 244 269 176 201 281 446 112 210 172 207
Labelled Cell Count 302 565 102 127 171 61 185 185 280 227 359 467 131 233 252 306 198 216 281 446 112 210 172 207


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.1 3.7 5.5 5.3 5.9 4.6 3.4 5.2 3.8 4.3 4.2 4.1 5.4 5.5 5.4 4.9 5.9 6.5 5.7 6.2 6.2
Std Deviation (1e-4) 0.9 0.7 1.0 1.3 1.3 1.2 1.1 1.7 1.1 1.2 1.3 0.8 0.9 1.3 1.1 1.2 1.3 1.7 1.0 1.4 1.1
Intensity Change (Log2) – – – -0.06 0.1 -0.26 -0.68 -0.07 -0.55 -0.35 -0.39 -0.43 -0.04 -0.0 -0.04 -0.16 0.09 0.24 0.04 0.17 0.18

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 2.6 3.1 2.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.4222 4.4672 4.4912 4.1159 3.8727 4.3684 4.1423 4.665 3.9241 4.156 4.1738 4.0224 2.2997 2.0175 1.9613 2.181 1.6801 1.7932
Actin 0.0441 0.0001 0.0124 0.0014 0.0233 0.0114 0.02 0.0001 0.0017 0 0.0016 0.0001 0.0587 0.0001 0.0126 0.0398 0.0021 0.0043
Bud 0.0004 0 0.0002 0 0.0004 0.0003 0.0003 0 0.0003 0 0.0004 0.0001 0.001 0 0.0003 0.0006 0.0001 0.0002
Bud Neck 0.006 0.0001 0.0012 0.0002 0.001 0.0015 0.0024 0.0001 0.0046 0.0001 0.0003 0.0009 0.0192 0.0003 0.0006 0.0016 0.0007 0.0012
Bud Periphery 0.0006 0 0.0003 0.0001 0.0028 0.0013 0.0006 0 0.0007 0 0.0005 0.0001 0.0012 0 0.0004 0.0023 0.0001 0.0004
Bud Site 0.0118 0.0001 0.005 0.0001 0.0004 0.0014 0.0066 0 0.0057 0 0.0006 0.0001 0.0287 0.0002 0.0066 0.0049 0.0001 0.0005
Cell Periphery 0.0006 0 0.0008 0 0.0001 0.0001 0.0004 0 0.0004 0 0.0001 0 0.0004 0 0.0001 0.0029 0 0.0001
Cytoplasm 0.0043 0.0012 0.0069 0.0004 0.0002 0.0023 0.0092 0.0031 0.003 0.0001 0.0045 0.0006 0.0197 0.0112 0.003 0.0143 0.0033 0.0018
Cytoplasmic Foci 0.0149 0 0.003 0.0005 0.0014 0.0015 0.0193 0.0003 0.0023 0 0.0111 0.0007 0.026 0.0003 0.0118 0.0013 0.001 0.0027
Eisosomes 0.0008 0 0.0001 0 0.0002 0.0002 0.0003 0 0.0002 0 0 0 0.0004 0 0.0002 0.0004 0 0
Endoplasmic Reticulum 0.0022 0.0005 0.0017 0 0.0007 0.0041 0.0026 0.0001 0.0008 0 0.0044 0 0.0037 0.0008 0.0002 0.0093 0.002 0.0005
Endosome 0.0236 0.0001 0.006 0.0009 0.0039 0.0087 0.0093 0.0001 0.0015 0 0.0243 0.0003 0.0198 0.0009 0.0047 0.0021 0.017 0.0059
Golgi 0.0103 0 0.0053 0.0014 0.0064 0.0021 0.0031 0 0.0006 0 0.0032 0.0003 0.0123 0 0.0041 0.0057 0.0008 0.0025
Lipid Particles 0.0139 0 0.0029 0.0013 0.007 0.0013 0.0057 0.0001 0.0016 0 0.0088 0.0044 0.0184 0.0001 0.0093 0.002 0.0004 0.0052
Mitochondria 0.0033 0.0005 0.0028 0.0302 0.0083 0.003 0.0018 0.0002 0.003 0.0001 0.0114 0.0004 0.0086 0.0003 0.0211 0.0014 0.0014 0.0074
None 0.0376 0.0061 0.0138 0.0002 0.0003 0.0006 0.0289 0.0655 0.0075 0 0.0006 0.0052 0.0123 0.0169 0.0017 0.0039 0.0018 0.0002
Nuclear Periphery 0.0057 0.0116 0.0095 0.0014 0.0143 0.0072 0.0082 0.0086 0.0054 0.0003 0.0064 0.0005 0.0125 0.0083 0.0018 0.0033 0.0245 0.0019
Nucleolus 0.0055 0.0072 0.0049 0.0076 0.0197 0.0092 0.0078 0.0051 0.0044 0.0044 0.0038 0.0091 0.0056 0.0054 0.0041 0.0024 0.0091 0.0097
Nucleus 0.7932 0.9681 0.9155 0.9306 0.8887 0.9311 0.841 0.9087 0.9455 0.9946 0.8673 0.9677 0.6762 0.9505 0.9052 0.8947 0.9292 0.9497
Peroxisomes 0.0105 0 0.0042 0.0022 0.0037 0.0014 0.0081 0 0.0033 0 0.043 0.0052 0.0449 0 0.0095 0.0015 0.0002 0.0032
Punctate Nuclear 0.0086 0.0037 0.0022 0.0211 0.0113 0.0061 0.0208 0.0076 0.0057 0.0004 0.0029 0.0039 0.0277 0.0038 0.0014 0.0045 0.0037 0.0013
Vacuole 0.0012 0.0002 0.0011 0.0001 0.0017 0.0039 0.0029 0.0002 0.0015 0 0.0031 0.0002 0.002 0.0006 0.0011 0.001 0.0011 0.0009
Vacuole Periphery 0.0006 0.0002 0.0004 0.0001 0.0041 0.0014 0.0007 0.0001 0.0003 0 0.0019 0 0.0007 0.0002 0.0003 0.0002 0.0013 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 14.0057 3.2661 12.926 18.7102 17.3695 12.1721 14.5856 21.9175 22.2998 17.6117
Translational Efficiency 0.5585 2.7396 0.7783 0.4797 0.499 0.7851 0.6704 0.5746 0.5389 0.619

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2527 1036 1410 1613 1610 1939 228 1716 4137 2975 1638 3329

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 771.63 793.71 852.15 892.08 659.82 852.61 954.41 926.45 728.12 832.10 866.38 909.80
Standard Deviation 90.14 111.23 110.31 133.55 91.79 103.62 109.73 125.03 105.89 109.97 115.77 130.37
Intensity Change Log 2 — 0.040703 0.143198 0.209264 — 0.369813 0.532537 0.489641 — 0.201768 0.335768 0.345295

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000035 0.000234 0.000328 0.001536 0.000102 0.000123 0.000460 0.001098 0.000061 0.000162 0.000346 0.001310
Bud Neck 0.002427 0.003466 0.006360 0.015867 0.001658 0.004729 0.004434 0.014938 0.002127 0.004289 0.006092 0.015388
Bud Site 0.000731 0.000945 0.001184 0.014629 0.000819 0.003268 0.000667 0.005870 0.000765 0.002459 0.001112 0.010114
Cell Periphery 0.000110 0.000108 0.000078 0.000176 0.000157 0.000191 0.000057 0.000131 0.000128 0.000162 0.000075 0.000153
Cytoplasm 0.035944 0.027846 0.005101 0.029310 0.047175 0.030546 0.002893 0.022775 0.040315 0.029606 0.004794 0.025941
Cytoplasmic Foci 0.002420 0.003654 0.000120 0.003892 0.004878 0.006318 0.000035 0.001326 0.003377 0.005390 0.000108 0.002569
Eisosomes 0.000010 0.000017 0.000017 0.000028 0.000017 0.000021 0.000023 0.000020 0.000013 0.000019 0.000018 0.000024
Endoplasmic Reticulum 0.001235 0.004852 0.004506 0.007894 0.001526 0.003059 0.005610 0.007341 0.001348 0.003683 0.004659 0.007609
Endosome 0.000293 0.001454 0.000251 0.004110 0.000763 0.002006 0.000182 0.001229 0.000475 0.001814 0.000242 0.002625
Golgi 0.000081 0.000299 0.000029 0.004783 0.000240 0.000555 0.000026 0.001019 0.000143 0.000466 0.000028 0.002843
Lipid Particles 0.000557 0.001450 0.000140 0.000524 0.001335 0.001546 0.000138 0.000185 0.000860 0.001513 0.000140 0.000349
Mitochondria 0.001858 0.002197 0.000678 0.006702 0.002188 0.004917 0.000597 0.003272 0.001987 0.003970 0.000666 0.004934
Mitotic Spindle 0.000810 0.001500 0.000603 0.029203 0.001357 0.002667 0.000070 0.008788 0.001023 0.002261 0.000529 0.018680
None 0.003099 0.008073 0.003079 0.004394 0.013467 0.007300 0.003097 0.005125 0.007134 0.007569 0.003082 0.004771
Nuclear Periphery 0.001504 0.000795 0.000540 0.003249 0.000589 0.001335 0.000445 0.001566 0.001148 0.001147 0.000527 0.002381
Nuclear Periphery Foci 0.000107 0.000325 0.000085 0.001669 0.000693 0.000209 0.000057 0.000236 0.000335 0.000249 0.000081 0.000930
Nucleolus 0.001731 0.003440 0.001983 0.001414 0.003871 0.003629 0.001886 0.001950 0.002564 0.003563 0.001969 0.001690
Nucleus 0.944999 0.931816 0.973025 0.847477 0.916765 0.919381 0.977126 0.913869 0.934011 0.923711 0.973596 0.881700
Peroxisomes 0.000368 0.001247 0.000067 0.000789 0.000886 0.001784 0.000072 0.000143 0.000570 0.001597 0.000068 0.000456
Vacuole 0.001519 0.005807 0.001713 0.016433 0.001258 0.005665 0.002071 0.007705 0.001417 0.005715 0.001763 0.011934
Vacuole Periphery 0.000163 0.000474 0.000115 0.005923 0.000257 0.000751 0.000055 0.001415 0.000200 0.000654 0.000106 0.003599

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -7.32 -17.55 -5.68 -4.69 -4.09 -0.84 -6.28 -2.26 -2.21 -0.91 -5.82 -16.24 -4.37 -3.97 -2.98
Bud Neck -1.30 -4.90 -13.66 -10.44 -6.68 -4.04 -5.60 -14.39 -9.85 -6.60 -3.81 -6.01 -19.69 -14.11 -8.38
Bud Site -0.60 -1.63 -7.21 -7.12 -6.81 -3.30 -1.52 -5.39 -1.73 -4.30 -3.35 -2.06 -8.94 -5.88 -8.14
Cell Periphery 0.06 2.10 -1.62 -1.52 -3.65 -0.97 3.00 1.41 3.29 -3.00 -1.81 3.39 0.12 2.21 -4.28
Cytoplasm 2.35 14.97 2.53 -0.28 -10.99 4.59 13.59 7.38 3.24 -8.99 4.55 19.96 7.11 2.04 -13.99
Cytoplasmic Foci -1.48 6.56 1.27 2.19 -3.44 -1.00 7.07 5.60 6.37 -2.01 -2.69 9.25 5.21 6.37 -3.57
Eisosomes -5.20 -8.20 -15.55 -8.36 -8.67 -1.11 -3.34 -3.89 -3.07 1.30 -4.40 -5.92 -13.67 -7.13 -7.15
Endoplasmic Reticulum -11.79 -13.10 -16.94 -8.10 -8.00 -3.72 -7.61 -15.10 -9.25 -0.97 -8.12 -14.86 -22.72 -12.34 -8.62
Endosome -2.73 0.27 -4.36 -1.30 -4.39 -2.39 2.02 -0.48 2.19 -3.21 -3.95 2.13 -4.27 0.53 -5.43
Golgi -2.34 1.61 -3.26 -2.87 -3.34 -1.38 2.64 -0.97 -0.00 -1.70 -2.29 3.17 -3.41 -2.34 -3.76
Lipid Particles -1.60 4.05 0.82 1.78 -4.71 -0.40 3.88 3.74 4.02 -1.04 -2.05 5.39 3.89 4.05 -4.64
Mitochondria -0.42 2.50 -3.71 -2.57 -6.33 -2.20 1.80 -0.63 1.87 -3.37 -2.51 3.06 -2.95 0.29 -6.92
Mitotic Spindle -0.70 -0.03 -8.10 -7.42 -8.10 -1.22 -0.44 -5.15 -4.15 -3.54 -1.69 0.01 -9.68 -8.34 -9.65
None -3.92 0.14 -2.56 2.81 -2.08 3.45 6.63 5.30 2.15 -3.03 -0.43 5.24 3.39 3.47 -3.04
Nuclear Periphery 3.71 4.59 -5.29 -7.88 -8.37 -5.88 -1.81 -15.33 -6.68 -10.57 -0.03 3.97 -8.86 -9.43 -12.76
Nuclear Periphery Foci -2.85 -0.30 -2.67 -2.02 -2.64 1.65 1.72 0.86 -2.61 -2.34 0.79 1.77 -1.80 -2.75 -3.49
Nucleolus -3.30 -0.89 0.41 3.67 1.42 0.57 3.81 3.33 2.86 -0.62 -2.22 1.91 2.69 4.48 0.70
Nucleus 2.30 -7.40 12.80 8.82 17.32 -0.53 -7.50 1.50 2.10 9.47 2.40 -11.53 11.22 7.83 20.86
Peroxisomes -2.54 3.27 -0.45 2.21 -2.51 -1.76 2.86 2.84 4.53 -0.22 -3.42 4.11 2.14 4.77 -2.72
Vacuole -2.77 -1.83 -12.30 -7.77 -11.94 -5.32 -3.79 -9.60 -5.25 -5.45 -5.60 -3.59 -15.46 -9.78 -14.24
Vacuole Periphery -2.52 0.81 -3.55 -3.09 -3.61 -2.54 1.57 -1.95 -0.16 -2.89 -3.79 1.40 -4.06 -2.81 -4.30
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages nucleus (95%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Cwc27

Cwc27


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cwc27-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available