Standard name
Human Ortholog
Description Essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; cotranslationally N-acetylated by NatA; other members are Sec63p, Sec66p, and Sec72p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0.06 0.11 0.19 0.1 0.12 0.11 0.06 – 0.09 0.1 0.11 0.07 0.09 0 0.14 0.17 0.15 0.07 0 0 0 0 0
Bud – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery – 0.09 0.09 0.19 0.08 0.08 0.08 0.12 – 0.12 0.17 0.18 0.12 0.2 0.26 0.49 0.53 0.39 0 0 0 0 0 0
Cytoplasm – 0.12 0.06 0 0.08 0.09 0.11 0.14 – 0.12 0.12 0.17 0.12 0.05 0.06 0.19 0.19 0.16 0 0 0 0 0 0
Endoplasmic Reticulum – 0.89 0.84 0.76 0.84 0.79 0.72 0.6 – 0.63 0.56 0.57 0.71 0.83 0.83 0 0 0 0.73 0.9 0.9 0.9 0.87 0.85
Endosome – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi – 0 0 0.19 0.08 0 0 0 – 0 0 0 0.09 0.05 0 0.22 0.2 0.44 0 0 0 0 0 0
Mitochondria – 0 0.1 0.15 0.05 0.15 0.28 0.3 – 0.19 0.4 0.34 0 0 0 0.08 0.08 0.06 0.05 0 0 0 0 0
Nucleus – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery – 0 0 0.06 0 0 0 0 – 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane – 0 0 0.06 0 0 0.06 0 – 0.11 0 0 0.14 0 0 0 0 0.21 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 12 16 10 18 28 35 15 – 34 23 24 26 47 21 23 21 19 2 5 5 6 16 13
Bud – 0 0 0 0 0 2 6 – 1 3 4 5 2 1 1 0 0 0 0 0 0 2 1
Bud Neck – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2
Bud Site – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery – 18 13 10 14 20 25 28 – 43 38 39 47 103 140 81 64 51 1 4 4 3 8 17
Cytoplasm – 25 8 2 15 22 33 34 – 43 28 37 47 25 35 31 23 21 1 3 1 3 6 5
Endoplasmic Reticulum – 184 118 41 157 191 220 145 – 231 127 125 268 421 448 1 5 0 30 191 123 258 390 404
Endosome – 0 0 0 0 0 0 0 – 1 0 0 0 0 0 0 0 0 0 2 0 0 1 0
Golgi – 0 5 10 14 0 3 1 – 2 0 0 34 24 8 37 24 57 0 0 0 3 5 5
Mitochondria – 0 14 8 9 36 84 73 – 69 91 74 0 2 1 13 10 8 2 0 0 2 5 9
Nucleus – 0 0 0 1 1 1 1 – 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0
Nuclear Periphery – 0 5 3 2 1 9 5 – 6 6 10 0 1 1 1 0 0 0 0 0 0 0 0
Nucleolus – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane – 2 1 3 8 4 17 9 – 41 8 6 54 11 5 4 2 27 0 2 0 3 6 10
Unique Cell Count 207 140 54 186 243 305 240 365 227 219 376 507 541 166 120 130 42 214 138 287 448 475
Labelled Cell Count 241 180 87 238 303 429 317 472 324 319 481 636 661 192 149 183 42 214 138 287 448 475


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) – 22.0 15.2 15.3 13.4 11.1 10.2 10.0 – 10.0 9.6 9.9 20.2 20.7 20.0 21.9 22.8 23.0 21.8 22.7 22.5
Std Deviation (1e-4) – 4.4 2.9 2.2 2.7 1.7 2.0 1.8 – 2.3 2.0 2.2 2.9 3.5 3.3 4.2 4.6 4.3 3.9 4.4 4.1
Intensity Change (Log2) – – – 0.0 -0.19 -0.46 -0.59 -0.61 – -0.62 -0.67 -0.63 0.41 0.44 0.39 0.52 0.58 0.59 0.52 0.57 0.56


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 1.3 -0.5 0 0 -1.8 – -0.7 -0.4 -0.1 -1.7 -0.8 -3.5 0.6 1.4 0.8
Bud 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cell Periphery 1.8 -0.6 -0.4 -0.4 0.7 – 0.8 2.0 2.2 1.0 3.0 4.2 7.5 7.8 5.8
Cytoplasm 0 0.8 1.2 1.7 2.5 – 2.0 2.1 3.1 2.2 -0.4 0.3 3.4 3.3 2.8
Endoplasmic Reticulum -1.4 0 -1.4 -2.8 -4.9 – -4.6 -5.6 -5.4 -3.0 -0.4 -0.4 -15.0 -12.9 -14.0
Endosome 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Golgi 0 1.5 0 0 0 – 0 0 0 2.1 0.6 0 4.7 4.2 7.9
Mitochondria 0.9 -1.8 1.3 4.1 4.6 – 2.4 6.2 5.1 0 0 0 -0.7 -0.5 -1.2
Nucleus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 – 0 0 0.5 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 2.4 0 – 3.8 0 0 4.5 0 0 0 0 5.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 16.9828 16.5588 16.5446 16.7797 15.892 16.0794 19.8902 20.6201 19.7866 18.6998 19.7706 19.6921 18.6704 16.7111 17.684 15.925 16.4171 16.837
Actin 0.0118 0.009 0.0217 0.0122 0.0074 0.0186 0.0369 0.0006 0.0104 0.001 0.0001 0.0046 0.0041 0.0018 0.0005 0.0218 0.0001 0.0006
Bud 0.0001 0.0003 0.0005 0 0.0006 0.0001 0.0005 0.0001 0.0001 0.0003 0 0.0003 0.0001 0.0001 0 0.0002 0 0
Bud Neck 0.0003 0.0007 0.0025 0.001 0.0083 0.0007 0.0006 0.0004 0.0007 0.0002 0.0002 0.001 0.0002 0.0012 0.0002 0.0005 0.0001 0.0017
Bud Periphery 0.0002 0.001 0.0007 0.0001 0.0006 0.0002 0.0012 0.0005 0.0003 0.0012 0.0001 0.0007 0.0002 0.0002 0.0001 0.0005 0 0.0001
Bud Site 0.0004 0.0029 0.0037 0 0.0136 0.0001 0.0013 0.0007 0.0053 0.0002 0 0.0002 0.0002 0.0059 0 0.0004 0 0
Cell Periphery 0.0022 0.022 0.0066 0.0047 0.0025 0.0009 0.0064 0.0169 0.0079 0.005 0.002 0.0016 0.0039 0.0099 0.0029 0.0016 0.0032 0.0015
Cytoplasm 0.019 0.0351 0.017 0.0028 0.0423 0.0061 0.0078 0.0095 0.0052 0.0111 0.0017 0.0019 0.0052 0.0347 0.0082 0.0143 0.0022 0.0025
Cytoplasmic Foci 0.0069 0.0021 0.0076 0.0023 0.0276 0.0051 0.0054 0.0004 0.0046 0.0036 0.0001 0.0002 0.0031 0.0019 0.0002 0.0003 0.0001 0.0001
Eisosomes 0.0006 0.0009 0.0002 0.0004 0.0001 0.0001 0.0011 0.0003 0.0013 0.0036 0 0.0001 0.0005 0.0001 0 0.0012 0.0001 0.0001
Endoplasmic Reticulum 0.8923 0.8864 0.9023 0.9236 0.8287 0.9225 0.85 0.9487 0.9211 0.9476 0.9903 0.9738 0.9386 0.9232 0.977 0.8992 0.9834 0.979
Endosome 0.0165 0.0063 0.0059 0.0076 0.0147 0.0102 0.0151 0.0018 0.0086 0.005 0.0005 0.0027 0.0044 0.0011 0.0009 0.0038 0.001 0.0016
Golgi 0.0087 0.01 0.0069 0.0371 0.0138 0.0166 0.0147 0.0029 0.0076 0.0017 0.0007 0.003 0.003 0.0021 0.0011 0.0046 0.0021 0.0007
Lipid Particles 0.0067 0.0076 0.0079 0.0018 0.0076 0.0045 0.0103 0.0082 0.0109 0.0022 0.0006 0.0008 0.0035 0.0068 0.0005 0.0013 0.0009 0.0005
Mitochondria 0.0013 0.0005 0.0058 0.0008 0.0027 0.0067 0.0054 0.0007 0.0015 0.0007 0.0001 0.0009 0.001 0.0001 0.0003 0.0386 0.0001 0.0002
None 0.0011 0.0001 0.0002 0.0001 0.0002 0.0001 0.0078 0.0001 0.0003 0.006 0 0.0001 0.0012 0 0 0.0003 0 0.0001
Nuclear Periphery 0.0199 0.0085 0.0046 0.0032 0.0039 0.0048 0.0196 0.0045 0.0044 0.005 0.0022 0.0057 0.0232 0.0081 0.0057 0.007 0.005 0.0089
Nucleolus 0.0002 0 0.0001 0 0.0002 0 0.0008 0 0.0001 0.0001 0 0 0.0001 0 0 0.0001 0 0
Nucleus 0.0012 0.0009 0.0003 0.0001 0.0005 0.0003 0.0031 0.0003 0.0002 0.0004 0.0001 0.0003 0.0019 0.0006 0.0002 0.0005 0.0001 0.0005
Peroxisomes 0.0015 0.0001 0.0022 0.0001 0.0187 0.0005 0.0013 0 0.0065 0.0002 0 0 0.0006 0.0001 0 0.0003 0 0
Punctate Nuclear 0.005 0.0002 0.0006 0 0.0005 0.0001 0.0049 0 0.0004 0.0003 0 0 0.0015 0.0001 0 0.0002 0 0.0002
Vacuole 0.0025 0.0049 0.0023 0.0015 0.0046 0.0013 0.004 0.003 0.0021 0.004 0.0012 0.0015 0.0025 0.0018 0.0014 0.0013 0.0013 0.0012
Vacuole Periphery 0.0016 0.0005 0.0004 0.0007 0.0008 0.0004 0.0016 0.0005 0.0005 0.0006 0.0002 0.0007 0.0009 0.0002 0.0007 0.0022 0.0002 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 123.715 98.0398 80.7345 90.2995 93.6401 129.6618 91.5725 97.5013 91.5682 102.8904
Translational Efficiency 1.1616 1.0455 1.2335 1.0146 1.089 1.0265 1.0239 0.9637 1.0282 0.9818

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2188 1456 3019 781 2251 1633 2455 1121 4439 3089 5474 1902

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1398.15 1455.21 1969.03 1991.44 1485.74 1579.14 2049.62 2028.66 1442.57 1520.73 2005.17 2013.38
Standard Deviation 233.94 319.61 279.99 336.85 253.39 277.27 304.44 335.89 247.90 304.33 293.95 336.78
Intensity Change Log 2 — 0.057708 0.493966 0.510293 — 0.087957 0.464175 0.449345 — 0.073371 0.478695 0.479215

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000362 0.001205 0.000131 0.002280 0.000260 0.001901 0.000910 0.001302 0.000310 0.001573 0.000481 0.001704
Bud Neck 0.000081 0.000440 0.000111 0.000887 0.000114 0.000170 0.000566 0.000762 0.000098 0.000297 0.000315 0.000813
Bud Site 0.001416 0.004709 0.000476 0.005953 0.001636 0.003348 0.002868 0.005488 0.001527 0.003989 0.001549 0.005679
Cell Periphery 0.004192 0.004288 0.011009 0.036051 0.005634 0.005854 0.026606 0.030333 0.004923 0.005115 0.018004 0.032681
Cytoplasm 0.001822 0.006866 0.002669 0.001466 0.001698 0.000743 0.003808 0.001847 0.001759 0.003629 0.003180 0.001690
Cytoplasmic Foci 0.005000 0.015564 0.001047 0.001173 0.005258 0.002907 0.001895 0.002064 0.005131 0.008873 0.001427 0.001698
Eisosomes 0.000102 0.000108 0.000082 0.000640 0.000109 0.000206 0.000451 0.000488 0.000105 0.000160 0.000248 0.000550
Endoplasmic Reticulum 0.968653* 0.888131* 0.961371* 0.892041* 0.966545* 0.966729* 0.917242* 0.906714* 0.967584* 0.929682* 0.941580* 0.900689*
Endosome 0.004977 0.018772 0.003064 0.006801 0.004662 0.004220 0.005542 0.006300 0.004817 0.011079 0.004175 0.006506
Golgi 0.003190 0.018152 0.001829 0.014693 0.003727 0.004091 0.005689 0.011372 0.003463 0.010719 0.003560 0.012735
Lipid Particles 0.003829 0.013870 0.009259 0.018187 0.004219 0.004382 0.018857 0.019883 0.004026 0.008854 0.013563 0.019187
Mitochondria 0.000880 0.000769 0.000590 0.001616 0.001023 0.000955 0.001162 0.000491 0.000952 0.000867 0.000846 0.000953
Mitotic Spindle 0.000060 0.000294 0.000072 0.001074 0.000055 0.000400 0.000429 0.000473 0.000057 0.000350 0.000232 0.000719
None 0.001256 0.002283 0.001301 0.000364 0.000943 0.000443 0.000735 0.000419 0.001097 0.001310 0.001047 0.000397
Nuclear Periphery 0.000145 0.000544 0.000463 0.002141 0.000162 0.000170 0.001325 0.001480 0.000154 0.000346 0.000849 0.001751
Nuclear Periphery Foci 0.000735 0.009905 0.000965 0.002324 0.000351 0.000364 0.001179 0.001201 0.000540 0.004861 0.001061 0.001662
Nucleolus 0.000004 0.000034 0.000008 0.000130 0.000007 0.000003 0.000018 0.000012 0.000006 0.000018 0.000012 0.000060
Nucleus 0.000054 0.000191 0.000081 0.000348 0.000060 0.000039 0.000217 0.000134 0.000057 0.000111 0.000142 0.000222
Peroxisomes 0.001275 0.000454 0.001756 0.000561 0.001398 0.000574 0.003861 0.000743 0.001337 0.000517 0.002700 0.000668
Vacuole 0.000918 0.008587 0.003155 0.008205 0.001170 0.001448 0.005661 0.006349 0.001046 0.004813 0.004279 0.007111
Vacuole Periphery 0.001049 0.004834 0.000560 0.003066 0.000970 0.001052 0.000982 0.002148 0.001009 0.002835 0.000749 0.002525

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.28 2.25 -2.33 -1.24 -2.60 -2.78 -3.99 -2.32 0.54 -0.97 -3.54 -2.03 -3.25 -0.47 -2.84
Bud Neck -5.45 -1.31 -3.61 -2.28 -3.50 -1.25 -3.78 -3.89 -3.51 -0.82 -5.13 -3.93 -5.29 -3.88 -3.55
Bud Site -4.92 2.93 -3.23 -1.14 -3.86 -1.93 -2.00 -2.88 -1.48 -1.89 -4.38 -0.17 -4.30 -1.82 -4.24
Cell Periphery -0.17 -8.35 -9.03 -9.04 -7.03 -0.27 -12.51 -9.68 -9.53 -1.25 -0.38 -14.80 -13.31 -13.21 -6.63
Cytoplasm -6.23 -3.03 -0.27 3.86 0.60 3.92 -4.20 -0.51 -2.17 2.56 -4.63 -5.21 -0.52 2.54 2.08
Cytoplasmic Foci -5.80 5.17 4.55 8.39 -0.34 2.48 4.39 3.63 1.04 -0.28 -3.74 6.87 5.54 7.73 -0.73
Eisosomes -0.18 0.74 -2.35 -2.33 -2.46 -1.73 -5.78 -2.85 -2.00 -0.26 -1.62 -4.71 -3.64 -3.14 -2.44
Endoplasmic Reticulum 13.67 2.64 10.35 -0.18 9.46 -0.05 12.04 10.21 9.69 1.57 11.04 10.80 14.57 5.57 8.64
Endosome -13.54 4.36 -2.87 10.91 -6.54 1.00 -2.07 -2.63 -3.22 -1.05 -11.40 1.92 -3.73 7.13 -5.22
Golgi -8.90 2.49 -6.36 1.46 -7.31 -0.41 -2.52 -5.06 -4.65 -3.73 -7.83 -0.24 -8.03 -1.45 -8.08
Lipid Particles -7.15 -5.40 -6.53 -1.77 -3.85 -0.21 -9.56 -7.86 -7.56 -0.35 -6.23 -10.81 -10.23 -6.41 -3.34
Mitochondria 0.41 1.21 -1.13 -1.34 -1.65 0.16 -0.50 1.76 1.26 3.70 0.32 0.51 -0.06 -0.31 -0.43
Mitotic Spindle -2.89 -0.63 -1.84 -1.43 -1.82 -1.61 -1.37 -1.73 -0.21 -0.06 -2.45 -1.42 -2.46 -1.31 -1.65
None -1.39 -0.14 3.17 2.68 3.81 1.98 1.05 2.16 0.08 1.47 -0.58 0.25 3.69 2.47 3.74
Nuclear Periphery -3.62 -12.29 -8.99 -6.42 -7.51 -0.56 -12.78 -11.16 -11.04 -1.03 -3.66 -15.96 -13.90 -11.10 -7.34
Nuclear Periphery Foci -7.54 -1.21 -3.19 5.65 -2.65 -0.26 -4.59 -4.33 -4.20 0.10 -7.45 -3.94 -4.67 5.02 -2.25
Nucleolus -1.61 -3.36 -1.06 -0.80 -1.03 2.58 -4.32 -1.74 -4.11 2.19 -1.35 -5.10 -1.12 -0.86 -0.98
Nucleus -2.95 -3.09 -1.71 -0.98 -1.56 2.43 -5.56 -2.94 -3.70 2.01 -2.40 -6.25 -2.27 -1.56 -1.18
Peroxisomes 3.88 -1.45 2.40 -0.43 3.38 3.07 -4.64 2.09 -0.58 5.75 4.74 -4.54 3.06 -0.77 6.48
Vacuole -7.96 -5.45 -6.39 0.02 -4.35 -0.53 -7.23 -6.28 -5.58 -0.49 -7.06 -8.92 -9.03 -2.93 -3.87
Vacuole Periphery -6.11 1.78 -4.07 2.44 -5.52 -0.29 -0.12 -3.16 -2.63 -3.33 -5.48 1.52 -5.01 0.76 -6.36
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; cotranslationally N-acetylated by NatA; other members are Sec63p, Sec66p, and Sec72p
Localization
Cell Percentages ER (100%)
Cell Cycle Regulation No
Subcompartmental Group ER-5

Sec62

Sec62


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sec62-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available