Standard name
Human Ortholog
Description ATPase component of heat shock protein Hsp90 chaperone complex; serves as nucleotide exchange factor to load ATP onto the SSA class of cytosolic Hsp70s; plays a role in prion propagation and determining prion variants; binds unfolded proteins; member of Hsp110 subclass of HSP70 proteins; deletion results in spindle elongation in S phase; SSE1 has a paralog, SSE2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0.05 0.06 0 0.06 0 0 0 0.08 0.09 0.05 0 0 0 0 0 0
Cytoplasm 0.99 0.99 0.99 0.98 0.98 0.97 0.94 – 0.9 0.9 0.88 0.86 0.99 0.98 1.0 0.97 0.96 0.99 0.96 0.96 0.96 0.89 0.89 0.9
Endoplasmic Reticulum 0 0 0 0 0 0 0.06 – 0.08 0.08 0.1 0.09 0 0 0 0 0 0.05 0 0 0 0 0.05 0.05
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 1 1 4 1 0 0 0 0 0 0 0 0 0 0 1 0
Bud 0 2 3 2 1 3 2 – 2 12 18 6 1 0 1 3 1 0 0 2 2 1 2 6
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 13 12 16 24 30 – 30 44 25 43 2 0 2 62 44 28 1 0 0 0 0 0
Cytoplasm 159 188 312 375 502 528 709 – 499 639 584 584 331 427 469 761 472 564 157 189 309 228 326 425
Endoplasmic Reticulum 1 0 0 4 9 15 43 – 42 59 65 64 3 8 2 22 19 26 1 0 1 9 17 25
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 1 0 0 0 0 0 2 2 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 1 3 0 0 1 1 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 1 0 1 1 1 0 0 1 2 2 3 4 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 1 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 1 1 0 0 – 1 2 3 1 1 0 1 8 2 3 0 0 2 9 4 7
Unique Cell Count 160 189 315 381 513 546 756 553 713 663 676 335 434 471 787 490 571 164 197 324 257 365 474
Labelled Cell Count 160 192 328 394 529 570 784 575 758 700 700 338 436 476 860 544 621 164 197 324 257 365 474


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 117.8 98.4 98.6 100.8 100.8 87.9 84.0 – 78.1 73.0 68.0 83.2 125.0 127.1 121.9 90.4 94.2 87.3 103.8 104.5 111.4
Std Deviation (1e-4) 31.2 31.6 26.2 26.5 22.0 20.0 19.2 – 20.7 19.2 19.3 22.2 31.0 35.5 36.7 29.0 30.5 25.9 26.7 32.0 30.9
Intensity Change (Log2) – – – 0.03 0.03 -0.17 -0.23 – -0.34 -0.43 -0.54 -0.24 0.34 0.37 0.31 -0.13 -0.07 -0.18 0.07 0.08 0.18


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 1.8 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery -0.7 -0.8 0.2 -0.1 – 0.8 1.3 -0.3 1.4 -3.0 -4.3 -3.7 2.2 2.6 0.5
Cytoplasm -0.7 -1.3 -2.1 -3.7 – -5.0 -5.3 -5.8 -6.3 -0.3 -0.8 0.9 -2.2 -2.4 -0.4
Endoplasmic Reticulum 0 0 3.0 4.3 – 5.0 5.3 5.8 5.6 0 0 0 3.0 3.5 3.8
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration – – – – – – – – – – – – – – – – – –
Actin 0.0105 0.0001 0.0005 0.0029 0.0021 0.002 0.0006 0.0005 0.0003 0.0001 0.0014 0.0001 0.0826 0.0009 0.0171 0.0001 0 0.0005
Bud 0.0019 0.0003 0.0011 0.0033 0.0037 0.0021 0.0007 0.0002 0.0002 0.0001 0.0022 0.0001 0.0033 0.0003 0.0008 0.0001 0.0001 0.0003
Bud Neck 0.001 0.0002 0.0004 0.0011 0.0014 0.0086 0.0001 0.0003 0.0002 0.0003 0.0009 0.0006 0.0013 0.0001 0.0002 0.0002 0.0001 0.0004
Bud Periphery 0.0024 0.0001 0.0005 0.002 0.0055 0.0011 0.0002 0 0 0 0.0019 0 0.0031 0.0001 0.0002 0 0 0
Bud Site 0.0037 0.0002 0.0005 0.0013 0.0005 0.0008 0.0007 0.0007 0.0004 0 0.0004 0 0.002 0.0038 0.0011 0 0 0
Cell Periphery 0.0054 0.0025 0.0012 0.011 0.0005 0.0031 0.0018 0.0013 0.0004 0.0001 0.0004 0 0.0007 0.0001 0.0001 0 0 0
Cytoplasm 0.7588 0.9849 0.9651 0.8995 0.9307 0.9393 0.8809 0.9896 0.9602 0.9881 0.6857 0.9951 0.0098 0.9928 0.9596 0.9913 0.9966 0.9875
Cytoplasmic Foci 0.0151 0.0002 0.0046 0.0017 0.0008 0.0014 0.0021 0.0006 0.0032 0.0004 0.004 0.0002 0.013 0.0005 0.0049 0.0021 0.0013 0.0031
Eisosomes 0.0026 0 0 0 0 0 0 0.0002 0.0001 0 0 0 0.0003 0 0 0 0 0
Endoplasmic Reticulum 0.0148 0.001 0.0038 0.0027 0.0015 0.0027 0.0029 0.0002 0.0004 0.0003 0.0103 0.0004 0.0336 0.0001 0.0006 0.0001 0.0001 0.0018
Endosome 0.0133 0.0001 0.0008 0.0056 0.0052 0.0016 0.0028 0.0002 0.0003 0.0002 0.1482 0.0001 0.3699 0.0002 0.0053 0.002 0.0007 0.0026
Golgi 0.0069 0 0.0001 0.0006 0.0004 0.0001 0.0002 0.0001 0.0001 0 0.0183 0 0.4029 0.0001 0.004 0 0 0.0002
Lipid Particles 0.0097 0.0002 0.0003 0.0004 0.0002 0.0002 0.0006 0.0001 0.001 0 0.0005 0 0.0042 0 0.0002 0 0 0
Mitochondria 0.0343 0.0001 0.0024 0.0011 0.0083 0.0011 0.0015 0.0001 0.0231 0 0.0079 0 0.031 0 0.0021 0.0001 0 0.0003
None 0.0134 0.0002 0.0011 0.0006 0.0003 0.0003 0.0047 0.0011 0.0026 0.0002 0.0003 0.0001 0.0008 0.0001 0.0002 0.0002 0.0001 0.0003
Nuclear Periphery 0.0262 0.0023 0.0019 0.0067 0.0066 0.0047 0.045 0.0009 0.0009 0.0012 0.0099 0.0011 0.0134 0.0001 0.0004 0.0003 0.0001 0.0007
Nucleolus 0.0143 0.0001 0.0035 0.0007 0.0004 0.0004 0.0044 0.001 0.0013 0 0.0001 0 0.0001 0 0 0 0 0
Nucleus 0.029 0.0027 0.003 0.0095 0.0098 0.0085 0.0305 0.0013 0.0017 0.0021 0.0023 0.0014 0.0012 0.0003 0.0006 0.0004 0.0003 0.0007
Peroxisomes 0.001 0 0.0002 0.0002 0.0001 0.0002 0.0001 0 0.0001 0 0.0001 0 0.0003 0 0.0004 0 0 0
Punctate Nuclear 0.0024 0 0.0001 0.0002 0.0001 0.0001 0.0003 0.0001 0.0002 0 0.0001 0 0.0005 0 0.0001 0 0 0
Vacuole 0.0244 0.0045 0.0076 0.0432 0.0143 0.0169 0.0154 0.0014 0.0022 0.0056 0.0542 0.0006 0.0102 0.0002 0.0016 0.0021 0.0005 0.001
Vacuole Periphery 0.009 0.0003 0.0015 0.0054 0.0078 0.0048 0.0045 0.0001 0.0011 0.001 0.0508 0.0002 0.0158 0 0.0006 0.0009 0.0002 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 1093.07 1102.9221 1166.1018 1099.2511 1051.3144 1005.3325 1073.7279 1065.2986 1106.2476 946.01
Translational Efficiency 1.4655 1.6399 1.5332 1.7415 1.629 1.4375 1.4743 1.4998 1.4523 1.5994

Hit Data

Dataset Hit
Protein Concentration –
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
101 1382 983 49 1323 1377 984 97 1424 2759 1967 146

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 6347.71 7614.90 4708.87 24501.29 6898.76 7368.09 13207.51 10824.33 6859.68 7491.72 8960.35 15414.54
Standard Deviation 1750.97 2069.93 2114.15 9235.99 1725.01 1891.78 3975.41 4991.91 1732.65 1986.85 5310.02 9321.76
Intensity Change Log 2 — 0.262589 -0.430855 1.948550 — 0.094954 0.936950 0.649869 — 0.177718 0.435671 1.415107

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000149 0.000058 0.000152 0.000267 0.000057 0.000091 0.000288 0.000226 0.000063 0.000075 0.000220 0.000240
Bud Neck 0.001243 0.000546 0.001988 0.007025 0.000623 0.000799 0.002988 0.003593 0.000667 0.000672 0.002488 0.004745
Bud Site 0.005131 0.001996 0.007774 0.007902 0.001243 0.002169 0.006513 0.008199 0.001518 0.002083 0.007143 0.008099
Cell Periphery 0.013229 0.004656 0.008817 0.026357 0.009075 0.006189 0.004501 0.063592 0.009369 0.005421 0.006658 0.051095
Cytoplasm 0.835902* 0.877418* 0.819904* 0.391346* 0.838290* 0.862543* 0.700240* 0.483564* 0.838121* 0.869994* 0.760042* 0.452614*
Cytoplasmic Foci 0.016181 0.008484 0.010940 0.018294 0.009697 0.011836 0.013236 0.011637 0.010157 0.010157 0.012089 0.013871
Eisosomes 0.000003 0.000001 0.000002 0.000022 0.000001 0.000002 0.000006 0.000009 0.000002 0.000001 0.000004 0.000013
Endoplasmic Reticulum 0.000052 0.000079 0.000090 0.000475 0.000068 0.000059 0.000186 0.000260 0.000067 0.000069 0.000138 0.000332
Endosome 0.000353 0.000182 0.000506 0.006715 0.000171 0.000231 0.000737 0.003109 0.000184 0.000206 0.000622 0.004319
Golgi 0.013797 0.012827 0.007025 0.064734 0.018684 0.010285 0.004159 0.013486 0.018337 0.011559 0.005592 0.030686
Lipid Particles 0.008999 0.004414 0.005551 0.018546 0.006202 0.006142 0.005395 0.026951 0.006400 0.005277 0.005473 0.024130
Mitochondria 0.000046 0.000101 0.000291 0.004886 0.000091 0.000191 0.001352 0.000084 0.000088 0.000146 0.000822 0.001695
Mitotic Spindle 0.001036 0.000934 0.002090 0.002913 0.000367 0.001005 0.004919 0.000727 0.000415 0.000970 0.003505 0.001461
None 0.008577 0.003545 0.003874 0.002003 0.004527 0.004980 0.003906 0.003136 0.004814 0.004261 0.003890 0.002756
Nuclear Periphery 0.000207 0.000391 0.000413 0.000857 0.000478 0.000343 0.000441 0.001058 0.000459 0.000367 0.000427 0.000990
Nuclear Periphery Foci 0.004488 0.004896 0.003045 0.003182 0.006627 0.004272 0.002533 0.006996 0.006476 0.004584 0.002789 0.005716
Nucleolus 0.000112 0.000056 0.000149 0.000453 0.000062 0.000090 0.000669 0.000142 0.000065 0.000073 0.000409 0.000246
Nucleus 0.041290 0.038538 0.064865 0.037497 0.042548 0.047255 0.093041 0.030869 0.042459 0.042888 0.078960 0.033093
Peroxisomes 0.000076 0.000009 0.000062 0.000051 0.000006 0.000015 0.000415 0.000052 0.000011 0.000012 0.000239 0.000052
Vacuole 0.038933 0.029978 0.055891 0.402611* 0.046877 0.036389 0.146490 0.325582* 0.046314 0.033178 0.101214 0.351434*
Vacuole Periphery 0.010195 0.010890 0.006569 0.003866 0.014305 0.005115 0.007985 0.016726 0.014014 0.008007 0.007277 0.012410

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.44 -0.82 -0.69 -2.72 -0.14 -2.38 -3.67 -3.67 -2.52 0.14 -1.61 -5.51 -4.36 -3.76 -0.08
Bud Neck 2.86 -3.32 -4.14 -4.82 -3.34 -2.53 -12.76 -5.20 -4.68 1.61 -0.75 -14.79 -6.81 -6.70 -1.83
Bud Site 3.25 -1.62 -0.65 -2.33 0.38 -2.76 -5.66 -3.72 -3.02 -0.87 -2.14 -7.61 -4.37 -3.85 -0.34
Cell Periphery 1.37 0.63 -1.68 -4.52 -3.47 3.47 6.83 -4.68 -5.00 -5.23 4.90 3.55 -5.13 -5.74 -5.62
Cytoplasm -2.24 1.37 8.54 10.46 8.64 -2.23 18.34 10.30 10.88 4.38 -4.06 14.22 13.70 14.93 9.34
Cytoplasmic Foci 2.61 1.28 0.68 -1.20 -0.20 -2.51 -2.53 -0.84 0.27 0.75 -0.60 -2.76 -1.02 -0.79 0.44
Eisosomes 2.88 0.59 -3.60 -4.49 -3.88 -0.62 -6.23 -5.65 -5.38 -2.00 1.33 -7.11 -6.60 -6.79 -4.56
Endoplasmic Reticulum -1.52 -2.25 -1.23 -0.96 -0.88 0.54 -1.58 -1.34 -1.39 -0.84 -0.47 -2.11 -1.72 -1.65 -1.24
Endosome 0.90 -0.98 -1.34 -1.40 -1.25 -2.36 -3.72 -1.41 -1.37 -1.17 -1.53 -3.82 -1.94 -1.91 -1.67
Golgi -0.29 0.87 -0.91 -0.86 -1.17 5.76 11.67 2.50 -0.91 -4.17 4.72 9.86 -0.06 -0.98 -1.91
Lipid Particles 1.43 0.91 -2.11 -4.15 -3.66 -0.13 -0.10 -5.29 -5.20 -5.24 1.26 0.24 -6.14 -6.48 -6.22
Mitochondria -3.20 -4.27 -1.39 -1.35 -1.22 -1.94 -1.90 0.01 1.80 1.90 -2.15 -2.44 -1.36 -1.22 -0.43
Mitotic Spindle 0.74 -0.06 0.32 -0.59 0.67 -2.35 -2.72 -1.21 1.06 2.41 -2.30 -3.84 -1.15 0.08 2.68
None 2.99 2.96 3.29 1.27 1.47 -0.56 2.42 1.03 1.21 0.23 1.02 3.07 1.86 1.42 0.80
Nuclear Periphery -3.16 -3.57 -1.84 -1.38 -1.07 2.16 -2.03 -2.66 -3.26 -2.09 1.66 -1.79 -2.77 -3.19 -2.24
Nuclear Periphery Foci 0.21 1.87 1.15 1.15 0.07 3.36 5.89 -0.02 -1.55 -2.66 3.10 6.12 0.86 -0.76 -2.26
Nucleolus 2.47 -1.77 -1.01 -1.18 -0.88 -1.93 -3.61 -4.27 -1.66 2.96 -1.21 -4.20 -1.65 -1.52 0.87
Nucleus 0.64 -4.71 -0.05 -0.42 2.86 -2.08 -13.99 2.38 3.53 12.66 -0.51 -14.50 1.63 1.95 11.01
Peroxisomes 2.44 0.59 1.43 -2.94 1.42 -2.35 -1.48 -2.06 -1.56 1.18 -0.29 -1.78 -2.34 -2.29 1.31
Vacuole 1.63 -1.57 -7.82 -8.41 -7.60 1.88 -16.15 -9.78 -10.07 -4.97 3.41 -13.95 -12.53 -13.08 -9.35
Vacuole Periphery -0.47 0.47 1.14 4.90 2.69 6.10 5.43 -0.35 -3.88 -3.56 3.85 5.47 1.23 -1.59 -2.71
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description ATPase component of heat shock protein Hsp90 chaperone complex; serves as nucleotide exchange factor to load ATP onto the SSA class of cytosolic Hsp70s; plays a role in prion propagation and determining prion variants; binds unfolded proteins; member of Hsp110 subclass of HSP70 proteins; deletion results in spindle elongation in S phase; SSE1 has a paralog, SSE2, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-1

Sse1

Sse1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sse1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available