Standard name
Human Ortholog
Description Trichostatin A-insensitive homodimeric histone deacetylase (HDAC); specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0.05 0 0.05 0 0 0 0 – 0 0 0 0 0 0.05 0.11 0 0 0 0 0 0 0
Bud 0 0 0 0 0.05 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.1 0.07 0.06 0.05 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.07 0.11 0.08 0 0 0 0 0 0
Cytoplasm 0.93 0.88 0.91 0.91 0.85 0.79 0.77 0.74 0.69 – 0.59 0.7 0.96 0.94 0.88 0.8 0.78 0.92 0.79 0.74 0.76 0.7 0.8 0.79
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.06 0 0.05 0 0 0 0.08 0.1 0.07
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0.08 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0.05 0.16 0.17 0.13 0.37 – 0.39 0.24 0 0 0 0.05 0.07 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0.05 0.09 0 – 0.08 0.07 0 0 0 0.08 0 0.08 0 0 0 0.07 0.05 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 3 9 24 14 26 12 17 9 8 – 3 10 3 7 12 4 5 1 7 11 5 1 3 2
Bud 5 15 11 11 23 25 28 8 22 – 20 26 8 3 12 2 2 0 6 19 17 3 1 7
Bud Neck 1 0 1 4 3 2 2 1 0 – 1 0 0 0 0 0 0 0 31 29 31 7 1 3
Bud Site 0 0 3 0 0 1 2 1 1 – 0 3 0 0 0 0 0 0 – – – – – –
Cell Periphery 2 4 19 13 8 14 13 8 9 – 15 14 2 12 6 6 5 5 0 0 0 0 0 0
Cytoplasm 284 357 439 404 408 490 660 475 393 – 325 425 333 419 467 69 36 59 252 310 401 118 271 349
Endoplasmic Reticulum 5 9 5 3 7 12 21 4 9 – 4 5 7 10 6 5 2 3 4 5 4 13 33 30
Endosome 3 16 1 6 5 15 10 13 4 – 2 7 0 7 41 0 0 1 9 10 12 5 0 2
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 4 1 0 1 2 3 0 0 2
Mitochondria 10 9 8 9 22 99 143 84 209 – 216 144 8 1 2 4 3 0 0 1 19 3 9 13
Nucleus 0 3 1 0 4 2 11 8 8 – 5 13 1 1 0 0 0 1 0 1 1 0 0 0
Nuclear Periphery 2 0 0 1 1 2 9 0 1 – 1 2 0 0 0 0 0 0 2 1 2 1 0 0
Nucleolus 4 3 0 0 1 4 6 8 3 – 5 5 0 0 1 0 0 0 0 1 0 0 0 0
Peroxisomes 0 2 5 0 2 5 3 2 1 – 1 1 0 1 8 0 0 1 0 1 3 0 1 0
SpindlePole 0 0 6 2 6 8 3 18 3 – 5 9 0 1 2 1 0 0 1 5 10 0 0 1
Vac/Vac Membrane 4 11 2 10 8 20 46 60 25 – 45 42 0 4 2 7 1 5 1 15 7 11 15 22
Unique Cell Count 304 407 482 445 481 623 853 641 568 554 604 346 448 530 86 46 64 321 420 526 169 341 443
Labelled Cell Count 323 438 525 477 524 711 974 699 696 648 706 362 466 559 102 55 76 321 420 526 169 341 443


Bud Neck

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.7 6.8 6.4 5.9 6.5 5.7 5.8 6.2 5.3 – 4.9 5.8 6.1 6.8 7.0 13.6 13.1 13.0 6.0 6.3 6.7
Std Deviation (1e-4) 0.8 1.2 0.8 0.9 1.1 0.9 0.8 0.9 1.0 – 0.8 1.0 0.9 0.8 1.0 2.1 1.8 2.7 0.8 1.0 1.2
Intensity Change (Log2) – – – -0.13 0.01 -0.18 -0.15 -0.06 -0.28 – -0.41 -0.16 -0.07 0.07 0.12 1.08 1.02 1.01 -0.11 -0.04 0.04

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -1.4 0.3 -2.8 -3.0 -3.5 -3.4 – 0 -3.1 -3.3 -2.9 -2.3 0 0 0
Bud 0.2 2.1 1.6 1.0 -1.3 1.5 – 0 1.8 0 -2.0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery -0.9 -2.1 -1.6 -2.8 -2.9 -2.4 – 0 -1.5 -3.0 -1.1 -2.9 0 0 0
Cytoplasm -0.2 -3.0 -5.6 -6.3 -7.2 -8.7 – -11.8 -8.4 2.9 1.4 -1.5 -3.0 -2.8 0.3
Endoplasmic Reticulum 0 0.6 1.2 1.8 0 0.8 – 0 0 1.2 1.4 0.1 0 0 0
Endosome 0 0 3.0 0 2.7 0 – 0 0 0 0 6.0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0.4 2.6 7.9 8.4 6.9 14.0 – 0 10.5 0.7 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 2.8 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0.7 0 0 0
SpindlePole 0 0 0.1 0 1.8 0 – 0 0.3 0 0 0 0 0 0
Vacuole 2.5 0 3.3 4.7 6.5 4.1 – 5.9 5.4 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.1079 1.6477 1.4266 1.6763 1.3909 1.6134 1.7846 2.5472 2.4757 2.3875 2.3438 2.457 1.4927 2.3709 2.1946 2.3628 2.5399 2.1542
Actin 0.0154 0.0038 0.0042 0.0011 0.0609 0.007 0.0281 0.006 0.0268 0.0234 0.1093 0.0134 0.0331 0.0008 0.0157 0.0057 0.0481 0.013
Bud 0.0049 0.0066 0.002 0.0006 0.0034 0.0025 0.0017 0.0055 0.0021 0.0013 0.0042 0.0017 0.0016 0.0019 0.0027 0.0009 0.001 0.0009
Bud Neck 0.0111 0.0067 0.1246 0.6848 0.5924 0.1145 0.0088 0.0042 0.1263 0.5063 0.5428 0.1324 0.011 0.0064 0.1317 0.6057 0.7523 0.1259
Bud Periphery 0.0053 0.0053 0.0017 0.0006 0.0066 0.0032 0.0016 0.0053 0.0024 0.0013 0.0116 0.0042 0.0013 0.0007 0.0024 0.001 0.0018 0.0016
Bud Site 0.0437 0.1186 0.041 0.0034 0.0097 0.002 0.0305 0.055 0.0206 0.0051 0.0119 0.0042 0.066 0.0702 0.028 0.0045 0.0023 0.0012
Cell Periphery 0.0025 0.0013 0.001 0.0003 0.0011 0.0004 0.0008 0.0006 0.0009 0.0004 0.0011 0.0004 0.0009 0.0004 0.0009 0.0006 0.0003 0.0002
Cytoplasm 0.5699 0.6213 0.619 0.2175 0.1044 0.6696 0.6324 0.771 0.6403 0.3195 0.0051 0.7267 0.6246 0.828 0.7032 0.3238 0.0139 0.7392
Cytoplasmic Foci 0.0635 0.0406 0.0461 0.0389 0.0407 0.0385 0.0737 0.0468 0.0566 0.0596 0.038 0.0237 0.0729 0.0101 0.0346 0.0228 0.0194 0.0216
Eisosomes 0.0004 0.0001 0.0004 0 0.0002 0.0001 0.0003 0.0001 0.0002 0.0001 0.0005 0.0001 0.0004 0 0.0001 0 0.0001 0
Endoplasmic Reticulum 0.0157 0.0072 0.0054 0.0014 0.0074 0.0148 0.0211 0.0068 0.0106 0.0013 0.0022 0.0094 0.0216 0.0048 0.0058 0.002 0.0028 0.0169
Endosome 0.0509 0.0381 0.0224 0.0197 0.0235 0.0453 0.0549 0.0351 0.04 0.041 0.0632 0.0363 0.0364 0.01 0.0227 0.0086 0.0258 0.0282
Golgi 0.0064 0.0043 0.0044 0.0018 0.0111 0.0044 0.0194 0.004 0.01 0.0102 0.0658 0.0081 0.0113 0.0011 0.0054 0.0018 0.0079 0.0041
Lipid Particles 0.0192 0.0036 0.0007 0.0004 0.0079 0.0022 0.0209 0.0013 0.0072 0.0016 0.03 0.0024 0.0133 0.0002 0.0019 0.0003 0.0084 0.0047
Mitochondria 0.0047 0.0016 0.0105 0.0005 0.0011 0.0015 0.0172 0.0023 0.0055 0.0022 0.0423 0.0028 0.0267 0.0003 0.0052 0.0002 0.0041 0.0021
None 0.1092 0.1 0.105 0.0191 0.0249 0.0463 0.0401 0.0271 0.0201 0.0016 0.0025 0.0097 0.041 0.0474 0.0276 0.0108 0.0013 0.0208
Nuclear Periphery 0.03 0.0054 0.0008 0.0007 0.0574 0.0187 0.0086 0.0027 0.0031 0.0006 0.0283 0.0084 0.0049 0.001 0.0016 0.0004 0.0155 0.0047
Nucleolus 0.0012 0.0022 0.0005 0.0004 0.0038 0.0011 0.0012 0.0007 0.0008 0.0001 0.0018 0.0004 0.0008 0.0016 0.0003 0.0024 0.0048 0.0011
Nucleus 0.0156 0.0175 0.0021 0.0029 0.0061 0.0105 0.0032 0.0028 0.002 0.0004 0.0022 0.0025 0.0052 0.0056 0.0013 0.0029 0.006 0.0035
Peroxisomes 0.0051 0.0016 0.0012 0.0005 0.0044 0.0021 0.0169 0.0075 0.0102 0.0206 0.021 0.0035 0.0131 0.0001 0.0015 0.0002 0.0023 0.0017
Punctate Nuclear 0.0067 0.004 0.0013 0.0011 0.025 0.0045 0.0089 0.0023 0.0042 0.001 0.0095 0.0048 0.0074 0.0008 0.0022 0.0008 0.0782 0.0036
Vacuole 0.0144 0.0091 0.0049 0.0039 0.0064 0.0093 0.008 0.0113 0.0086 0.0017 0.0041 0.0038 0.0051 0.0079 0.0042 0.0041 0.0022 0.0037
Vacuole Periphery 0.0042 0.0011 0.0006 0.0004 0.0017 0.0017 0.0018 0.0016 0.0015 0.0006 0.0026 0.0012 0.0012 0.0006 0.001 0.0006 0.0015 0.0011

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 19.4966 44.7496 9.088 12.8293 17.7631 17.3793 29.8864 28.288 19.0449 23.168
Translational Efficiency 0.8208 0.6034 0.7856 0.5039 0.7783 0.8076 0.7698 0.5623 0.6368 0.5799

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1528 1300 734 1270 1965 1102 1263 174 3493 2402 1997 1444

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 735.14 861.53 1187.27 1029.42 842.81 854.69 1063.74 1090.74 795.71 858.39 1109.14 1036.81
Standard Deviation 91.36 126.66 161.58 134.76 98.80 121.91 130.01 134.17 109.52 124.55 154.38 136.16
Intensity Change Log 2 — 0.228882 0.691557 0.485741 — 0.020194 0.335866 0.372028 — 0.121183 0.512521 0.426122

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000414 0.000947 0.001616 0.002780 0.000483 0.000682 0.000891 0.003021 0.000453 0.000826 0.001158 0.002809
Bud Neck 0.048696 0.031225 0.044733 0.048907 0.057344 0.045970 0.085673 0.058732 0.053561 0.037990 0.070626 0.050091
Bud Site 0.050009 0.073493 0.201354 0.214330 0.072069 0.076012 0.243437 0.265094 0.062419 0.074649 0.227969 0.220447
Cell Periphery 0.000260 0.000179 0.000214 0.000172 0.000259 0.000229 0.000187 0.000170 0.000259 0.000202 0.000197 0.000171
Cytoplasm 0.470186 0.476838 0.524774 0.369277 0.480496 0.436412 0.367019 0.236773 0.475986 0.458291 0.425002 0.353310
Cytoplasmic Foci 0.234506 0.233713 0.059985 0.050930 0.218520 0.221984 0.049439 0.077004 0.225513 0.228332 0.053315 0.054072
Eisosomes 0.000148 0.000086 0.000024 0.000031 0.000129 0.000137 0.000045 0.000041 0.000137 0.000110 0.000037 0.000032
Endoplasmic Reticulum 0.004362 0.002521 0.001159 0.001567 0.005569 0.001628 0.001783 0.003949 0.005041 0.002111 0.001553 0.001854
Endosome 0.044246 0.045729 0.009002 0.021000 0.031792 0.056703 0.022081 0.037238 0.037240 0.050763 0.017273 0.022956
Golgi 0.010667 0.012027 0.000939 0.002718 0.011220 0.015270 0.000672 0.001339 0.010978 0.013514 0.000770 0.002552
Lipid Particles 0.012317 0.004308 0.001657 0.003753 0.007934 0.007250 0.002027 0.004573 0.009851 0.005658 0.001891 0.003852
Mitochondria 0.004537 0.002812 0.000250 0.002401 0.003735 0.006939 0.000581 0.001358 0.004086 0.004705 0.000460 0.002275
Mitotic Spindle 0.009245 0.015227 0.028388 0.153702 0.010999 0.015124 0.036492 0.111581 0.010232 0.015179 0.033513 0.148627
None 0.003327 0.000549 0.001181 0.000479 0.001223 0.000405 0.000669 0.000349 0.002143 0.000483 0.000858 0.000463
Nuclear Periphery 0.000367 0.000212 0.001507 0.004229 0.000402 0.000239 0.001635 0.003702 0.000386 0.000224 0.001588 0.004165
Nuclear Periphery Foci 0.002069 0.002993 0.008996 0.022526 0.003797 0.001784 0.006960 0.023722 0.003041 0.002438 0.007708 0.022670
Nucleolus 0.000893 0.000617 0.003435 0.000215 0.000834 0.000849 0.001295 0.000829 0.000860 0.000723 0.002082 0.000289
Nucleus 0.015019 0.006624 0.037442 0.005323 0.013898 0.008396 0.018927 0.006451 0.014388 0.007437 0.025733 0.005459
Peroxisomes 0.008351 0.009992 0.009329 0.017959 0.008487 0.012855 0.013360 0.026891 0.008427 0.011305 0.011879 0.019035
Vacuole 0.075000 0.076323 0.063440 0.075157 0.067355 0.086179 0.146214 0.134129 0.070699 0.080845 0.115790 0.082263
Vacuole Periphery 0.005381 0.003585 0.000574 0.002545 0.003455 0.004954 0.000611 0.003054 0.004298 0.004213 0.000598 0.002607

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.06 -5.19 -5.45 -3.59 -1.46 -2.31 -4.15 -1.49 -1.31 -1.18 -3.70 -6.54 -5.57 -4.28 -3.34
Bud Neck 3.98 2.85 3.42 -0.94 0.21 2.26 -1.28 2.75 1.03 3.63 4.68 0.10 5.75 0.95 5.52
Bud Site -4.70 -10.04 -14.06 -10.37 -0.36 -0.65 -13.14 -5.30 -5.08 0.16 -3.18 -16.84 -13.84 -11.76 1.49
Cell Periphery 4.42 0.87 7.83 2.37 6.66 1.13 4.35 5.23 4.27 1.89 3.43 4.58 7.90 4.46 4.87
Cytoplasm -0.64 -3.32 3.34 3.74 5.62 3.81 7.76 8.57 6.39 4.38 2.17 4.22 6.17 4.25 2.15
Cytoplasmic Foci 0.19 30.55 33.10 29.93 1.15 -0.47 35.21 16.39 15.32 -3.68 -0.49 46.95 42.42 37.20 -1.69
Eisosomes 5.47 14.63 14.18 6.96 -0.66 -0.58 10.96 10.42 8.19 0.73 3.19 17.51 18.02 11.27 2.74
Endoplasmic Reticulum 1.97 4.18 4.68 1.86 1.09 5.02 4.90 1.94 -0.91 -0.86 4.62 6.34 6.58 1.60 0.81
Endosome -0.43 17.46 12.69 11.24 -4.59 -8.27 7.43 0.77 4.90 -1.83 -6.34 15.93 11.96 15.40 -1.57
Golgi -1.29 16.42 9.62 9.89 -1.38 -2.96 17.60 15.71 11.55 -1.45 -3.03 24.02 12.30 12.68 -1.69
Lipid Particles 5.65 7.32 6.41 1.40 -1.82 0.46 7.41 3.14 2.21 -1.22 4.38 10.34 7.78 3.05 -2.73
Mitochondria 2.18 8.54 4.52 1.53 -3.59 -2.01 6.00 4.44 3.94 -1.08 -0.69 9.80 4.95 3.71 -3.31
Mitotic Spindle -2.24 -4.89 -14.80 -13.60 -11.13 -1.43 -6.67 -4.13 -3.85 -2.61 -2.53 -8.32 -15.34 -14.33 -11.42
None 4.46 3.48 4.54 0.13 4.26 6.49 3.41 5.40 0.36 3.00 5.81 4.38 5.61 -0.19 3.55
Nuclear Periphery 1.34 -2.55 -4.11 -4.37 -1.82 1.40 -2.39 -2.50 -2.69 -1.03 1.96 -3.36 -4.48 -4.77 -2.12
Nuclear Periphery Foci -0.94 -5.54 -5.47 -4.91 -1.84 2.46 -2.70 -2.54 -2.88 -1.92 0.94 -5.47 -5.63 -5.88 -3.08
Nucleolus 1.43 -1.60 4.93 2.42 2.16 -0.10 -0.69 0.98 0.81 1.28 0.70 -1.72 5.08 2.81 2.93
Nucleus 8.26 -12.38 3.36 -4.26 13.83 5.69 -7.54 3.87 0.39 8.90 10.12 -13.80 4.10 -3.52 15.32
Peroxisomes -1.17 1.23 -2.62 -1.65 -3.64 -2.59 -1.35 -2.62 -1.32 -2.18 -2.71 -0.50 -3.47 -1.35 -3.18
Vacuole -0.56 -6.44 -10.17 -9.72 -1.92 -4.50 -18.74 -8.51 -7.56 -1.83 -3.72 -19.12 -13.75 -11.59 3.25
Vacuole Periphery 3.44 10.55 5.30 3.19 -2.16 -3.17 13.97 1.34 2.54 -1.33 0.31 16.16 4.83 4.60 -2.47
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Trichostatin A-insensitive homodimeric histone deacetylase (HDAC); specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
Localization
Cell Percentages cytoplasm (86%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-4

Hos3

Hos3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Hos3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available