Standard name
Human Ortholog
Description Conserved casein kinase; regulates diverse events including: vesicular traffic, DNA repair, the CVT pathway, monopolar attachment of sister kinetochores at meiosis I, and ribosomal subunit biogenesis; monopolin subunit; binds the RNAPII CTD; phosphorylates COPII coat subunits; interacts with Sit4p phosphatase; antagonizes calcineurin signaling, reducing nuclear accumulation of Crz1p; phosphorylates Dsn1p, the kinetochore receptor for monopolin; homolog of mammalian CK1delta
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0.05 0 0 0 0.08 0 0.08 0 0 0 0.05 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0.05 0 0.06 0 0.08 0.07 0 0 0 0 0 0 0.06 0.11 0 0.08 0.09 0.09
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.71 0.75 0.68 0.34 0.38 0.59 0.5 0.5 0.44 0.5 0.48 0.54 0.52 0.63 0.6 0.79 0.65 0.78 0.41 0.37 0.5 0.5 0.36 0.41
Endoplasmic Reticulum 0.1 0.19 0.05 0 0.08 0.22 0.13 0.13 0.07 0.18 0.11 0.15 0.12 0.05 0.11 0 0 0 0.06 0 0 0.06 0 0.05
Endosome 0 0 0.05 0.05 0.08 0 0.12 0.1 0.09 0.06 0 0 0 0 0 0 0.07 0 0.08 0 0 0 0.07 0.05
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0.06 0 0 0.05 0.1 0 0.09 0.1 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.1 0 0.06 0.16 0.07 0 0 0 0.06 0 0.06 0 0.07 0.08 0.07 0.06 0 0 0.14 0.22 0.17 0.08 0.15 0.12
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0
Vac/Vac Membrane 0.18 0.06 0.17 0.46 0.32 0.06 0.18 0.16 0.21 0.13 0.15 0.07 0.35 0.28 0.26 0.11 0.3 0.15 0.08 0.1 0.05 0.12 0.17 0.16
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 3 0 1 4 7 10 8 13 11 23 7 21 5 2 0 6 3 3 4 2 1 1 4 3
Bud 0 0 0 0 8 8 18 10 15 13 20 19 2 3 0 3 1 1 10 7 3 5 19 30
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 1 4 2 7 7
Bud Site 0 0 0 0 0 0 1 0 2 2 2 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 1 1 2 2 9 6 9 16 0 2 5 3 5 4 0 0 0 0 0 0
Cytoplasm 104 12 44 31 71 126 191 156 113 153 120 145 100 151 161 105 86 98 78 25 52 34 76 136
Endoplasmic Reticulum 15 3 3 2 15 47 49 40 17 55 27 40 23 12 30 1 5 5 11 1 3 4 7 17
Endosome 1 0 3 5 15 9 46 30 23 19 10 9 2 1 6 3 9 3 15 3 4 1 15 16
Golgi 0 0 0 0 0 0 0 3 0 1 0 0 0 0 1 1 1 0 0 0 0 0 0 1
Mitochondria 0 0 2 2 11 5 14 15 25 12 23 27 0 0 0 1 0 0 0 1 1 0 1 4
Nucleus 14 0 4 15 13 8 7 3 16 7 16 12 13 19 19 8 1 3 26 15 18 5 31 40
Nuclear Periphery 0 0 0 0 0 0 0 1 1 0 1 0 0 0 0 0 0 0 7 1 0 0 3 7
Nucleolus 0 0 4 0 4 4 17 8 3 4 3 9 0 0 0 0 0 0 1 0 2 0 0 2
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 8 0 6 0 3 3
Vac/Vac Membrane 27 1 11 42 61 12 68 50 55 40 36 19 67 68 70 15 39 19 14 6 4 8 37 51
Unique Cell Count 146 16 65 92 188 212 379 310 256 303 248 271 191 241 270 133 132 126 192 68 107 69 214 332
Labelled Cell Count 164 16 72 101 206 230 421 331 290 335 274 318 212 258 292 146 151 136 192 68 107 69 214 332


Ambiguous, Bud, Bud Neck, Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 12.6 12.9 9.1 9.6 9.2 8.6 8.6 8.9 9.1 9.3 9.2 9.5 11.9 11.0 12.1 11.5 12.1 12.4 – 14.7 15.5
Std Deviation (1e-4) 2.1 1.6 1.6 1.6 1.7 1.3 1.4 1.5 1.7 1.8 1.8 1.8 1.4 1.7 1.6 2.1 2.0 2.2 – 2.4 2.8
Intensity Change (Log2) – – – 0.08 0.02 -0.07 -0.07 -0.03 0.0 0.04 0.03 0.08 0.4 0.27 0.41 0.34 0.42 0.45 – 0.7 0.78

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -4.2 -4.2 -1.2 -2.6 -2.6 -3.4 -2.5 -2.8 -2.1 -2.2 -0.7 -1.2 1.7 -0.4 1.5
Endoplasmic Reticulum 0 0 3.2 1.9 1.9 0 2.7 1.5 2.2 1.7 0 1.6 0 0 0
Endosome 0 0 0 1.8 1.3 1.2 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 1.7 0 1.6 1.8 0 0 0 0 0 0
Nucleus 1.9 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 3.7 2.4 -2.9 0.2 -0.2 0.8 -0.8 -0.5 -2.5 2.7 1.8 1.5 -1.1 1.9 -0.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration – – – – – – – – – – – – – – – – – –
Actin 0.023 0.006 0.0382 0.0112 0.0096 0.0181 0.0256 0.0068 0.0683 0.0297 0.0118 0.0152 0.1744 0.0651 0.1607 0.1306 0.0004 0.0448
Bud 0.0007 0.0021 0.0036 0.0013 0.0179 0.0011 0.0007 0.0011 0.0013 0.0007 0.003 0.0003 0.0028 0.0014 0.0011 0.0048 0.0001 0.0006
Bud Neck 0.0217 0.0063 0.0387 0.0131 0.0138 0.2562 0.0502 0.0127 0.0344 0.0203 0.0048 0.2709 0.0385 0.007 0.0524 0.0108 0.0029 0.4576
Bud Periphery 0.0007 0.0007 0.0013 0.0014 0.0029 0.0016 0.0005 0.0005 0.0008 0.0004 0.0045 0.0003 0.0015 0.0004 0.0003 0.006 0 0.0004
Bud Site 0.0037 0.0113 0.0077 0.0027 0.0055 0.0032 0.0119 0.0162 0.007 0.0019 0.0012 0.0003 0.0195 0.0523 0.0064 0.0028 0 0.0006
Cell Periphery 0.0004 0.0003 0.0006 0.0004 0.0006 0.0003 0.0008 0.0008 0.0005 0.0002 0.0002 0.0002 0.0013 0.0006 0.0004 0.0013 0 0.0002
Cytoplasm 0.6555 0.6373 0.5936 0.687 0.7129 0.4471 0.729 0.6982 0.6748 0.6363 0.7234 0.4934 0.6143 0.7874 0.6803 0.4558 0.9625 0.4005
Cytoplasmic Foci 0.0103 0.0106 0.0128 0.0061 0.0165 0.0051 0.0108 0.0077 0.0127 0.03 0.033 0.0025 0.0517 0.0282 0.017 0.0129 0.0005 0.0174
Eisosomes 0.0001 0 0 0 0 0.0001 0.0001 0 0.0001 0 0 0 0.0002 0 0.0001 0.0007 0 0
Endoplasmic Reticulum 0.0149 0.0074 0.0175 0.021 0.0297 0.0086 0.0161 0.0067 0.0163 0.0102 0.0326 0.009 0.0089 0.0032 0.009 0.0359 0.0007 0.0026
Endosome 0.0082 0.0025 0.0055 0.004 0.0199 0.0034 0.0111 0.0063 0.0068 0.0151 0.0246 0.0019 0.0228 0.0018 0.002 0.1002 0.0001 0.0028
Golgi 0.0013 0.0003 0.001 0.0004 0.0029 0.0007 0.0021 0.0014 0.0033 0.008 0.0041 0.0003 0.0159 0.001 0.0009 0.134 0 0.0124
Lipid Particles 0.0048 0.0003 0.0012 0.001 0.0029 0.0006 0.0015 0.0004 0.0019 0.0025 0.0013 0.0002 0.002 0.0003 0.0003 0.001 0 0.0008
Mitochondria 0.0008 0.0014 0.0007 0.0004 0.0145 0.0043 0.0013 0.0004 0.0017 0.001 0.002 0.0004 0.0021 0.0006 0.0004 0.0851 0 0.0074
None 0.0017 0.0021 0.002 0.0021 0.004 0.001 0.0038 0.0013 0.0055 0.0025 0.0026 0.0011 0.0032 0.0028 0.002 0.002 0.0007 0.0005
Nuclear Periphery 0.0249 0.0225 0.0275 0.0224 0.0297 0.0166 0.0248 0.0136 0.0205 0.0185 0.0245 0.0165 0.0129 0.0064 0.0149 0.0046 0.0011 0.0025
Nucleolus 0.0005 0.0009 0.0009 0.0005 0.0008 0.0005 0.0004 0.0006 0.0006 0.0003 0.0002 0.0003 0.0002 0.0002 0.0001 0.0001 0 0
Nucleus 0.2138 0.2666 0.2154 0.1941 0.0831 0.2169 0.0935 0.2015 0.116 0.1644 0.0913 0.1766 0.0142 0.02 0.0286 0.0024 0.03 0.0121
Peroxisomes 0.0018 0.0007 0.001 0.0003 0.002 0.0006 0.0014 0.0004 0.0023 0.0022 0.0034 0.0003 0.0033 0.0044 0.0025 0.0005 0 0.0293
Punctate Nuclear 0.0092 0.0189 0.0286 0.0289 0.023 0.0123 0.0124 0.0218 0.0236 0.0548 0.0273 0.0091 0.009 0.0164 0.0202 0.0016 0.0009 0.0069
Vacuole 0.0018 0.0016 0.0018 0.0016 0.0063 0.0014 0.0016 0.0014 0.0014 0.0008 0.0033 0.001 0.001 0.0006 0.0003 0.0031 0.0001 0.0002
Vacuole Periphery 0.0003 0.0002 0.0003 0.0002 0.0016 0.0003 0.0004 0.0002 0.0004 0.0003 0.0007 0.0002 0.0004 0.0001 0.0002 0.0038 0 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 29.7213 23.2479 34.009 51.0676 44.7969 27.477 38.2811 40.7955 41.88 48.8261
Translational Efficiency 1.4366 1.6119 1.0627 0.7229 0.8417 1.5198 0.8499 0.7098 0.8568 0.8033

Hit Data

Dataset Hit
Protein Concentration –
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
581 469 2278 1248 1703 833 1725 115 2284 1302 4003 1363

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 985.50 1263.36 1579.49 1675.04 1103.92 1150.78 1569.38 1831.29 1073.80 1191.33 1575.13 1688.22
Standard Deviation 138.40 192.45 236.81 236.26 159.96 192.87 222.54 303.09 163.13 200.16 230.82 246.46
Intensity Change Log 2 — 0.358338 0.680531 0.765268 — 0.059976 0.507559 0.730225 — 0.208407 0.591732 0.746859

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001272 0.004792 0.011949 0.132636 0.002506 0.005512 0.040715 0.145151 0.002192 0.005252 0.024345 0.133692
Bud Neck 0.040449 0.070807 0.215868 0.057273 0.060342 0.051257 0.134388 0.058276 0.055281 0.058299 0.180756 0.057358
Bud Site 0.057451 0.127114 0.346574 0.452254 0.063003 0.089280 0.483960 0.444915 0.061591 0.102908 0.405778 0.451635
Cell Periphery 0.000411 0.000772 0.001759 0.004945 0.000497 0.000933 0.002061 0.009172 0.000475 0.000875 0.001889 0.005301
Cytoplasm 0.485633 0.297528 0.118066 0.139681 0.387443 0.375762 0.148709 0.096563 0.412421 0.347581 0.131271 0.136043
Cytoplasmic Foci 0.064431 0.035059 0.005747 0.024761 0.046362 0.062519 0.012822 0.035875 0.050959 0.052628 0.008796 0.025699
Eisosomes 0.000073 0.000086 0.000133 0.000874 0.000070 0.000136 0.000231 0.001878 0.000071 0.000118 0.000175 0.000959
Endoplasmic Reticulum 0.008069 0.011596 0.005636 0.002575 0.010788 0.014034 0.004442 0.007128 0.010097 0.013156 0.005121 0.002960
Endosome 0.006145 0.005286 0.001980 0.005540 0.004102 0.006859 0.004710 0.010656 0.004622 0.006292 0.003156 0.005972
Golgi 0.001058 0.004472 0.000276 0.003259 0.000856 0.002756 0.001239 0.007306 0.000908 0.003374 0.000691 0.003600
Lipid Particles 0.003860 0.006546 0.006726 0.043197 0.004917 0.007297 0.016554 0.074148 0.004648 0.007027 0.010961 0.045808
Mitochondria 0.000763 0.001923 0.003227 0.001079 0.002088 0.001670 0.001243 0.000364 0.001751 0.001761 0.002372 0.001019
Mitotic Spindle 0.015692 0.044665 0.050205 0.028455 0.024047 0.041274 0.035840 0.005832 0.021921 0.042496 0.044015 0.026546
None 0.005733 0.005606 0.003832 0.000265 0.004636 0.003632 0.000741 0.000098 0.004915 0.004343 0.002500 0.000251
Nuclear Periphery 0.000833 0.001297 0.001359 0.000173 0.002053 0.001133 0.000434 0.000119 0.001743 0.001192 0.000961 0.000168
Nuclear Periphery Foci 0.023159 0.027752 0.002550 0.002612 0.025910 0.025039 0.004867 0.002440 0.025210 0.026016 0.003548 0.002598
Nucleolus 0.001028 0.000913 0.000515 0.000072 0.002052 0.001014 0.000181 0.000022 0.001791 0.000978 0.000371 0.000067
Nucleus 0.217157 0.291996 0.186998 0.017913 0.310770 0.228866 0.048411 0.007026 0.286956 0.251606 0.127277 0.016995
Peroxisomes 0.001739 0.002048 0.001412 0.011378 0.001969 0.004516 0.004188 0.007014 0.001910 0.003627 0.002609 0.011009
Vacuole 0.064743 0.059370 0.034942 0.069026 0.045127 0.075632 0.053959 0.083771 0.050117 0.069774 0.043137 0.070270
Vacuole Periphery 0.000300 0.000370 0.000247 0.002032 0.000463 0.000881 0.000305 0.002246 0.000421 0.000697 0.000272 0.002050

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.70 -14.30 -19.52 -18.57 -17.50 -4.45 -13.81 -6.06 -5.87 -4.04 -6.41 -17.45 -20.26 -19.54 -16.23
Bud Neck -2.77 -20.48 -3.18 0.68 24.30 2.31 -8.77 1.18 -0.51 7.20 0.74 -20.70 0.80 -0.12 25.30
Bud Site -4.23 -22.87 -28.13 -20.43 -10.33 -2.84 -32.56 -10.43 -9.69 -0.61 -4.71 -39.09 -31.89 -27.03 -6.73
Cell Periphery -5.82 -16.97 -13.26 -11.62 -7.84 -4.67 -13.35 -5.87 -5.50 -4.20 -6.50 -20.75 -14.13 -12.60 -8.38
Cytoplasm 10.38 24.20 19.67 8.06 -5.17 1.26 21.35 12.49 11.11 3.53 6.65 34.48 25.36 15.99 -1.94
Cytoplasmic Foci 5.63 13.13 7.33 1.18 -11.83 -2.15 14.74 0.30 1.19 -3.61 1.26 21.25 8.42 6.23 -10.65
Eisosomes -1.25 -6.68 -11.46 -11.17 -10.62 -4.91 -14.01 -3.85 -3.60 -3.25 -5.06 -15.62 -12.14 -11.20 -10.41
Endoplasmic Reticulum -3.70 0.23 7.24 9.49 13.85 -2.50 7.71 3.98 5.02 1.36 -3.75 6.41 15.68 14.80 13.58
Endosome 2.53 7.34 4.02 1.96 -3.31 -2.86 2.09 -0.43 0.39 -0.87 -1.36 8.17 2.69 3.37 -2.10
Golgi -1.12 2.84 -1.46 0.51 -3.07 -1.56 0.55 -1.59 -0.87 -1.66 -1.89 2.86 -2.12 0.26 -3.04
Lipid Particles -3.63 -7.40 -12.95 -11.32 -10.85 -3.05 -10.16 -5.02 -4.82 -3.71 -4.22 -11.60 -13.47 -12.46 -10.08
Mitochondria -2.19 -17.05 -0.07 2.17 17.57 1.18 0.87 4.18 4.33 8.63 0.31 -5.76 2.97 3.30 15.83
Mitotic Spindle -3.68 -7.96 -1.37 2.96 7.67 -2.05 -3.50 1.12 2.28 2.91 -3.69 -8.34 0.13 3.52 7.43
None -1.28 1.96 7.55 8.56 9.09 1.89 13.54 17.25 7.39 9.78 0.36 6.81 17.91 10.96 10.53
Nuclear Periphery -5.03 -14.11 9.07 9.56 22.40 5.26 6.94 13.11 12.27 14.51 2.58 -2.06 14.00 14.74 25.07
Nuclear Periphery Foci -1.58 7.76 8.36 8.16 3.05 0.68 12.32 13.14 9.11 2.55 -0.34 14.99 16.54 12.66 5.25
Nucleolus -1.05 3.01 4.05 3.57 7.28 2.87 10.39 11.14 4.34 10.74 0.85 9.31 11.13 5.27 8.44
Nucleus -5.10 -4.86 18.44 21.07 37.15 6.63 25.47 39.46 23.88 17.22 2.74 11.34 42.48 30.44 36.97
Peroxisomes 0.50 4.61 -6.36 -6.44 -7.60 -2.83 -1.30 -1.90 -0.99 -1.65 -2.49 2.15 -6.51 -4.96 -7.05
Vacuole -0.30 1.31 -10.45 -9.71 -14.62 -8.77 -16.93 -6.46 -4.34 -2.71 -7.70 -12.68 -18.32 -11.64 -11.52
Vacuole Periphery -0.51 0.26 -1.61 -1.54 -1.64 -0.83 1.45 -0.66 -0.42 -0.82 -0.80 1.41 -1.51 -1.13 -1.79
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Conserved casein kinase; regulates diverse events including: vesicular traffic, DNA repair, the CVT pathway, monopolar attachment of sister kinetochores at meiosis I, and ribosomal subunit biogenesis; monopolin subunit; binds the RNAPII CTD; phosphorylates COPII coat subunits; interacts with Sit4p phosphatase; antagonizes calcineurin signaling, reducing nuclear accumulation of Crz1p; phosphorylates Dsn1p, the kinetochore receptor for monopolin; homolog of mammalian CK1delta
Localization
Cell Percentages cytoplasm (55%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-6

Hrr25

Hrr25


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Hrr25-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available