Standard name
Human Ortholog
Description Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.1 0.14 0 0 0 0 0 0 0
Cytoplasm 1.0 1.0 1.0 0.98 0.93 0.95 0.88 0.82 0.89 – 0.77 0.83 0.99 0.99 1.0 0.95 0.94 1.0 0.98 0.94 0.97 0.93 0.9 0.85
Endoplasmic Reticulum 0 0 0 0 0.05 0 0.1 0.14 0.08 – 0.18 0.13 0 0 0 0 0.06 0.07 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 1 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 1 4 2 10 4 6 7 5 – 16 6 0 0 0 1 1 0 2 3 2 0 0 2
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 4 4 10 4 14 15 12 13 6 – 11 7 0 0 0 9 10 1 0 1 0 0 0 0
Cytoplasm 394 326 456 236 349 480 450 363 334 – 323 259 138 155 144 89 68 41 382 316 460 40 111 138
Endoplasmic Reticulum 0 1 0 2 17 14 51 63 31 – 77 40 0 0 0 3 4 3 0 1 2 0 2 5
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 1 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 1 – 0 1 0 0 0 0 0 0 0 0 0 0 0 1
Mitochondria 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Nucleus 0 0 0 0 0 0 0 0 2 – 1 0 1 0 0 0 0 0 1 4 1 0 0 2
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 2 0 0 0
Nucleolus 0 0 0 0 0 0 0 4 1 – 5 4 0 1 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 2 2 0 0 0 1 0 – 2 3 0 0 0 0 0 0 0 4 2 0 6 2
Unique Cell Count 394 327 458 241 375 504 510 444 377 422 313 139 157 144 94 72 41 389 338 475 44 125 163
Labelled Cell Count 398 332 472 246 390 513 519 451 381 435 320 139 157 144 102 83 45 389 338 475 44 125 163


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 144.5 133.0 135.2 108.9 144.7 146.5 151.9 152.7 143.2 – 132.7 145.7 133.8 182.5 203.9 404.3 415.6 361.0 – 171.1 252.7
Std Deviation (1e-4) 48.9 53.6 50.8 51.0 48.5 41.8 46.1 49.9 50.3 – 46.2 53.3 44.8 58.4 64.5 159.3 135.0 165.8 – 57.1 108.9
Intensity Change (Log2) – – – -0.31 0.1 0.12 0.17 0.18 0.08 – -0.03 0.11 -0.01 0.43 0.59 1.58 1.62 1.42 – 0.34 0.9

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP7000200400WT3HU80HU120HU1600200400WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30200400WT1AF140AF1800200400
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 2.0 0 0 1.0 0 – 2.9 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 0 1.3 0.8 0.2 0.7 -0.6 – 0.4 0 0 0 0 0 0 0
Cytoplasm -2.1 -5.2 -4.1 -7.2 -9.2 -7.0 – -10.7 -8.8 -0.4 -1.1 0.8 -3.9 -3.8 0.4
Endoplasmic Reticulum 0 4.6 3.6 7.0 8.4 6.3 – 9.6 7.9 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 56.1238 88.976 72.9336 61.6881 72.6916 69.1789 77.0377 111.1848 101.1799 86.8495 76.2118 107.871 71.6126 103.5199 86.5988 88.3481 75.4265 91.4043
Actin 0.0122 0.0003 0.0001 0.0001 0.0023 0.0085 0.0043 0.0002 0.0009 0.001 0.0053 0.0001 0.0055 0.0001 0.0004 0.0001 0.0045 0.0092
Bud 0.0019 0.0031 0.0005 0.0002 0.0006 0.0005 0.0007 0 0.0002 0.0001 0.0028 0.0001 0.0005 0.0001 0.0006 0.0002 0.0009 0.0001
Bud Neck 0.0008 0.0001 0.0003 0.0003 0.0008 0.0007 0.0004 0.0001 0.0001 0.0002 0.0004 0.0008 0.0002 0.0001 0.0001 0.0002 0.0005 0.0003
Bud Periphery 0.0017 0.0005 0.0003 0.0001 0.002 0.0005 0.0004 0 0.0002 0.0001 0.0035 0.0001 0.0004 0 0.0006 0.0001 0.0006 0.0001
Bud Site 0.0021 0.0002 0.0003 0.0001 0.0018 0.0003 0.0009 0.0002 0.0001 0.0002 0.0025 0.0001 0.0005 0.0001 0.0001 0.0004 0.0009 0
Cell Periphery 0.0014 0.0001 0.0002 0.0004 0.003 0.0001 0.001 0.0001 0.0012 0.0002 0.0029 0.0002 0.0006 0.0001 0.0003 0.0003 0.0006 0
Cytoplasm 0.845 0.9912 0.9779 0.9375 0.9197 0.9157 0.94 0.9918 0.9826 0.925 0.8404 0.9826 0.9312 0.9896 0.961 0.9674 0.8602 0.9777
Cytoplasmic Foci 0.0176 0.0004 0.0046 0.0093 0.0128 0.0112 0.009 0.0022 0.0003 0.0162 0.0112 0.0036 0.009 0.0003 0.0076 0.0076 0.0219 0.0005
Eisosomes 0.0002 0 0 0 0.0002 0.0001 0.0001 0.0001 0.0003 0.0002 0.0013 0 0.0001 0 0 0 0.0006 0
Endoplasmic Reticulum 0.003 0.0002 0.0003 0.0017 0.0089 0.0017 0.0015 0.0002 0.0005 0.0005 0.0038 0.0005 0.0019 0.0002 0.0006 0.0004 0.0012 0.0006
Endosome 0.0175 0 0.0003 0.0024 0.0033 0.0082 0.005 0.0001 0.0002 0.0024 0.0064 0.0004 0.004 0 0.001 0.0009 0.012 0.0009
Golgi 0.0057 0 0.0001 0.0001 0.0007 0.0021 0.0017 0.0001 0.0003 0.0006 0.0013 0 0.0014 0 0.0004 0.0001 0.0015 0.0008
Lipid Particles 0.0095 0 0.0009 0.0012 0.0059 0.0027 0.0035 0.0014 0.0015 0.0064 0.0052 0.0006 0.0058 0 0.0085 0.0015 0.0059 0.0001
Mitochondria 0.0081 0.0003 0.0018 0.0013 0.0021 0.0058 0.0064 0.0007 0.0062 0.0021 0.0371 0.0003 0.0043 0.0006 0.0032 0.0027 0.0328 0.0002
None 0.0124 0.0003 0.0012 0.0162 0.0091 0.004 0.0041 0.0003 0.0004 0.0128 0.0186 0.0008 0.005 0.0002 0.0037 0.006 0.0186 0.0004
Nuclear Periphery 0.0092 0.0005 0.0007 0.0043 0.0056 0.0109 0.0029 0.0005 0.0007 0.0028 0.0079 0.0009 0.0054 0.0012 0.001 0.0007 0.0024 0.004
Nucleolus 0.0071 0 0.004 0.0023 0.0024 0.0009 0.0017 0.0002 0.0001 0.0073 0.011 0.0022 0.0042 0.0042 0.0015 0.0029 0.0049 0
Nucleus 0.0165 0.0015 0.0023 0.004 0.0051 0.0071 0.0052 0.0011 0.0014 0.0039 0.0087 0.0035 0.008 0.0027 0.0018 0.0027 0.0065 0.0037
Peroxisomes 0.0054 0 0.0002 0.0001 0.0005 0.0011 0.0008 0.0002 0.0001 0.0071 0.0018 0.0001 0.0043 0 0.0041 0.0004 0.003 0
Punctate Nuclear 0.0021 0 0.0004 0.0014 0.0019 0.0027 0.0012 0.0001 0 0.0078 0.0007 0.0005 0.0015 0.0001 0.0003 0.0006 0.0038 0.0006
Vacuole 0.0151 0.0007 0.0024 0.0119 0.0093 0.0104 0.0072 0.0003 0.0016 0.0015 0.0171 0.002 0.0044 0.0002 0.0023 0.0032 0.0127 0.0003
Vacuole Periphery 0.0055 0.0002 0.001 0.0049 0.0022 0.0047 0.0019 0.0001 0.0009 0.0016 0.0099 0.0006 0.0018 0.0001 0.0009 0.0015 0.0039 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 372.9818 602.4767 633.6553 502.567 529.2593 507.9063 615.0164 675.0226 833.4645 461.4782
Translational Efficiency 1.4463 1.6276 1.2102 2.1699 1.5838 1.0934 1.4781 1.7678 1.3955 1.5657

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
857 1382 1869 120 1779 1477 2132 15 2636 2859 4001 135

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 11417.51 8605.48 11703.10 8364.51 6296.77 7715.97 17158.80 10487.21 7961.59 8145.95 14610.26 8600.37
Standard Deviation 3715.48 3389.85 5609.34 2529.01 1891.83 3244.98 5606.72 2101.04 3557.68 3345.46 6233.62 2573.08
Intensity Change Log 2 — -0.407920 0.035643 -0.448895 — 0.293236 1.446265 0.735947 — -0.118144 0.704253 0.089783

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000082 0.000078 0.000071 0.000109 0.000043 0.000076 0.000057 0.000613 0.000055 0.000077 0.000063 0.000165
Bud Neck 0.000887 0.000371 0.002237 0.003110 0.000430 0.000433 0.000837 0.003641 0.000578 0.000403 0.001491 0.003169
Bud Site 0.002567 0.000640 0.005045 0.001676 0.001151 0.001270 0.002000 0.037881 0.001611 0.000965 0.003422 0.005698
Cell Periphery 0.003145 0.002197 0.000662 0.012354 0.001466 0.001099 0.001170 0.010319 0.002011 0.001630 0.000933 0.012128
Cytoplasm 0.800906 0.723046 0.760578 0.586109 0.799317 0.682804 0.591214 0.620169 0.799833 0.702257 0.670330 0.589893
Cytoplasmic Foci 0.006311 0.004967 0.009362 0.039484 0.004393 0.007215 0.003824 0.032087 0.005016 0.006128 0.006411 0.038662
Eisosomes 0.000001 0.000001 0.000001 0.000007 0.000001 0.000001 0.000001 0.000005 0.000001 0.000001 0.000001 0.000007
Endoplasmic Reticulum 0.000037 0.000025 0.000032 0.000013 0.000029 0.000027 0.000025 0.000051 0.000032 0.000026 0.000028 0.000017
Endosome 0.000048 0.000018 0.000092 0.000083 0.000036 0.000037 0.000040 0.000546 0.000040 0.000028 0.000064 0.000134
Golgi 0.002525 0.000774 0.000557 0.002019 0.001807 0.001118 0.000328 0.016352 0.002041 0.000952 0.000435 0.003611
Lipid Particles 0.001099 0.000250 0.000541 0.009514 0.000528 0.000319 0.000638 0.010122 0.000714 0.000286 0.000593 0.009582
Mitochondria 0.000362 0.000231 0.000332 0.000071 0.000224 0.000389 0.000304 0.000060 0.000269 0.000313 0.000317 0.000070
Mitotic Spindle 0.001505 0.000417 0.007615 0.000132 0.000236 0.000608 0.001770 0.001077 0.000649 0.000516 0.004500 0.000237
None 0.015583 0.021991 0.011480 0.003504 0.009507 0.015060 0.009426 0.002652 0.011482 0.018411 0.010385 0.003409
Nuclear Periphery 0.000165 0.000131 0.000262 0.000650 0.000132 0.000162 0.000222 0.000561 0.000143 0.000147 0.000241 0.000640
Nuclear Periphery Foci 0.001094 0.000523 0.000665 0.003618 0.001053 0.000514 0.000325 0.003549 0.001066 0.000518 0.000484 0.003611
Nucleolus 0.000184 0.000250 0.000165 0.000085 0.000060 0.000268 0.000111 0.000103 0.000100 0.000260 0.000136 0.000087
Nucleus 0.147988 0.239611 0.193705 0.205676 0.172156 0.279938 0.371712 0.098138 0.164299 0.260444 0.288559 0.193728
Peroxisomes 0.000015 0.000016 0.000033 0.000014 0.000006 0.000008 0.000024 0.000372 0.000009 0.000012 0.000028 0.000053
Vacuole 0.010741 0.003473 0.006119 0.131039 0.005891 0.005309 0.015502 0.151026 0.007468 0.004422 0.011119 0.133260
Vacuole Periphery 0.004754 0.000990 0.000446 0.000734 0.001537 0.003345 0.000470 0.010675 0.002583 0.002207 0.000459 0.001839

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.05 0.29 -3.21 -2.50 -4.04 -2.43 -2.96 -1.69 -1.56 -1.59 -2.04 -2.55 -3.63 -2.78 -3.03
Bud Neck 2.26 -5.26 -5.83 -6.67 -3.10 -0.55 -10.62 -2.30 -2.26 -1.37 1.48 -9.40 -6.75 -6.98 -4.24
Bud Site 3.76 -3.75 0.35 -4.42 4.47 -0.25 -2.02 -1.56 -1.56 -1.51 2.47 -4.92 -1.79 -2.16 -0.70
Cell Periphery 1.45 6.44 -3.31 -3.79 -4.94 1.50 2.19 -2.99 -3.18 -3.27 1.19 5.78 -4.49 -4.72 -5.37
Cytoplasm 8.63 7.52 13.14 9.58 10.33 16.55 34.89 2.69 0.68 -1.67 17.97 29.70 13.64 8.47 4.89
Cytoplasmic Foci 1.29 -3.82 -8.13 -8.40 -7.37 -4.01 -1.41 -3.50 -3.13 -3.39 -2.34 -4.82 -8.88 -8.62 -8.32
Eisosomes 0.47 -0.61 -7.83 -7.85 -7.72 -2.53 -5.47 -3.90 -3.48 -2.83 -1.94 -5.55 -8.84 -8.41 -7.81
Endoplasmic Reticulum 1.09 0.04 2.81 1.85 6.83 0.61 -0.57 -0.60 -0.78 -0.49 1.17 -0.54 3.90 1.92 5.91
Endosome 2.56 -4.17 -2.93 -4.45 -0.34 -0.20 -4.68 -1.42 -1.41 -1.27 1.82 -6.49 -3.34 -3.69 -1.79
Golgi 3.82 4.29 1.49 -3.18 -3.93 2.88 7.71 -1.13 -1.25 -1.36 5.09 8.15 -0.63 -2.10 -2.74
Lipid Particles 3.51 1.29 -5.95 -6.79 -6.33 1.34 -2.15 -3.24 -3.31 -3.05 3.70 -0.95 -6.95 -7.35 -6.82
Mitochondria 1.49 -0.48 4.13 5.13 14.40 -1.88 -4.64 4.98 3.62 8.23 -0.80 -3.63 7.62 5.68 16.53
Mitotic Spindle 1.30 -5.07 1.61 2.13 7.56 -1.79 -5.60 -1.12 -0.91 0.05 0.41 -7.49 0.74 0.53 8.17
None -2.73 2.15 6.98 13.02 13.56 -4.49 1.08 6.34 8.09 5.86 -5.97 1.93 12.45 16.53 16.93
Nuclear Periphery 0.56 -4.86 -7.15 -7.85 -4.99 -0.85 -13.80 -4.14 -3.57 -1.05 -0.41 -12.71 -8.39 -8.06 -4.92
Nuclear Periphery Foci 3.31 1.46 -5.71 -7.56 -6.66 3.17 4.61 -2.00 -2.59 -2.74 4.69 3.82 -6.44 -7.89 -7.66
Nucleolus -0.50 -0.12 1.53 1.24 6.46 -2.13 -10.54 -1.41 1.74 3.22 -1.95 -3.89 0.20 2.05 7.83
Nucleus -11.41 -8.15 -2.61 2.93 1.05 -15.93 -30.37 2.22 6.84 11.73 -18.85 -26.95 -1.42 5.14 8.32
Peroxisomes 0.03 -1.87 -0.71 -0.51 1.57 -1.02 -1.77 -1.15 -1.14 -0.99 -0.62 -2.55 -1.53 -1.39 -0.35
Vacuole 4.43 1.28 -8.75 -9.20 -8.90 -0.30 -11.75 -2.44 -2.44 -1.89 3.03 -9.74 -9.28 -9.44 -8.48
Vacuole Periphery 2.49 2.97 2.84 0.77 -1.20 -1.57 3.10 -0.90 -0.56 -1.14 0.64 4.07 1.79 1.15 -1.43
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-2

Hsp82

Hsp82


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Hsp82-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available