Standard name
Human Ortholog
Description High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.13 0 0 0 0 0 – 0 0 0 0 0 0.06 0.1 0.13 0 0.09 0.06 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0.05 0.12 – 0.15 0.12 0.13 0.17 0.15 0 0 0 0.05 0.1 0.12 0 0 0 0 0 0
Nucleus 0.86 0.93 0.88 0.87 0.71 0.67 – 0.57 0.66 0.58 0.6 0.58 0.85 0.75 0.67 0.79 0.73 0.71 0.89 0.87 0.83 0.54 0.37 0.3
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.08 0.11 0.19 0.23 0.37 0.51 – 0.63 0.57 0.65 0.65 0.6 0.12 0.27 0.26 0.24 0.26 0.29 0 0.07 0.12 0.21 0.28 0.29
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.21 0.29 0.33
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 0 0 0 0 – 0 0 0 0 0 0 2 1 0 0 0 0 0 0 0 0 0
Bud 0 1 0 0 1 0 – 0 0 1 0 1 0 2 1 0 0 0 8 0 0 1 3 6
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 1 1 0 1 – 3 1 5 3 12 0 1 0 0 0 0 – – – – – –
Cell Periphery 1 0 0 0 0 0 – 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0
Cytoplasm 82 5 11 5 11 12 – 4 10 10 7 11 24 49 63 5 15 9 1 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 1 1 2 1 1 0 0 0 0
Endosome 1 0 0 0 0 0 – 0 0 0 0 0 1 5 5 0 1 0 1 2 0 2 0 4
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 2
Mitochondria 9 4 10 12 17 44 – 64 41 58 62 50 0 4 2 9 18 17 1 0 0 1 6 9
Nucleus 539 293 261 255 230 249 – 242 219 262 224 192 320 368 317 142 128 102 573 291 254 178 119 133
Nuclear Periphery 0 0 1 0 0 0 – 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 8
Nucleolus 50 35 57 69 120 191 – 268 187 293 243 198 47 134 121 43 45 42 26 24 35 68 92 131
Peroxisomes 1 0 0 0 0 0 – 0 0 0 0 0 1 1 1 0 0 0 0 0 0 0 0 0
SpindlePole 1 0 0 0 0 0 – 0 0 0 0 0 0 4 7 0 0 0 3 0 2 0 4 2
Vac/Vac Membrane 5 2 3 0 5 0 – 3 3 2 1 2 7 8 13 6 2 0 15 9 9 67 93 147
Unique Cell Count 625 316 295 294 322 373 423 330 450 374 332 376 492 471 179 175 144 641 336 306 329 324 448
Labelled Cell Count 689 341 344 342 384 497 584 461 631 541 467 401 578 531 206 211 172 641 336 306 329 324 448


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 40.4 43.5 21.7 30.9 30.7 29.1 – 26.2 27.1 25.6 25.3 25.2 39.2 38.8 37.3 55.0 53.3 48.9 37.6 40.8 38.3
Std Deviation (1e-4) 18.4 13.2 7.9 12.3 11.2 12.4 – 9.5 12.4 11.1 10.5 13.4 14.0 15.7 15.5 21.5 23.0 23.6 12.7 13.8 11.9
Intensity Change (Log2) – – – 0.51 0.5 0.42 – 0.27 0.32 0.23 0.22 0.21 0.85 0.84 0.78 1.34 1.29 1.17 0.79 0.91 0.82


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 2.9 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -1.5 -0.2 -0.4 – -2.6 -0.5 -1.2 -1.5 -0.3 1.5 3.2 4.4 -0.5 2.2 1.2
Endoplasmic Reticulum 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.4 1.1 4.0 – 5.1 4.1 4.4 5.5 5.0 0 -2.6 0 0.9 3.1 3.4
Nucleus -0.6 -5.2 -6.6 – -9.0 -6.5 -8.8 -8.2 -8.6 -1.3 -4.6 -6.6 -2.7 -4.3 -4.6
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 1.2 4.9 8.5 – 11.7 9.6 12.2 11.8 10.3 -2.4 2.5 2.0 1.2 1.6 2.3
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 – 0 0 0 0 0 0 0 1.6 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 47.4194 37.7149 38.2691 38.0886 36.8427 36.2152 37.5153 34.1859 32.314 31.7571 29.6904 31.7681 48.8346 42.5478 40.3615 42.634 39.7615 40.123
Actin 0.0002 0 0 0 0 0 0.0239 0 0.0081 0 0.0003 0.0007 0.0031 0 0.0032 0 0.0001 0.0053
Bud 0 0 0 0 0 0 0.0005 0 0.0002 0 0.0001 0 0.0001 0 0.0001 0 0.0001 0.0001
Bud Neck 0 0 0 0 0.0001 0.0001 0.0004 0 0.0002 0 0.0002 0.0002 0 0 0.0001 0 0.0001 0.0001
Bud Periphery 0 0 0 0.0001 0.0001 0.0001 0.0003 0 0.0001 0 0.0001 0.0001 0.0001 0 0.0001 0 0.0001 0.0001
Bud Site 0 0 0 0 0 0 0.0007 0 0.007 0 0.0002 0 0.0001 0 0.0003 0 0.0001 0
Cell Periphery 0.0001 0 0 0.0001 0.0002 0.0002 0.0004 0 0.0002 0.0001 0.0005 0.0001 0.0003 0 0.0002 0 0.0004 0.0002
Cytoplasm 0.0006 0 0 0 0 0 0.0028 0 0.0007 0 0.0009 0.0001 0.0002 0 0.0016 0 0.001 0
Cytoplasmic Foci 0.0003 0 0 0 0.0001 0 0.004 0 0.0057 0 0.0255 0.0005 0.0035 0 0.002 0 0.0178 0.0001
Eisosomes 0 0 0 0 0 0 0.0002 0 0.0001 0 0.0009 0 0.0002 0 0 0 0.0004 0.0001
Endoplasmic Reticulum 0.0002 0 0 0 0 0 0.0051 0 0.0001 0 0.0001 0.0001 0.0003 0 0.0011 0 0.0001 0.0003
Endosome 0.002 0 0 0 0 0 0.0113 0 0.0009 0 0.0001 0.0021 0.0013 0 0.0049 0 0.0001 0.0008
Golgi 0.0001 0 0 0 0 0 0.0026 0 0.0016 0 0.0001 0.0004 0.0007 0 0.0013 0 0.0001 0.0005
Lipid Particles 0.0003 0 0 0 0 0 0.0038 0 0.0022 0 0.0101 0.001 0.0022 0 0.0011 0 0.0092 0.0002
Mitochondria 0.001 0.0003 0.0004 0.0007 0.0019 0.0003 0.0022 0.0003 0.0066 0.0014 0.0165 0.001 0.0033 0.0004 0.0032 0.0003 0.0098 0.0004
None 0.0007 0 0 0 0.0001 0 0.004 0 0.0006 0 0.0049 0.0003 0.0009 0 0.0008 0 0.0048 0.0002
Nuclear Periphery 0.0077 0.0003 0.0005 0.0005 0.0001 0.0001 0.011 0.0006 0.0007 0.0002 0.0007 0.0009 0.003 0.001 0.0014 0.0003 0.0009 0.0008
Nucleolus 0.046 0.0264 0.0378 0.0581 0.4625 0.1739 0.0542 0.0208 0.0353 0.1135 0.2813 0.1822 0.0867 0.0363 0.0384 0.0334 0.4182 0.1581
Nucleus 0.9318 0.9728 0.9598 0.9396 0.5341 0.8245 0.8636 0.978 0.9269 0.8837 0.6509 0.8085 0.8915 0.9618 0.9373 0.9659 0.5317 0.8319
Peroxisomes 0.0001 0 0 0 0 0 0.0037 0 0.0013 0 0.0021 0.0008 0.0004 0 0.0004 0 0.0004 0.0001
Punctate Nuclear 0.0024 0 0.0013 0 0.0001 0 0.0032 0 0.0005 0 0.0005 0.0006 0.0005 0.0001 0.0011 0 0.0014 0.0001
Vacuole 0.0007 0 0 0.0002 0.0003 0.0004 0.0011 0 0.0004 0.0003 0.0013 0.0002 0.0005 0 0.0006 0 0.0008 0.0003
Vacuole Periphery 0.0058 0.0001 0.0001 0.0007 0.0006 0.0003 0.0011 0.0001 0.0005 0.0006 0.0026 0.0002 0.0012 0.0002 0.0007 0.0001 0.0025 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 324.7609 388.2545 316.6522 256.6161 268.8739 269.8325 367.8074 335.3697 290.3135 258.5726
Translational Efficiency 1.779 2.0152 1.9155 2.785 2.3723 2.3099 1.8646 2.5305 2.1241 2.1577

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
122 1449 414 1163 2058 1374 1176 1027 2180 2823 1590 2190

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1507.46 2405.87 3378.10 4082.13 1482.58 2303.22 3016.39 3898.16 1483.97 2355.91 3110.57 3995.86
Standard Deviation 420.92 650.85 782.66 1092.22 533.79 599.21 881.68 1105.07 528.14 628.34 871.58 1102.10
Intensity Change Log 2 — 0.674439 1.164092 1.437202 — 0.635542 1.024713 1.394683 — 0.655284 1.096665 1.416276

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000592 0.000611 0.000749 0.000808 0.000542 0.000583 0.000587 0.000723 0.000545 0.000597 0.000629 0.000768
Bud Neck 0.002626 0.001714 0.005698 0.005643 0.001110 0.002151 0.005496 0.005579 0.001195 0.001927 0.005548 0.005613
Bud Site 0.000366 0.000537 0.000763 0.000713 0.000241 0.000547 0.000797 0.001246 0.000248 0.000541 0.000788 0.000963
Cell Periphery 0.000033 0.000089 0.000029 0.000073 0.000196 0.000076 0.000263 0.000105 0.000187 0.000082 0.000202 0.000088
Cytoplasm 0.000052 0.000964 0.000033 0.000147 0.001600 0.000271 0.000214 0.000389 0.001513 0.000627 0.000167 0.000260
Cytoplasmic Foci 0.000124 0.000416 0.000843 0.001915 0.000207 0.001199 0.001230 0.003431 0.000202 0.000797 0.001130 0.002626
Eisosomes 0.000147 0.000635 0.000308 0.000153 0.000409 0.000420 0.000282 0.000153 0.000394 0.000530 0.000289 0.000153
Endoplasmic Reticulum 0.000303 0.000285 0.000155 0.000137 0.000519 0.000350 0.000241 0.000152 0.000507 0.000317 0.000219 0.000144
Endosome 0.000011 0.000018 0.000004 0.000413 0.000014 0.000064 0.000013 0.001109 0.000014 0.000040 0.000011 0.000739
Golgi 0.000025 0.000019 0.000039 0.000288 0.000049 0.000314 0.000039 0.000359 0.000047 0.000163 0.000039 0.000321
Lipid Particles 0.000002 0.000006 0.000004 0.000012 0.000110 0.000103 0.000003 0.000122 0.000104 0.000054 0.000003 0.000064
Mitochondria 0.000914 0.000706 0.001552 0.002039 0.000848 0.001041 0.001221 0.001861 0.000852 0.000869 0.001307 0.001956
Mitotic Spindle 0.000010 0.000039 0.000038 0.000545 0.000181 0.000996 0.000195 0.002387 0.000172 0.000505 0.000154 0.001409
None 0.001044 0.000602 0.000532 0.000640 0.004744 0.000782 0.002883 0.000920 0.004537 0.000689 0.002271 0.000771
Nuclear Periphery 0.000025 0.000014 0.000021 0.000131 0.000020 0.000033 0.000055 0.000107 0.000021 0.000023 0.000046 0.000120
Nuclear Periphery Foci 0.000005 0.000023 0.000003 0.000049 0.000087 0.000196 0.000013 0.000125 0.000082 0.000107 0.000010 0.000085
Nucleolus 0.075410 0.040145 0.062666 0.143701 0.027147 0.047712 0.054791 0.130026 0.029848 0.043828 0.056842 0.137288
Nucleus 0.911618* 0.948975* 0.907401* 0.830458* 0.959464* 0.938333* 0.925146* 0.839574* 0.956786* 0.943795* 0.920526* 0.834733*
Peroxisomes 0.006440 0.003090 0.018791 0.009989 0.001407 0.003577 0.005951 0.009484 0.001689 0.003327 0.009294 0.009752
Vacuole 0.000133 0.000753 0.000206 0.001078 0.000874 0.000748 0.000401 0.001331 0.000832 0.000751 0.000351 0.001197
Vacuole Periphery 0.000120 0.000357 0.000166 0.001068 0.000231 0.000505 0.000178 0.000817 0.000225 0.000429 0.000175 0.000950

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.44 -3.24 -4.53 -4.19 -1.57 -1.20 -1.95 -5.86 -4.22 -4.83 -1.64 -3.49 -8.22 -5.89 -6.32
Bud Neck 2.48 -6.76 -5.43 -7.83 -0.29 -4.30 -17.47 -12.58 -8.27 -0.48 -5.13 -20.81 -14.17 -11.17 -0.49
Bud Site -0.95 -5.21 -2.61 -0.48 0.08 -1.88 -5.09 -3.66 -2.30 -1.31 -2.05 -6.05 -4.69 -2.01 -0.78
Cell Periphery -2.70 0.33 -2.02 0.49 -2.39 2.23 -0.30 1.42 -1.38 1.20 2.12 0.12 1.84 -0.69 1.22
Cytoplasm -1.48 0.71 -2.77 1.32 -3.73 2.11 2.59 1.26 -0.88 -1.44 1.16 2.69 2.03 0.76 -1.47
Cytoplasmic Foci -1.96 -8.40 -2.38 -1.97 -1.53 -1.99 -2.58 -3.06 -1.93 -1.46 -2.29 -2.90 -3.81 -2.68 -1.52
Eisosomes -3.55 -6.18 -0.37 3.52 7.27 -0.13 1.66 3.58 8.31 3.69 -1.38 1.49 3.59 5.23 5.23
Endoplasmic Reticulum 0.30 3.98 3.81 3.09 0.76 2.28 6.40 8.28 2.90 2.39 3.73 7.48 9.49 4.18 2.86
Endosome -0.67 2.07 -1.32 -1.29 -1.35 -2.28 -0.11 -2.19 -2.07 -2.19 -2.18 0.54 -2.55 -2.44 -2.56
Golgi 0.37 -3.16 -1.44 -1.46 -1.35 -1.14 0.03 -2.11 -0.04 -2.15 -1.01 0.07 -2.25 -0.82 -2.32
Lipid Particles -1.33 -4.95 -1.65 -0.87 -1.34 -0.04 1.02 -0.08 -0.06 -1.08 0.44 1.01 0.35 -0.10 -1.18
Mitochondria 2.19 -5.98 -9.25 -13.12 -4.15 -1.04 -3.95 -7.50 -4.40 -5.36 -0.16 -5.11 -10.25 -10.21 -7.77
Mitotic Spindle -1.04 -1.19 -2.41 -2.28 -2.30 -2.22 -0.61 -2.46 -1.61 -2.37 -1.56 -0.35 -2.78 -2.10 -2.75
None 1.47 1.84 1.37 -0.44 -1.79 3.97 1.38 3.72 -1.16 1.86 4.09 1.96 3.95 -1.16 1.96
Nuclear Periphery 1.26 0.40 -1.97 -2.15 -2.03 -1.63 -4.70 -4.80 -3.77 -2.73 -0.79 -4.56 -3.35 -3.21 -2.45
Nuclear Periphery Foci -1.26 1.11 -2.03 -0.86 -2.11 -1.17 1.13 -0.28 0.91 -1.49 -0.40 1.20 0.10 0.68 -1.96
Nucleolus 3.27 0.94 -5.83 -15.41 -9.90 -5.95 -7.32 -15.44 -11.63 -9.61 -5.45 -8.30 -22.44 -19.13 -14.15
Nucleus -3.21 0.54 6.52 15.82 8.01 5.01 7.58 15.85 12.20 9.48 4.19 9.09 22.50 19.77 13.03
Peroxisomes 2.94 -5.83 -3.03 -8.67 4.34 -5.17 -5.21 -8.59 -5.94 -2.35 -5.22 -8.99 -13.57 -10.18 -0.14
Vacuole -3.58 -4.37 -1.74 -0.56 -1.60 0.68 2.60 -0.63 -0.87 -1.47 0.57 2.99 -0.72 -1.00 -2.01
Vacuole Periphery -5.97 -3.69 -2.40 -1.80 -2.28 -2.09 2.13 -1.81 -0.86 -1.95 -2.98 2.34 -2.80 -1.94 -2.97
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages nucleus (98%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-2

Nhp6a

Nhp6a


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Nhp6a-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available