Standard name
Human Ortholog
Description Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0.06 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0.07 0 0.08 0.09 0.12 – 0.1 0.08 0.05 0 0.07 0.09 0.12 0.05 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.07 0 0 0 0 0 0 – 0.07 0.14 0.23 0.18 0 0 0 0 0.05 0 0 0 0 0 0 0
Nucleus 0.84 0.92 0.9 0.93 0.89 0.83 0.76 – 0.71 0.71 0.66 0.74 0.87 0.82 0.78 0.84 0.84 0.86 0.81 0.85 0.68 0.75 0.71 0.71
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.35 0.15 0.14 0.1 0.05 0.12 0.15 – 0.26 0.31 0.39 0.32 0.09 0.13 0.11 0.14 0.12 0.13 0.14 0.08 0.16 0.11 0.16 0.14
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 1 0 0 0 1 0 1 – 0 0 0 3 0 0 0 0 0 1 1 2 1 1 1 0
Bud Neck 0 0 0 0 0 1 0 – 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 2 1 0 0 1 1 4 – 4 1 10 14 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 1 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1 1 5 4 16 22 29 – 16 12 11 9 11 12 21 7 4 6 0 0 0 0 1 2
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 2 1 3 0 0 0 0 1 1
Endosome 0 0 1 0 0 6 0 – 0 0 0 0 2 1 1 2 1 0 1 0 2 0 1 0
Golgi 0 0 0 0 0 1 0 – 0 0 0 0 0 1 1 0 3 1 0 1 0 0 0 0
Mitochondria 12 0 1 2 0 8 8 – 11 22 53 39 1 2 0 5 9 5 0 0 1 0 0 0
Nucleus 147 159 62 135 188 206 187 – 117 110 150 163 139 112 131 122 150 149 147 160 64 45 96 93
Nuclear Periphery 5 1 0 1 0 1 3 – 1 0 1 1 1 0 2 0 3 0 0 0 0 0 0 0
Nucleolus 62 25 10 15 11 29 38 – 43 49 89 70 15 18 19 21 22 23 25 15 15 6 21 18
Peroxisomes 0 0 0 1 0 0 0 – 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 1 1 0 1 1 2 – 1 0 0 3 0 2 0 0 1 2 1 1 0 2 2 3
Vac/Vac Membrane 0 2 0 0 2 5 2 – 0 0 1 0 2 0 2 2 5 6 4 4 1 1 6 8
Unique Cell Count 176 172 69 145 212 248 247 164 156 228 220 159 136 169 146 178 174 183 188 94 61 135 131
Labelled Cell Count 230 190 80 158 221 281 274 194 194 315 302 171 149 177 161 199 196 183 188 94 61 135 131


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.8 9.4 8.3 8.0 8.4 8.0 7.2 – 6.4 6.2 5.8 5.5 8.9 9.1 9.0 10.5 10.4 9.4 6.3 8.9 8.9
Std Deviation (1e-4) 1.4 1.8 2.0 1.8 1.9 4.0 2.0 – 2.2 2.2 1.8 1.4 1.7 2.5 2.0 2.5 2.7 2.5 1.1 2.1 1.7
Intensity Change (Log2) – – – -0.07 0.01 -0.06 -0.22 – -0.38 -0.43 -0.53 -0.6 0.09 0.12 0.11 0.33 0.32 0.17 -0.4 0.1 0.08


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0.1 0.4 1.1 – 0.6 0.1 0 0 0 0.4 1.2 0 0 0
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 – 0 2.9 4.1 3.4 0 0 0 0 0 0
Nucleus 0.8 -0.3 -1.4 -2.5 – -3.1 -3.2 -3.9 -2.8 -0.5 -1.4 -2.2 -1.2 -1.1 -0.9
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus -0.9 -2.6 -0.6 0.2 – 1.9 2.7 3.8 2.8 -1.1 -0.2 -0.7 0 -0.4 -0.3
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.5721 3.356 3.2691 3.3265 2.8791 3.3094 2.1935 3.2474 2.4022 2.1589 2.334 2.3466 2.8806 3.5568 2.7513 2.9002 2.3121 2.6526
Actin 0.0078 0 0.0007 0.0051 0 0 0.0015 0 0.0033 0.0349 0.0678 0.0004 0.0114 0 0.0198 0 0.0033 0
Bud 0.0004 0 0.0002 0.0004 0.0001 0 0.0002 0 0.0005 0.0007 0.003 0 0.0003 0 0.0001 0.0001 0.0005 0
Bud Neck 0.0008 0.0001 0.0006 0.0007 0.0012 0.0006 0.0004 0.0001 0.0002 0.0008 0.0016 0.001 0.0006 0.0001 0.0002 0.0002 0.0036 0.0008
Bud Periphery 0.0009 0 0.0007 0.0005 0.0003 0 0.0006 0 0.0006 0.0023 0.0041 0.0001 0.0005 0 0.0001 0.0001 0.0014 0.0001
Bud Site 0.0015 0 0.0007 0.0009 0.0002 0 0.0005 0 0.0042 0.0014 0.0117 0.0001 0.0013 0 0.0003 0.0001 0.0013 0.0001
Cell Periphery 0.0003 0 0.0005 0.0001 0.0001 0 0.0001 0 0.0001 0.0006 0.0003 0 0.0002 0 0 0 0.0003 0
Cytoplasm 0.0013 0.0001 0.0001 0.0007 0.0002 0 0.0083 0.0008 0.001 0.0008 0.002 0.0002 0.0005 0 0.0004 0 0.0012 0
Cytoplasmic Foci 0.0046 0 0.0015 0.002 0 0 0.0108 0 0.0122 0.0024 0.0089 0.0018 0.007 0 0.0015 0 0.0024 0
Eisosomes 0.0002 0 0 0 0 0 0.0001 0 0.0001 0.0002 0.0002 0 0.0001 0 0.0001 0 0.0001 0
Endoplasmic Reticulum 0.0008 0 0.0002 0.0015 0.0009 0 0.0014 0.0001 0.0014 0.0014 0.0044 0.0002 0.0005 0 0.0003 0 0.0011 0
Endosome 0.0095 0 0.0055 0.0209 0.0021 0 0.0136 0.0003 0.0096 0.0303 0.039 0.0032 0.0052 0 0.0024 0 0.0059 0
Golgi 0.0025 0 0.0023 0.005 0 0 0.0019 0 0.0032 0.0045 0.0092 0.0009 0.0037 0 0.0016 0 0.0024 0
Lipid Particles 0.0106 0 0.006 0.0019 0.0002 0 0.0139 0 0.0051 0.0036 0.0733 0.0006 0.0073 0 0.0074 0 0.0083 0
Mitochondria 0.0094 0 0.0076 0.0026 0.0007 0 0.0177 0 0.0041 0.0095 0.0514 0.0004 0.0053 0.0001 0.0006 0.0001 0.0115 0.0002
None 0.0042 0 0.0002 0.0006 0.0001 0 0.0032 0.0165 0.0013 0.0009 0.0009 0.0001 0.0006 0 0.0003 0 0.0006 0
Nuclear Periphery 0.008 0.0048 0.0031 0.0065 0.008 0.0002 0.0125 0.0023 0.0038 0.0148 0.01 0.0003 0.0054 0.0003 0.0015 0.0012 0.0091 0.0011
Nucleolus 0.0633 0.0504 0.0397 0.1033 0.2319 0.1386 0.0387 0.0407 0.0288 0.0474 0.1191 0.0724 0.0486 0.0413 0.0242 0.026 0.1866 0.1033
Nucleus 0.8472 0.9394 0.9193 0.8206 0.7288 0.8584 0.8491 0.9365 0.9036 0.8023 0.5534 0.9168 0.8858 0.9573 0.9361 0.9713 0.7295 0.8932
Peroxisomes 0.0072 0 0.0017 0.0004 0 0 0.003 0 0.0132 0.0072 0.0103 0.0001 0.0072 0 0.0006 0 0.0018 0
Punctate Nuclear 0.0151 0.005 0.0065 0.0234 0.0118 0.002 0.0181 0.0024 0.0029 0.0246 0.0189 0.001 0.0063 0.0008 0.0021 0.0008 0.0257 0.0009
Vacuole 0.0031 0 0.0018 0.0015 0.0091 0 0.0028 0.0003 0.0005 0.0058 0.0075 0.0002 0.0015 0 0.0002 0 0.0022 0.0001
Vacuole Periphery 0.0015 0 0.0012 0.0013 0.0042 0 0.0018 0.0001 0.0004 0.0035 0.0031 0.0001 0.0008 0 0.0002 0 0.0014 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 11.0276 8.6982 9.0362 16.4636 11.3541 5.8349 12.899 15.4332 12.807 17.8298
Translational Efficiency 0.9145 1.1023 0.9041 0.4804 0.6778 1.5917 0.7112 0.5618 0.7951 0.6411

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2039 1130 128 951 1289 1747 161 654 3328 2877 289 1605

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 777.69 903.44 1231.36 1170.34 841.23 896.14 1273.82 1102.50 802.30 899.01 1255.01 1142.70
Standard Deviation 100.60 158.65 175.60 174.26 124.46 150.84 149.71 188.24 114.71 154.00 163.06 183.15
Intensity Change Log 2 — 0.216234 0.662986 0.589661 — 0.091224 0.598589 0.390206 — 0.152629 0.629883 0.489464

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000222 0.000690 0.002004 0.002126 0.000465 0.000631 0.002176 0.001381 0.000316 0.000654 0.002100 0.001822
Bud Neck 0.003584 0.007458 0.014135 0.035247 0.004929 0.012615 0.014317 0.025834 0.004105 0.010589 0.014237 0.031411
Bud Site 0.000412 0.000690 0.002289 0.006018 0.000372 0.001450 0.002046 0.005016 0.000397 0.001152 0.002154 0.005610
Cell Periphery 0.000046 0.000050 0.000092 0.000286 0.000027 0.000068 0.000057 0.000167 0.000039 0.000061 0.000072 0.000238
Cytoplasm 0.000816 0.000800 0.000268 0.003825 0.000592 0.001178 0.000327 0.019914 0.000729 0.001029 0.000301 0.010381
Cytoplasmic Foci 0.000221 0.000678 0.000198 0.000723 0.000162 0.001033 0.000076 0.003020 0.000198 0.000893 0.000130 0.001659
Eisosomes 0.000019 0.000033 0.000085 0.000042 0.000030 0.000034 0.000083 0.000039 0.000023 0.000033 0.000084 0.000041
Endoplasmic Reticulum 0.001681 0.002137 0.002332 0.003376 0.001975 0.002658 0.004723 0.004716 0.001795 0.002453 0.003664 0.003922
Endosome 0.000131 0.000524 0.000116 0.002438 0.000078 0.000765 0.000144 0.003967 0.000110 0.000670 0.000131 0.003061
Golgi 0.000081 0.000613 0.000284 0.002446 0.000098 0.000759 0.000233 0.002290 0.000088 0.000702 0.000255 0.002382
Lipid Particles 0.000074 0.000285 0.000105 0.000147 0.000046 0.000507 0.000153 0.004405 0.000063 0.000420 0.000132 0.001882
Mitochondria 0.000583 0.001751 0.002360 0.010545 0.000805 0.003125 0.002247 0.007953 0.000669 0.002585 0.002297 0.009489
Mitotic Spindle 0.001784 0.003526 0.001275 0.029194 0.001117 0.005190 0.013656 0.037984 0.001525 0.004536 0.008172 0.032776
None 0.003529 0.003565 0.002073 0.004171 0.001979 0.002137 0.001643 0.014585 0.002928 0.002698 0.001833 0.008414
Nuclear Periphery 0.000197 0.000324 0.000182 0.002705 0.000109 0.000495 0.000215 0.001639 0.000163 0.000428 0.000200 0.002270
Nuclear Periphery Foci 0.000562 0.000624 0.000141 0.001986 0.000194 0.001104 0.000216 0.000947 0.000419 0.000915 0.000183 0.001563
Nucleolus 0.089351 0.109774 0.089169 0.046174 0.112725 0.100773 0.079728 0.034982 0.098404 0.104308 0.083910 0.041613
Nucleus 0.896200* 0.864733* 0.876672* 0.837642* 0.873373* 0.862898* 0.873467* 0.813865* 0.887359* 0.863619* 0.874887* 0.827954*
Peroxisomes 0.000263 0.001234 0.004927 0.000634 0.000662 0.000702 0.002712 0.000636 0.000417 0.000911 0.003693 0.000635
Vacuole 0.000135 0.000290 0.001027 0.005726 0.000132 0.000908 0.001528 0.009870 0.000134 0.000665 0.001306 0.007414
Vacuole Periphery 0.000109 0.000224 0.000270 0.004551 0.000130 0.000971 0.000253 0.006791 0.000117 0.000678 0.000260 0.005464

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -10.79 -12.36 -8.47 -6.42 0.12 -2.97 -4.70 -15.71 -13.65 1.32 -9.17 -7.61 -13.07 -10.54 1.24
Bud Neck -6.80 -8.15 -19.92 -17.90 -10.48 -11.83 -6.30 -15.83 -12.14 -8.25 -14.00 -10.07 -25.42 -20.82 -13.31
Bud Site -1.91 -6.16 -9.70 -9.19 -3.77 -2.80 -8.25 -8.48 -6.74 -5.02 -3.11 -9.96 -12.85 -10.46 -6.37
Cell Periphery -0.37 -2.29 -2.89 -2.82 -1.71 -2.28 -5.60 -12.65 -4.74 -7.17 -1.88 -4.09 -4.70 -3.76 -3.02
Cytoplasm 0.17 1.98 -3.86 -3.98 -4.70 -1.20 0.47 -4.50 -4.09 -4.65 -1.03 1.57 -5.82 -5.26 -6.30
Cytoplasmic Foci -1.30 -0.52 -1.02 0.65 -0.70 -1.64 0.75 -1.75 -0.04 -2.66 -2.20 0.54 -2.04 0.62 -2.80
Eisosomes -8.81 -10.70 -15.95 -8.79 5.21 -2.54 -10.76 -10.69 -8.55 5.38 -9.02 -15.63 -19.22 -12.05 7.64
Endoplasmic Reticulum -2.24 -3.34 -12.17 -8.50 -7.24 -3.89 -7.67 -10.36 -8.22 -2.31 -4.89 -8.17 -15.64 -11.43 -4.29
Endosome -1.81 -0.30 -3.07 -1.55 -3.05 -3.49 -3.07 -3.65 -1.94 -3.34 -3.83 -2.73 -4.73 -2.29 -4.46
Golgi -2.23 -6.02 -2.22 -0.94 -1.46 -2.67 -6.29 -3.14 -0.69 -2.32 -3.47 -8.67 -3.31 -1.06 -2.32
Lipid Particles -1.03 -2.16 -5.17 0.19 -2.90 -1.56 -3.05 -1.29 -0.89 -1.13 -1.82 -3.48 -1.49 -0.73 -1.23
Mitochondria -2.80 -13.81 -4.32 -3.30 -2.80 -3.54 -2.95 -4.34 -1.87 -1.88 -4.56 -5.22 -5.87 -3.42 -3.18
Mitotic Spindle -1.12 -1.50 -7.48 -7.01 -6.21 -2.91 -1.84 -7.52 -6.77 -2.81 -2.88 -2.09 -10.57 -9.63 -4.78
None -0.01 1.87 -1.47 -1.19 -3.55 -0.38 -0.11 -4.39 -4.52 -4.46 0.33 1.55 -4.48 -4.99 -5.73
Nuclear Periphery -0.94 -1.33 -7.92 -6.81 -7.74 -3.43 -4.59 -11.38 -8.04 -9.96 -3.02 -3.91 -11.78 -9.51 -11.03
Nuclear Periphery Foci -0.13 1.42 -0.91 -0.65 -2.25 -2.00 -0.70 -3.34 0.52 -1.84 -1.48 0.53 -1.87 0.04 -2.52
Nucleolus -4.54 -2.31 9.03 11.82 5.05 2.46 2.13 12.78 11.15 4.44 -2.00 -0.76 14.98 16.07 6.65
Nucleus 5.96 4.11 10.02 5.56 0.96 2.19 1.80 7.71 6.44 3.34 6.53 4.49 12.68 8.32 2.95
Peroxisomes -3.46 -7.74 -9.23 1.44 6.97 -0.36 -7.45 -2.56 -1.19 6.77 -3.77 -10.33 -8.80 0.55 9.20
Vacuole -1.37 -7.03 -7.22 -6.98 -5.60 -2.86 -4.58 -6.29 -5.76 -4.84 -3.17 -6.36 -9.23 -8.43 -6.82
Vacuole Periphery -3.57 -8.91 -2.19 -2.02 -1.87 -2.72 -4.62 -1.83 -1.05 -1.67 -2.99 -8.18 -2.83 -1.84 -2.50
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
Localization
Cell Percentages nucleus (99%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Med1

Med1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Med1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available