Standard name
Human Ortholog
Description Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0.07 0.05 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0.06 0.07 – 0.09 0.06 0.06 0 0.05 0.13 0.16 0.07 0 0.07 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.09 0 0 0 0.25 0.1 – 0.16 0.19 0.31 0.31 0 0 0 0.1 0.06 0 0 0 0 0 0 0
Nucleus 0.96 0.94 0.95 0.93 0.92 0.83 0.85 – 0.81 0.83 0.78 0.81 0.93 0.85 0.81 0.85 0.86 0.83 0.89 0.94 0.87 0.92 0.79 0.72
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0.05 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0.06 0 0 0 0 0 – 0.05 0 0.06 0 0 0 0 0.05 0.07 0.09 0 0 0 0 0.1 0.14
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Bud 0 0 0 0 0 4 1 – 2 1 5 7 0 0 1 0 0 0 4 0 1 3 6 8
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 1 0 3 1 – 14 8 23 20 0 1 0 0 0 0 – – – – – –
Cell Periphery 1 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 2 1 0 8 11 12 28 – 28 21 17 15 13 67 79 24 10 22 0 0 1 0 1 1
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 1 0 0 7 5 12 0 0 0 1 0 1
Endosome 2 0 1 1 6 0 5 – 0 1 2 0 0 3 7 1 6 5 2 0 0 0 3 3
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 1 1 1 0 0 0 1 0 0 1 2 1
Mitochondria 7 24 4 6 7 48 38 – 53 72 95 113 6 6 8 35 16 10 0 0 0 0 1 7
Nucleus 270 247 94 187 250 158 333 – 265 309 241 294 226 444 412 289 229 271 250 249 99 349 416 339
Nuclear Periphery 2 0 1 7 11 1 8 – 11 9 3 6 2 6 4 3 4 5 1 0 0 0 1 4
Nucleolus 0 1 1 1 1 9 4 – 11 9 11 15 1 0 6 2 2 8 7 2 4 5 24 26
Peroxisomes 1 0 0 0 1 0 0 – 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 2 1 0 1 3 – 3 3 6 1 0 2 5 4 3 3 1 0 0 2 8 3
Vac/Vac Membrane 1 15 1 2 5 4 6 – 16 3 17 7 0 4 5 16 19 29 10 9 4 13 51 68
Unique Cell Count 280 262 99 201 272 190 390 329 373 309 365 244 520 509 341 267 327 282 266 114 380 525 470
Labelled Cell Count 286 288 104 214 292 240 427 403 436 420 479 250 534 529 381 294 365 282 266 114 380 525 470


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.9 5.6 5.9 6.3 7.2 4.7 5.5 – 5.5 5.1 5.2 4.9 6.4 6.4 6.3 6.3 6.8 7.7 6.0 6.1 6.4
Std Deviation (1e-4) 0.9 0.9 1.0 1.7 4.0 1.4 1.7 – 1.8 1.4 1.9 1.3 1.6 1.5 1.6 1.6 1.8 9.8 1.5 1.6 1.6
Intensity Change (Log2) – – – 0.11 0.29 -0.33 -0.08 – -0.09 -0.19 -0.18 -0.26 0.12 0.13 0.11 0.11 0.21 0.4 0.02 0.05 0.13


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 2.8 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 2.7 – 3.0 0 0 0 0 3.8 4.2 2.7 0 2.7
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 1.8 – 3.1 3.7 5.4 5.5 0 0 0 1.9 0.7 0
Nucleus -0.6 -1.0 -2.8 -2.6 – -3.4 -3.0 -3.8 -3.4 -0.8 -2.6 -3.4 -2.7 -2.4 -3.0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 – 0 0 0 0 0 0 0 0 2.3 2.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.2857 0.5989 0.2319 -0.2561 -0.367 0.2293 1.9929 2.0532 1.8763 1.4764 2.0783 1.9299 3.4946 3.6308 3.2967 3.4334 4.1618 3.6642
Actin 0 0 0 0 0.0014 0 0.0165 0 0.0012 0 0.0015 0.0007 0.0104 0 0.0003 0 0.0486 0.0159
Bud 0 0 0 0 0.0001 0 0.0004 0 0.0001 0 0.0001 0 0.0002 0 0 0 0.0038 0.0002
Bud Neck 0 0.0001 0 0.0001 0.0005 0.0003 0.0023 0 0.0001 0 0.0006 0.0007 0.0011 0.0001 0.0001 0 0.0009 0.0048
Bud Periphery 0 0 0 0 0.0001 0 0.0009 0 0.0002 0 0.0004 0.0002 0.0004 0 0.0002 0 0.0086 0.0006
Bud Site 0 0 0 0 0.0002 0 0.0009 0 0.0009 0 0.0001 0.0001 0.0011 0 0.0001 0 0.004 0.0006
Cell Periphery 0 0 0 0 0 0 0.0003 0 0.0001 0 0 0.0001 0.0001 0 0.0001 0 0.0002 0.0002
Cytoplasm 0.0009 0.0001 0.0003 0.0002 0.0015 0.0001 0.0043 0.0001 0.0024 0 0.0009 0.0004 0.001 0.0001 0.0002 0.0001 0.0196 0.0008
Cytoplasmic Foci 0 0 0 0 0.0026 0 0.0049 0 0.0015 0 0.0001 0.0015 0.0116 0 0.0006 0 0.0227 0.0045
Eisosomes 0 0 0 0 0 0 0.0002 0 0 0 0 0 0.0001 0 0.0001 0 0.0003 0.0001
Endoplasmic Reticulum 0.0001 0 0 0 0.0016 0 0.0038 0 0.0014 0 0.0011 0.0003 0.0015 0 0.0001 0 0.0011 0.0005
Endosome 0.0002 0 0 0 0.0085 0 0.0137 0 0.0042 0 0.0025 0.0031 0.007 0 0.0023 0 0.0204 0.0065
Golgi 0 0 0 0 0.001 0 0.0025 0 0.0006 0 0.0004 0.0004 0.0046 0 0.001 0 0.0235 0.0052
Lipid Particles 0 0 0 0 0.0068 0 0.007 0 0.0032 0 0.0002 0.0026 0.0062 0 0.0066 0 0.0558 0.0023
Mitochondria 0.0001 0.0001 0.0001 0.0001 0.0009 0 0.0032 0.0001 0.002 0.0001 0.0015 0.0014 0.0067 0.0001 0.0222 0.0001 0.0238 0.0037
None 0.0003 0 0.0015 0.0001 0.0014 0 0.0038 0 0.0015 0 0.0003 0.0005 0.0005 0 0.0001 0 0.0024 0.0049
Nuclear Periphery 0.0044 0.0029 0.0065 0.0027 0.0165 0.0021 0.0189 0.0019 0.0068 0.0005 0.0309 0.0083 0.0134 0.0006 0.0033 0.0007 0.0036 0.0019
Nucleolus 0.0054 0.0109 0.0056 0.0056 0.0208 0.0193 0.0086 0.0049 0.0074 0.0021 0.0299 0.0165 0.0055 0.0075 0.0049 0.0031 0.0275 0.0214
Nucleus 0.9878 0.985 0.9835 0.9898 0.9194 0.9743 0.8932 0.9926 0.9553 0.9971 0.9236 0.9553 0.9166 0.9912 0.955 0.9958 0.7014 0.9183
Peroxisomes 0 0 0 0 0.0008 0 0.0019 0 0.0017 0 0 0.0005 0.0081 0 0.0006 0 0.0206 0.0031
Punctate Nuclear 0.0005 0.0009 0.0024 0.0015 0.0146 0.0037 0.009 0.0003 0.0075 0.0001 0.003 0.0064 0.0027 0.0003 0.0011 0.0001 0.0079 0.0033
Vacuole 0.0001 0 0 0 0.0007 0 0.0025 0 0.0011 0 0.0007 0.0004 0.0006 0 0.0005 0 0.0014 0.0006
Vacuole Periphery 0.0001 0 0 0 0.0006 0 0.0014 0 0.0007 0 0.0022 0.0005 0.0009 0 0.0006 0 0.0018 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 11.4938 3.7363 6.9312 12.673 12.1927 2.0886 13.6943 9.5615 11.9784 14.8878
Translational Efficiency 1.8645 6.6663 3.3064 2.0739 2.0572 12.3883 1.9612 2.5402 1.9597 1.8312

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
943 217 240 47 1005 1855 351 1403 1948 2072 591 1450

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 743.50 917.90 1054.57 1028.08 761.13 807.32 979.08 959.21 752.60 818.90 1009.74 961.44
Standard Deviation 89.67 123.24 120.00 151.90 94.56 158.99 118.69 134.79 92.65 159.27 124.85 135.93
Intensity Change Log 2 — 0.304004 0.504250 0.467548 — 0.084998 0.363284 0.333704 — 0.197372 0.434663 0.401394

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000180 0.000662 0.001524 0.000992 0.000216 0.000162 0.001102 0.000760 0.000199 0.000214 0.001273 0.000767
Bud Neck 0.001625 0.007940 0.008098 0.005052 0.002326 0.007423 0.005815 0.033852 0.001987 0.007477 0.006742 0.032918
Bud Site 0.000506 0.002015 0.001237 0.000894 0.001047 0.001200 0.001081 0.011391 0.000785 0.001285 0.001144 0.011051
Cell Periphery 0.000175 0.000063 0.000068 0.000159 0.000080 0.000270 0.000063 0.000116 0.000126 0.000248 0.000065 0.000117
Cytoplasm 0.010314 0.006527 0.001464 0.008872 0.008622 0.015940 0.003295 0.016042 0.009441 0.014954 0.002551 0.015810
Cytoplasmic Foci 0.002037 0.001654 0.000071 0.002475 0.001854 0.003872 0.000906 0.002260 0.001943 0.003640 0.000567 0.002267
Eisosomes 0.000021 0.000025 0.000047 0.000062 0.000019 0.000251 0.000037 0.000022 0.000020 0.000228 0.000041 0.000023
Endoplasmic Reticulum 0.002996 0.007846 0.009942 0.009552 0.002306 0.003714 0.009614 0.006551 0.002640 0.004147 0.009747 0.006649
Endosome 0.000653 0.000998 0.000397 0.003688 0.000306 0.000714 0.002368 0.003377 0.000474 0.000744 0.001568 0.003387
Golgi 0.000113 0.000385 0.000125 0.000851 0.000171 0.000501 0.000595 0.003064 0.000143 0.000489 0.000404 0.002992
Lipid Particles 0.001413 0.000305 0.000344 0.001183 0.000443 0.000989 0.000417 0.000192 0.000913 0.000917 0.000387 0.000224
Mitochondria 0.000972 0.001097 0.001131 0.010388 0.001142 0.002505 0.000966 0.003195 0.001060 0.002358 0.001033 0.003428
Mitotic Spindle 0.001637 0.000304 0.001758 0.000535 0.000992 0.004823 0.000636 0.027156 0.001304 0.004350 0.001092 0.026293
None 0.009949 0.003025 0.001495 0.002573 0.006067 0.039542 0.004613 0.006587 0.007946 0.035717 0.003346 0.006457
Nuclear Periphery 0.000797 0.001207 0.000681 0.001340 0.000541 0.001074 0.000618 0.002354 0.000665 0.001088 0.000643 0.002321
Nuclear Periphery Foci 0.000443 0.000352 0.000467 0.000722 0.000274 0.000492 0.000268 0.000910 0.000355 0.000477 0.000349 0.000904
Nucleolus 0.013316 0.011560 0.009238 0.010731 0.010149 0.010667 0.008744 0.005481 0.011682 0.010761 0.008945 0.005651
Nucleus 0.951466* 0.950401* 0.956645* 0.911939* 0.961927* 0.903681* 0.953551* 0.864032* 0.956863* 0.908574* 0.954807* 0.865585*
Peroxisomes 0.000634 0.000741 0.000429 0.000423 0.000697 0.000570 0.000307 0.000334 0.000667 0.000588 0.000357 0.000337
Vacuole 0.000605 0.002691 0.004676 0.008141 0.000716 0.001357 0.004826 0.008056 0.000662 0.001497 0.004765 0.008058
Vacuole Periphery 0.000146 0.000201 0.000163 0.019428 0.000108 0.000252 0.000178 0.004268 0.000126 0.000247 0.000172 0.004760

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.68 -12.43 -3.83 -2.62 -0.44 1.52 -12.20 -12.23 -14.27 2.67 -0.70 -17.43 -13.81 -13.69 4.18
Bud Neck -5.40 -9.79 -3.42 -0.80 0.36 -4.36 -4.75 -15.06 -12.47 -12.90 -6.30 -10.04 -16.05 -12.55 -12.08
Bud Site -1.89 -6.75 -2.21 -0.72 -1.19 -0.29 -0.96 -5.59 -5.66 -5.52 -1.24 -2.83 -6.11 -5.65 -5.53
Cell Periphery 1.76 1.57 0.31 -2.25 -1.97 -5.34 0.48 -1.87 4.84 -3.19 -2.89 1.65 0.55 4.62 -3.99
Cytoplasm 1.43 4.65 1.12 -0.31 -2.31 -3.28 3.04 -2.80 0.56 -6.49 -2.77 5.26 -2.52 0.21 -7.54
Cytoplasmic Foci 0.38 3.76 0.63 0.07 -1.72 -2.02 1.52 1.09 3.98 -0.85 -2.29 2.95 1.66 3.91 -1.73
Eisosomes -1.31 -7.41 -4.15 -3.75 -1.99 -2.39 -7.35 -7.28 2.24 3.65 -2.39 -10.27 -8.43 2.22 4.84
Endoplasmic Reticulum -5.31 -9.29 -5.43 -2.30 -0.88 -4.69 -12.64 -16.95 -12.10 3.17 -5.48 -15.51 -17.03 -11.41 3.67
Endosome -0.18 0.70 -1.00 -0.91 -1.24 -2.30 -1.08 -4.34 -3.11 -0.11 -0.56 -0.82 -3.23 -3.15 -0.76
Golgi -0.87 -0.73 -1.19 -0.38 -1.12 -1.50 -0.76 -2.56 -1.79 -1.64 -1.82 -0.84 -2.67 -1.83 -2.09
Lipid Particles 2.34 2.13 0.47 -2.08 -1.82 -1.97 -0.56 2.20 2.50 2.44 -0.12 1.93 2.58 2.39 2.27
Mitochondria -0.79 -2.44 -1.11 -1.07 -1.04 -1.66 0.00 -4.01 -1.07 -6.10 -1.94 -0.70 -5.43 -1.48 -5.84
Mitotic Spindle 1.62 -0.59 -1.01 -1.54 -0.28 -2.91 0.17 -7.10 -5.31 -7.21 -2.41 -0.46 -6.96 -5.53 -6.10
None 3.14 3.97 3.11 0.09 -1.24 -8.68 1.08 0.16 8.81 -1.01 -7.82 3.32 1.64 8.70 -2.22
Nuclear Periphery -1.55 -1.79 -2.62 -1.05 -1.97 -4.25 -2.69 -10.00 -8.03 -9.24 -3.94 -2.95 -9.84 -8.04 -9.03
Nuclear Periphery Foci 0.28 -0.64 -1.02 -1.08 -0.84 -1.93 -0.94 -3.57 -1.80 -2.42 -1.08 -0.94 -3.01 -2.02 -2.13
Nucleolus 0.87 1.85 0.92 0.49 0.11 -0.54 1.11 3.06 3.59 1.53 0.73 2.28 5.00 3.81 2.19
Nucleus 0.19 1.09 1.86 1.74 1.54 8.99 2.16 13.49 4.32 10.10 8.52 2.18 13.53 5.06 11.08
Peroxisomes 0.01 1.46 0.40 0.33 -0.90 0.19 1.09 1.32 2.61 1.22 0.35 1.76 2.16 2.79 1.60
Vacuole -1.42 -4.48 -3.12 -2.26 -1.29 0.11 -2.71 -7.60 -9.29 -1.24 -1.06 -4.38 -9.50 -9.28 -1.86
Vacuole Periphery -1.51 -1.88 -1.01 -1.00 -1.00 -3.35 -1.85 -3.07 -2.84 -2.95 -3.18 -2.32 -3.15 -2.98 -3.06
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p
Localization
Cell Percentages nucleus (97%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Snt309

Snt309


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Snt309-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available