Standard name
Human Ortholog
Description Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with LSB1 cooperatively inhibits the nucleation of actin filaments; short-lived protein whose levels increase in response to thermal stress; induces the formation of the [PIN+] and [RNQ+] prions when overproduced; PIN3 has a paralog, LSB1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.95 0.98 0.97 0.9 0.83 0.83 0.78 0.67 0.75 0.7 0.72 0.68 0.98 0.97 0.97 0.84 0.9 0.92 0.9 0.91 0.94 0.94 0.91 0.86
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.11 0 0.05 0 0.09 0.1 0.13 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0.08 0.25 0.07 0.27 0.31 0.21 0.21 0.17 0.19 0 0 0.05 0.18 0.1 0.09 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 1 0 1 0 1 0 0 0 0 0 0 0 0 1 3 0 0 2 2
Bud 0 0 0 0 0 3 0 1 1 1 2 0 0 0 0 0 1 0 0 0 3 0 2 8
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 5 2 3 1 3 8 2 7 8 7 1 1 2 4 4 4 0 0 0 0 0 0
Cytoplasm 161 330 188 185 269 138 209 244 174 203 149 140 315 407 422 178 179 175 161 310 182 308 341 378
Endoplasmic Reticulum 1 6 2 1 3 1 2 1 1 4 4 7 6 0 1 5 2 5 1 2 0 1 6 8
Endosome 0 0 1 0 0 0 0 1 0 0 1 1 0 0 0 0 0 0 3 3 1 0 3 14
Golgi 1 1 0 0 0 0 0 0 1 0 0 0 0 0 0 1 2 1 2 1 0 1 2 2
Mitochondria 3 1 0 3 1 18 6 17 10 27 21 26 1 0 0 7 3 2 1 3 0 0 1 0
Nucleus 0 2 1 1 1 4 4 6 3 13 6 9 4 1 0 4 5 3 0 3 2 2 2 4
Nuclear Periphery 0 1 0 0 0 0 0 0 0 2 1 2 0 0 0 0 0 0 1 0 0 0 0 4
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 3 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 2 4
Vac/Vac Membrane 4 1 5 17 81 12 73 112 50 61 35 40 3 18 20 38 19 17 2 4 0 4 3 4
Unique Cell Count 169 338 194 205 323 166 267 366 233 290 208 206 322 418 437 211 200 190 179 340 194 327 373 441
Labelled Cell Count 170 342 202 209 358 178 297 391 242 319 227 233 330 427 445 241 215 207 179 340 194 327 373 441


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.7 9.8 9.9 9.5 11.1 7.1 9.9 9.7 9.0 9.0 9.0 8.6 9.3 10.6 10.9 16.8 16.2 15.2 8.8 10.1 11.1
Std Deviation (1e-4) 1.2 1.8 1.7 1.5 1.7 1.7 2.2 1.9 2.3 2.1 2.4 2.0 1.9 2.0 1.9 6.1 5.2 5.8 1.8 2.0 2.3
Intensity Change (Log2) – – – -0.07 0.16 -0.49 -0.01 -0.04 -0.15 -0.15 -0.15 -0.2 -0.09 0.1 0.14 0.75 0.71 0.61 -0.17 0.02 0.16

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70005101520WT3HU80HU120HU16005101520WT3rpd3Δ_1rpd3Δ_2rpd3Δ_305101520WT1AF100AF140AF18005101520
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0.7 0.5 0 0 0 0 0 0
Cytoplasm -2.7 -4.7 -4.5 -5.7 -8.1 -6.4 -7.4 -6.9 -7.5 0.6 0.3 -0.2 -4.3 -2.9 -2.1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 4.7 0 3.0 0 4.4 4.5 5.1 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 2.6 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 2.5 6.7 2.1 7.0 7.8 5.8 5.8 4.8 5.3 0 1.0 1.2 5.0 2.9 2.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.8839 5.3711 4.1951 3.4719 3.591 4.1487 5.5378 7.1806 6.1087 5.1042 5.767 6.1453 7.9033 9.8486 8.5967 8.8534 8.211 8.5948
Actin 0.0336 0.0024 0.0218 0.0323 0.0302 0.0059 0.0324 0.0035 0.0285 0.0849 0.046 0.0057 0.0594 0.0012 0.0276 0.0027 0.0256 0.0034
Bud 0.0009 0.0131 0.0036 0.0012 0.002 0.001 0.0011 0.0001 0.0021 0.0015 0.0003 0.0003 0.0008 0.0001 0.0007 0.0005 0.0015 0.0001
Bud Neck 0.0051 0.0006 0.0023 0.0025 0.0048 0.0035 0.0025 0.0003 0.0022 0.002 0.0011 0.0019 0.008 0.0003 0.0049 0.0009 0.0011 0.0018
Bud Periphery 0.0008 0.0028 0.0015 0.0016 0.0022 0.0005 0.0021 0 0.0022 0.002 0.0004 0.0002 0.0014 0 0.0012 0.0002 0.0013 0.0001
Bud Site 0.0035 0.0119 0.0084 0.0024 0.0048 0.0002 0.0027 0.0017 0.0164 0.0013 0.0009 0.0002 0.0079 0.0005 0.0059 0.0008 0.0004 0.0001
Cell Periphery 0.0002 0.0003 0.0005 0.0003 0.0003 0.0001 0.0002 0.0001 0.0008 0.0002 0.0001 0 0.0012 0.0001 0.0012 0.0001 0.0001 0.0001
Cytoplasm 0.7266 0.911 0.8656 0.808 0.7237 0.9002 0.8279 0.9776 0.8553 0.8541 0.8743 0.9126 0.8438 0.9823 0.9048 0.9556 0.895 0.9443
Cytoplasmic Foci 0.0425 0.0138 0.0203 0.016 0.0285 0.0231 0.0271 0.0036 0.01 0.0027 0.0094 0.0125 0.005 0.0015 0.0042 0.0078 0.0034 0.0026
Eisosomes 0.0003 0 0.0005 0.0003 0.0013 0 0.0001 0.0001 0.0003 0.0003 0.0002 0 0.0007 0 0.0009 0 0.0001 0.0002
Endoplasmic Reticulum 0.008 0.0015 0.005 0.0048 0.0061 0.0033 0.0025 0.0011 0.003 0.0017 0.0062 0.0027 0.007 0.0012 0.0038 0.0025 0.0065 0.0035
Endosome 0.0472 0.0015 0.0103 0.019 0.0471 0.0104 0.0223 0.0006 0.0163 0.007 0.0063 0.0105 0.008 0.0002 0.003 0.0026 0.0117 0.003
Golgi 0.015 0.0003 0.0036 0.0178 0.0178 0.0018 0.0122 0.0003 0.0139 0.0157 0.004 0.0058 0.0031 0.0001 0.0018 0.0004 0.0021 0.0008
Lipid Particles 0.0164 0.0001 0.0025 0.0058 0.0129 0.0016 0.009 0.0007 0.0057 0.0019 0.0096 0.0041 0.0013 0 0.0021 0.0004 0.0016 0.0005
Mitochondria 0.0056 0.0006 0.0052 0.0212 0.0113 0.0035 0.0104 0.0002 0.0135 0.0075 0.0011 0.0048 0.0015 0.0001 0.0012 0.0002 0.0031 0.0009
None 0.0248 0.015 0.0169 0.032 0.0347 0.0115 0.0167 0.0052 0.0074 0.0035 0.0057 0.0127 0.0245 0.0059 0.0263 0.0042 0.0078 0.0152
Nuclear Periphery 0.0119 0.0016 0.0032 0.0076 0.0128 0.0067 0.0029 0.0006 0.0016 0.0011 0.0025 0.0016 0.0083 0.0007 0.0018 0.0028 0.021 0.0054
Nucleolus 0.0005 0.0003 0.0005 0.0004 0.003 0.0001 0.0003 0 0.0024 0.0001 0.0002 0 0.0005 0 0.0002 0.0001 0.0005 0.0007
Nucleus 0.0214 0.0172 0.0163 0.0169 0.0244 0.0149 0.015 0.0032 0.0103 0.0099 0.0053 0.009 0.0083 0.0052 0.0057 0.0104 0.0086 0.0146
Peroxisomes 0.0223 0.0032 0.0057 0.002 0.0073 0.0041 0.007 0.0004 0.0031 0.0006 0.0192 0.0137 0.0008 0 0.0005 0.0002 0.0005 0.0001
Punctate Nuclear 0.0096 0.002 0.0042 0.0057 0.0198 0.0058 0.0025 0.0003 0.0019 0.0005 0.006 0.001 0.0073 0.0003 0.001 0.0071 0.0063 0.002
Vacuole 0.0023 0.0007 0.0017 0.0015 0.0034 0.0014 0.0018 0.0003 0.0021 0.0008 0.0009 0.0003 0.0008 0.0002 0.0009 0.0005 0.0009 0.0004
Vacuole Periphery 0.0014 0.0001 0.0004 0.0009 0.0015 0.0004 0.001 0 0.0009 0.0006 0.0002 0.0003 0.0005 0 0.0002 0.0001 0.0008 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 40.8668 24.355 33.8858 46.7354 26.4928 44.2479 50.7896 59.2102 44.463 47.7991
Translational Efficiency 2.184 3.1075 1.8488 1.0241 2.5955 2.958 1.9678 1.8235 2.3387 1.8345

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
225 1342 832 1873 1552 2095 181 2219 1777 3437 1013 4092

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1472.09 1079.34 1372.93 1437.41 944.86 1092.65 1521.46 1640.33 1011.62 1087.45 1399.47 1547.45
Standard Deviation 334.13 183.66 213.49 320.08 132.44 170.45 218.11 382.01 245.35 175.85 221.75 369.12
Intensity Change Log 2 — -0.447716 -0.100608 -0.034394 — 0.209659 0.687284 0.795814 — -0.154170 0.260072 0.348684

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001809 0.000249 0.000783 0.002416 0.000218 0.000468 0.001613 0.003401 0.000419 0.000382 0.000931 0.002950
Bud Neck 0.004299 0.002399 0.004341 0.005266 0.003270 0.002441 0.006303 0.007474 0.003400 0.002425 0.004691 0.006463
Bud Site 0.034292 0.006364 0.014107 0.033238 0.008941 0.009149 0.017969 0.041481 0.012151 0.008061 0.014797 0.037708
Cell Periphery 0.000596 0.000087 0.000264 0.000308 0.000121 0.000079 0.000515 0.000184 0.000181 0.000082 0.000309 0.000241
Cytoplasm 0.684721 0.795575 0.553074 0.636301 0.711533 0.767248 0.427772 0.647241 0.708138 0.778309 0.530686 0.642233
Cytoplasmic Foci 0.106074 0.047766 0.015155 0.016301 0.097972 0.045857 0.025699 0.023667 0.098998 0.046602 0.017039 0.020296
Eisosomes 0.000025 0.000014 0.000028 0.000018 0.000040 0.000023 0.000050 0.000014 0.000038 0.000019 0.000032 0.000016
Endoplasmic Reticulum 0.011332 0.000991 0.003555 0.000896 0.001483 0.000758 0.003908 0.000393 0.002730 0.000849 0.003619 0.000623
Endosome 0.006379 0.002053 0.004408 0.002103 0.004866 0.001921 0.003791 0.004891 0.005057 0.001972 0.004298 0.003615
Golgi 0.004258 0.000484 0.000307 0.004928 0.000854 0.001244 0.000325 0.002941 0.001285 0.000947 0.000310 0.003850
Lipid Particles 0.010584 0.000575 0.002311 0.001944 0.001511 0.000699 0.003708 0.001411 0.002660 0.000651 0.002561 0.001655
Mitochondria 0.001961 0.000444 0.000431 0.001126 0.001356 0.000282 0.000394 0.001524 0.001432 0.000345 0.000424 0.001341
Mitotic Spindle 0.012054 0.004066 0.024230 0.033548 0.004112 0.004940 0.006806 0.069335 0.005118 0.004599 0.021117 0.052954
None 0.001359 0.006641 0.006710 0.007664 0.003127 0.003572 0.002487 0.009098 0.002903 0.004770 0.005956 0.008442
Nuclear Periphery 0.000518 0.000148 0.001536 0.000374 0.000206 0.000179 0.001464 0.000544 0.000245 0.000167 0.001523 0.000466
Nuclear Periphery Foci 0.012611 0.003332 0.008587 0.003691 0.002446 0.001307 0.010982 0.001541 0.003733 0.002098 0.009015 0.002525
Nucleolus 0.000276 0.000477 0.000278 0.000161 0.000224 0.000541 0.000182 0.000351 0.000230 0.000516 0.000261 0.000264
Nucleus 0.063282 0.091627 0.213503 0.195353 0.088968 0.109517 0.246198 0.127637 0.085716 0.102532 0.219344 0.158632
Peroxisomes 0.000831 0.000695 0.000767 0.001057 0.000987 0.000993 0.000300 0.002745 0.000967 0.000877 0.000684 0.001972
Vacuole 0.039324 0.035197 0.145336 0.052035 0.067259 0.048132 0.239329 0.052106 0.063722 0.043082 0.162130 0.052074
Vacuole Periphery 0.003415 0.000818 0.000289 0.001271 0.000507 0.000652 0.000204 0.002022 0.000875 0.000716 0.000273 0.001678

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 6.22 4.32 -0.27 -4.87 -3.50 -1.88 -8.94 -3.78 -2.97 -0.44 0.39 -6.58 -5.22 -5.17 -3.50
Bud Neck 3.06 -0.99 0.24 -5.07 2.14 0.97 -5.74 -5.78 -8.68 1.76 1.92 -5.73 -5.17 -9.89 1.59
Bud Site 6.64 5.38 2.82 -9.25 -5.72 -0.18 -3.79 -7.55 -8.00 -2.08 2.99 -0.42 -6.73 -11.81 -6.88
Cell Periphery 7.32 4.35 4.02 -12.85 -1.02 6.35 -9.84 -8.61 -11.72 6.76 8.79 -7.90 -6.15 -17.45 3.19
Cytoplasm -7.18 11.58 5.64 30.29 -11.52 -6.06 26.98 17.68 25.41 -18.18 -9.84 30.95 21.01 38.57 -17.70
Cytoplasmic Foci 6.59 11.00 10.41 11.86 -3.27 13.70 21.67 22.67 12.09 -1.93 15.42 28.37 26.03 17.12 -5.17
Eisosomes 4.17 -1.21 0.66 -5.85 3.03 5.19 -4.88 12.17 2.09 10.61 8.35 -0.06 9.37 -1.08 9.57
Endoplasmic Reticulum 2.32 1.77 2.36 0.68 8.58 3.63 -6.06 6.25 3.71 9.98 3.29 -1.17 3.89 2.36 11.98
Endosome 3.37 2.58 4.32 3.00 8.04 7.64 3.63 7.41 0.57 3.49 8.35 5.16 10.12 2.40 6.95
Golgi 2.94 3.14 2.06 -1.43 -1.88 -0.66 2.93 0.35 0.85 -1.72 1.01 4.44 0.73 -0.23 -2.56
Lipid Particles 4.53 3.59 3.41 -10.42 -1.37 4.75 -9.59 -5.79 -8.05 2.35 6.16 -1.18 -1.78 -12.08 -1.09
Mitochondria 1.20 1.01 1.09 -0.53 0.71 1.90 1.40 1.11 -2.31 -0.74 2.04 1.50 1.46 -2.09 -0.06
Mitotic Spindle 2.56 -1.17 -2.03 -6.61 -0.89 -0.38 -1.89 -9.83 -9.89 -4.00 0.42 -4.67 -10.61 -11.86 -3.62
None -7.93 -10.08 -13.24 0.94 -0.67 -0.40 -0.96 -4.53 -4.71 -2.21 -2.48 -3.61 -5.38 -3.47 -2.28
Nuclear Periphery 2.28 -10.07 -0.97 -20.02 15.97 0.38 -13.76 -10.84 -10.81 9.63 2.57 -22.68 -12.86 -17.37 17.35
Nuclear Periphery Foci 5.40 3.75 5.57 0.87 4.55 4.38 -6.48 1.41 -3.73 6.88 4.93 -5.10 3.55 -1.45 7.92
Nucleolus -1.20 -0.90 0.62 1.71 4.12 -1.33 0.19 -2.33 0.73 -2.61 -1.72 -2.08 -1.59 1.33 0.17
Nucleus -4.51 -20.69 -20.67 -23.92 5.25 -6.01 -10.92 -18.28 -12.60 5.54 -6.23 -24.77 -28.71 -24.87 9.65
Peroxisomes 1.22 2.12 1.56 0.61 -1.25 -0.11 2.64 -0.89 -0.85 -3.89 0.46 2.83 0.22 -0.30 -3.52
Vacuole 2.79 -14.64 -8.95 -20.44 9.22 3.69 -15.32 -16.40 -20.04 10.94 6.02 -22.37 -19.72 -28.12 12.66
Vacuole Periphery 1.34 1.78 1.69 0.80 -1.00 -0.39 2.76 0.10 0.41 -1.66 0.39 2.75 1.56 0.90 -1.77
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with LSB1 cooperatively inhibits the nucleation of actin filaments; short-lived protein whose levels increase in response to thermal stress; induces the formation of the [PIN+] and [RNQ+] prions when overproduced; PIN3 has a paralog, LSB1, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Pin3

Pin3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pin3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available